Papers by Neil R McGregor
Journal of Chronic Fatigue Syndrome, 2003
Acta Clinica Belgica, 2004
... CFS in the Primary Care Practice: A Practicing Clinician's Approach Charles W. Lapp ... more ... CFS in the Primary Care Practice: A Practicing Clinician's Approach Charles W. Lapp REVIEW Chronic Fatigue Syndrome in Children and Adolescents James M. Oleske Kenneth J. Friedman Kenneth R. Kaufman Donna Palumbo Jonathan Sterling Terri Lynn Evans Index ...
Journal of Chronic Fatigue Syndrome, Jun 16, 2008
This issue of the journal has articles on Lyme disease in US myalgic encephalomyelitis/chronic fa... more This issue of the journal has articles on Lyme disease in US myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients, a psychiatric data analysis article related to the apathy construct, cortisol levels, and treatment outcomes in CFS patients and a article evaluating the naming of ME/CFS. Chronic Fatigue Syndrome Patients Subsequently Diagnosed with Lyme Disease (Borrelia burgdorferi infection): Evidence for Mycoplasma Species Co-infections Nicholson et al. have previously published articles on the carriage and infection of ME/CFS patients with intracellular and L-form bacterial pathogens. These earlier articles revealed that ME/CFS patients had evidence of multiple carriage of these types of pathogens compared with controls. This article shows that the infection rates of North American ME/CFS
The Medical Journal of Australia, Sep 1, 1995
Objective: To determine whether serum levels of chlorinated hydrocarbons are elevated in patients... more Objective: To determine whether serum levels of chlorinated hydrocarbons are elevated in patients with chronic fatigue syndrome. Methods: Chlorinated hydrocarbon levels were measured in 22 patients with chronic fatigue syndrome (CFS) (a s defined by the Centers for Disease Control [CDC)); in 17 patients with CFS symptoms whose history of exposure to toxic chemicals excluded them from the research definition of CFS; and in 34 non-CFS control subjects matched for age and sex. R es u lts : DDE (1,I-dichloro-2 ,2-bis (p-chlorophenyl) ethene) was detected in all serum samples at levels over 0.4 ppb. The incidence of hexachlorobenzene (HCB) contamination (> 2.0 ppb) was 45% in the CFS group, compared with 21% in the non-CFS control group (P < 0.05). The CFS group had a significantly higher total organochlorine level (15.9ppb; SEM, 4.4) than the control group (6.3 ppb; SEM, 1.1; P< 0.05). The toxic exposure group also had a higher mean organochlorine level (13.6 ppb; SEM, 6.2) than the control group, but the difference was not statistically significant. DDE and HCB comprised more than 90 % of the total organochlorines measured in each of the groups. Conclusion: The results suggest that recalcitrant organochlorines may have an aetiological role in CFS. There were no significant differences in erum organochlorine concentrations between CFS patients and chronic fatigue patients with a history of toxic chemical exposure. Therefore, exclusion of patients from the CDC research definition of CFS on the basis of a reported history of known exposure to toxic chemicals is not valid. The role oflow-Ievel organochlorine bioaccumulation in the development of CFS symptoms requires further investigation.
CRC Press eBooks, Feb 27, 2002
... 5.2 Analgesics, Antipyretics, and Anti-Inflammatory Drugs..... ... Current Advances in CFS The... more ... 5.2 Analgesics, Antipyretics, and Anti-Inflammatory Drugs..... ... Current Advances in CFS Therapy 235 when treatment is resumed. ... 42 In a recent study, low-dose hydrocortisone treatment appeared to have little impact on GH function. ...
CRC Press eBooks, Feb 27, 2002
Journal of Pain and Relief, Jul 8, 2016
A Biological Approach, 2002
... 5.2 Analgesics, Antipyretics, and Anti-Inflammatory Drugs..... ... Current Advances in CFS The... more ... 5.2 Analgesics, Antipyretics, and Anti-Inflammatory Drugs..... ... Current Advances in CFS Therapy 235 when treatment is resumed. ... 42 In a recent study, low-dose hydrocortisone treatment appeared to have little impact on GH function. ...
Metabolomics, 2016
Introduction The human gut microbiota has the ability to modulate host metabolism. Metabolic prof... more Introduction The human gut microbiota has the ability to modulate host metabolism. Metabolic profiling of the microbiota and the host biofluids may determine associations significant of a host-microbe relationship. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a long-term disorder of fatigue that is poorly understood, but has been linked to gut problems and altered microbiota. Objectives Find changes in fecal microbiota and metabolites in ME/CFS and determine their association with blood serum and urine metabolites.. Methods A workflow was developed that correlates microbial counts with fecal, blood serum and urine metabolites quantitated by high-throughput 1 H NMR spectroscopy. The study consists of thirty-four females with ME/CFS (34.9 ± 1.8 SE years old) and twenty-five non-ME/CFS female (33.0 ± 1.6 SE years old). Results The workflow was validated using the non-ME/CFS cohort where fecal short chain fatty acids (SCFA) were associated with serum and urine metabolites indicative of host metabolism changes enacted by SCFA. In the ME/CFS cohort a decrease in fecal lactate and an increase in fecal butyrate, isovalerate and valerate were observed along with an increase in Clostridium spp. and a decrease in Bacteroides spp. These differences were consistent with an increase in microbial fermentation of fiber and amino acids to produce SCFA in the gut of ME/CFS patients. Decreased fecal amino acids positively correlated with substrates of gluconeogenesis and purine synthesis in the serum of ME/CFS patients. Conclusion Increased production of SCFA by microbial fermentation in the gut of ME/CFS patients may be associated with deleterious effects on the host energy metabolism. .
Diagnostics, 2019
Post-exertional malaise (PEM) is a cardinal predictive symptom in the definition of Myalgic Encep... more Post-exertional malaise (PEM) is a cardinal predictive symptom in the definition of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). If the cases overexert themselves they have what is termed "payback" resulting in a worsening of symptoms or relapse which can last for days, weeks or even months. The aim was to assess the changes in biochemistry associated with the cases self-reported PEM scores over a 7-day period and the frequency of reporting over a 12-month period. Forty-seven ME/CFS cases and age/sex-matched controls had a clinical examination, completed questionnaires; were subjected to standard serum biochemistry; had their serum and urine metabolomes analyzed in an observational study. Thirty-five of the 46 ME/CFS cases reported PEM in the last 7-days and these were allocated to the PEM group. The principal biochemical change related to the 7-day severity of PEM was the fall in the purine metabolite, hypoxanthine. This decrease correlated with alterations in the glucose:lactate ratio highly suggestive of a glycolytic anomaly. Increased excretion of urine metabolites within the 7-day response period indicated a hypermetabolic event was occurring. Increases in urine excretion of methylhistidine (muscle protein degradation), mannitol (intestinal barrier deregulation) and acetate were noted with the hypermetabolic event. These data indicate hypoacetylation was occurring, which may also be related to deregulation of multiple cytoplasmic enzymes and DNA histone regulation. These findings suggest the primary events associated with PEM were due to hypoacetylation and metabolite loss during the acute PEM response.
Archives of Internal Medicine, 2000
Widespread pain is noted in many patients with Chronic Fatigue Syndrome (MECFS), Fibromyalgia (FM... more Widespread pain is noted in many patients with Chronic Fatigue Syndrome (MECFS), Fibromyalgia (FM) and Temporomandibular disorders (TMD). These conditions usually start as a localized condition and spread to a widespread pain condition with increasing illness duration. The aim was to assess the changes in biochemistry associated with pain expression and alterations in renal function.Forty-seven MECFS patients and age/sex matched controls had: a clinical examination, completed questionnaires, standard serum biochemistry, glucose tolerance tests and serum and urine metabolomes in an observational study. Increases in pain distribution were associated with reductions in serum essential amino acids, urea, serum sodium and increases in serum glucose and the 24-hour urine volume however the biochemistry was different for each pain area. Regression modelling revealed potential acetylation and methylation defects in the pain subjects. These findings confirm and extend our earlier findings. These changes appear consistent with repeated minor inflammatory mediated alterations in kidney function resulting in essential amino acid deprivation and inhibition of protein synthesis and genetic translation within tissues.
Journal of Chronic Fatigue Syndrome
ABSTRACT ABSTRACT Objectives: To investigate fatty acid and sterol homeo-stasis in patients with ... more ABSTRACT ABSTRACT Objectives: To investigate fatty acid and sterol homeo-stasis in patients with CFS. Methods: Plasma samples were collected from CFS and control subjects and analyzed for lipid composition by GC-MS metabolic profiling techniques. Results: CFS patients had significantly different profiles of fatty acids and sterols compared with control subjects. The 1st and 2nd most important factors discriminating the CFS patients from the controls, were a decrease in elaidic acid (frims-9-octadecenoic acid) and an increase in stearic acid (octadecanoic acid), respectively. The CFS patients also had lower levels of cholesterol, which has potential impact on membrane integrity and function, steroid hormone synthesis, energy metabolism and bile production. The CFS patients could also be subdivided into subgroups based on their fatty acid and sterol composition. The results of cluster analyses and multivariate analyses revealed that several types of homeostasis exist in different types of CFS patients, whereas the control group was largely homogeneous. Viral infections can contribute to the nature of the lipid-based anomalies in CFS patients and lipid profiles from patients with prior viral infections could be differentiated from those without viral histories. Conclusions: The assessment of fatty acids and sterols in fasting plasma samples can indicate essential fatty acid deficits, suggest appropriate types of essential fatty acid oils for formulations, indicate potential cholesterol deficit-associated anomalies, provide evidence for mitochondrial dysfunction and categorize CFS patients into biochemical subgroups. These evaluations provide a basis for devising individually tailored patient management protocols.
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Papers by Neil R McGregor