Full blood count normal reference values for adults in France

Downloaded from jcp.bmj.com on October 31, 2013 - Published by group.bmj.com Full blood count normal reference values for adults in France Xavier Troussard, Sylviane Vol, Edouard Cornet, et al. J Clin Pathol published online October 29, 2013 doi: 10.1136/jclinpath-2013-201687 Updated information and services can be found at: http://jcp.bmj.com/content/early/2013/10/29/jclinpath-2013-201687.full.html These include: Data Supplement "Supplementary Data" http://jcp.bmj.com/content/suppl/2013/10/29/jclinpath-2013-201687.DC1.html References This article cites 10 articles, 1 of which can be accessed free at: http://jcp.bmj.com/content/early/2013/10/29/jclinpath-2013-201687.full.html#ref-list-1 P<P Email alerting service Published online October 29, 2013 in advance of the print journal. Receive free email alerts when new articles cite this article. Sign up in the box at the top right corner of the online article. 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To view please visit the journal online (http://dx.doi.org/10.1136/ jclinpath-2013-201687). 1 Laboratoire d’Hématologie, CHU Côte de Nacre, Caen Cedex 9, France 2 IRSA, La Riche Cedex, France 3 Service d’Hématologie Biologique, CHU Cochin-Port Royal, Paris Cedex 14, France 4 Laboratoire Hémato-biologie, CH Cahors, Cahors, France 5 Laboratoire d’Hématologie, CHU Timone, Marseille Cedex 5, France 6 Marketing Hématologie, Siemens Healthcare Diagnostics, Saint Denis, France 7 Service d’Hématologie biologique, Hôpital Européen Georges Pompidou, Paris, France 8 Laboratoire d’Hématologie, CHU Toulouse—Rangueil, Toulouse Cedex 9, France Correspondence to Dr Xavier Troussard, Laboratoire d’Hématologie, CHU Côte de Nacre, Caen 14000, France; [email protected] Received 16 April 2013 Revised 17 September 2013 Accepted 23 September 2013 To cite: Troussard X, Vol S, Cornet E, et al. J Clin Pathol Published Online First: [please include Day Month Year] doi:10.1136/jclinpath2013-201687 ABSTRACT Aims To determine full blood count (FBC) normal reference values for adults. Methods FBC normal values for healthy adults were defined, after establishing preanalytical conditions, in a population of 33 258 subjects, 19 612 men and 13 646 women. The values were established after excluding from this population all people having conditions liable to modify, directly or indirectly, FBC parameters. Results Results for values of standard parameters are provided in detail for each parameter, by sex and by age group from 16 to 69 years of age. In addition, we present FBC values from a population of 339 subjects aged over 69 years with no comorbidities. Conclusions These normal values are proposed for use in everyday practice. They make it possible to distinguish, without ambiguity, a normal situation from a pathological situation. Moreover, they might be used over all mainland France. The full blood count (FBC) is the most frequently requested laboratory test in France. The wealth of information provided by this multiparameter analysis can notably suggest specific diagnoses and can lead to discovery of a haematological disease in a fortuitous and timely manner so that appropriate clinical management can be instigated. Requesting physicians lacking a solid haematology background base their interpretation of an FBC on the quantitative reference values provided by the laboratory. In France, as a usual practice, patients consult or receive, in most cases, the results of their FBC, read the results by themselves and then attempt to interpret them and to compare them with the reference values given on the results sheet. The quality of laboratory tests is constantly improving. The technological development of analysers and control over the analytical phase reduce the risk of having to question the accuracy of the quantitative data of the FBC. Nevertheless, patients present to haematologists after interpreting their values as abnormal in comparison with the reference values given on their results sheet. There is no need to carry out structured surveys to demonstrate the very wide variability in the reference values provided by laboratories in mainland France. Clinical pathology is currently undergoing change and restructuring and a regulatory requirement for all laboratories is to prove their Troussard X, et al. JArticle Clin Patholauthor 2013;0:1–4. doi:10.1136/jclinpath-2013-201687 Copyright (or their employer) 2013. accreditation procedures and hence to have recognised and validated reference values. A group of experts from the French-Speaking Cellular Hematology Group propose on the basis of established methodological principles FBC normal reference values for use by all clinical pathology laboratories in mainland France. MATERIALS AND METHODS Population Data from 142 110 adult subjects, 63 729 men (44.8%) and 78 381 women (55.2%), were analysed. All subjects were aged 16–69 years and had a periodic health assessment (PHA) at the Inter-Regional Health Institute (IRSA) between 1 January 2008 and 31 July 2010. IRSA consists of 11 Prevention and Public Health Centers (CPSP) located in the Central-West area of France. The number of subjects from each CPSP were: La Riche: 21 307 (15%), Hérouville-St-Clair: 20 981 (15%), St-Lô: 6747 (5%), Alençon: 11 605 (8%), Le Mans: 21 806 (15%), Angers: 19 812 (14%), Cholet: 7869 (5.5%), Saint Doulchard: 6217 (4.5%), Châteauroux: 10 789 (8%), Le Havre: 6727 (5%) and Laval: 8250 (6%). French legislation does not allow knowing the ethnicity of patients. However, the regions covered by the study are not known to be regions with a high percentage of non-Caucasians. In France, the PHA is a regulatory service governed by law and available to all people affiliated to the general health insurance scheme, which covers 85% of the French population. The content of the PHA is determined by a reference document under the authority of the National Health Insurance Fund (Caisse Nationale d’Assurance Maladie) with input from medical experts. It is updated periodically and consists of three parts: (1) a selfquestionnaire (146 items) for the collection of socioprofessional and family data, behaviours notably diet habits, physical activity, habits of smoking and alcohol, and the subject’s past and present health status, (2) laboratory tests including an FBC, lipids profile, a blood glucose measurement, liver function tests, and a urinary dipstick test for glucose, proteins, blood and acetone. Other tests (ferritin, serology for hepatitis B and C) may be added according to age, sex and context. HIV serology can also be carried out on the patient’s request during the medical visit and (3) a medical Produced by BMJ Publishing Group Ltd under licence. 1 Original article examination based on the preceding elements to establish a summary of the subject’s health. A total of 142 110 individuals were initially analysed of whom 42 589 (30%) were in a situation of deprivation. The target populations in precarious situations are all remote system health people: lack of identification of referring physician, homelessness, unemployed, recipients of minimum income or assisted contracts. The score EPICES (Evaluation of insecurity and Health Inequalities in Health Examination Centers) is based on 11 questions to determine if a person is in a precarious situation.1 Given that the percentage of deprived individuals in the French population is estimated at 13%, the initial population was rectified in line with this criterion. A random number was assigned to every precarious subject and 27 717 of them, the ones with the n lowest random numbers, were excluded. After rectification, the population consisted of 114 393 subjects, including 51 636 men (45%), 62 757 women (55%), and 14 872 precarious subjects (13%). In order to determine normal FBC values in healthy subjects, 81 135 subjects were excluded from our study because of criteria liable to directly or indirectly modify FBC parameters. Eighteen exclusion criteria were used (table 1), most commonly ‘medication use’ in 58 009 subjects (52.5%) or ‘follow-up for disease’ in 23 150 subjects (21%). In the end, 33 258 subjects, 19 612 men (59%) and 13 646 women (41%), were used to determine normal values in healthy adult subjects. Note that our study does not allow excluding patients with iron deficiency and/or thalassaemia/haemoglobinopathies. The FBC was performed on an Advia 2120 analyser (Siemens France Holding SAS, 9 boulevard Finot—93 527 Saint-Denis Cedex 2, France) that was quality control tested three times per week by Eurocell Diagnostics (EUROCELL Diagnostics, 27, rue du Village de la Métairie—35131 Chartres de Bretagne, France) using three samples (low, normal, high) with a monthly report of results. Haematocrit on ADVIA 2120 is calculated. The result comes from mean cell volume (MCV) (measure) and red blood cell (RBC) (measure) with a cytometry flow technology. MCV on ADVIA system is measured directly cell by cell after a specific reaction used RBCs reagent. No impact of potential residual plasma could be observed, as with a manual technology. International units were used.2 Statistics All analyses were carried out using Number Crunching Statistical Software 2007. The age groups had a width of 10 years, with the exception of one 4-year group (16–19 years) and four 5-year groups in women aged 40–59 years in order to refine FBC changes associated with the menopause. FBC variables by age and sex were described with means and SDs as well as by 23 percentiles, from the 1st to the 99th. The 2.5 and 97.5 percentiles were used to describe normal values. When establishing the normal values, adjacent age groups were merged when the statistical difference between them was non-significant. Comparisons between age ranges and between sexes were made using Kruskal–Wallis test. RESULTS Full blood count Blood samples from subjects in a fasting state were collected from the elbow crease between 07:00 and 10:30 into Sarstedt tubes with K3 EDTA. They reached the IRSA central laboratory in Tours in less than 5 h. This laboratory is ISO 9001 certified. Table 1 Exclusion criteria applied to the initial population of 114 393 subjects, of whom 14 872 were in a situation of precariousness, to obtain the analysis reference population of 32 919 individuals 2 Exclusion criteria Men (%) Women (%) Total (n) Taking medication Follow-up/treatment for disease Asthma Regular cough Blood in stools Personal cardiovascular history Transfusion Polyps Blood donation less than 3 months ago Pathological bleeding Diabetes Epilepsy Tuberculosis Follow-up for kidney failure Pregnancy Ulcerative colitis Crohn’s disease Colon cancer Population without exclusion criteria (%, n) 37.9 21.4 11.1 11.0 7.8 7.6 3.9 7.2 5.5 64.5 25.1 10.9 6.3 6.5 6.5 7.5 5.2 4.3 6.1 3.1 2.6 2.1 2.4 1.2 1.5 0.8 0.5 1.0 0.7 0.6 0.2 0.3 0.3 0.2 37.6% 21.6% n=19 393 n=13 526 58 009 23 150 10 446 8730 7268 7120 5920 5761 4958 3265 2663 2119 1257 635 534 590 255 232 28.8% n=32 919 The selected population, with age and sex distribution, is shown in table 2. It consists of 32 919 subjects, including 19 393 men and 13 526 women, aged 16–69 years, and closely representative of the population of mainland France. In addition, 339 subjects aged 70–79 years, 219 men and 120 women, were also analysed, giving a total of 33 258 subjects. Results for the values of standard parameters used in everyday practice for the interpretation of the FBC are provided for every parameter, by sex and by age group, in the appendix section. The summary table (table 3) provides reference values by sex with upper and lower limits for subjects aged 16–69 years. Given the fact that a high percentage (91.7%) of subjects aged 70–79 are not eligible in a reference population, we present reference values for that healthy limited population (339 subjects) with no known comorbidities in online supplementary appendix 1. Variation between different age groups was observed. Red cell parameters (see online supplementary appendix 2): For haemoglobin, in the age group 16–69 years, the mean Table 2 Age distribution of analysis population Age group (years) 16–19 20–29 30–39 40–49 50–54 55–59 60–64 65–69 Total Men 1387 3054 4258 5146 3801 1747 19 393 Women 0901 1370 2711 1873 1932 1870 1578 1291 13 526 Total 2288 4424 6969 8951 7249 3038 32 919 Troussard X, et al. J Clin Pathol 2013;0:1–4. doi:10.1136/jclinpath-2013-201687 Original article Table 3 Full blood count normal reference values defined by values comprised between the 2.5 and 97.5 percentiles Men (years) Min–max Haematocrit (%) 16–69 39.2–48.6 Haemoglobin (g/L) 16–69 134–167 Red blood cells (1012/L) 16–29 30–59 60–69 16–19 20–39 40–49 50–59 60–69 16–19 20–69 16–69 16–49 50–59 60–69 4.53–5.79 4.38–5.65 4.28–5.57 78.0–91.9 79.6–94.0 81.0–94.9 82.2–96.3 82.1–97.0 26.3–32.1 27.3–32.8 324–363 4.09–11.00 4.06–10.46 4.05–9.92 Neutrophils (109/L) 16–49 50–59 60–69 1.780–6.946 1.915–6.634 1.847–6.138 Eosinophils (109/L) 16–19 20–29 30–59 60–69 16–39 40–69 16–39 40–69 16–39 40–69 0.046–0.630 0.048–0.593 0.046–0.547 0.052–0.576 0.000–0.097 0.000–0.091 1.340–3.919 1.241–3.617 0.228–0.773 0.233–0.725 16–59 60–69 16–69 172–398 161–393 7.4–10.8 MCV (fL) MCH (pg/cell) MCHC (g/L) Leucocytes (109/L) Basophils (109/L) Lymphocytes (109/ L) Monocytes (109/L) Platelets (109/L) MPV (fL) Women (years) Min–max 16–44 45–54 55–69 16–49 50–54 55–69 16–29 30–49 50–69 16–19 20–29 30–39 40–69 34.4–43.9 34.7–44.6 35.9–44.6 115–149 118–151 121–150 4.01–5.19 3.93–5.09 3.99–5.12 75.7–92.7 74.7–94.2 77.9–95.3 79.9–95.6 16–29 30–69 16–69 16–44 45–49 50–54 55–69 16–44 45–49 50–54 55–69 16–19 20–49 50–69 24.4–32.1 26.4–32.6 319–358 4.02–11.42 4.01–11.02 3.78–9.70 3.78–9.42 1.750–7.500 1.812–7.154 1.720–6.299 1.692–5.839 0.040–0.576 0.041–0.549 0.044–0.474 16–19 20–69 16–29 30–69 16–29 30–49 50–69 16–54 55–69 16–69 0.000–0.081 0.000–0.085 1.370–3.966 1.240–3.561 0.201–0.714 0.205–0.663 0.192–0.608 185–445 187–420 7.5–10.9 Min, minimum, 2.5 percentiles; Max, maximum, 97.5 percentiles. MCH, mean corpuscular haemoglobin; MCHC, mean cell haemoglobin concentration; MCV, mean cell volume; MPV, mean platelet volume. value is 150 g/L (134–167 g/L) for men and 134 (117–150) for women ( p<10−6). For women, haemoglobin concentration is higher in the age group 45–69 years than in the age group 16– 44 years (135 vs 133 g/L, p<10−6). A slight variation in haemoglobin concentration, namely, a significant increase ( p<10−6), is seen in women in the age groups (45–49 vs 50–54, p=10−3; 50–54 vs 55–59, p=0.399 (NS); 55–59 vs 60–69, p=8×10−4) in comparison with lower age groups in which the level is stable. For the MCV, the mean value is 87.3 fL (80.2–95.0) in men and 87.5 (78.4–95.3) in women ( p=0.014). Regular increases in the values with increasing age are seen in both sexes (significant increase at each age group and in both sexes, p<10−6). The variation is approximately 3 fL for the age limits at the extremities. For the mean cell haemoglobin concentration, the mean value is 343 g/L (324–363) for men and 338 (319– 358) for women ( p<10−6). For the mean corpuscular haemoglobin, the mean value is 30.0 pg/cell (27.2–32.8) in men and 29.7 (26.1–32.5) in women ( p<10−6). Troussard X, et al. J Clin Pathol 2013;0:1–4. doi:10.1136/jclinpath-2013-201687 Platelet parameters (see online supplementary appendix 3): For the platelet count, mean values in women are higher than those in men. The values are, respectively, 269×109/L (171– 397) in men and 394×109/L (186–440) in women ( p<10−6). This difference is seen in all age groups analysed ( p<10−6 for each age group). For the mean platelet volume, the mean value is 8.7 fL (7.4–10.8) in men and 8.8 fL (7.5–10.9) in women ( p<10−6). White cell parameters (see online supplementary appendix 4): The values of white cell parameters are expressed in absolute values (#) not percentages (%) (table 3). The mean value of leucocytes is 6.6×109/L (4.1–10.8) in men and 6.6×109/L (3.9–10.9) in women ( p=0.130). For neutrophils, the mean value is 3.6×109/L (1.8–6.8) in men and 3.7×109/L (1.7–7.1) in women ( p<10−6). For eosinophils, the mean value is 0.21×109/L (0.05–0.56) in men and 0.19×109/L (0.04–0.53) in women ( p<10−6). For basophils, values are identical in men and women: 0.04×109/L (0.00–0.09) ( p<10−6). For lymphocytes, the mean value is 2.3×109/L (1.3–3.8) in men and 2.2×109/L (1.3–3.6) in women ( p<10−6). For monocytes, the value is 0.43×109/L (0.23–0.74) in men and 0.38×109/L (0.20–0.65) in women ( p<10−6). DISCUSSION The FBC is the most frequently requested laboratory test: it guides later additional investigations essential for diagnosing and monitoring the patient. It provides valuable information, provided that it is possible to distinguish between a normal situation and a pathological situation in a very diverse range of conditions. Under French regulations, all public- and private-sector laboratories must give normal reference ranges on FBC results sheets. These values vary widely between laboratories and are liable to lead to interpretation errors and also unnecessary worry in patients. As other tests, the results of FBC analyses could be dependent on the analytical phase. Furthermore, technical advances in automation and the continual improvement of quality programmes also contribute to the high homogeneity of the analytical phase of the FBC. The auto-analyser we used could have impacted on the values obtained, especially values from healthy subjects. If they do exist, they are probably minor and non-significant with the proviso that all requirements of the quality programme are respected ( preanalytical, internal and external quality controls). Mainland France, situated on the 45th North parallel, has a temperate climate even if mountain ranges are present. The French population living at an altitude higher than 2500 m is limited and so variations due to environmental pressure are of little significance. Although individual variations, in particular ethnic characteristics, cannot be ignored, we can consider that in mainland France, individuals do not exhibit variation inherent to where they live or where the blood sample was collected. For this reason, the values that we report in this study can be used by all laboratories in mainland France, regardless of the technical analysis platform in use, and their adoption by all laboratories would eliminate the risk of interpretation errors by physicians or patients. Defining reference values is a delicate undertaking. The studies in the literature that include a sufficient number of patients investigated with current methods for performing an FBC3 4 are limited. The FBC normal values given in French and foreign textbooks are also arbitrary, lacking references and usually old.5 In September 1997, the National Health Accreditation and Evaluation Agency (Agence Nationale 3 Original article d’Accréditation et d’Evaluation en Santé) published a document giving FBC normal values based on a literature review covering articles less than 10-years-old and involving more than 200 patients.6 Laboratories are therefore faced with the problem of providing normal values and not having national recommendations. With accreditation programmes, this problem is becoming a veritable cause for concern for directors of clinical pathology laboratories. We have presented FBC normal data obtained between 2008 and 2010 in a population living in mainland France with established preanalytical conditions and modern analytical methods based on recent technologies. The population studied was large, consisting of 32 919 subjects selected after analysis of advanced clinical and biological criteria combined with a statistical/epidemiological approach to perform a final smoothing for societal criteria liable to interfere with the nutritional state (nutrient deficiencies, addiction, etc). The population investigated in this study can be considered to be representative of the current adult population of mainland France. We have also presented normal reference values for the population of healthy subjects aged 70–79 years, a population that often receives little attention in the literature.7 For methodological reasons, this study did not include children; it only included adult subjects. Paediatric normal values have been presented in other works.8–10 Given the French ban on entering the ethnic origin of an individual into an electronic database, it is impossible to present the biological variation related to ethnic origin, despite the multiethnic nature of the French population. Modifications in white cells and neutrophils count in subjects of African ancestry are known.11 12 The questionnaire used for the PHA does not take into consideration exposure to environmental factors, pesticides, radiation, electromagnetic waves or genetic factors liable to modify certain haematological factors. Another limitation of our study is the lack of ability to eliminate in our population iron deficiency or any haemoglobinopathies. Our study did not envisage normal values for reticulocytes as there is no reason to perform this investigation systematically beyond cases of suspected anaemia or in a PHA. Parameters provided by the auto-analysers and dependent on the analytical techniques or the mode of result expression implemented by the manufacturer, such as red cell distribution width or platelet parameters other than mean platelet volume, were not analysed. The normal reference values presented here, very close to other data,13 are proposed for use in everyday practice in order to be able to affirm without ambiguity the abnormal nature of any FBC parameter. Adoption of these normal values by all laboratories in mainland France should make it possible to interpret correctly an FBC from any adult subject, regardless of the laboratory and its geographic location. 4 Take home messages ▸ The full blood count is the most frequently requested laboratory test: it guides later additional investigations essential for diagnosing and monitoring the patient. ▸ Laboratories are faced with the problem of providing normal values and not having national recommendations. ▸ We presented normal reference values in 32 919 subjects considered to be representative of the French population. ▸ These normal values are proposed for use in everyday practice. They make it possible to distinguish a normal situation from a pathological situation. Acknowledgements The authors thank all the collaborators, particularly Christine Geslain, and the subjects participating in the study. Contributors XT, EC and JC designed the study and wrote the manuscript. SV performed the statistical analysis. VB, J-PC, CF, EM and VS discussed the results. J-CL analysed the biological samples. JT and OL enrolled the patients and provided the clinical data. Competing interests None. Ethics approval Institut inter Régional pour la Santé (IRSA). Provenance and peer review Not commissioned; externally peer reviewed. REFERENCES 1 2 3 4 5 6 7 8 9 10 11 12 13 Sass C, Moulin JJ, Guéguen R, et al. Le score EPICES : un score individuel de précarité et évaluation du score dans une population de 197389 personnes. Bull Epidemiol Hebdo 2006;14:93–6. Kratz A, Ferraro M, Sluss PM, et al. Laboratory reference values. N Engl J Med 2004;351:1548–63. Nordin G, Mårtensson A, Swolin B, et al. A multicentre study of reference intervals for haemoglobin, basic blood cell counts and erythrocyte indices in the adult population of the Nordic countries. Scand J Clin Lab Invest 2004;64:385–98. Wakeman L, Al-Ismail S, Benton A, et al. Robust, routine haematology reference ranges for healthy adults. Int J Lab Hematol 2007;29:279–83. Perkins SL. Normal blood and bone marrow values in humans. Wintrobe’s Clinical Hematology (Tenth Edition). Lee GR, Foerster J, Lukens J, Paraskevas F, Greer JP, Rodgers GM. Williams Wilkins, 1999:2738–48. Lecture critique de l’hémogramme : valeurs seuils à reconnaître comme probablement pathologiques et principales variations non pathologiques. http://www.has-sante.fr Tsang CW, Lazarus R, Smith W, et al. Hematological indices in an older population sample: derivation of healthy reference values. Clin Chem 1998;44:96–101. Bellamy GJ, Hinchliffe RF, Crawshaw KC, et al. Total and differential leucocyte counts in infants at 2, 5 and 13 months of age. Clin Lab Haematol 2000;22:81–7. Geaghan SM. Hematologic values and appearances in the healthy fetus, neonate, and child. Clin Lab Med 1999;19:1–37. Taylor MR, Holland CV, Spencer R, et al. Haematological reference ranges for schoolchildren. Clin Lab Haematol 1997;19:1–15. Karita E, Ketter N, Price MA, et al. CLSI-derived hematology and biochemistry reference intervals for healthy adults in eastern and southern Africa. PLoS One 2009;4:e4401. Roshan TM, Rosline H, Ahmed SA, et al. Hematological reference values of healthy Malaysian population. Int J Lab Hematol 2009;31:505–12. Barbara J. Bain. Blood cells: a practical guide. Normal ranges. Oxford, UK: Blackwell Publishing, 2006:198–216. Troussard X, et al. J Clin Pathol 2013;0:1–4. doi:10.1136/jclinpath-2013-201687 Appendix 1. CBC normal values for the age group 70 – 79 years 219 men Variable 120 women p Mean (standard deviation) 2.5th – 97.5th centile Mean (standard deviation) 2.5th – 97.5th centile Hematocrit (%) 43.3 (2.84) 37.9 – 48.5 40.0 (2.39) 34.9 -44.6 Hemoglobin (g/L) 147 (9.60) 129 – 167 134 (7.70) 4.822 (0.383) 4.08 – 5.60 MCV (fL) 90.1 (3.72) MCH (pg/cell) 339 men and women Mean (standard deviation) 2.5th – 97.5th centile 0.0001 42.2 (3.13) 36.2 (48.2) 118 – 150 0.0001 143 (110) 120 – 164 4.480 (0.311) 3.84 – 5.12 0.0001 4.701 (0.395) 3.91 – 5.55 83.1 – 97.3 89.5 (3.74) 82.6 – 97.5 0.15 89.9 (3.73) 83.0 – 97.3 30.7 (1.49) 27.8 – 33.9 30.0 (1.32) 27.5 – 33.2 0.0001 30.4 (1.47) 27.6 – 33.7 MCHC (g/L) 340 (10.2) 323 – 361 335 (10) 319 – 359 0.0001 338 (10) 320 – 360 Leukocytes (109/L) 6.36 (1.50) 3.84 – 9.80 5.73 (1.26) 3.77 – 9.05 0.0001 6.14 (1.45) 3.84 – 9.52 Neutrophils (109/L) 3.55 (1.09) 1.58 – 5.93 3.13 (0.91) 1.90 – 5.72 0.0001 3.40 (1.04) 1.73 – 5.81 Eosinophils (109/L) 0.21 (0.13) 0.03 – 0.50 0.19 (0.11) 0.04 – 0.52 0.18 0.20 (0.13) 0.04 – 0.50 Basophils (109/L) 0.03 (0.02) 0.00 – 0.09 0.03 (0.02) 0.00 – 0.09 0.01 0.035 (0.02) 0.000– 0.09 2.11 (0.71) 1.07 – 4.10 2.00 (0.66) 1.07 – 3.90 0.16 2.07 (0.69) 1.07 – 4.03 Monocytes (109/L) 0.44 (0.13) 0.23 – 0.71 0.35 (0.10) 0.17 – 0.56 0.0001 0.41 (0.13) 0.18 – 0.69 Platelets (109/L) 243 (59.4) 140 – 385 274 (54.2) 177 – 379 0.0001 254 (59.4) 148 – 379 MPV (fL) 8.91 (0.95) 7.6 – 11.2 8.90 (0.83) 7.6 – 10.4 0.57 8.90 (0.91) 7.6 – 11.0 Red blood cells (1012/L) Lymphocytes (109/L) Appendix 2. Normal values for CBC red blood cell parameters Variation in hemoglobin (g/L) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 152 20-29 3054 152 30-39 4258 151 Men 40-49 5146 150 50-59 3801 150 60-69 1747 149 Total 19393 150 16-19 901 133 20-29 1370 133 30-39 2711 133 40-44 1873 133 Women 45-49 1932 134 50-54 1870 135 55-59 1578 135 60-69 1291 136 Total 13526 134 9 9 8 8 8 9 9 9 9 9 9 9 9 7 8 9 172 168 166 163 160 159 158 157 155 154 153 152 151 150 148 147 146 144 142 140 136 133 128 172 168 165 163 161 159 157 156 155 154 153 152 151 150 149 147 146 145 143 141 138 135 132 170 167 164 161 159 158 156 155 154 153 152 151 150 149 148 147 145 144 142 140 137 134 131 170 166 164 161 158 157 155 154 153 152 151 150 149 148 147 146 145 143 142 140 137 134 131 170 167 163 160 158 157 155 154 153 152 151 150 149 147 146 145 144 142 141 139 136 134 130 171 166 163 161 158 157 155 154 153 152 151 150 149 147 146 145 143 142 140 138 135 132 127 170 167 164 161 159 157 156 155 154 153 151 150 149 148 147 146 145 143 142 140 137 134 130 152 147 145 143 141 140 139 138 137 135 134 133 132 131 130 129 128 127 125 122 119 115 107 154 149 147 144 142 140 139 138 137 135 134 133 132 132 130 129 128 126 125 122 118 114 108 152 149 146 144 142 140 139 138 136 135 134 133 132 132 131 129 128 127 125 123 120 115 109 151 149 147 144 142 140 139 138 136 135 134 133 132 131 131 129 128 127 126 123 119 115 107 155 151 148 144 142 141 139 138 137 136 135 134 133 132 131 130 128 127 125 123 119 114 108 154 151 149 146 144 142 140 139 138 137 136 135 134 133 132 131 130 128 127 125 122 118 113 153 150 147 144 143 141 140 139 138 137 136 135 134 133 133 132 130 129 128 126 124 121 118 155 152 148 145 143 142 140 139 138 137 137 136 135 134 133 132 131 130 128 126 123 121 118 154 150 147 144 142 141 139 138 137 136 135 134 133 132 131 130 129 128 126 124 120 117 110 Variation in red blood cells (1012/L) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 5.159 20-29 3054 5.111 30-39 4258 5.050 Men 40-49 5146 4.998 50-59 3801 4.949 60-69 1747 4.916 Total 19393 5.022 16-19 901 4.584 20-29 1370 4.559 30-39 2711 4.490 40-44 1873 4.465 Women 45-49 1932 4.482 50-54 1870 4.525 55-59 1578 4.543 60-69 1291 4.556 Total 13526 4.516 0.326 0.331 0.317 0.318 0.323 0.331 0.330 0.291 0.314 0.320 0.295 0.301 0.300 0.282 0.285 0.303 5.98 5.82 5.69 5.57 5.49 5.42 5.36 5.30 5.26 5.24 5.19 5.15 5.11 5.07 5.03 4.98 4.93 4.89 4.83 4.74 4.64 4.57 4.47 5.93 5.78 5.65 5.54 5.44 5.37 5.31 5.27 5.22 5.18 5.14 5.10 5.07 5.02 4.98 4.93 4.88 4.83 4.77 4.71 4.61 4.50 4.38 5.90 5.70 5.58 5.45 5.37 5.30 5.25 5.21 5.15 5.11 5.07 5.03 5.00 4.96 4.93 4.88 4.84 4.79 4.74 4.66 4.55 4.44 4.34 5.78 5.65 5.51 5.40 5.32 5.25 5.20 5.15 5.11 5.07 5.03 4.99 4.96 4.92 4.88 4.84 4.79 4.74 4.68 4.60 4.49 4.38 4.24 5.74 5.58 5.47 5.35 5.26 5.21 5.16 5.10 5.06 5.03 4.99 4.95 4.91 4.87 4.83 4.78 4.74 4.69 4.62 4.54 4.43 4.32 4.18 5.71 5.57 5.44 5.34 5.25 5.19 5.13 5.08 5.03 4.99 4.95 4.90 4.87 4.83 4.78 4.75 4.70 4.64 4.57 4.50 4.40 4.28 4.18 5.84 5.68 5.57 5.44 5.35 5.28 5.23 5.18 5.14 5.09 5.05 5.01 4.98 4.93 4.89 4.85 4.81 4.75 4.69 4.61 4.50 4.39 4.27 5.27 5.15 5.05 4.96 4.89 4.83 4.78 4.73 4.69 4.65 4.62 4.59 4.54 4.51 4.47 4.44 4.39 4.33 4.28 4.21 4.11 4.03 3.93 5.46 5.22 5.09 4.94 4.85 4.79 4.74 4.68 4.65 4.61 4.57 4.54 4.51 4.47 4.44 4.40 4.36 4.32 4.26 4.18 4.08 3.99 3.90 5.25 5.08 4.98 4.86 4.79 4.73 4.68 4.64 4.59 4.56 4.52 4.48 4.45 4.42 4.39 4.35 4.29 4.25 4.19 4.11 4.02 3.94 3.84 5.21 5.09 4.96 4.84 4.77 4.71 4.66 4.61 4.56 4.52 4.48 4.45 4.42 4.38 4.35 4.31 4.27 4.23 4.18 4.11 4.00 3.90 3.79 5.20 5.09 5.01 4.88 4.78 4.72 4.67 4.63 4.59 4.55 4.51 4.47 4.44 4.40 4.36 4.32 4.27 4.23 4.18 4.10 4.01 3.93 3.82 5.26 5.13 5.05 4.92 4.84 4.77 4.72 4.67 4.63 4.59 4.55 4.51 4.48 4.44 4.40 4.36 4.31 4.27 4.22 4.16 4.05 3.98 3.86 5.24 5.11 5.01 4.90 4.82 4.77 4.73 4.68 4.65 4.61 4.57 4.54 4.51 4.47 4.43 4.40 4.36 4.31 4.26 4.19 4.09 4.01 3.87 5.26 5.13 5.04 4.92 4.85 4.79 4.74 4.70 4.66 4.62 4.58 4.55 4.51 4.48 4.44 4.41 4.37 4.33 4.28 4.21 4.09 4.01 3.86 5.26 5.12 5.02 4.90 4.82 4.76 4.71 4.66 4.62 4.58 4.54 4.51 4.47 4.44 4.40 4.36 4.32 4.27 4.22 4.15 4.05 3.96 3.84 Variation in hematocrit (%) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 43.99 20-29 3054 44.12 30-39 4258 43.79 Men 40-49 5146 43.72 50-59 3801 43.72 60-69 1747 43.71 Total 19393 43.82 16-19 901 39.12 20-29 1370 39.28 30-39 2711 39.21 40-44 1873 39.35 Women 45-49 1932 39.50 50-54 1870 39.93 55-59 1578 40.09 60-69 1291 40.25 Total 13526 39.57 2.45 2.42 2.37 2.35 2.43 2.56 2.41 2.36 2.47 2.61 2.43 2.51 2.46 2.18 2.25 2.47 50.0 48.9 48.1 47.1 46.5 46.0 45.6 45.3 44.9 44.6 44.3 44.0 43.7 43.4 43.0 42.7 42.3 41.8 41.4 40.9 40.1 39.3 38.3 49.8 48.9 48.1 47.2 46.6 46.1 45.8 45.4 45.0 44.7 44.4 44.1 43.8 43.5 43.2 42.9 42.5 42.0 41.6 41.1 40.3 39.5 38.7 49.6 48.4 47.7 46.8 46.2 45.8 45.4 45.0 44.7 44.4 44.1 43.7 43.5 43.2 42.9 42.5 42.2 41.8 41.3 40.8 39.9 39.2 38.3 49.4 48.5 47.6 46.7 46.1 45.6 45.2 44.9 44.6 44.3 44.0 43.7 43.4 43.1 42.8 42.5 42.1 41.7 41.3 40.7 39.9 39.3 38.5 49.5 48.5 47.7 46.8 46.2 45.7 45.3 44.9 44.6 44.3 44.0 43.7 43.4 43.1 42.8 42.5 42.1 41.7 41.2 40.6 39.8 39.0 38.1 50.1 48.7 47.9 46.8 46.3 45.8 45.4 45.1 44.7 44.4 44.1 43.7 43.4 43.0 42.7 42.3 42.0 41.6 41.1 40.5 39.6 38.7 37.9 49.6 48.6 47.8 46.9 46.3 45.8 45.4 45.0 44.7 44.4 44.1 43.8 43.5 43.2 42.9 42.5 42.2 41.8 41.3 40.8 39.9 39.2 38.3 44.2 43.3 42.7 42.0 41.4 41.2 40.7 40.4 40.0 39.7 39.5 39.2 38.9 38.6 38.4 38.0 37.7 37.3 36.9 36.3 35.2 34.6 32.4 45.2 44.4 43.2 42.2 41.7 41.2 40.9 40.6 40.3 39.9 39.6 39.3 39.0 38.7 38.4 38.1 37.7 37.4 36.9 36.2 35.2 34.2 32.9 44.7 43.8 43.0 42.2 41.6 41.1 40.8 40.5 40.1 39.8 39.5 39.3 39.0 38.7 38.4 38.1 37.8 37.4 36.8 36.2 35.3 34.5 32.7 45.3 44.1 43.3 42.4 41.8 41.3 40.9 40.5 40.2 39.9 39.6 39.3 39.1 38.8 38.5 38.1 37.9 37.5 37.0 36.5 35.3 34.0 32.7 45.4 44.5 43.5 42.5 41.9 41.4 41.1 40.7 40.4 40.1 39.8 39.6 39.2 38.9 38.7 38.4 38.0 37.6 37.1 36.5 35.5 34.5 33.0 45.6 44.6 44.0 43.1 42.4 41.9 41.5 41.2 40.8 40.5 40.1 39.9 39.6 39.3 39.0 38.7 38.4 38.0 37.5 36.9 36.0 35.3 34.1 45.3 44.5 43.7 42.8 42.3 41.9 41.5 41.2 40.9 40.5 40.3 40.1 39.8 39.5 39.2 39.0 38.6 38.3 37.9 37.4 36.6 35.9 35.1 45.8 44.7 44.0 43.0 42.4 42.0 41.7 41.3 41.1 40.8 40.6 40.3 40.1 39.7 39.5 39.1 38.8 38.4 38.0 37.4 36.6 35.9 34.7 45.2 44.4 43.5 42.5 42.0 41.5 41.1 40.8 40.5 40.2 39.9 39.6 39.3 39.0 38.7 38.4 38.1 37.7 37.2 36.6 35.6 34.7 33.5 Variation of MCV (fL) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 85.27 20-29 3054 86.41 30-39 4258 86.72 Men 40-49 5146 87.51 50-59 3801 88.35 60-69 1747 88.97 Total 19393 87.30 16-19 901 85.34 20-29 1370 86.13 30-39 2711 87.12 40-44 1873 87.97 Women 45-49 1932 88.07 50-54 1870 87.84 55-59 1578 88.15 60-69 1291 88.11 Total 13526 87.47 4.92 4.40 4.65 4.64 4.82 5.06 4.80 5.04 6.22 6.76 6.57 5.86 7.78 5.72 6.46 6.52 94.1 91.9 91.0 89.7 88.8 88.0 87.5 87.1 86.6 86.2 85.8 85.5 85.1 84.8 84.4 83.9 83.5 82.8 82.4 81.9 79.5 78.0 74.2 95.8 93.6 92.3 90.9 90.0 89.3 88.8 88.2 87.8 87.3 86.9 86.5 86.0 85.7 85.2 84.7 84.2 83.6 83.0 82.4 81.1 79.1 76.4 95.8 94.1 92.6 91.2 90.2 89.5 88.9 88.4 88.0 87.5 87.1 86.8 86.3 85.9 85.5 85.0 84.5 84.0 83.5 82.8 82.0 80.0 78.0 97.3 94.9 93.6 92.1 91.1 90.4 89.8 89.3 88.8 88.4 87.9 87.5 87.1 86.6 86.2 85.7 85.2 84.7 84.1 83.3 82.4 81.0 78.4 98.0 96.3 94.4 92.9 91.9 91.2 90.7 90.1 89.6 89.2 88.7 88.3 87.9 87.5 87.0 86.6 86.2 85.6 85.0 84.2 83.1 82.2 79.7 98.8 97.0 95.3 93.8 92.8 92.0 91.4 90.8 90.4 89.9 89.5 89.0 88.6 88.2 87.7 87.3 86.8 86.2 85.6 84.7 83.1 82.1 78.4 97.2 95.0 93.5 92.0 91.0 90.3 89.7 89.1 88.7 88.2 87.7 87.3 86.9 86.4 86.0 85.5 85.0 84.5 83.8 83.0 82.2 80.2 77.8 94.1 92.7 91.5 89.9 89.1 88.6 88.0 87.4 87.0 86.5 86.1 85.7 85.3 84.8 84.4 83.9 83.5 82.8 82.2 80.7 78.5 75.7 69.4 95.7 94.2 93.2 91.4 90.6 90.0 89.3 88.7 88.1 87.7 87.2 86.6 86.2 85.7 85.2 84.6 84.1 83.4 82.4 81.0 78.3 74.7 67.3 96.8 95.3 93.7 92.3 91.4 90.6 90.1 89.5 88.9 88.4 88.0 87.6 87.1 86.7 86.2 85.7 85.1 84.5 83.8 82.7 80.7 77.9 72.2 97.5 95.8 94.5 93.3 92.3 91.6 91.0 90.4 89.8 89.4 88.9 88.4 88.0 87.5 86.9 86.4 85.9 85.3 84.2 83.2 81.6 78.9 72.4 97.3 96.0 94.5 93.0 92.1 91.4 90.8 90.3 89.8 89.4 88.9 88.5 88.1 87.6 87.1 86.6 86.0 85.4 84.6 83.4 81.5 78.2 74.6 96.9 95.3 94.3 93.0 92.0 91.3 90.7 90.2 89.8 89.3 88.9 88.4 88.0 87.5 87.2 86.7 86.2 85.6 84.9 83.9 82.3 79.2 70.6 97.1 95.4 94.0 92.6 91.8 91.2 90.6 90.1 89.6 89.2 88.8 88.4 87.9 87.5 87.1 86.6 86.1 85.5 84.9 83.9 82.6 81.1 79.2 96.7 95.0 94.1 92.5 91.8 91.1 90.6 90.1 89.7 89.3 88.9 88.5 88.1 87.6 87.2 86.7 86.2 85.8 85.1 84.4 82.9 81.7 79.1 96.8 95.3 94.0 92.6 91.7 90.9 90.3 89.8 89.3 88.8 88.4 87.9 87.5 87.0 86.5 86.0 85.5 84.8 84.0 83.0 81.0 78.4 72.8 Variation of MCHC (g/L) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 344.6 20-29 3054 343.9 30-39 4258 344.2 Men 40-49 5146 343.3 50-59 3801 342.4 60-69 1747 341.7 Total 19393 343.4 16-19 901 339.7 20-29 1370 338.7 30-39 2711 339.3 40-44 1873 338.5 Women 45-49 1932 338.2 50-54 1870 338.0 55-59 1578 337.5 60-69 1291 337.3 Total 13526 338.4 10.1 10.4 10.0 9.9 9.7 10.1 10.0 10.6 11.0 13.7 10.1 10.3 9.7 9.8 10.2 11.0 367 362 359 356 354 352 351 349 348 347 345 344 343 342 341 339 338 336 334 331 327 322 319 367 364 361 357 355 353 351 350 348 347 345 344 343 341 340 339 337 335 334 331 327 324 319 368 363 360 357 355 352 351 349 348 347 346 344 343 342 341 339 337 336 334 331 328 324 320 367 363 359 356 354 351 350 348 347 346 345 343 342 341 339 338 337 335 333 331 328 324 321 365 362 358 355 353 351 349 347 346 345 343 342 341 340 339 337 336 334 332 330 327 324 320 365 362 358 355 352 350 349 347 345 344 343 342 340 339 337 336 335 333 332 329 325 323 319 367 363 360 356 354 352 350 349 347 346 345 343 342 341 340 338 337 335 333 331 327 324 320 362 360 357 353 350 349 347 345 344 342 341 340 339 338 336 335 334 331 329 326 322 318 311 363 360 356 352 349 347 346 344 343 342 341 339 338 337 335 334 332 330 328 326 322 316 307 362 359 356 352 350 348 346 345 344 342 341 340 339 337 336 335 333 332 330 327 323 319 313 361 358 354 351 349 347 345 344 343 341 340 339 337 336 335 334 332 330 328 326 323 320 314 361 357 354 351 348 347 345 344 342 341 340 339 337 336 335 333 332 330 328 326 321 318 310 361 356 353 350 348 346 345 343 342 341 339 338 337 336 334 333 332 330 328 326 322 319 315 361 357 354 350 348 346 344 343 341 340 338 337 336 335 333 332 331 329 327 325 322 320 317 360 358 354 351 348 346 344 343 341 340 338 337 336 334 333 331 330 329 327 324 321 319 316 361 358 355 351 349 347 345 344 343 341 340 339 337 336 335 333 332 330 328 326 322 319 314 Variation of MCH (pg/cell) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 29.43 20-29 3054 29.74 30-39 4258 29.88 Men 40-49 5146 30.06 50-59 3801 30.29 60-69 1747 30.43 Total 19393 30.00 16-19 901 29.03 20-29 1370 29.25 30-39 2711 29.68 40-44 1873 29.88 Women 45-49 1932 29.86 50-54 1870 29.87 55-59 1578 29.82 60-69 1291 29.83 Total 13526 29.70 1.52 1.54 1.39 1.44 1.41 1.56 1.48 1.80 1.98 1.89 1.72 1.75 1.60 1.40 1.36 1.73 32.5 32.1 31.5 31.1 30.8 30.6 30.4 30.2 30.0 29.9 29.7 29.6 29.4 29.2 29.1 28.9 28.7 28.4 28.2 27.8 27.2 26.3 24.3 33.0 32.4 32.0 31.4 31.1 30.9 30.7 30.5 30.3 30.1 30.0 29.8 29.7 29.5 29.3 29.1 28.9 28.7 28.4 28.0 27.6 26.8 25.3 33.2 32.5 32.0 31.5 31.2 30.9 30.7 30.5 30.4 30.2 30.0 29.9 29.7 29.6 29.4 29.3 29.1 28.9 28.6 28.3 27.8 27.2 26.3 33.5 32.8 32.3 31.7 31.4 31.1 30.9 30.7 30.5 30.4 30.2 30.1 29.9 29.8 29.6 29.4 29.2 29.0 28.8 28.4 27.9 27.4 26.3 33.7 33.0 32.5 31.9 31.6 31.4 31.1 30.9 30.8 30.6 30.4 30.3 30.1 30.0 29.8 29.6 29.4 29.2 29.0 28.7 28.2 27.6 26.6 34.0 33.2 32.6 32.2 31.9 31.6 31.3 31.1 31.0 30.8 30.6 30.5 30.3 30.2 30.0 29.8 29.6 29.4 29.1 28.7 28.1 27.5 26.0 33.4 32.8 32.2 31.7 31.4 31.1 30.9 30.7 30.5 30.4 30.2 30.0 29.9 29.7 29.5 29.4 29.2 29.0 28.7 28.3 27.8 27.2 26.1 32.2 31.7 31.3 31.0 30.7 30.4 30.2 30.0 29.8 29.6 29.4 29.2 29.1 28.9 28.7 28.5 28.2 27.8 27.5 27.1 26.1 24.5 22.7 32.7 32.3 31.9 31.4 31.0 30.7 30.4 30.2 30.0 29.9 29.7 29.5 29.3 29.1 28.9 28.7 28.4 28.1 27.7 27.0 25.9 24.3 21.3 33.3 32.6 32.1 31.6 31.3 31.0 30.8 30.5 30.3 30.2 30.0 29.8 29.7 29.5 29.3 29.1 28.9 28.6 28.2 27.7 26.9 25.9 23.4 33.3 32.9 32.3 31.7 31.4 31.1 30.9 30.7 30.5 30.4 30.2 30.0 29.8 29.6 29.5 29.2 29.0 28.8 28.5 27.9 27.2 26.4 23.7 33.5 32.7 32.2 31.7 31.4 31.1 30.9 30.7 30.5 30.3 30.2 30.0 29.8 29.6 29.4 29.2 29.0 28.8 28.6 28.0 27.1 25.7 24.0 33.0 32.5 32.1 31.6 31.3 31.1 30.9 30.7 30.5 30.3 30.1 30.0 29.8 29.7 29.5 29.3 29.0 28.8 28.5 28.2 27.3 26.6 24.1 33.1 32.4 31.9 31.4 31.2 30.9 30.7 30.5 30.3 30.1 30.0 29.9 29.7 29.5 29.4 29.2 29.0 28.8 28.5 28.2 27.6 27.0 26.2 33.0 32.5 32.1 31.5 31.2 30.9 30.7 30.5 30.3 30.1 30.0 29.8 29.7 29.5 29.4 29.2 29.1 28.8 28.5 28.2 27.7 27.1 26.3 33.1 32.5 32.1 31.6 31.2 31.0 30.8 30.5 30.3 30.2 30.0 29.8 29.7 29.5 29.3 29.1 28.9 28.6 28.3 27.8 27.0 26.1 23.9 Appendix 3. Normal values for CBC platelet parameters Variation of platelets (109/L) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 267.5 20-29 3054 265.7 30-39 4258 270.2 Men 40-49 5146 272.5 50-59 3801 269.6 60-69 1747 260.3 Total 19393 268.9 16-19 901 300.0 20-29 1370 294.7 30-39 2711 290.6 40-44 1873 293.0 Women 45-49 1932 300.1 50-54 1870 297.5 55-59 1578 291.6 60-69 1291 287.3 Total 13526 294.1 56.0 57.7 57.0 57.9 59.7 59.7 58.2 66.7 65.3 66.4 64.6 67.0 65.1 58.6 62.7 64.9 432 398 365 340 323 309 301 290 282 274 268 261 256 250 244 237 229 223 213 201 187 173 159 428 394 366 339 322 309 298 289 280 273 266 261 254 248 240 234 226 218 210 199 184 170 151 435 398 372 344 327 315 304 294 286 279 271 264 258 252 245 238 231 223 214 204 185 172 158 438 398 373 348 331 317 307 298 290 283 275 267 260 253 246 239 233 224 215 203 187 174 159 453 404 374 347 326 313 303 293 285 277 271 265 257 251 244 236 230 222 212 200 185 170 153 441 393 366 337 319 307 296 286 277 268 260 252 245 239 232 226 219 211 200 191 179 161 148 437 397 371 344 326 313 303 293 285 277 270 263 256 250 243 236 229 221 212 200 185 171 155 480 457 419 390 369 353 340 327 318 311 301 293 286 276 269 261 252 243 234 222 205 190 169 482 443 407 376 362 346 335 325 315 307 298 290 281 273 266 257 248 239 229 216 198 183 166 484 440 408 374 357 341 328 320 310 302 292 285 278 271 264 254 244 234 224 212 195 179 162 476 440 407 372 356 341 330 319 309 302 295 288 279 273 266 257 249 241 230 217 199 183 171 509 461 422 387 364 349 337 327 317 309 301 293 285 277 270 263 254 245 235 222 205 190 175 480 441 412 377 358 345 334 324 315 308 300 291 284 277 269 262 252 243 233 221 207 192 175 446 420 393 366 350 338 329 319 309 301 293 287 280 272 266 258 250 243 234 223 204 188 177 477 420 397 366 349 337 325 315 304 297 289 282 274 267 260 252 243 235 226 214 196 186 164 480 440 408 376 357 343 331 321 312 304 296 288 281 273 266 258 249 240 230 218 200 186 169 Variation of mean platelet volume (fL) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 8.65 20-29 3054 8.69 30-39 4258 8.71 Men 40-49 5146 8.76 50-59 3801 8.80 60-69 1747 8.82 Total 19393 8.74 16-19 901 8.69 20-29 1370 8.78 30-39 2711 8.81 40-44 1873 8.88 Women 45-49 1932 8.86 50-54 1870 8.82 55-59 1578 8.74 60-69 1291 8.79 Total 13526 8.81 0.83 0.86 0.84 0.85 0.86 0.84 0.85 0.81 0.90 0.94 0.87 0.88 0.83 0.82 0.89 0.88 11.1 10.7 10.2 9.7 9.4 9.2 9.1 9.0 8.9 8.8 8.6 8.5 8.5 8.4 8.3 8.2 8.1 8.0 7.8 7.7 7.5 7.4 7.2 11.5 10.8 10.3 9.8 9.5 9.3 9.1 9.0 8.9 8.8 8.7 8.5 8.5 8.4 8.3 8.2 8.1 8.0 7.9 7.7 7.6 7.4 7.2 11.2 10.7 10.2 9.8 9.5 9.3 9.1 9.0 8.9 8.8 8.7 8.6 8.5 8.4 8.3 8.2 8.1 8.0 7.9 7.8 7.6 7.4 7.2 11.4 10.8 10.3 9.9 9.6 9.4 9.2 9.1 8.9 8.8 8.7 8.6 8.5 8.5 8.4 8.3 8.2 8.1 8.0 7.8 7.6 7.5 7.3 11.5 10.8 10.4 9.9 9.6 9.4 9.2 9.1 9.0 8.9 8.8 8.7 8.6 8.5 8.4 8.3 8.2 8.1 8.0 7.9 7.6 7.5 7.3 11.4 10.8 10.4 9.9 9.6 9.4 9.3 9.1 9.0 8.9 8.8 8.7 8.6 8.5 8.4 8.3 8.2 8.1 8.0 7.9 7.7 7.6 7.4 11.4 10.8 10.3 9.8 9.5 9.4 9.2 9.1 8.9 8.8 8.7 8.6 8.5 8.4 8.3 8.3 8.2 8.1 7.9 7.8 7.6 7.4 7.3 11.3 10.7 10.2 9.7 9.5 9.3 9.1 9.0 8.9 8.7 8.7 8.6 8.5 8.4 8.3 8.2 8.1 8.0 7.9 7.8 7.6 7.4 7.2 11.9 11.1 10.5 9.9 9.6 9.4 9.2 9.1 9.0 8.9 8.8 8.6 8.5 8.4 8.4 8.3 8.2 8.1 8.0 7.8 7.6 7.5 7.2 11.7 10.9 10.4 9.9 9.6 9.4 9.3 9.1 9.0 8.9 8.8 8.7 8.6 8.5 8.4 8.3 8.2 8.1 8.0 7.8 7.7 7.5 7.3 11.6 10.9 10.4 10.0 9.8 9.6 9.4 9.2 9.1 9.0 8.8 8.8 8.7 8.6 8.5 8.4 8.3 8.2 8.0 7.9 7.7 7.5 7.4 11.6 10.9 10.5 10.0 9.7 9.5 9.3 9.2 9.1 8.9 8.8 8.7 8.7 8.6 8.5 8.4 8.2 8.1 8.0 7.9 7.7 7.5 7.3 11.4 10.8 10.4 9.9 9.6 9.4 9.3 9.1 9.0 8.9 8.8 8.7 8.6 8.5 8.4 8.3 8.3 8.2 8.1 7.9 7.7 7.5 7.3 11.4 10.6 10.2 9.8 9.5 9.3 9.2 9.0 8.9 8.8 8.7 8.7 8.6 8.5 8.4 8.3 8.2 8.1 8.0 7.8 7.6 7.4 7.2 11.8 10.9 10.4 9.8 9.6 9.4 9.2 9.1 9.0 8.9 8.8 8.6 8.5 8.5 8.4 8.3 8.2 8.1 8.0 7.8 7.7 7.5 7.4 11.6 10.9 10.4 9.9 9.6 9.4 9.3 9.1 9.0 8.9 8.8 8.7 8.6 8.5 8.4 8.3 8.2 8.1 8.0 7.8 7.7 7.5 7.3 Appendix 4. Normal values for CBC leukocyte parameters Variation of leukocytes (109/L) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 6.567 20-29 3054 6.760 30-39 4258 6.747 Men 40-49 5146 6.611 50-59 3801 6.516 60-69 1747 6.418 Total 19393 6.625 16-19 901 7.006 20-29 1370 7.058 30-39 2711 6.839 40-44 1873 6.852 Women 45-49 1932 6.763 50-54 1870 6.242 55-59 1578 5.964 60-69 1291 5.957 Total 13526 6.595 1.615 1.759 1.844 1.742 1.771 1.633 1.759 1.931 1.947 1.876 1.838 1.800 1.605 1.556 1.486 1.810 11.42 10.70 9.56 8.57 8.12 7.72 7.37 7.08 6.87 6.68 6.49 6.36 6.18 5.98 5.80 5.61 5.47 5.28 5.10 4.87 4.45 4.15 3.72 12.63 10.96 9.95 8.95 8.39 7.98 7.64 7.39 7.12 6.92 6.73 6.53 6.33 6.13 5.93 5.72 5.56 5.37 5.12 4.85 4.44 4.12 3.68 12.87 11.25 10.12 8.99 8.42 7.93 7.62 7.34 7.09 6.85 6.66 6.48 6.28 6.08 5.89 5.71 5.52 5.33 5.08 4.79 4.36 4.04 3.73 12.66 10.77 9.80 8.73 8.18 7.76 7.42 7.13 6.92 6.71 6.51 6.33 6.16 5.97 5.81 5.63 5.46 5.27 5.04 4.78 4.42 4.11 3.82 11.60 10.46 9.42 8.51 8.04 7.65 7.28 7.04 6.83 6.62 6.43 6.26 6.08 5.93 5.77 5.59 5.40 5.23 5.02 4.75 4.43 4.06 3.76 11.53 9.92 9.13 8.42 7.97 7.53 7.24 6.96 6.73 6.52 6.34 6.18 6.02 5.85 5.69 5.52 5.38 5.17 4.98 4.69 4.31 4.05 3.69 12.30 10.81 9.74 8.75 8.19 7.80 7.47 7.18 6.95 6.74 6.55 6.36 6.18 5.99 5.83 5.64 5.47 5.28 5.05 4.79 4.40 4.08 3.74 13.26 11.52 10.54 9.51 8.81 8.44 8.08 7.66 7.38 7.11 6.89 6.70 6.49 6.24 6.08 5.91 5.69 5.43 5.22 4.93 4.55 4.11 3.74 12.50 11.52 10.56 9.58 9.05 8.56 8.21 7.87 7.53 7.30 7.06 6.81 6.54 6.36 6.15 5.93 5.73 5.45 5.15 4.90 4.35 3.89 3.47 12.48 11.38 10.29 9.21 8.63 8.16 7.81 7.52 7.26 6.99 6.77 6.56 6.38 6.20 6.00 5.80 5.62 5.35 5.09 4.78 4.41 3.97 3.46 12.42 11.38 10.15 9.23 8.60 8.17 7.82 7.50 7.27 7.05 6.79 6.58 6.39 6.19 6.01 5.81 5.61 5.40 5.17 4.86 4.38 4.09 3.71 12.09 11.02 10.15 9.10 8.51 8.08 7.76 7.43 7.19 6.97 6.75 6.54 6.35 6.12 5.92 5.72 5.52 5.30 5.04 4.74 4.31 4.01 3.59 10.64 9.70 9.05 8.22 7.77 7.39 7.11 6.84 6.60 6.44 6.24 6.07 5.88 5.73 5.58 5.37 5.18 4.99 4.78 4.49 4.10 3.78 3.38 10.87 9.45 8.54 7.76 7.30 6.96 6.64 6.45 6.25 6.08 5.94 5.80 5.65 5.51 5.31 5.13 4.99 4.79 4.60 4.36 4.00 3.75 3.35 10.80 9.39 8.50 7.74 7.30 6.95 6.69 6.50 6.31 6.13 5.95 5.77 5.62 5.45 5.31 5.13 4.98 4.81 4.62 4.37 4.06 3.81 3.40 12.15 10.88 9.89 8.91 8.31 7.89 7.53 7.24 6.97 6.74 6.53 6.34 6.14 5.96 5.77 5.59 5.37 5.16 4.92 4.63 4.24 3.91 3.53 Variation of neutrophil count (109/L) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 3.45 20-29 3054 3.59 30-39 4258 3.67 Men 40-49 5146 3.66 50-59 3801 3.63 60-69 1747 3.55 Total 19393 3.62 16-19 901 3.91 20-29 1370 3.95 30-39 2711 3.97 40-44 1873 4.02 Women 45-49 1932 3.91 50-54 1870 3.47 55-59 1578 3.19 60-69 1291 3.19 Total 13526 3.73 1.26 1.2655 1.3107 1.2462 1.1785 1.0729 1.2389 1.4820 1.4863 1.4334 1.4073 1.3462 1.1978 1.0906 1.0619 1.3655 8.089 6.976 5.842 4.951 4.530 4.271 3.995 3.813 3.622 3.474 3.340 3.233 3.118 2.989 2.869 2.773 2.651 2.504 2.355 2.165 1.866 1.671 1.389 8.106 6.813 6.018 5.158 4.704 4.420 4.196 4.014 3.845 3.678 3.514 3.375 3.245 3.119 2.987 2.859 2.735 2.600 2.419 2.259 2.013 1.749 1.300 8.189 7.054 6.143 5.294 4.876 4.535 4.283 4.075 3.892 3.729 3.584 3.429 3.298 3.183 3.053 2.939 2.811 2.664 2.504 2.307 2.015 1.708 1.355 7.916 6.898 6.099 5.218 4.773 4.464 4.238 4.056 3.879 3.720 3.563 3.435 3.312 3.205 3.094 2.967 2.846 2.719 2.560 2.375 2.108 1.894 1.576 7.543 6.634 5.923 5.137 4.718 4.435 4.195 4.005 3.838 3.684 3.553 3.434 3.330 3.205 3.081 2.982 2.855 2.721 2.566 2.384 2.153 1.915 1.565 6.960 6.138 5.475 4.917 4.620 4.311 4.107 3.928 3.788 3.662 3.521 3.409 3.301 3.178 3.065 2.940 2.833 2.691 2.545 2.385 2.099 1.847 1.640 7.901 6.814 5.983 5.170 4.737 4.434 4.205 4.010 3.841 3.686 3.539 3.408 3.289 3.171 3.050 2.926 2.809 2.673 2.512 2.332 2.060 1.816 1.488 8.600 7.632 6.767 5.874 5.381 5.045 4.753 4.468 4.254 4.030 3.857 3.651 3.447 3.293 3.146 3.023 2.861 2.691 2.536 2.333 1.983 1.653 1.338 8.587 7.353 6.726 5.936 5.466 5.081 4.803 4.509 4.249 4.080 3.899 3.719 3.573 3.426 3.247 3.112 2.930 2.740 2.569 2.309 1.853 1.566 1.159 8.431 7.568 6.680 5.826 5.339 4.997 4.744 4.510 4.297 4.091 3.894 3.730 3.579 3.434 3.274 3.142 2.979 2.820 2.635 2.422 2.092 1.798 1.300 8.343 7.473 6.679 5.902 5.378 4.979 4.709 4.513 4.318 4.126 3.976 3.811 3.648 3.506 3.375 3.209 3.067 2.885 2.730 2.521 2.197 1.873 1.493 7.885 7.154 6.538 5.667 5.227 4.905 4.698 4.464 4.283 4.057 3.858 3.706 3.532 3.406 3.289 3.151 2.990 2.826 2.623 2.396 2.109 1.812 1.433 7.465 6.299 5.653 5.060 4.592 4.318 4.099 3.905 3.724 3.583 3.421 3.305 3.187 3.053 2.921 2.787 2.663 2.532 2.361 2.187 1.952 1.720 1.202 7.227 5.915 5.232 4.499 4.144 3.841 3.651 3.495 3.378 3.245 3.138 3.029 2.937 2.812 2.707 2.604 2.471 2.367 2.227 2.060 1.839 1.703 1.462 6.731 5.768 5.099 4.532 4.086 3.821 3.640 3.498 3.377 3.260 3.173 3.046 2.922 2.820 2.723 2.605 2.499 2.385 2.266 2.106 1.873 1.674 1.446 8.160 7.099 6.335 5.514 5.044 4.718 4.444 4.203 3.992 3.805 3.638 3.487 3.356 3.219 3.082 2.940 2.791 2.644 2.471 2.269 1.979 1.737 1.339 Variation of lymphocyte count (109/L) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 2.4014 20-29 3054 2.4369 30-39 4258 2.3516 Men 40-49 5146 2.2345 50-59 3801 2.1692 60-69 1747 2.1385 Total 19393 2.2826 16-19 901 2.3759 20-29 1370 2.4289 30-39 2711 2.2354 40-44 1873 2.1729 Women 45-49 1932 2.1845 50-54 1870 2.1629 55-59 1578 2.1794 60-69 1291 2.1753 Total 13526 2.2261 0.6404 0.6712 0.6540 0.6103 0.6213 0.6489 0.6460 0.6431 0.6907 0.5999 0.5844 0.6113 0.6136 0.6250 0.6275 0.6253 4.490 3.920 3.578 3.189 3.021 2.843 2.723 2.650 2.553 2.469 2.394 2.332 2.270 2.191 2.116 2.047 1.968 1.898 1.792 1.660 1.516 1.389 1.243 4.406 4.000 3.671 3.326 3.098 2.931 2.797 2.691 2.593 2.515 2.429 2.352 2.279 2.203 2.127 2.049 1.976 1.892 1.795 1.670 1.516 1.390 1.199 4.310 3.869 3.519 3.180 2.977 2.829 2.711 2.607 2.510 2.423 2.350 2.271 2.202 2.133 2.057 1.981 1.908 1.821 1.728 1.626 1.451 1.297 1.154 4.019 3.642 3.329 3.013 2.845 2.700 2.576 2.482 2.390 2.310 2.231 2.153 2.085 2.021 1.951 1.878 1.806 1.728 1.643 1.544 1.394 1.284 1.100 4.036 3.572 3.275 2.959 2.748 2.612 2.503 2.408 2.321 2.237 2.156 2.086 2.019 1.956 1.893 1.825 1.751 1.668 1.587 1.474 1.329 1.220 1.055 4.158 3.612 3.208 2.898 2.712 2.549 2.445 2.354 2.274 2.191 2.117 2.055 1.993 1.932 1.844 1.784 1.707 1.635 1.546 1.447 1.330 1.214 1.060 4.188 3.777 3.436 3.106 2.898 2.753 2.633 2.533 2.439 2.358 2.279 2.203 2.129 2.056 1.986 1.918 1.839 1.758 1.663 1.558 1.403 1.270 1.129 4.415 3.862 3.475 3.149 3.008 2.842 2.740 2.632 2.549 2.448 2.369 2.291 2.233 2.168 2.075 1.998 1.949 1.863 1.757 1.645 1.498 1.367 1.207 4.656 3.987 3.699 3.334 3.124 2.936 2.819 2.704 2.613 2.490 2.411 2.331 2.237 2.160 2.097 2.029 1.953 1.872 1.773 1.668 1.499 1.370 1.201 3.931 3.579 3.287 3.001 2.815 2.688 2.571 2.478 2.390 2.314 2.234 2.169 2.103 2.036 1.974 1.901 1.823 1.750 1.664 1.561 1.427 1.299 1.116 3.814 3.518 3.238 2.910 2.754 2.614 2.501 2.409 2.322 2.248 2.176 2.108 2.052 1.986 1.915 1.851 1.773 1.699 1.602 1.503 1.368 1.241 1.061 3.945 3.621 3.243 2.989 2.810 2.663 2.539 2.435 2.352 2.276 2.182 2.108 2.045 1.971 1.898 1.818 1.749 1.674 1.587 1.482 1.335 1.213 1.062 3.842 3.546 3.284 2.987 2.775 2.610 2.499 2.388 2.298 2.216 2.144 2.087 2.025 1.949 1.884 1.824 1.755 1.690 1.608 1.505 1.359 1.223 0.972 4.109 3.526 3.200 2.955 2.753 2.604 2.505 2.398 2.323 2.249 2.188 2.108 2.023 1.960 1.914 1.835 1.761 1.688 1.604 1.501 1.366 1.266 1.082 4.088 3.611 3.282 2.945 2.790 2.657 2.544 2.423 2.352 2.263 2.181 2.106 2.030 1.962 1.898 1.833 1.746 1.666 1.571 1.458 1.323 1.199 1.005 4.065 3.639 3.333 3.026 2.836 2.691 2.576 2.470 2.378 2.298 2.222 2.149 2.080 2.012 1.945 1.875 1.798 1.724 1.633 1.528 1.382 1.258 1.079 Variation of monocyte count (109/L) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 0.4299 20-29 3054 0.4401 30-39 4258 0.4319 Men 40-49 5146 0.4255 50-59 3801 0.4267 60-69 1747 0.4296 Total 19393 0.4301 16-19 901 0.4055 20-29 1370 0.4021 30-39 2711 0.3803 40-44 1873 0.3872 Women 45-49 1932 0.3916 50-54 1870 0.3664 55-59 1578 0.3523 60-69 1291 0.3562 Total 13526 0.3793 0.1391 0.1374 0.1381 0.1277 0.1236 0.1236 0.1314 0.1334 0.1318 0.1227 0.1197 0.1195 0.1088 0.1067 0.1028 0.1193 0.887 0.770 0.684 0.601 0.559 0.524 0.499 0.477 0.460 0.439 0.424 0.407 0.394 0.380 0.363 0.349 0.335 0.319 0.302 0.280 0.252 0.232 0.198 0.881 0.776 0.696 0.611 0.568 0.537 0.512 0.489 0.471 0.455 0.439 0.421 0.406 0.392 0.376 0.362 0.345 0.328 0.310 0.286 0.254 0.231 0.208 0.879 0.770 0.681 0.608 0.561 0.531 0.505 0.481 0.461 0.444 0.426 0.411 0.395 0.381 0.367 0.352 0.337 0.321 0.302 0.280 0.252 0.222 0.198 0.830 0.726 0.653 0.590 0.553 0.522 0.496 0.474 0.455 0.438 0.424 0.409 0.394 0.379 0.365 0.351 0.335 0.321 0.304 0.282 0.255 0.231 0.201 0.815 0.717 0.650 0.584 0.541 0.517 0.493 0.473 0.455 0.440 0.425 0.409 0.396 0.383 0.371 0.358 0.344 0.328 0.309 0.289 0.262 0.237 0.207 0.810 0.729 0.645 0.591 0.552 0.522 0.493 0.476 0.458 0.441 0.423 0.408 0.397 0.385 0.374 0.362 0.346 0.333 0.314 0.292 0.260 0.236 0.210 0.843 0.743 0.667 0.596 0.555 0.525 0.500 0.478 0.460 0.443 0.426 0.411 0.396 0.383 0.369 0.355 0.340 0.324 0.306 0.284 0.255 0.231 0.204 0.862 0.745 0.640 0.571 0.533 0.496 0.469 0.455 0.433 0.415 0.401 0.388 0.376 0.360 0.344 0.329 0.314 0.297 0.279 0.258 0.230 0.209 0.180 0.826 0.702 0.632 0.565 0.533 0.499 0.473 0.451 0.433 0.413 0.399 0.386 0.370 0.356 0.343 0.327 0.312 0.294 0.279 0.256 0.224 0.197 0.157 0.772 0.658 0.597 0.530 0.497 0.464 0.441 0.423 0.406 0.390 0.374 0.362 0.349 0.336 0.322 0.310 0.298 0.283 0.268 0.250 0.225 0.200 0.169 0.730 0.663 0.599 0.546 0.507 0.480 0.456 0.435 0.419 0.402 0.388 0.370 0.356 0.342 0.330 0.318 0.303 0.287 0.271 0.252 0.226 0.203 0.176 0.765 0.669 0.603 0.548 0.508 0.477 0.451 0.435 0.420 0.405 0.390 0.378 0.366 0.353 0.338 0.324 0.310 0.293 0.276 0.256 0.227 0.208 0.192 0.683 0.614 0.561 0.508 0.474 0.447 0.424 0.406 0.392 0.376 0.365 0.350 0.341 0.331 0.320 0.308 0.296 0.281 0.267 0.250 0.221 0.191 0.141 0.733 0.586 0.525 0.479 0.451 0.424 0.408 0.394 0.378 0.367 0.354 0.342 0.329 0.316 0.305 0.294 0.281 0.268 0.253 0.234 0.212 0.188 0.161 0.665 0.611 0.544 0.486 0.450 0.429 0.409 0.393 0.379 0.366 0.353 0.343 0.331 0.323 0.312 0.300 0.289 0.274 0.259 0.245 0.218 0.199 0.173 0.749 0.655 0.592 0.531 0.493 0.464 0.441 0.422 0.406 0.391 0.376 0.363 0.350 0.338 0.325 0.312 0.299 0.284 0.268 0.249 0.223 0.199 0.170 Variation of eosinophil count (109/L) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 0.2151 20-29 3054 0.2138 30-39 4258 0.2103 Men 40-49 5146 0.2066 50-59 3801 0.2053 60-69 1747 0.2160 Total 19393 0.2097 16-19 901 0.1795 20-29 1370 0.1909 30-39 2711 0.1914 40-44 1873 0.1884 Women 45-49 1932 0.1939 50-54 1870 0.1795 55-59 1578 0.1858 60-69 1291 0.1852 Total 13526 0.1876 0.1730 0.1524 0.1424 0.1440 0.1317 0.1392 0.1446 0.1458 0.1506 0.1787 0.1305 0.1624 0.1179 0.1488 0.1389 0.1503 0.928 0.630 0.484 0.392 0.326 0.288 0.261 0.238 0.219 0.202 0.185 0.173 0.160 0.147 0.136 0.126 0.116 0.106 0.093 0.078 0.060 0.046 0.028 0.739 0.593 0.488 0.391 0.337 0.296 0.266 0.240 0.223 0.207 0.191 0.176 0.164 0.151 0.139 0.128 0.118 0.105 0.094 0.080 0.061 0.048 0.030 0.689 0.563 0.472 0.387 0.335 0.299 0.270 0.247 0.225 0.206 0.188 0.174 0.161 0.149 0.137 0.126 0.114 0.102 0.090 0.077 0.060 0.046 0.032 0.666 0.535 0.450 0.370 0.325 0.293 0.263 0.241 0.222 0.203 0.188 0.174 0.162 0.149 0.136 0.124 0.113 0.102 0.090 0.077 0.059 0.046 0.030 0.639 0.549 0.451 0.371 0.323 0.291 0.264 0.240 0.220 0.202 0.188 0.174 0.162 0.148 0.137 0.126 0.114 0.104 0.093 0.079 0.060 0.045 0.028 0.709 0.576 0.490 0.393 0.335 0.302 0.273 0.254 0.235 0.217 0.199 0.183 0.168 0.155 0.144 0.131 0.121 0.109 0.094 0.079 0.063 0.052 0.031 0.696 0.561 0.466 0.382 0.329 0.294 0.266 0.243 0.223 0.205 0.189 0.175 0.163 0.150 0.138 0.126 0.115 0.104 0.092 0.078 0.060 0.047 0.030 0.730 0.576 0.455 0.320 0.272 0.244 0.220 0.202 0.180 0.166 0.151 0.140 0.128 0.118 0.110 0.104 0.093 0.083 0.073 0.065 0.050 0.040 0.022 0.723 0.612 0.465 0.353 0.298 0.265 0.239 0.215 0.191 0.179 0.168 0.157 0.142 0.129 0.119 0.107 0.098 0.087 0.077 0.064 0.045 0.033 0.010 0.661 0.536 0.436 0.352 0.301 0.263 0.242 0.217 0.199 0.184 0.169 0.154 0.142 0.130 0.119 0.109 0.099 0.089 0.080 0.067 0.052 0.040 0.009 0.698 0.501 0.431 0.345 0.292 0.261 0.237 0.217 0.194 0.180 0.168 0.158 0.145 0.134 0.123 0.113 0.104 0.093 0.084 0.070 0.056 0.045 0.025 0.738 0.573 0.434 0.345 0.292 0.259 0.233 0.212 0.196 0.182 0.169 0.159 0.149 0.137 0.127 0.117 0.106 0.097 0.085 0.074 0.059 0.048 0.029 0.636 0.466 0.400 0.320 0.278 0.243 0.223 0.205 0.189 0.176 0.163 0.151 0.140 0.130 0.122 0.112 0.103 0.094 0.084 0.071 0.056 0.043 0.006 0.589 0.464 0.405 0.324 0.285 0.252 0.227 0.209 0.193 0.181 0.167 0.155 0.144 0.133 0.123 0.114 0.104 0.095 0.086 0.074 0.054 0.042 0.030 0.629 0.503 0.417 0.335 0.284 0.247 0.224 0.207 0.191 0.178 0.166 0.154 0.144 0.133 0.124 0.115 0.107 0.096 0.084 0.074 0.053 0.046 0.015 0.681 0.526 0.426 0.339 0.289 0.256 0.231 0.211 0.193 0.179 0.166 0.154 0.143 0.131 0.122 0.112 0.102 0.092 0.082 0.070 0.054 0.042 0.022 Variation of basophil count (109/L) by age and sex Age n Mean Standard deviation Centiles 99 97.5 95 90 85 80 75 70 65 60 55 50 45 40 35 30 25 20 15 10 5 2.5 1 16-19 1387 0.0347 20-29 3054 0.0382 30-39 4258 0.0404 Men 40-49 5146 0.0394 50-59 3801 0.0382 60-69 1747 0.0379 Total 19393 0.0387 16-19 901 0.0307 20-29 1370 0.0346 30-39 2711 0.0341 40-44 1873 0.0350 Women 45-49 1932 0.0353 50-54 1870 0.0352 55-59 1578 0.0351 60-69 1291 0.0363 Total 13526 0.0347 0.0233 0.0229 0.0236 0.0224 0.0228 0.0222 0.0229 0.0210 0.0210 0.0205 0.0195 0.0204 0.0205 0.0203 0.0211 0.0205 0.103 0.100 0.084 0.063 0.054 0.049 0.045 0.042 0.039 0.036 0.034 0.032 0.029 0.027 0.024 0.022 0.020 0.017 0.014 0.010 0.000 0.000 0.000 0.110 0.095 0.081 0.068 0.060 0.055 0.051 0.046 0.043 0.040 0.037 0.034 0.032 0.029 0.027 0.025 0.023 0.020 0.018 0.014 0.008 0.000 0.000 0.112 0.098 0.085 0.071 0.063 0.058 0.053 0.049 0.045 0.042 0.039 0.037 0.034 0.032 0.029 0.027 0.024 0.022 0.019 0.015 0.009 0.000 0.000 0.111 0.091 0.080 0.069 0.061 0.055 0.051 0.047 0.044 0.041 0.038 0.036 0.033 0.031 0.029 0.026 0.024 0.022 0.019 0.016 0.010 0.000 0.000 0.107 0.091 0.080 0.068 0.059 0.054 0.049 0.046 0.042 0.039 0.037 0.034 0.032 0.030 0.028 0.025 0.023 0.021 0.018 0.015 0.009 0.000 0.000 0.110 0.090 0.077 0.067 0.060 0.054 0.050 0.046 0.043 0.039 0.037 0.034 0.032 0.029 0.027 0.025 0.023 0.021 0.018 0.015 0.007 0.000 0.000 0.110 0.094 0.081 0.068 0.061 0.055 0.050 0.047 0.043 0.040 0.038 0.035 0.032 0.030 0.028 0.026 0.023 0.021 0.018 0.015 0.008 0.000 0.000 0.101 0.081 0.068 0.056 0.051 0.044 0.041 0.038 0.035 0.032 0.029 0.027 0.025 0.023 0.021 0.019 0.017 0.014 0.012 0.008 0.000 0.000 0.000 0.109 0.085 0.073 0.061 0.054 0.049 0.045 0.041 0.038 0.035 0.033 0.031 0.029 0.026 0.025 0.022 0.020 0.018 0.016 0.013 0.009 0.000 0.000 0.101 0.085 0.072 0.061 0.053 0.048 0.044 0.041 0.038 0.035 0.033 0.031 0.028 0.026 0.024 0.022 0.020 0.018 0.016 0.013 0.008 0.000 0.000 0.096 0.080 0.073 0.061 0.055 0.049 0.045 0.042 0.039 0.037 0.034 0.032 0.030 0.028 0.025 0.023 0.021 0.019 0.017 0.014 0.010 0.000 0.000 0.100 0.086 0.077 0.062 0.054 0.049 0.045 0.042 0.039 0.036 0.034 0.031 0.029 0.027 0.025 0.023 0.021 0.019 0.017 0.014 0.010 0.000 0.000 0.100 0.087 0.074 0.063 0.055 0.049 0.045 0.042 0.039 0.036 0.034 0.031 0.029 0.027 0.026 0.023 0.021 0.019 0.017 0.014 0.009 0.000 0.000 0.095 0.083 0.072 0.061 0.055 0.050 0.046 0.043 0.040 0.037 0.034 0.032 0.030 0.028 0.025 0.023 0.021 0.019 0.016 0.014 0.009 0.000 0.000 0.102 0.090 0.075 0.063 0.056 0.051 0.047 0.043 0.040 0.037 0.035 0.033 0.031 0.028 0.027 0.024 0.022 0.020 0.017 0.014 0.010 0.000 0.000 0.100 0.085 0.073 0.061 0.054 0.049 0.045 0.042 0.039 0.036 0.033 0.031 0.029 0.027 0.025 0.023 0.021 0.018 0.016 0.013 0.008 0.000 0.000