Contents Vol. 36, 2013

Vol. 36, 2013 International Society of Blood Purification Editorial Representative G. Lonnemann, Hannover Official Journal of the International Society of Blood Purification (ISBP) Official Journal of the Japan Society for Blood Purification in Critical Care (JSBPCC) Official Journal of the Japanese Society of Hemodiafiltration (JS-HDF) Official Journal of the Chinese Society of Blood Purification Administration (CSBPA) Japan Society for Blood Purification in Critical Care Editorial Representatives S. Oda, Chiba K. Matsuda, Yamanashi Japanese Society of Hemodiafiltration Editorial Representative A. Yamashita, Tokyo Chinese Society of Blood Purification Administration Editorial Representative M. Wang, Beijing Founded 1983 by K. Schaefer; continued by L.W. Henderson (1989–2000), K.M.L. Leunissen (2001–2007) Editor-in-Chief C. Ronco, Vicenza Critical Care Nephrology Peritoneal Dialysis Hemodialysis Stefan D. Anker, Berlin Massimo Antonelli, Rome Sean M. Bagshaw, Edmonton, Alta. Ian C. Baldwin, Heidelberg, Vic. Fabio Barbarigo, Vicenza Rinaldo Bellomo, Melbourne, Vic. Guido Bertolini, Ranica W. Kline Bolton, Charlottesville, Va. Joseph V. Bonventre, Boston, Mass. John Burkart, Winston-Salem, N.C. Jorge Cerda, Albany, N.Y. Lakhmir Chawla, Washington, D.C. Maria Rosa Costanzo, Naperville, Ill. Dinna N. Cruz, Vicenza Andrew Davenport, London Salvatore Di Somma, Rome Enrico Fiaccadori, Parma Mihai Gheorghiade, Chicago, Ill. Stuart L. Goldstein, Cincinnatti, Ohio Michael Haase, Magdeburg William L. Henrich, San Antonio, Tex. Patrick Honoré, Brussels Eric Hoste, Ghent Nevin Katz, Washington, D.C. Richard Amerling, New York, N.Y. George L. Bakris, Chicago, Ill. Jordi Bover, Barcelona Joanne M. Bargman, Toronto, Ont. Edwina A. Brown, London Giovambattista Capasso, Naples Ricardo Correa-Rotter, Mexico Carlo Crepaldi, Vicenza Olivier Devuyst, Zurich Mariano Feriani, Mestre Fredric Finkelstein, New Haven, Conn. Guido Garosi, Siena David Goldsmith, London Roger N. Greenwood, Stevenage Olof Heimburger, Stockholm Achim Joerres, Berlin Raymond Krediet, Amsterdam Zhi-Hong Liu, Nanjing Francesca Martino, Vicenza Rajnish Mehrotra, Seattle, Wash. Piergiorgio Messa, Milan Andrew Mooney, Leeds K. Shivanand Nayak, Hyderabad Karl D. Nolph, Columbia, Mo. Pedro Aljama, Cordoba Stefano Bianchi, Arezzo Prem K.G. Chandran, Des Moines, Iowa John Collins, Auckland Rosanna Coppo, Turin Adrian A. Covic, Iasi Mario Cozzolino, Milan Angel M. de Francisco, Santander Francesco Galli, Perugia Victor Gura, Beverly Hills, Calif. Stephan von Haehling, Berlin Jorgen Hegbrant, Lund Nicholas Hoenich, Newcastle upon Tyne Alp Ikizler, Nashville, Tenn. Hideki Kawanishi, Hiroshima William F. Keane, Minneapolis, Minn. John A. Kellum, Pittsburgh, Pa. Peter Kotanko, New York, N.Y. Martin K. Kuhlmann, Berlin Nathan W. Levin, New York, N.Y. Francesco Locatelli, Lecco Peter McCullough, Novi, Mich. Madhukar Misra, Columbia, Mo. (Continued on next page) Basel • Freiburg • Paris • London • New York • Chennai • New Delhi • Bangkok • Beijing • Shanghai • Tokyo • Kuala Lumpur • Singapore • Sydney (Continued) Critical Care Nephrology Peritoneal Dialysis Hemodialysis Norbert Lameire, Ghent Alan Maisel, San Diego, Calif. Alexandre Mebazaa, Paris Ravindra L. Mehta, San Diego, Calif. Bruce Molitoris, Indianapolis, Ind. Patrick T. Murray, Dublin Federico Nalesso, Vicenza Mark Okusa, Charlottesville, Va. Heleen M. Oudemans-Van Straaten, Amsterdam Paul M. Palevsky, Pittsburgh, Pa. Didier Payen, Paris Pasquale Piccinni, Vicenza Piotr Ponikowski, Wroclaw John R. Prowle, London V. Marco Ranieri, Turin Zaccaria Ricci, Rome Marie Schetz, Leuven Andrew Shaw, Durham, N.C. Shigehiko Uchino, Tokio David Warnock, Birmingham, Ala. Miguel Perez Fontan, A Coruña Beth M. Piraino, Pittsburgh, Pa. Giuseppe Remuzzi, Bergamo Miguel C. Riella, Curitiba Bengt Rippe, Lund Jean-Philippe Ryckelynk, Caen Dirk G. Struijk, Amsterdam Isaac Teitelbaum, Aurora, Colo. Josep Teixido-Planas, Badalona Wim Van Biesen, Ghent Christian Verger, Pontoise Enrico E. Verrina, Genoa Janusz Witowski, Poznan Allen R. Nissenson, Los Angeles, Calif. Mark Okusa, Charlottesville, Va. Vincenzo Panichi, Pisa Mauro Pittiruti, Rome Michael Rocco, Winston-Salem, N.C. Mitchell Rosner, Charlottesville, Va. Antonio Santoro, Bologna Daniel Schneditz, Graz Stanley Shaldon, Monaco Sergio Stefoni, Bologna Peter Stenvinkel, Stockholm Andrea Stopper, Bad Homburg Ciro Tetta, Bad Homburg Angela Y. Wang, Hong Kong Richard Ward, Louisville, Ky. Dick de Zeeuw, Groningen Robert Zietse, Rotterdam Carmine Zoccali, Reggio Calabria © 2013 S. Karger AG, Basel E-Mail [email protected] www.karger.com Contents Vol. 36, 2013 No. 1 No. 2 Chronic Kidney Disease Old Outcomes and New Answers Guest Editors: Biagio R. Di lorio, Solofra, Mitchell H. Rosner, (Charlottesville, Va.); Vincenzo Bellizzi, (Salerno) Editorial 65 Kidney Attack: Overdiagnosis of Acute Kidney Injury or Comprehensive Definition of Acute Kidney Syndromes? Ronco, C. (Vicenza) Editorial 5 Chronic Kidney Disease: Old Outcomes and New Answers Rosner, M.H. (Charlottesville, Va.) 7 Genomics and Proteomics: How Long Do We Need to Reach Clinical Results? Matafora, V. (Naples/Milan); Bachi, A. (Milan); Capasso, G. (Naples) 12 Paricalcitol and Cardiorenal Outcome: From the IMPACT Study to Clinical Practice Bellasi, A. (Como/Milan); Galassi, A. (Desio); Salvi, P.; Cozzolino, M. (Milan) 17 Coronary Artery Calcification and Outcomes in Diabetic Patients with and without Chronic Kidney Disease Russo, D. (Naples); Morrone, L.F.P. (Benevento); Imbriaco, M.; Pota, A.; Russo, L.; Scognamiglio, B. (Naples); Sorrentino, R. (Pompei) 21 Does It Make Sense to Measure Only the Brachial Blood Pressure? Salvi, P. (Milan); Bellasi, A. (Como); Di Iorio, B. (Solofra) 26 Subendocardial Viability Ratio Predicts Cardiovascular Mortality in Chronic Kidney Disease Patients Di Micco, L. (Solofra); Salvi, P. (Milan); Bellasi, A. (Como); Sirico, M.L.; Di Iorio, B. (Solofra) 29 Higher Doses of Erythropoietin-Stimulating Agents and Hyporesponsiveness to Their Effects Are Associated with Increased Mortality among Prevalent Hemodialysis Patients Nishio, A.; Chhatkuli, B.P.; Ma, J.Z.; Kalantari, K. (Charlottesville, Va.) 37 Therapy of Anemia: Is It Only a Number to Reach or Are There Other Variables to Control? Del Vecchio, L.; Locatelli, F. (Lecco) 41 Low-Protein Diet or Nutritional Therapy in Chronic Kidney Disease? Bellizzi, V. (Salerno) 47 Personal Daily Dialysis: The Evolution of the Artificial Kidney Kim, J.C.; Ronco, C. (Vicenza) 52 FGF23: A Mature Renal and Cardiovascular Risk Factor? Zoccali, C. (Reggio Calabria); Yilmaz, M.I. (Etlik-Ankara); Mallamaci, F. (Reggio Calabria) 58 Blood Pressure Variability in Chronic Kidney Disease Patients Mallamaci, F.; Tripepi, G. (Reggio Calabria) 63 Author Index/Subject Index Original Papers 69 Conversion from Epoetin and Darbepoetin to C.E.R.A. in Non-Dialysis CKD Patients: A Multicenter Italian Prospective Study in Nephrology Practice Minutolo, R.; Conte, G. (Naples); Cozzolino, M. (Milan); Polito, P. (Tivoli); Manno, C. (Bari); Di Iorio, B.R. (Solofra); Santoro, D. (Messina); Di Luca, M. (Pesaro); Nappi, F. (Nola); Feriozzi, S. (Viterbo); Sasso, F.C.; De Nicola, L. (Naples) 78 Elevated Removal of Middle Molecules without Significant Albumin Loss with Mixed-Dilution Hemodiafiltration for Patients Unable to Provide Sufficient Blood Flow Rates Potier, J. (Cherbourg); Le Roy, F. (Rouen); Faucon, J.P. (Elbeuf); Besselièvre, T. (Alençon); Renaudineau, E. (Saint-Malo); Farquet, C. (Cholet); Soihan, P. (Quimper); Touzard, D. (Laval); Djema, A. (Cholet); Ilinca, T. (Angers) 84 A Comparison of the Potential for Acute Cardiopulmonary Adverse Effects in Dogs during Continuous Veno-Venous Hemofiltration with Accusol 35 Solution with and without Induced Calcium Carbonate Particles McKee, J.S.; Brooks, B.D.; Daller, J.R.; Safron, J.; Gass, J.H. (Round Lake); Pantaleone, D.P.; Zieske, P.A. (McGaw Park, Ill.); Mussi, P.; Moreaux, B. (Braine-l’Alleud) 92 Therapeutic Apheresis in Pediatric Patients with Acute CNS Inflammatory Demyelinating Disease Koziolek, M.; Mühlhausen, J.; Friede, T.; Ellenberger, D.; Sigler, M.; Huppke, B.; Gärtner, J.; Müller, G.-A.; Huppke, P. (Göttingen) 98 Diastolic Dysfunction and High Levels of New Cardiac Biomarkers as Risk Factors for Cardiovascular Events and Mortality in Hemodialysis Patients Quiroga, B.; Villaverde, M.; Abad, S.; Vega, A.; Reque, J.; López-Gómez, J.M. (Madrid) 107 Myoglobin Removal Using High-Volume High-Flux Hemofiltration in Patients with Oliguric Acute Kidney Injury Guzman, N.; Podoll, A.S.; Bell, C.S.; Finkel, K.W. (Houston, Tex.) 116 Short- and Long-Term Impact of Subtotal Parathyroidectomy on the Achievement of Bone and Mineral Parameters Recommended by Clinical Practice Guidelines in Dialysis Patients: A 12-Year Single-Center Experience Tsai, W.-C.; Peng, Y.-S.; Yang, J.-Y.; Hsu, S.-P.; Wu, H.-Y.; Pai, M.-F.; Chang, J.-F.; Chen, H.-Y. (New Taipei City) 122 Compliance with Mineral Metabolism Targets in Haemodialysis Patients: Moving Backwards? Palomares, I.; Ramos, R. (Madrid); Martin-Malo, A. (Cordoba); Merello, J.I.; Praga, M.; Luño, J. (Madrid); de Francisco, A.L.M. (Santander) on behalf of the ORD Group © 2013 S. Karger AG, Basel E-Mail [email protected] www.karger.com Access to full text and tables of contents, including tentative ones for forthcoming issues: www.karger.com/bpu_issues 136 A Target-Oriented Algorithm for Citrate-Calcium Anticoagulation in Clinical Practice Strobl, K.; Hartmann, J. (Krems); Wallner, M. (Wels); Brandl, M.; Falkenhagen, D. (Krems) Commentary 280 Methylation Status of Immune Response Genes Promoters in Cell-Free DNA Differs in Hemodialyzed Patients with Diabetic Nephropathy According to the Intensity of Anemia Therapy Korabecna, M.; Pazourkova, E.; Horinek, A.; Mokrejsova, M.; Tesar, V. (Prague) 287 Elimination of Middle-Sized Uremic Solutes with High-Flux and High-Cut-Off Membranes: A Randomized in vivo Study 132 Guideline Bone Disease Amerling, R. (New York, N.Y.) Kneis, C. (Berlin); Beck, W. (Hechingen); Boenisch, O.; Klefisch, F. (Berlin); Deppisch, R. (Hechingen); Zickler, D.; Schindler, R. (Berlin) Case Report 295 Effect of Different Hemodialyzers on Serum Levels of 112 A Lethal Case of Influenza and Type 5 Cardiorenal Syndrome Larsen, T.R.; Kinni, V.; Zaks, J.; David, S.; McCullough, P.A. (Southfield, Mich.) Interleukin-6, Interleukin-10 and Interleukin-18 Shu, K.-H.; Cheng, C.-H.; Wu, M.-J.; Chen, C.-H.; Yu, T.-M.; Chuang, Y.-W.; Huang, S.-T.; Tsai, S.-F.; Lo, Y.-C. (Taichung) Case Report 274 Successful Treatment of Extreme Hyponatremia in an Anuric No. 3–4 Patient Using Continuous Venovenous Hemodialysis Viktorsdottir, O.; Indridason, O.S.; Palsson, R. (Reykjavik) Papers and Abstracts 16th International Conference on Dialysis 301 Acknowledgement to the Reviewers 151 Advances in Chronic Kidney Disease 2014 January 22–25, 2014, Caesars Palace, Las Vegas, Nev. Editors: P. Kotanko; N.W. Levin (New York, N.Y.); C. Ronco (Vicenza) (available online only) Original Papers 265 Pre-Emptive Replacement of Water Treatment Components Improves Responsiveness to Erythropoiesis-Stimulating Agents in Maintenance Haemodialysis Patients: A Quality Improvement Report Singh, S.K.; Loucaidou, M.; Power, A.; Beagle, S.; Nevin, M.; Edwards, C.; Corbett, R.; Ashby, D.R.; Duncan, N.; Choi, P. (London) S. Karger Medical and Scientific Publishers Basel • Freiburg • Paris • London • New York • Chennai • New Delhi • Bangkok • Beijing • Shanghai • Tokyo • Kuala Lumpur • Singapore • Sydney Disclaimer The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. IV Blood Purif Vol. 36, 2013 All rights reserved. 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