Vic Nurcombe

The University of Queensland, Australia, School of Biomedical Sciences, Emeritus

The University of Sydney, Physiology, Graduate Student

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DMed(Res) DSc (Qld) PhD (Sydney) MBA (Nanyang) MA (Birm) BSc (Hons)(Sydney) Dip CLTT (Temasek)Retired Biomedical Researcher, now Military Historian, specialising in WW1
Supervisors: Rupert Timpl, Hans Thoenen, David Edgar

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Nerissa Russell

Cornell University

Dr.Shriniwas Kashalikar

Maharashtra University 0f Health Science

Miljana Radivojević

University College London

Kristian Kristiansen

University of Gothenburg

Yannis Hamilakis

Brown University

Alexander Fantalkin

Tel Aviv University

PETER M M G AKKERMANS

Leiden University

Marc Buggeln

Europa-Universität Flensburg

Eszter Banffy

Hungarian Academy of Sciences

Viacheslav Kuleshov

Stockholm University

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Papers by Vic Nurcombe

From heparan glycobiology to stem cell therapy: a historical perspective

Academia biology, Apr 29, 2024

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From heparan glycobiology to stem cell therapy: a historical perspective

Academia Biology, Apr 29, 2024

Glycobiology is one of the most diverse and exciting fields in biochemistry and has direct releva... more Glycobiology is one of the most diverse and exciting fields in biochemistry and has direct relevance to all biomedical disciplines, particularly for tissue development, homeostasis, and regulation, as well as for essential cell/cell communication and immunological processes. This overview discusses a number of milestones in the field from a historical perspective, which reflect the importance of glycobiological insights into tissue growth and repair. We discuss the importance of key experiments that revealed the important functions of heparan sugars in the extracellular matrix (ECM), such as the Gospodarowicz revolution for cell culture, the Edgar doseresponse shift induced by ECM, and the Moscatelli migration experiment. The role of heparan sugars in sculpting developmental stem cell niches is extensively discussed. Furthermore, structure-function relationships are presented, which resulted in the recognition that specific sugar-moieties and sulfation states provide a “glycocode” that is analogous to the “genetic code” and the epigenetic “histone code”. Translational avenues include the selection and biochemical tuning of heparan sugars as nanoscale scaffolds that support cell signaling for specific applications in tissue engineering and regenerative medicine. If the important progress in the past 40 years is any guide, the field of glycobiology is about to enter a golden era, with realistic prospects for glycotherapies that encompass a range of clinical disorders.

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Two steps forward, one step back: a historical perspective of glycobiology and regenerative medicine

Academia Biology, 2024

Glycobiology is one of the most diverse and exciting fields in biochemistry and has direct releva... more Glycobiology is one of the most diverse and exciting fields in biochemistry and has direct relevance for all the biomedical disciplines, but particularly for tissue development, homeostasis and regulation, as well as for essential cell/cell communication and immunological processes. This overview discusses a number of milestones in the field that reflect the importance of glycobiological insights for tissue growth and repair from a historical perspective; we discuss the relevance of key experiments that revealed the functional contributions of heparan sugars in the extracellular matrix (ECM), such as the Gospadorowicz revolution for cell culture, the Edgar dose-response shift induced by ECM and the Moscatelli migration experiment. The role of heparan sugars in sculpting developmental stem cell niches is extensively discussed. Furthermore, structure-function relationships are presented that resulted in the recognition that specific sugar-moieties and sulfation states provide a 'glycocode' that is analogous to the 'genetic code' and the epigenetic 'histone code'. Translational avenues include the selection and biochemical tuning of heparan sugars as nanoscale scaffolds that support cell signaling for specific applications in tissue engineering and regenerative medicine. If the major progress in the past forty years is any guide, the field of glycobiology is about to enter a golden era, with realistic prospects for glycotherapies that encompass a range of clinical disorders.

Download

From heparan glycobiology to stem cell therapy: a historical perspective

Academia biology, Apr 29, 2024

Download

From heparan glycobiology to stem cell therapy: a historical perspective

Academia Biology, Apr 29, 2024

Download

Two steps forward, one step back: a historical perspective of glycobiology and regenerative medicine

Academia Biology, 2024

Glycobiology is one of the most diverse and exciting fields in biochemistry and has direct releva... more Glycobiology is one of the most diverse and exciting fields in biochemistry and has direct relevance for all the biomedical disciplines, but particularly for tissue development, homeostasis and regulation, as well as for essential cell/cell communication and immunological processes. This overview discusses a number of milestones in the field that reflect the importance of glycobiological insights for tissue growth and repair from a historical perspective; we discuss the relevance of key experiments that revealed the functional contributions of heparan sugars in the extracellular matrix (ECM), such as the Gospadorowicz revolution for cell culture, the Edgar dose-response shift induced by ECM and the Moscatelli migration experiment. The role of heparan sugars in sculpting developmental stem cell niches is extensively discussed. Furthermore, structure-function relationships are presented that resulted in the recognition that specific sugar-moieties and sulfation states provide a 'glycocode' that is analogous to the 'genetic code' and the epigenetic 'histone code'. Translational avenues include the selection and biochemical tuning of heparan sugars as nanoscale scaffolds that support cell signaling for specific applications in tissue engineering and regenerative medicine. If the major progress in the past forty years is any guide, the field of glycobiology is about to enter a golden era, with realistic prospects for glycotherapies that encompass a range of clinical disorders.

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