Papers by Omolola Soji-omoniwa
Biscuit, a popular snack, serve as an ideal vehicle for incorporating therapeutic agents for dise... more Biscuit, a popular snack, serve as an ideal vehicle for incorporating therapeutic agents for disease management. This study aimed to assess the effect of Vernonia amygdalina (VO) and fish oil (FO)supplemented biscuits (VFSB) on the total lipid profile and blood glucose concentration of diabetic rats. Forty-nine Wistar rats were allocated into seven groups (A to G). Upon induction and confirmation of diabetes in experimental rats, fasting blood glucose (FBG) level were monitored weekly using glucometer. Twenty-four hours after the last day of treatment, rats were sacrificed and serum total cholesterol (TC), triglyceride (TG), High-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDLc) concentrations were assayed using assay kits. Results showed a significant (p < 0.05) reduction in FBG, TC, LDL-c, and TG concentrations in biscuit fed groups D, E, and F compared to group B fed VFSB. High-density lipoprotein cholesterol levels significantly increased (p < 0.05) in groups D, E, and F compared to Group B. In conclusion, Vernonia amygdalina and fish oil-supplemented biscuits exhibited a glucose-lowering effect and mitigated dyslipidemia associated with diabetes mellitus.
Journal of Ethnopharmacology
Modulatory properties of Thespesia garckeana (F. Hoffm.) Exell & Hillc. Aqueous fruit extract on ... more Modulatory properties of Thespesia garckeana (F. Hoffm.) Exell & Hillc. Aqueous fruit extract on female rats reproductive hormones and tissues histology and potential inhibitory activity of its constituents against SRD5α2
World Academy of Science, Engineering and Technology, International Journal of Bioengineering and Life Sciences, 2015
Journal of Pharmacy & Bioresources, 2018
The in vitro antiplasmodial activities of cold and hot aqueous extracts of Ochna schweinfurthiana... more The in vitro antiplasmodial activities of cold and hot aqueous extracts of Ochna schweinfurthiana leaf was evaluated against Plasmodium falciparum at concentrations 10, 20, 40 and 80 μg/ml. Parasitaemia was observed after 24, 48 and 72 hours under a light microscope at X100 magnification. The antiplasmodial activity of the extracts were compared with a standard Artemisinin-based Combination Therapy (ACT), artemether/lumefantrine. Phytochemical analysis showed the presence of flavonoids (65.97 mg/100g), alkaloids (0.20 mg/100g), saponins (47.39 mg/100g) and tannins (0.53 mg/100g). There was a significant reduction (P< 0.05) in parasitemia of groups treated with the various doses of the extracts when compared to the control group. The reduction in parasitemia was however not as pronounced as that observed for the standard drug-treated groups. The 10, 20, 40 1nd 80 μg/ml doses of the extracts gave a percentage parasite inhibition of 79.77, 81.86, 83.38 and 86.42 (cold extract) and 76.26, 78.54, 82.72 and 85.06 (hot extract) respectively which are lower than 99.71, 99.81, 100.00 and 100.00 respectively observed for the standard drug after 72 hours. However, in vitro assay of plasmodium lactate dehydrogenase (pLDH) activity did not show any significant difference among the extract-treated groups and those treated with artemether/lumefantrine standard. Findings from this study show that hot and cold aqueous extracts of Ochna schweinfurthiana leaf possess high inhibitory activity against Plasmodium falciparum in vitro especially after 72 hours and justifies it folkloric use as an antimalarial. Keywords: Antiplasmodial; Ochna schweinfurthiana ; Extracts; Parasitemia; ACT
International Blood Research & Reviews, 2014
The aim of this study was to investigate the effect of leaf essential oil of Citrus sinensis (Rut... more The aim of this study was to investigate the effect of leaf essential oil of Citrus sinensis (Rutaceae) on haematological parameters of alloxan-induced diabetic rats. Methodology: Diabetes was induced in albino rats by intraperitoneal administration of single dose of alloxan monohydrate (150 mg/kg body weight). The leaf essential oil of Citrus sinensis at a dose of 110 mg/kg b.wt was administered every other day to the diabetic rats during 15 days. The effects of leaf essential oil on the erythrocyte and leucocyte indices were then evaluated. Results: Red Blood Cell, Packed Cell Volume, White blood cell, Neutrophils and Leucocytes were reduced significantly in diabetic animals. However, treatment with leaf oil of C. sinensis increased these parameters subsequently. Conclusion: It is concluded that leaf essential oil of Citrus sinensis improved the erythrocyte and leucocyte indices of diabetic rats.
Journal of Medical Sciences(Faisalabad), 2013
CERN European Organization for Nuclear Research - Zenodo, May 30, 2022
Background. Diabetes mellitus is an important factor that contribute to non-healing chronic wound... more Background. Diabetes mellitus is an important factor that contribute to non-healing chronic wound and 2 out of 10 diabetic patients in Nigeria present with diabetic foot ulcer. The aim of this study was to evaluate the effect of cod liver oil-enriched Vernonia amygdalina leaf-based diet (CLVA) on wound healing in wound-inflicted type 2 diabetic rats. Methods. Thirty-six albino rats were randomly assigned into 6 groups namely; control (C), diabetic untreated control (DC), reference drug control (RD), 10% CLVA, 20% CLVA and 30% CLVA. All the groups except C were diabetic rats inflicted with wound, while C were non diabetic rats inflicted with wound. Groups C, DC and RC were fed diet without cod liver oil (CLO) and Vernonia amygdalina (VA) leaves. The last 3 groups were fed 10, 20 and 30 % inclusion VA leaves and CLO in their diet. Feeding was done ad libitum for 14 days. Wound areas images, fasting blood glucose (FBG), Serum insulin, nitric oxide (NO) concentrations, wound contraction rate, interleukins-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-kappa B (NF-κB) and vascular endothelial growth factor (VEGF) were monitored. Results. Results showed significant reduction (p < 0.05) in FBG, insulin, NO, IL-1β, IL-6 and TNF-α concentrations of rats fed on 10, 20 and 30 % to DC, while VEGF increased significantly (p < 0.05). Expression of iNOS, COX-2 and NF-κB were downregulated in rats fed on all CLVA inclusion levels. Wound contraction rate increased significantly (p < 0.05) at the various inclusion levels compared to DC, with wound area images showing progressive wound closure in CLVA-fed groups. Conclusion. Consumption of CLVA promoted wound healing in wound-inflicted diabetic rats.
Journal of Pharmacy & Bioresources, 2018
The effect of oral administration of geophagic soil from Uzola on the liver of albino rats was ev... more The effect of oral administration of geophagic soil from Uzola on the liver of albino rats was evaluated in this study. Major oxides composition analysis showed the presence of SiO 2 (55.70%), MnO (0.01%), Al 2 O 3 (23.81%), Fe 2 O 3 (3.03%) etc. Forty-five elements were detected and quantified. Zirconium had highest concentration (344.4ppm) followed by Barium (287ppm) while Molybdenum, Silver, Cadmium and Antimony had the lowest concentration of <0.1ppm. Rats were divided into 4 groups (i.e. A, B, C and D). Group, A which served as the control, was orally administered with distilled water while groups B, C and D were orally administered with 400, 800 and 1200 mg/kg body weight dose of the soil solution respectively. The rats were sacrificed 24 hours after soil solution administration for 1, 7 and 21 days. Liver alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and concentrations of serum total bilirubin, conjugated bilirubin, total protein and albumin were determined. There was a significant increase (p< 0.05) in liver alanine aminotransferase and aspartate aminotransferase activities and serum alanine aminotransferase activities in the experimental animals. Serum total protein concentration also increased significantly (p< 0.05) in the experimental animals when compared to the control group but was reversed to control levels after 21 days administration. Available results show that geophagic clay soil from Uzola, Edo State, Nigeria may have a deleterious effect on liver synthetic functions and may also cause an overproduction of aspartate aminotransferase and alanine aminotransferase in the liver at the doses considered. Keywords: Geophagy; Major oxides; Liver function; Aminotransferases; Hepatotoxic; Uzola
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Papers by Omolola Soji-omoniwa