Anees Muhammed

University Of calicut, Department of Physics, Graduate Student

Followers

Following

Co-authors

Public Views

A Medical Physicist with over 7 years of experience in cancer diagnosis and treatment, Skilled in
Radiation Oncology, Nuclear Medicine , Diagnostic Radiology and Clinical Research, A Healthcare professional with a master
degree in Radiation Physics from University of Calicut, Currently working as Medical Physicist at Molecular
cyclotrons Kochi, Kerala. Scientific and technical expert in production of artificial radioactivity using high
energy linear accelerators/ cyclotron and production of different radiopharmaceuticals
Phone: +91 9746240625

less

InterestsView All (25)

Uploads

Papers by Anees Muhammed

A cost effective method for the preparation of sodium fluoride [18F]NaF for PET-CT imaging by using an in-house designed module

Applied Radiation and Isotopes

We report the development of a manual module for the preparation of [ 18 F]NaF for metastatic bon... more We report the development of a manual module for the preparation of [ 18 F]NaF for metastatic bone cancer imaging. By using this simple module, [ 18 F]NaF production can be carried out inexpensively without using commercially available kits. The module can be used for making [ 18 F]NaF from freshly irradiated H 2 18 O water or with left over activity in the target after [ 18 F]FDG production. The product meets all quality control parameters.

Synthesis of [18F]PSMA-1007 for Imaging Prostate Cancer by using an Automated Module and Clinical Studies

Nucleophilic Synthesis of [18F]FDOPA by using an Automated Module: A Summary of the Results of Twenty Five Batches

Dosimetric Comparison between Intensity Modulated Radiation Therapy and Volumetric Modulated Arc Therapy (RapidArc) in Rectal Carcinoma

Sparing Hippocampus in Whole Brain Radiotherapy: A Comparative Study between Volumetric Modulated Arc Therapy (RapidArc) and Intensity Modulated Radiation Therapy (IMRT)

Evaluation of Oxygen-18 Water Enriched for the Production of Fluorine-18 in a Medical Cyclotron

Fluorine-18 Production Yield in an 11 MeV Medical Cyclotron: Comparison of Theoretical and Practical Yields

Preparation of [68Ga]PSMA-11 for PET-CT imaging using a manual synthesis module and organic matrix based 68Ge/68Ga generator

Nuclear Medicine and Biology, 2016

[(68)Ga]PSMA-11 is a relatively recently introduced radiopharmaceutical for PET-CT imaging of pro... more [(68)Ga]PSMA-11 is a relatively recently introduced radiopharmaceutical for PET-CT imaging of prostate cancer patients. The availability of (68)Ge/(68)Ga generator and PSMA-11 ligand from commercial sources is facilitating the production of the radiopharmaceutical in-house. This paper describes our experience on the preparation of ~200 batches of [(68)Ga]PSMA-11 for conducting PET-CT imaging in patients suspected/suffering from prostate cancer. The radiosynthesis of [(68)Ga]PSMA-11 was done in a hospital based nuclear medicine department using (68)Ge/(68)Ga generator and a manual synthesis module, both supplied by Isotope Technologies Garching (ITG), Germany. The production involved the reaction of 5μg (5.3nmol) of PSMA-11 ligand in 1 ml of 0.25M sodium acetate buffer with 4ml of (68)GaCl3 in 0.05M HCl for 5min at 105°C; followed by purification in a C18 cartridge and collection through a 0.22μm pore size filter. The radiochemical yields obtained were consistently high, 93.19%±3.76%, and there was hardly any batch failure. The radiochemical purity of the product was &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;99% and the product was stable for over 2h; however it was used in patients immediately after preparation. About 200 batches of [(68)Ga]PSMA-11 were prepared during the period and more than 300 patients received the tracer during the 14months of study. No adverse reaction was observed in any of the patients and the image qualities were consistent with literature reports. [(68)Ga]PSMA-11 with high radiochemical and radionuclidic purity is conveniently prepared by using a (68)Ge/(68)Ga generator and manual synthesis module. The radiochemical yields are very high; and activity sufficient for 3-4 patients can be prepared in a single batch; multiple batches can be done on the same day and when needed after a gap of 1.5-2h.

Antidiabetic and Antioxidant Potentials of Amaranthus hybridus in Streptozotocin-Induced Diabetic Rats

Journal of dietary supplements, Jan 4, 2017

Amaranthus hybridus (Amaranthaceae) has been used as a folk medicine in southern parts of India f... more Amaranthus hybridus (Amaranthaceae) has been used as a folk medicine in southern parts of India for the treatment of diabetes. This research evaluates the antidiabetic and antioxidant effects of Amaranthus hybridus ethanol leaf extract (AHELE) in streptozotocin-induced diabetic rats. Blood glucose levels of diabetic rats were measured on days 1, 4, 7, and 15 after oral administration of AHELE at doses of 200 and 400 mg/kg for 14 days. The effects of extract were observed on serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase, cholesterol, high- and low-density lipoprotein, antioxidant potential, and histopathological changes. AHELE (200 and 400 mg/kg) caused a significant (p < 0.001) reduction in blood glucose levels on day 15 (152.2 and 181.2 mg/dL, respectively versus diabetic control 287.0 mg/dL). The extract also improved serum biochemical parameters associated with diabetes. A significant (p < 0.001) decrease in mal...

Automatic image annotation using SURF descriptors

2012 Annual IEEE India Conference (INDICON), 2012

ABSTRACT In recent years there is an apparent shift in research from content based image retrieva... more ABSTRACT In recent years there is an apparent shift in research from content based image retrieval (CBIR) to automatic image annotation in order to bridge the gap between low level features and high level semantics of images. Automatic Image Annotation (AIA) techniques facilitate extraction of high level semantic concepts from images by machine learning techniques. Many AIA techniques use feature analysis as the first step to identify the objects in the image. However, the high dimensional image features make the performance of the system worse. This paper describes and evaluates an automatic image annotation framework which uses SURF descriptors to select right number of features and right features for annotation. The proposed framework uses a hybrid approach in which k-means clustering is used in the training phase and fuzzy K-NN classification in the annotation phase. The performance of the system is evaluated using standard metrics.

Diagnostic Value of 68Ga PSMA-11 PET/CT Imaging of Brain Tumors—Preliminary Analysis

Clinical Nuclear Medicine, 2016

To evaluate the feasibility of using Ga PSMA-11 PET/CT for imaging brain lesions and its comparis... more To evaluate the feasibility of using Ga PSMA-11 PET/CT for imaging brain lesions and its comparison with F-FDG. Ten patients with brain lesions were included in the study. Five patients were treated cases of glioblastoma with suspected recurrence. F-FDG and Ga PSMA-11 brain scans were done for these patients. Five patients were sent for assessing the nature (primary lesion/metastasis) of space occupying lesion in brain. They underwent whole body F-FDG PET/CT scan and a primary site elsewhere in the body was ruled out. Subsequently they underwent Ga PSMA-11 brain PET/CT imaging. Target to background ratios (TBR) for the brain lesions were calculated using contralateral cerebellar uptake as background. In five treated cases of glioblastoma with suspected recurrence the findings of Ga PSMA-11 PET/CT showed good correlation with that of F-FDG PET/CT scan. Compared to the F-FDG, Ga PSMA-11 PET/CT showed better visualization of the recurrent lesion (presence/absence) owing to its significantly high TBR. Among the five cases evaluated for lesion characterization glioma and atypical meningioma patients showed higher SUVmax in the lesion with Ga PSMA-11 than with F-FDG and converse in cases of lymphoma. TBR was better with Ga PSMA PET/CT in all cases. Ga PSMA-11 PET/CT brain imaging is a potentially useful imaging tool in the evaluation of brain lesions. Absence of physiological uptake of Ga PSMA-11 in the normal brain parenchyma results in high TBR values and consequently better visualization of metabolically active disease in brain.

Preparation of [ 68 Ga]PSMA-11 for PET–CT imaging using a manual synthesis module and organic matrix based 68 Ge/ 68 Ga generator

by Pillai M.R.A., Raviteja Nanabala, and Anees Muhammed

Introduction: [ 68 Ga]PSMA-11 is a relatively recently introduced radiopharmaceutical for PET–CT ... more Introduction: [ 68 Ga]PSMA-11 is a relatively recently introduced radiopharmaceutical for PET–CT imaging of prostate cancer patients. The availability of 68 Ge/ 68 Ga generator and PSMA-11 ligand from commercial sources is facilitating the production of the radiopharmaceutical in-house. This paper describes our experience on the preparation of ~200 batches of [ 68 Ga]PSMA-11 for conducting PET–CT imaging in patients suspected/suffering from prostate cancer. Methods: The radiosynthesis of [ 68 Ga]PSMA-11 was done in a hospital based nuclear medicine department using 68 Ge/ 68 Ga generator and a manual synthesis module, both supplied by Isotope Technologies Garching (ITG), Germany. The production involved the reaction of 5 μg (5.3 nmol) of PSMA-11 ligand in 1 ml of 0.25 M sodium acetate buffer with 4 ml of 68 GaCl 3 in 0.05 M HCl for 5 min at 105 °C; followed by purification in a C18 cartridge and collection through a 0.22 μm pore size filter. Results: The radiochemical yields obtained were consistently high, 93.19% ± 3.76%, and there was hardly any batch failure. The radiochemical purity of the product was N 99% and the product was stable for over 2 h; however it was used in patients immediately after preparation. About 200 batches of [ 68 Ga]PSMA-11 were prepared during the period and more than 300 patients received the tracer during the 14 months of study. No adverse reaction was observed in any of the patients and the image qualities were consistent with literature reports. Conclusion: [ 68 Ga]PSMA-11 with high radiochemical and radionuclidic purity is conveniently prepared by using a 68 Ge/ 68 Ga generator and manual synthesis module. The radiochemical yields are very high; and activity sufficient for 3–4 patients can be prepared in a single batch; multiple batches can be done on the same day and when needed after a gap of 1.5–2 h.

Download

A cost effective method for the preparation of sodium fluoride [18F]NaF for PET-CT imaging by using an in-house designed module

Applied Radiation and Isotopes