Ringkasan El Nino mempengaruhi kandungan uap air di atmosfer yang mengakibatkan rendahnya proses ... more Ringkasan El Nino mempengaruhi kandungan uap air di atmosfer yang mengakibatkan rendahnya proses pembentukan awan. Kurangnya tutupan awan menyebabkan radiasi matahari dapat secara langsung sampai ke permukaan bumi dan digunakan tanaman untuk melakukan proses fotosintesis. Semakin tinggi radiasi yang diterima maka proses fotosintesis dapat berlangsung secara optimal dan meningkatkan Indeks Luas Daun (ILD) tanaman padi, yang berpengaruh pada biomassa dan
Vascular endothelial growth factor (VEGF) plays a major role in tumor angiogenesis. VEGF-C, howev... more Vascular endothelial growth factor (VEGF) plays a major role in tumor angiogenesis. VEGF-C, however, is thought to stimulate the growth of lymphatic vessels because an expression of its specific receptor, VEGF receptor-3 (VEGFR-3), was demonstrated to be restricted to lymphatic vessels. Here we demonstrate that the inactivation of VEGFR-3 by a novel blocking monoclonal antibody (mAb) suppresses tumor growth by inhibiting the neo-angiogenesis of tumor-bearing tis-sues. Although VEGFR-3 is not expressed in adult blood vessels, it is induced in vascular endothelial cells of the tumor-bearing tissues. Hence, VEGFR-3 is another receptor tyrosine kinase involved in tumor-induced angiogenesis. Micro-hemorrhage in the tumorbearing tissue was the most conspicuous histologic finding specific to AFL4 mAbtreated mice. Scanning microscopy demonstrated disruptions of the endothelial lining of the postcapillary venule, prob-ably the cause of micro-hemorrhage and the subsequent collapse of the proximal vessels. These findings suggest the involvement of VEGFR-3 in maintaining the integrity of the endothelial lining during angiogenesis. Moreover, our results suggest that the VEGF-C/VEGFR-3 pathway may serve another candidate target for cancer therapy. (Blood. 2000;96:546-553)
A review is carried out on the characterisation and algorithmic implementation of an extended pro... more A review is carried out on the characterisation and algorithmic implementation of an extended product-form approximation, based on the principle of maximum entropy (ME), for a wide class of arbitrary finite capacity open queueing network models (QNMs) with ...
To evaluate the therapeutic efficacy of oral angiotensin-converting inhibition (ACE) with captopr... more To evaluate the therapeutic efficacy of oral angiotensin-converting inhibition (ACE) with captopril in chronic normotensive congestive heart failure (CHF), acute and cardiocirculatory actions were determined by cardiac catheterization and forearm plethysmography, and ambulatory effects were assessed by echocardiography, nuclear angiography, treadmill exercise, and clinical symptomatology in 10 severe CHF patients. Captopril (90 mg) produced marked (peak 1 hour) and sustained (5 hours) left ventricular filling pressure (23 to 15 mm Hg), systemic vascular resistance decreases, and cardiac index increase (1.99 to 2.41 L/min/m2), while mean blood pressure declined mildly (87 to 80 mm Hg) without heart rate change. Both forearm venous tone and vascular resistance decreased considerably. After 1 week of ambulatory therapy (90 mg three times daily), nuclear angiographic ejection and echocardiogram shortening fractions increased, and exercise duration (341 to 453 sec) and New York Heart Association functional class (3.6 to 2.2) improved. Thus ACE-induced vasodilation by oral captopril improved cardiac performance and clinical status in refractory CHF.
Ringkasan El Nino mempengaruhi kandungan uap air di atmosfer yang mengakibatkan rendahnya proses ... more Ringkasan El Nino mempengaruhi kandungan uap air di atmosfer yang mengakibatkan rendahnya proses pembentukan awan. Kurangnya tutupan awan menyebabkan radiasi matahari dapat secara langsung sampai ke permukaan bumi dan digunakan tanaman untuk melakukan proses fotosintesis. Semakin tinggi radiasi yang diterima maka proses fotosintesis dapat berlangsung secara optimal dan meningkatkan Indeks Luas Daun (ILD) tanaman padi, yang berpengaruh pada biomassa dan
Vascular endothelial growth factor (VEGF) plays a major role in tumor angiogenesis. VEGF-C, howev... more Vascular endothelial growth factor (VEGF) plays a major role in tumor angiogenesis. VEGF-C, however, is thought to stimulate the growth of lymphatic vessels because an expression of its specific receptor, VEGF receptor-3 (VEGFR-3), was demonstrated to be restricted to lymphatic vessels. Here we demonstrate that the inactivation of VEGFR-3 by a novel blocking monoclonal antibody (mAb) suppresses tumor growth by inhibiting the neo-angiogenesis of tumor-bearing tis-sues. Although VEGFR-3 is not expressed in adult blood vessels, it is induced in vascular endothelial cells of the tumor-bearing tissues. Hence, VEGFR-3 is another receptor tyrosine kinase involved in tumor-induced angiogenesis. Micro-hemorrhage in the tumorbearing tissue was the most conspicuous histologic finding specific to AFL4 mAbtreated mice. Scanning microscopy demonstrated disruptions of the endothelial lining of the postcapillary venule, prob-ably the cause of micro-hemorrhage and the subsequent collapse of the proximal vessels. These findings suggest the involvement of VEGFR-3 in maintaining the integrity of the endothelial lining during angiogenesis. Moreover, our results suggest that the VEGF-C/VEGFR-3 pathway may serve another candidate target for cancer therapy. (Blood. 2000;96:546-553)
A review is carried out on the characterisation and algorithmic implementation of an extended pro... more A review is carried out on the characterisation and algorithmic implementation of an extended product-form approximation, based on the principle of maximum entropy (ME), for a wide class of arbitrary finite capacity open queueing network models (QNMs) with ...
To evaluate the therapeutic efficacy of oral angiotensin-converting inhibition (ACE) with captopr... more To evaluate the therapeutic efficacy of oral angiotensin-converting inhibition (ACE) with captopril in chronic normotensive congestive heart failure (CHF), acute and cardiocirculatory actions were determined by cardiac catheterization and forearm plethysmography, and ambulatory effects were assessed by echocardiography, nuclear angiography, treadmill exercise, and clinical symptomatology in 10 severe CHF patients. Captopril (90 mg) produced marked (peak 1 hour) and sustained (5 hours) left ventricular filling pressure (23 to 15 mm Hg), systemic vascular resistance decreases, and cardiac index increase (1.99 to 2.41 L/min/m2), while mean blood pressure declined mildly (87 to 80 mm Hg) without heart rate change. Both forearm venous tone and vascular resistance decreased considerably. After 1 week of ambulatory therapy (90 mg three times daily), nuclear angiographic ejection and echocardiogram shortening fractions increased, and exercise duration (341 to 453 sec) and New York Heart Association functional class (3.6 to 2.2) improved. Thus ACE-induced vasodilation by oral captopril improved cardiac performance and clinical status in refractory CHF.
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