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Acute scrotum secondary to filarial infection: A case report

2002

A 23-year-old man immigrated from Sri Lanka came to our observation for an acute painful volume increase of the right scrotum without fever. Clinical examination suggested a diagnosis of testis torsion. An exploratory surgical procedure was performed. An inflammatory spermatic cord and epididymis with a purple nodule of the middle portion were found. The nodule was excised and sent to pathologist that diagnosed a filarial infection. The patient was successfully treated with diethylcarbamazine.

International Urology and Nephrology 34: 385–386, 2002. © 2003 Kluwer Academic Publishers. Printed in the Netherlands. 385 Acute scrotum secondary to filarial infection: A case report Mauro Pacella, Carlo Corbu, Angelo Naselli, Paolo Quilici & Giorgio Carmignani Departments of Urology and Pathology, San Martino Hospital, University of Genoa, Italy Abstract. A 23-year-old man immigrated from Sri Lanka came to our observation for an acute painful volume increase of the right scrotum without fever. Clinical examination suggested a diagnosis of testis torsion. An exploratory surgical procedure was performed. An inflammatory spermatic cord and epididymis with a purple nodule of the middle portion were found. The nodule was excised and sent to pathologist that diagnosed a filarial infection. The patient was successfully treated with diethylcarbamazine. Key words: Case report, Epididymitis, Filariasis Introduction Genital presentation of filarial disease is common in endemic areas of the world like Sri Lanka [1]. Scrotal elephantiasis, hydrocele and acute illness involving the epididymis and spermatic cord are the most frequent of many such presentations. In non endemic areas, however, bancroftian filariasis is a rare cause of acute scrotum that can be diagnosed only by histological examination after surgery, performed for a suspected testis torsion [2]. Case report A 23-year-old man immigrated from Sri Lanka came to our observation for an acute painful swelling volume increase of the right scrotum without fever. Physical examination evidenced one concrete, intensely tender volume increase of the right epididymis and spermatic cord. Clinical examination suggested diagnosis of testis torsion. Laboratory investigations did not show any significant alteration. An exploratory surgical procedure was performed through a scrotal access. We found an inflammatory spermatic cord and epididymis and a purple nodule of the middle portion of epididymis that was easy excised and sent to pathologist for examination. Although the testis appeared normal, it was biopsied to obtain histological confirmation. The specimen contained enlarged clusters of vessels with bancroftian filarial larvae (Wuchereria bancrofti), in a pattern of tissue reaction including exudative, infiltrative and granulomatous lesions (Figures 1, 2). The testicular biopsy did not evidence any histological alteration. The patient was successfully treated with diethylcarbamazine. Discussion Filariasis is mainly caused by Wuchereria bancrofti. The larvae enter the blood through the wound made by mosquito (Culcicine or anopheline mosquito, Aedes polynesiensis). They then migrate to lymph glands where they mature in adult worms ending the incubation period. Periaortic, iliac, inguinal lymph vessels are preferred sites of maturation. An intense immune reaction to adult worms is responsible of repeated lymphangitis and fever that characterize the early clinical phase of the disease. A subsequent fibrous reaction and the worms invasion of lymph vessels are responsible of lymph stasis that can result in the most relevant clinical manifestations of the late clinical phase of the disease. Genital presentation occurs commonly in endemic areas of the world like Sri Lanka [1] and is mainly represented by genital elephantiasis, hydrocele and funiculoepididymitis. In non endemic areas, however, bancroftian filariasis is a rare cause of acute scrotum [2]. Our patient presented an acute scrotum without fever mimicking a testis torsion. Diagnosis of filariasis could only be achieved by histological examination after surgery. Nowadays it could be increasingly easier to observe such clinical 386 Figure 1. Longitudinal section of an adult worm in a lymphatic vessel, surrounded by fibrin and a dense mono- and polymorphonuclear infiltrate. In the periphery (top half of photograph) the vessel wall partially destroyed by the inflammation is evident (stain: EE; original magnification: 100×). Figure 2. High magnification showing and adult worm (longitudinal section) within a lymphatic vessel whose walls are partially destroyed by a dense flogistic infiltrate. Worm cuticle and hypodermis with characteristic rings and bowel tract are evident (stain: Trichrome; original magnification: 250×). case in our first generation multiethnic society due to intense immigration from endemic areas. 2. Mussner W, Bosch J, Buhl D et al. Filaria: a tropical disease as the etiology of acute scrotum. Urologe A 1997; 36(1): 84–86. References Address for correspondence: Dr Angelo Naselli, Via Guerrazzi 24, 16146, Genova, Italy Phone: +390105552430; Fax: +39010354004 E-mail: [email protected] 1. Weerasooriya MV, Weerasooriya TR, Gunawardena NK et al. Epidemiology of bancroftian filariasis in three suburban areas of Matara. Sri Lanka Annals of Tropical Medicine and Parasitology 2001; 95(3): 263–273.