Serum hepcidin levels and stroke in thalassemia patients

Haematologica

Hepcidin production is homeostatically regulated by iron stores, anemia and hypoxia. We evaluated the effect of iron overload and of ineffective erythropoeisis on hepcidin expression in patients with thalassemia major. Liver hepcidin mRNA levels correlated with hemoglobin concentration and inversely correlated with serum transferrin receptor, erythropoietin and non-transferrin-bound iron. They did not correlate with indices of iron load. Urinary hepcidin levels were disproportionably suppressed in regards to iron burden. We conclude that hepcidin expression is regulated mainly by increased erythropoietic activity rather than by iron load and that hepcidin plays a central regulatory role in iron circulation and iron toxicity in patients with thalassemia.

The Egyptian Journal of Hospital Medicine

Background: Beta thalassemia is a disorder of hemoglobin leading to hemolytic anemia, ineffective erythropoiesis and iron overload that mediates much of the morbidity and mortality of the disease. Hepcidin is a peptide hormone that plays a crucial role in iron homeostasis. Objectives: Here we assessed the value of serum hepcidin level as a marker of iron overload in thalassemia patients. Patients and Methods: This case control study involved 30 thalassemia patients and 10 controls. The patients were selected from the Hematology Department of Ain Shams University Hospitals. We assessed the value of serum hepcidin level and see how it is correlated to values of serum ferritin along with MRI T2*on the liver and the heart in the same patients. Results: The median hepcidin level for cases was significantly lower than that for controls with P value (0.004), but serum hepcidin was not a statistically significant marker of iron overload when correlated with either serum ferritin or hepatic and/or cardiac MRI T2* findings of the patients. However, we found a significant correlation between hepcidin and gender, blood transfusion frequency and hepatitis C infection. Conclusion: hepcidin is not directly correlated to markers of iron overload in thalassemia patients. In these patients with anemia and iron overload, the erythropoietic drive is the dominant factor influencing hepcidin levels. Therefore, hepcidin is not a good marker of iron overload, but rather a good marker of erythropoietic drive.

Indian journal of pediatrics, 2017

To investigate potential usefulness of serum hepcidin in the diagnosis of iron overload in children with β-thalassemia. A study was conducted on 30 thalassemia major (TM), 30 thalassemia intermedia (TI) and 60 healthy children as controls. Serum hepcidin was measured by Human Hepcidin, ELISA Kit. β-thalassemia patients had a higher serum hepcidin compared to the controls (p < 0.001). TM group had higher hepcidin and ferritin compared to the TI group (p = 0.034; < 0.001, respectively). Among controls, hepcidin did not correlate with age (r = 0.225, p = 0.084). Among β-thalassemia patients, it correlated positively with age (r = 0.4; p = 0.001), disease duration (r = 0.5; p < 0.001), transfusion frequency (r = 0.35; p = 0.007), total number of transfusions (r = 0.4; p = 0.003), and ferritin (r = 0.3; p = 0.027). Total hemoglobin and serum ferritin were significantly related to hepcidin, which tended to increase by 0.514 ng/ml with each 1 g/dl rise in hemoglobin (p = 0.023) an...

Annals of the New York Academy of Sciences, 2010

Hepcidin (HAMP) negatively regulates iron absorption, degrading the iron exporter ferroportin at the level of enterocytes and macrophages. We showed that mice with β-thalassemia intermedia (th3/+) have increased anemia and iron overload. However, their hepcidin expression is relatively low compared to their iron burden. We also showed that the iron metabolism gene Hfe is downregulated in concert with hepcidin in th3/+ mice. These observations suggest that low hepcidin levels are responsible for abnormal iron absorption in thalassemic mice and that down-regulation of Hfe might be involved in the pathway that controls hepcidin synthesis in β-thalassemia. Therefore, these studies suggest that increasing hepcidin and/or Hfe expression could be a strategy to reduces iron overload in these animals. The goal of this paper is to review recent findings that correlate hepcidin, Hfe, and iron metabolism in β-thalassemia and to discuss potential novel therapeutic approaches based on these recent discoveries.

Haematologica, 2008

Thalassemia associates anemia and iron overload, two opposite stimuli regulating hepcidin gene expression. We characterized hepatic hepcidin expression in 10 thalassemia major and 13 thalassemia intermedia patients. Hepcidin mRNA levels were decreased in the thalassemia intermedia group which presented both lower hemoglobin and higher plasma soluble transferrin receptor levels. There was no relationship between hepcidin mRNA levels and those of genes controlling iron metabolism, including HFE, hemojuvelin, transferrin receptor-2 and ferroportin. These results underline the role of erythropoietic activity on hepcidin decrease in thalassemic patients and suggest that mRNA modulations of other studied genes do not have a significant impact. © F e r r a t a S t o r t i F o u n d a t i o n © F e r r a t a S t o r t i F o u n d a t i o n © F e r r a t a S t o r t i F o u n d a t i o n E. Camberlein et al. | 112 | haematologica/the hematology journal | 2008; 93(1) © F e r r a t a S t o r t i F o u n d a t i o n © F e r r a t a S t o r t i F o u n d a t i o n © F e r r a t a S t o r t i F o u n d a t i o n 105:4103-5. 9. Kattamis A, Papassotiriou I, Palaiologou D, Apostolakou F, Galani A, Ladis V, et al. The effect of ery-© F e r r a t a S t o r t i F o u n d a t i o n © F e r r a t a S t o r t i F o u n d a t i o n © F e r r a t a S t o r t i F o u n d a t i o n © F e r r a t a S t o r t i F o u n d a t i o n © F e r r a t a S t o r t i F o u n d a t i o n © F e r r a t a S t o r t i F o u n d a t i o n

Blood, 2007

Asian Pacific journal of tropical medicine, 2016

Iron deficiency anemia and iron overload conditions affect more than one billion people worldwide. Iron homeostasis involves the regulation of cells that export iron into the plasma and cells that utilize or store iron. The cellular iron balance in humans is primarily mediated by the hepcidin-ferroportin axis. Ferroportin is the sole cellular iron export protein, and its expression is regulated transcriptionally, post-transcriptionally and post-translationally. Hepcidin, a hormone produced by liver cells, post-translationally regulates ferroportin expression on iron exporting cells by binding with ferroportin and promoting its internalization by endocytosis and subsequent degradation by lysosomes. Dysregulation of iron homeostasis leading to iron deposition in vital organs is the main cause of death in beta-thalassemia patients. Beta-thalassemia patients show marked hepcidin suppression, ineffective erythropoiesis, anemia and iron overload. Beta-thalassemia is common in the Mediterr...

1. d (x, y) ≥ 0. d (x, y) = 0 si y sólo si x = y. 2. d (x, y) = d (y, x) para cada x, y ∈ R n . 3. Se cumple la llamada desigualdad triangular,

Los morlacos y las redes sociales, 2024

El impacto comunicacional que ha generado las re- des sociales en la vida de las personas es una verdad indiscutible de nuestros días; su uso progresivo a la par de los avances tecnológicos y de comunicaciones, las ha convertido en una herramienta clave para los procesos comunicativos y sociales. Pero, ¿cómo ha sido esta transición a la comunicación virtual de la sociedad cuencana en los últimos años? El objetivo de este estudio es analizar las formas de comunicación interpersonal mediante la red social Facebook y observar los efectos que ha tenido en las relacio- nes sociales en Cuenca en comparación con los antiguos medios de comunicación tradicionales. Las preguntas de esta investigación se respondieron a través de entrevistas a profundidad a 30 residentes de Cuenca, Ecuador mediante plataformas en línea. Las respuestas obtenidas demuestran la cantidad de usuarios activos de esta red social que se encuentran satisfechos con sus facilidades, su aprovechamiento para el acceso y difusión de la información tanto para promocionar y publicitar sus negocios, como para informarse sobre noticias de actualidad. Se comprendió también la aceptación que tiene la plataforma dentro de la sociedad considerando la opinión de la muestra en lo referente a si la integración de redes sociales ha mejorado o empeorado las relaciones sociales en la población de Cuenca. Estos resultados indicaron el cambio comunicacional que ha tenido el paso de redes sociales en la ciudad y las diferencias más destacables entre el antes y después de su inmersión en la vida cotidiana.

Aula 03: Propriedades dos fluidos (Massa específica, Peso específico, Viscosidade cinemática, etc) Fluido ideal e escoamento incompressível Equação de estado dos gases Prof. Fabiano Pagliosa Branco Exercícios 1.3. O peso de 3dm 3 de uma substância é 23,5N. A viscosidade cinemática é 10 -5 m 2 /s. Se g=10m/s 2 , qual será sua viscosidade dinâmica nos sistemas SI, CGS e MK*S e em N.min/km 2 1.16. Um fluido escoa sobre uma placa com o diagrama dado. Calcular: a) A função da velocidade em relação distância da placa v=f(y). b) A tensão de cisalhamento junto a placa.