andmutual cooperation during the exercises (with and without cooperation). Each group received a ... more andmutual cooperation during the exercises (with and without cooperation). Each group received a distinct exercise protocol. At three months they were reversed about variables and protocols. The hypothesis is the beneficial effect in the analyzed aspects. To evaluate the results, it was used the SPSS17.0 software (Statistical Package for Social Sciences), the Friedman test for descriptive analysis and for analysis of the tests performance it was applied the SPAD (Syst eme Portables d’Analyse dês Don ees). Significant difference (p<0,05) in behavior ("GDS") with improvement of depression as well as trends towards improvements in the tests analysed, in distinct phases. Analysis of performance in tests classified them into three groups: mixed results, good results and bad results. Although the short period and frequency of intervention,this physiotherapeutical protocolproved positive for the elderly with Alzheimer ’s Disease, a neurodegenerative pathology.
recruited. Patient dependence (Dependence Scale, DS), patient self-assessed QoL and utility (DEMQ... more recruited. Patient dependence (Dependence Scale, DS), patient self-assessed QoL and utility (DEMQOL; Bath Assessment of Quality of Life in Dementia, BASQID; EQ-5D) were completed by patients with MMSE of 10 only and caregiver proxy assessed scales (DEMQOL proxy, EQ-5D proxy) were completed for all patients. EQ-5D responses were converted into utility scores using a UK algorithm. Bivariate (Pearson correlation) and multivariate analyses (GLM) were used to assess relationships between patient dependence and QoL and utility. Results: Data on 249 participants with AD were analysed. The mean (SD) age of patients was 79(8.5) years and 53.8% were female. The mean (SD) score for MMSE was 14.6(6.8).Pearson correlations revealed significant associations between DS and EQ-5D utility (r ¼-0.19, p<0.05), proxy-assessed EQ-5D utility (r ¼-0.42, p<0.0001) and BASQID total scores (r ¼-0.38, p<0.0001) and no significant associations with the DEMQOL (r ¼-14, NS) and DEM-QOL proxy(r ¼-0.12, NS). Multivariate analyses using GLM, controlling for patient age and gender, confirmed significant associations between dependence and the two EQ-5D utility assessments (P <0.01) and BASQID total score (P <0.0001). When patient age and gender were controlled for, significant associations between dependence and both the DEMQOL and DEMQOL-proxy were observed (P <0.05). It is expected that a one point increase in dependence is associated with the following point decreases: 0.017 (EQ-5D utility), 0.039 (EQ-5D proxy utility), 1.03(DEM-QOL), 0.66(DEMQOL proxy) and 1.395 in the BASQID total score. Conclusions: Patient QoL and utility decrease as AD illness progresses and dependence on others increases. Associations between the dependence and the EQ-5D utility and BASQID total scores were consistently more significant than associations with the DEMQOL and DEMQOL proxy.
The opinions expressed in this publication are those of the authors/researchers and do not necess... more The opinions expressed in this publication are those of the authors/researchers and do not necessarily reflect the official views of the Public Health Agency of Canada. Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Major depression (MDE) is prevalent in men and affects men's health and productivity. Because... more Major depression (MDE) is prevalent in men and affects men's health and productivity. Because of the stigma against depression and social/gender norms, men are less likely to seek help for emotion and stress-related issues. Therefore, innovative solutions tailored for men are needed. With rapid development of the Internet and information technologies, one promising solution that has drawn considerable attentions is electronic mental (e-mental) health programs and services. The objective of our study is to evaluate the effectiveness of the e-mental health program BroHealth on reducing the risk of having MDE and improving productivity and return to investment. The target population is Canadian working men who are at high risk of having MDE (N=1200). Participants will be recruited using the method of random digit dialing across the country and workplace advertisement. Eligible participants will be randomly allocated into the following groups: (1) a control group, (2) a group receiv...
Background Timely assessment of the burden of HIV/AIDS is essential for policy setting and progra... more Background Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. Methods For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes. Our estimation strategy links the GBD 2015 assessment of all-cause mortality and estimation of incidence and prevalence so that for each draw from the uncertainty distribution all assumptions used in each step are internally consistent. We estimated incidence, prevalence, and death with GBD versions of the Estimation and Projection Package (EPP) and Spectrum software originally developed by the Joint United Nations Programme on HIV/AIDS (UNAIDS). We used an open-source version of EPP and recoded Spectrum for speed, and used updated assumptions from systematic reviews of the literature and GBD demographic data. For countries with high-quality vital registration data, we developed the cohort incidence bias adjustment model to estimate HIV incidence and prevalence largely from the number of deaths caused by HIV recorded in cause-of-death statistics. We corrected these statistics for garbage coding and HIV misclassifi cation. Findings Global HIV incidence reached its peak in 1997, at 3•3 million new infections (95% uncertainty interval [UI] 3•1-3•4 million). Annual incidence has stayed relatively constant at about 2•6 million per year (range 2•5-2•8 million) since 2005, after a period of fast decline between 1997 and 2005. The number of people living with HIV/AIDS has been steadily increasing and reached 38•8 million (95% UI 37•6-40•4 million) in 2015. At the same time, HIV/AIDS mortality has been declining at a steady pace, from a peak of 1•8 million deaths (95% UI 1•7-1•9 million) in 2005, to 1•2 million deaths (1•1-1•3 million) in 2015. We recorded substantial heterogeneity in the levels and trends of HIV/AIDS across countries. Although many countries have experienced decreases in HIV/AIDS mortality and in annual new infections, other countries have had slowdowns or increases in rates of change in annual new infections. Interpretation Scale-up of ART and prevention of mother-to-child transmission has been one of the great successes of global health in the past two decades. However, in the past decade, progress in reducing new infections has been slow, development assistance for health devoted to HIV has stagnated, and resources for health in low-income countries have grown slowly. Achievement of the new ambitious goals for HIV enshrined in Sustainable Development Goal 3 and the 90-90-90 UNAIDS targets will be challenging, and will need continued eff orts from governments and international agencies in the next 15 years to end AIDS by 2030.
Major depression is a prevalent mental disorder and imposes considerable burden on health and pro... more Major depression is a prevalent mental disorder and imposes considerable burden on health and productivity. Men are not immune to major depression, yet they often delay seeking help because of perceived stigma and gender norms. E-mental health programs hold potential for early prevention of major depression. However, we have little knowledge about men&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s preferences for design features of e-mental health programs. The objective of this study was to (1) estimate and compare the proportions of Internet use for medical information, preferred design features, and likely use of e-mental health programs; (2) examine factors associated with the likely use of e-mental health programs; and (3) understand potential barriers to the use of e-mental health programs among Canadian working men, who were at high risk of a major depressive episode (MDE). A cross-sectional survey in 10 Canadian provinces was conducted between March and December 2015. Random digit dialing method was used through household landlines and cell phones to collect data from 511 working men who were at high risk of having an MDE and 330 working men who were at low risk of having an MDE. High-risk men were more likely to endorse the importance of accessing health resources on the Internet than low-risk men (83.4% vs 75.0%, respectively; P=.01). Of the 17 different features assessed, the top three features most likely to be used by high-risk men were: &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;information about improving sleep hygiene&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (61.3%), &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;practice and exercise to help reduce symptoms of stress and depression&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (59.5%), and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;having access to quality information and resources about work stress issues&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (57.8%). Compared with men at low risk for MDE, men at high risk for MDE were much more likely to consider using almost every one of the different design features. Differences in preferences for the design features by age among men at high risk of MDE were found only for 3 of 17 features. Differences in preferences for design features between English- and French-speaking participants were found only for 4 out of the 17 features. Analysis of qualitative data revealed that privacy issues, perceived stigma, ease of navigation, personal relevance, and lack of personal interaction, time, and knowledge were identified as barriers to the use of e-mental health programs in working men who were at high risk of MDE. E-mental health programs may be a promising strategy for prevention of depression in working men. Development of e-mental health programs should consider men&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s…
expenditures as a result of their comorbidities. This study assessed the risk of potentially avoi... more expenditures as a result of their comorbidities. This study assessed the risk of potentially avoidable hospitalizations (PAHs) that might be prevented with good outpatient management among ADRD patients. Methods: We examined the proportions of subjects with PAHs among Medicare beneficiaries with and without ADRD using data from 2007-2008 Medicare claims files. We used logistic regression to calculate propensity scores of having ADRD, matching cases (n1⁄4195,024) and an equal number of controls based on age, sex, race, Medicare-Medicaid dual eligibility, residence in a metropolitan statistical area, and number of comorbidities. We defined PAHs as admissions for: serious short-term complications of diabetes, serious long-term complications of diabetes, COPD or asthma, hypertension, and heart failure, based on the Medicare Ambulatory Care Indicators for the Elderly. We used logistic regression to investigate patient characteristics associated with PAHs. Results: Approximately one in five (20.2%) beneficiaries with ADRD and concurrent COPD/asthma had a PAH directly related to COPD/asthma. Corresponding proportions of patients with PAHs were 11.7% for heart failure, 2.8% for diabetes long-term complications, 1.3% for diabetes short-term complications, and 0.5% for hypertension. Compared to propensity-matched non-ADRD subjects, ADRD beneficiaries were more likely to have PAHs for diabetes shortterm complications (OR1⁄41.43; 95% CI1⁄41.31-1.57), diabetes long-term complications (OR1⁄41.08; 95% CI1⁄41.02-1.14), and hypertension (OR1⁄41.22; 95% CI1⁄41.08-1.38), but less likely to have PAHs for COPD/ asthma (OR1⁄40.85; 95% CI1⁄40.82-0.87) and heart failure (OR1⁄40.89; 95% CI1⁄40.86-0.92). Among ADRD patients, the risk of PAHs increased with comorbidity burden and the presence of medical complications associated with late-stage ADRD (ulcers, feeding disorders and malnutrition, aspiration pneumonia, and incontinence). Conclusions: A substantial proportion of Medicare beneficiaries with ADRD had preventable hospital admissions related to uncontrolled comorbidities. For some conditions, such as diabetes and hypertension, ADRD patients had a higher risk of condition-related PAHs compared to matched controls without dementia. Future ADRD management programs should improve care coordination between ambulatory, inpatient, and post-acute care, and these efforts should target high-risk patients, especially patients with multiple chronic conditions.
Academia Mental Health and Well-Being, Sep 13, 2024
Background and Aims: It is not yet well understood whether physical activity may protect against... more Background and Aims: It is not yet well understood whether physical activity may protect against elevated mortality in major depression. Answering this question has implications for policy and practice. The aim of this study was to estimate the association of physical activity (PA) with mortality in major depressive disorder. Methods: We used data from the Canadian Community Health Survey (CCHS) Mental Health and Wellbeing, conducted in 2001 (n=31,200) and the CCHS Mental Health Survey, conducted in 2012 (n=20,935) in this analysis. Recreational physical activity was measured using MET values, classifying participants as active, moderately active, and physically inactive in the 2001 survey and as very active, active, moderately active and physically inactive in the 2012 survey. Major depression was assessed using a fully structured diagnostic instrument, the Composite International Diagnostic Interview. Mortality data was obtained through data linkage. The analysis used Cox proportional hazard models to explore the associations. Results: Physical activity in the 2001 survey was protective: HR 0.69 (95%CI .64-.74), HR 0.77 (95%CI .72-.83) for active and moderately active groups, respectively. In the 2012 survey the HRs were 0.55 (95%CI .43-.70), 0.57 (95%CI .43-.75) and 0.59 (95%CI .46-.76), for very active, active, and moderately active groups. No interactions were significant. Conclusions: These results indicate that physical activity protects against elevated mortality to the same extent in those with MDD as those without. These results support continued efforts to integrate physical activity into the management of depressive disorders.
Journal of the American Medical Directors Association, 2015
Assisted living (AL) is an increasingly used residential option for older adults with dementia; h... more Assisted living (AL) is an increasingly used residential option for older adults with dementia; however, lower staffing rates and service availability raise concerns that such residents may be at increased risk for adverse outcomes. Our objectives were to determine the incidence of hospitalization over 1 year for dementia residents of designated AL (DAL) facilities, compared with long-term care (LTC) facilities, and identify resident- and facility-level predictors of hospitalization among DAL residents. Participants were 609 DAL (mean age 85.7 ± 6.6 years) and 691 LTC (86.4 ± 6.9 years) residents with dementia enrolled in the Alberta Continuing Care Epidemiological Studies. Research nurses completed a standardized comprehensive assessment of residents and interviewed family caregivers at baseline (2006-2008) and 1 year later. Standardized administrator interviews provided facility level data. Hospitalization was determined via linkage with the provincial Inpatient Discharge Abstract Database. Multivariable Cox proportional hazards models were used to identify predictors of hospitalization. The cumulative annual incidence of hospitalization was 38.6% (34.5%-42.7%) for DAL and 10.3% (8.0%-12.6%) for LTC residents with dementia. A significantly increased risk for hospitalization was observed for DAL residents aged 90+ years, with poor social relationships, less severe cognitive impairment, greater health instability, fatigue, high medication use (11+ medications), and 2+ hospitalizations in the preceding year. Residents from DAL facilities with a smaller number of spaces, no chain affiliation, and from specific health regions showed a higher risk of hospitalization. DAL residents with dementia had a hospitalization rate almost 4-fold higher than LTC residents with dementia. Our findings raise questions about the ability of some AL facilities to adequately address the needs of cognitively impaired residents and highlight potential clinical, social, and policy areas for targeted interventions to reduce hospitalization risk.
Background: Epilepsy severity has been recognized as a significant predictor of health-related qu... more Background: Epilepsy severity has been recognized as a significant predictor of health-related quality of life in patients with epilepsy. However, clinical markers of epilepsy severity such as seizure frequency often fail to capture important aspects of the disease. This study investigates the factors associated with patient-reported severity of epilepsy, assessed by the Global Assessment of Severity of Epilepsy (GASE) scale in adults with epilepsy. Methods: Data from a cohort of 250 patients consecutively enrolled in the Neurological Diseases and Depression Study (NEEDS) were used to assess the determinants of epilepsy severity as measured by the GASE scale. Multiple linear regression analyses were used to examine the mediation effect of clinical and sociodemographic characteristics on patients' ratings on the GASE scale. Results: The mean age of the study participants was 39.8 (SD = 14.9) years, of which 44.4% were male. About 66.8% of the participants reported "not at all severe" or "a little severe" epilepsy, while 0.4% reported "extremely severe" epilepsy. One-year seizure freedom, number of antiseizure medications, medication side effects, depression, anxiety, and seizure-related disability were identified as significant determinants of patients' ratings of epilepsy severity. Seizure-related disability mediated the effects of 1-year seizure freedom, number of antiseizure medications, and medication side effects on epilepsy severity. Conclusion: Overall, patients with epilepsy who reported higher GASE scores were less likely to achieve 1-year seizure freedom and more likely to be on more antiseizure medications, experience more side effects from medication, endorse more depression and anxiety symptoms, and have increased self-reported seizure-related disability. The identified determinants of global, self-rated epilepsy severity can aid the design of appropriate interventions and support services for patients with severe epilepsy.
Depression and anxiety are common among people with multiple sclerosis (MS), as are adverse healt... more Depression and anxiety are common among people with multiple sclerosis (MS), as are adverse health behaviours, but the associations between these factors are unclear. To evaluate the associations between cigarette smoking, alcohol use, and depression and anxiety in MS in a cross-Canada prospective study. From July 2010 to March 2011 we recruited consecutive MS patients from four MS clinics. At three visits over two years, clinical and demographic information was collected, and participants completed questionnaires regarding health behaviours and mental health. Of 949 participants, 75.2% were women, with a mean age of 48.6 years; most had a relapsing-remitting course (72.4%). Alcohol dependence was associated with increased odds of anxiety (OR: 1.84; 95% CI: 1.32-2.58) and depression (OR: 1.53; 95% CI: 1.05-2.23) adjusting for age, sex, Expanded Disability Status Scale (EDSS), and smoking status. Smoking was associated with increased odds of anxiety (OR: 1.29; 95% CI: 1.02-1.63) and depression (OR: 1.37; 95% CI: 1.04-1.78) adjusting for age, sex, EDSS, and alcohol dependence. Alcohol dependence was associated with an increased incidence of depression but not anxiety. Depression was associated with an increased incidence of alcohol dependence. Alcohol dependence and smoking were associated with anxiety and depression. Awareness of the effects of adverse health behaviours on mental health in MS might help target counselling and support for those &amp;amp;amp;amp;#39;at risk&amp;amp;amp;amp;#39;.
Seizure-related disability is an important contributor to health-related quality of life in perso... more Seizure-related disability is an important contributor to health-related quality of life in persons with epilepsy. Yet, there is little information on patient-centered reports of seizure-related disability, as most studies focus on specific constructs of health-related disability, rather than epilepsy. We investigated how patients rate their own disability and how these ratings correlate with various clinical and sociodemographic characteristics. In a prospective cohort of 250 adults with epilepsy consecutively enrolled in the Neurological Disease and Depression Study (NEEDs), we obtained a broad range of clinical and patient-reported measures, including patients&amp;amp;#39; ratings of seizure-related disability and epilepsy severity using self-completed, single-item, 7-point response global assessment scales. Spearman&amp;amp;#39;s correlation, multiple linear regression, and mediation analyses were used to examine the association between seizure-related disability scores and clinical and demographic characteristics of persons with epilepsy. The mean age and duration of epilepsy was 39.8 and 16.7 years, respectively. About 29.5% of the patients reported their seizures as &amp;amp;quot;not at all disabling,&amp;amp;quot; whereas 5.8% of the patients reported them as &amp;amp;quot;extremely disabling.&amp;amp;quot; Age, seizure freedom at 1 year, anxiety, and epilepsy severity were identified as statistically significant predictors of disability scores. The indirect effects of age and seizure freedom, attributable to mediation through epilepsy severity, accounted for 25.0% and 30.3% of the total effects of these determinants on seizure-related disability, respectively. Measuring seizure-related disability has heuristic value and it has important correlates and mediators that can be targeted for intervention in practice. Addressing modifiable factors associated with disability (e.g., seizure freedom and anxiety) could have a significant impact on decreasing the burden of disability in people with epilepsy.
Please cite this article as: Ganesh A, et al. Corrigendum to "The case for vitamin D supplementat... more Please cite this article as: Ganesh A, et al. Corrigendum to "The case for vitamin D supplementation in multiple sclerosis" [Mult. Scler. Relat. Disord. 2 (2013) 281-306]. Multiple Sclerosis and Related Disorders (2014), http://dx.
andmutual cooperation during the exercises (with and without cooperation). Each group received a ... more andmutual cooperation during the exercises (with and without cooperation). Each group received a distinct exercise protocol. At three months they were reversed about variables and protocols. The hypothesis is the beneficial effect in the analyzed aspects. To evaluate the results, it was used the SPSS17.0 software (Statistical Package for Social Sciences), the Friedman test for descriptive analysis and for analysis of the tests performance it was applied the SPAD (Syst eme Portables d’Analyse dês Don ees). Significant difference (p<0,05) in behavior ("GDS") with improvement of depression as well as trends towards improvements in the tests analysed, in distinct phases. Analysis of performance in tests classified them into three groups: mixed results, good results and bad results. Although the short period and frequency of intervention,this physiotherapeutical protocolproved positive for the elderly with Alzheimer ’s Disease, a neurodegenerative pathology.
recruited. Patient dependence (Dependence Scale, DS), patient self-assessed QoL and utility (DEMQ... more recruited. Patient dependence (Dependence Scale, DS), patient self-assessed QoL and utility (DEMQOL; Bath Assessment of Quality of Life in Dementia, BASQID; EQ-5D) were completed by patients with MMSE of 10 only and caregiver proxy assessed scales (DEMQOL proxy, EQ-5D proxy) were completed for all patients. EQ-5D responses were converted into utility scores using a UK algorithm. Bivariate (Pearson correlation) and multivariate analyses (GLM) were used to assess relationships between patient dependence and QoL and utility. Results: Data on 249 participants with AD were analysed. The mean (SD) age of patients was 79(8.5) years and 53.8% were female. The mean (SD) score for MMSE was 14.6(6.8).Pearson correlations revealed significant associations between DS and EQ-5D utility (r ¼-0.19, p<0.05), proxy-assessed EQ-5D utility (r ¼-0.42, p<0.0001) and BASQID total scores (r ¼-0.38, p<0.0001) and no significant associations with the DEMQOL (r ¼-14, NS) and DEM-QOL proxy(r ¼-0.12, NS). Multivariate analyses using GLM, controlling for patient age and gender, confirmed significant associations between dependence and the two EQ-5D utility assessments (P <0.01) and BASQID total score (P <0.0001). When patient age and gender were controlled for, significant associations between dependence and both the DEMQOL and DEMQOL-proxy were observed (P <0.05). It is expected that a one point increase in dependence is associated with the following point decreases: 0.017 (EQ-5D utility), 0.039 (EQ-5D proxy utility), 1.03(DEM-QOL), 0.66(DEMQOL proxy) and 1.395 in the BASQID total score. Conclusions: Patient QoL and utility decrease as AD illness progresses and dependence on others increases. Associations between the dependence and the EQ-5D utility and BASQID total scores were consistently more significant than associations with the DEMQOL and DEMQOL proxy.
The opinions expressed in this publication are those of the authors/researchers and do not necess... more The opinions expressed in this publication are those of the authors/researchers and do not necessarily reflect the official views of the Public Health Agency of Canada. Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Major depression (MDE) is prevalent in men and affects men's health and productivity. Because... more Major depression (MDE) is prevalent in men and affects men's health and productivity. Because of the stigma against depression and social/gender norms, men are less likely to seek help for emotion and stress-related issues. Therefore, innovative solutions tailored for men are needed. With rapid development of the Internet and information technologies, one promising solution that has drawn considerable attentions is electronic mental (e-mental) health programs and services. The objective of our study is to evaluate the effectiveness of the e-mental health program BroHealth on reducing the risk of having MDE and improving productivity and return to investment. The target population is Canadian working men who are at high risk of having MDE (N=1200). Participants will be recruited using the method of random digit dialing across the country and workplace advertisement. Eligible participants will be randomly allocated into the following groups: (1) a control group, (2) a group receiv...
Background Timely assessment of the burden of HIV/AIDS is essential for policy setting and progra... more Background Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. Methods For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes. Our estimation strategy links the GBD 2015 assessment of all-cause mortality and estimation of incidence and prevalence so that for each draw from the uncertainty distribution all assumptions used in each step are internally consistent. We estimated incidence, prevalence, and death with GBD versions of the Estimation and Projection Package (EPP) and Spectrum software originally developed by the Joint United Nations Programme on HIV/AIDS (UNAIDS). We used an open-source version of EPP and recoded Spectrum for speed, and used updated assumptions from systematic reviews of the literature and GBD demographic data. For countries with high-quality vital registration data, we developed the cohort incidence bias adjustment model to estimate HIV incidence and prevalence largely from the number of deaths caused by HIV recorded in cause-of-death statistics. We corrected these statistics for garbage coding and HIV misclassifi cation. Findings Global HIV incidence reached its peak in 1997, at 3•3 million new infections (95% uncertainty interval [UI] 3•1-3•4 million). Annual incidence has stayed relatively constant at about 2•6 million per year (range 2•5-2•8 million) since 2005, after a period of fast decline between 1997 and 2005. The number of people living with HIV/AIDS has been steadily increasing and reached 38•8 million (95% UI 37•6-40•4 million) in 2015. At the same time, HIV/AIDS mortality has been declining at a steady pace, from a peak of 1•8 million deaths (95% UI 1•7-1•9 million) in 2005, to 1•2 million deaths (1•1-1•3 million) in 2015. We recorded substantial heterogeneity in the levels and trends of HIV/AIDS across countries. Although many countries have experienced decreases in HIV/AIDS mortality and in annual new infections, other countries have had slowdowns or increases in rates of change in annual new infections. Interpretation Scale-up of ART and prevention of mother-to-child transmission has been one of the great successes of global health in the past two decades. However, in the past decade, progress in reducing new infections has been slow, development assistance for health devoted to HIV has stagnated, and resources for health in low-income countries have grown slowly. Achievement of the new ambitious goals for HIV enshrined in Sustainable Development Goal 3 and the 90-90-90 UNAIDS targets will be challenging, and will need continued eff orts from governments and international agencies in the next 15 years to end AIDS by 2030.
Major depression is a prevalent mental disorder and imposes considerable burden on health and pro... more Major depression is a prevalent mental disorder and imposes considerable burden on health and productivity. Men are not immune to major depression, yet they often delay seeking help because of perceived stigma and gender norms. E-mental health programs hold potential for early prevention of major depression. However, we have little knowledge about men&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s preferences for design features of e-mental health programs. The objective of this study was to (1) estimate and compare the proportions of Internet use for medical information, preferred design features, and likely use of e-mental health programs; (2) examine factors associated with the likely use of e-mental health programs; and (3) understand potential barriers to the use of e-mental health programs among Canadian working men, who were at high risk of a major depressive episode (MDE). A cross-sectional survey in 10 Canadian provinces was conducted between March and December 2015. Random digit dialing method was used through household landlines and cell phones to collect data from 511 working men who were at high risk of having an MDE and 330 working men who were at low risk of having an MDE. High-risk men were more likely to endorse the importance of accessing health resources on the Internet than low-risk men (83.4% vs 75.0%, respectively; P=.01). Of the 17 different features assessed, the top three features most likely to be used by high-risk men were: &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;information about improving sleep hygiene&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (61.3%), &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;practice and exercise to help reduce symptoms of stress and depression&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (59.5%), and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;having access to quality information and resources about work stress issues&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; (57.8%). Compared with men at low risk for MDE, men at high risk for MDE were much more likely to consider using almost every one of the different design features. Differences in preferences for the design features by age among men at high risk of MDE were found only for 3 of 17 features. Differences in preferences for design features between English- and French-speaking participants were found only for 4 out of the 17 features. Analysis of qualitative data revealed that privacy issues, perceived stigma, ease of navigation, personal relevance, and lack of personal interaction, time, and knowledge were identified as barriers to the use of e-mental health programs in working men who were at high risk of MDE. E-mental health programs may be a promising strategy for prevention of depression in working men. Development of e-mental health programs should consider men&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s…
expenditures as a result of their comorbidities. This study assessed the risk of potentially avoi... more expenditures as a result of their comorbidities. This study assessed the risk of potentially avoidable hospitalizations (PAHs) that might be prevented with good outpatient management among ADRD patients. Methods: We examined the proportions of subjects with PAHs among Medicare beneficiaries with and without ADRD using data from 2007-2008 Medicare claims files. We used logistic regression to calculate propensity scores of having ADRD, matching cases (n1⁄4195,024) and an equal number of controls based on age, sex, race, Medicare-Medicaid dual eligibility, residence in a metropolitan statistical area, and number of comorbidities. We defined PAHs as admissions for: serious short-term complications of diabetes, serious long-term complications of diabetes, COPD or asthma, hypertension, and heart failure, based on the Medicare Ambulatory Care Indicators for the Elderly. We used logistic regression to investigate patient characteristics associated with PAHs. Results: Approximately one in five (20.2%) beneficiaries with ADRD and concurrent COPD/asthma had a PAH directly related to COPD/asthma. Corresponding proportions of patients with PAHs were 11.7% for heart failure, 2.8% for diabetes long-term complications, 1.3% for diabetes short-term complications, and 0.5% for hypertension. Compared to propensity-matched non-ADRD subjects, ADRD beneficiaries were more likely to have PAHs for diabetes shortterm complications (OR1⁄41.43; 95% CI1⁄41.31-1.57), diabetes long-term complications (OR1⁄41.08; 95% CI1⁄41.02-1.14), and hypertension (OR1⁄41.22; 95% CI1⁄41.08-1.38), but less likely to have PAHs for COPD/ asthma (OR1⁄40.85; 95% CI1⁄40.82-0.87) and heart failure (OR1⁄40.89; 95% CI1⁄40.86-0.92). Among ADRD patients, the risk of PAHs increased with comorbidity burden and the presence of medical complications associated with late-stage ADRD (ulcers, feeding disorders and malnutrition, aspiration pneumonia, and incontinence). Conclusions: A substantial proportion of Medicare beneficiaries with ADRD had preventable hospital admissions related to uncontrolled comorbidities. For some conditions, such as diabetes and hypertension, ADRD patients had a higher risk of condition-related PAHs compared to matched controls without dementia. Future ADRD management programs should improve care coordination between ambulatory, inpatient, and post-acute care, and these efforts should target high-risk patients, especially patients with multiple chronic conditions.
Academia Mental Health and Well-Being, Sep 13, 2024
Background and Aims: It is not yet well understood whether physical activity may protect against... more Background and Aims: It is not yet well understood whether physical activity may protect against elevated mortality in major depression. Answering this question has implications for policy and practice. The aim of this study was to estimate the association of physical activity (PA) with mortality in major depressive disorder. Methods: We used data from the Canadian Community Health Survey (CCHS) Mental Health and Wellbeing, conducted in 2001 (n=31,200) and the CCHS Mental Health Survey, conducted in 2012 (n=20,935) in this analysis. Recreational physical activity was measured using MET values, classifying participants as active, moderately active, and physically inactive in the 2001 survey and as very active, active, moderately active and physically inactive in the 2012 survey. Major depression was assessed using a fully structured diagnostic instrument, the Composite International Diagnostic Interview. Mortality data was obtained through data linkage. The analysis used Cox proportional hazard models to explore the associations. Results: Physical activity in the 2001 survey was protective: HR 0.69 (95%CI .64-.74), HR 0.77 (95%CI .72-.83) for active and moderately active groups, respectively. In the 2012 survey the HRs were 0.55 (95%CI .43-.70), 0.57 (95%CI .43-.75) and 0.59 (95%CI .46-.76), for very active, active, and moderately active groups. No interactions were significant. Conclusions: These results indicate that physical activity protects against elevated mortality to the same extent in those with MDD as those without. These results support continued efforts to integrate physical activity into the management of depressive disorders.
Journal of the American Medical Directors Association, 2015
Assisted living (AL) is an increasingly used residential option for older adults with dementia; h... more Assisted living (AL) is an increasingly used residential option for older adults with dementia; however, lower staffing rates and service availability raise concerns that such residents may be at increased risk for adverse outcomes. Our objectives were to determine the incidence of hospitalization over 1 year for dementia residents of designated AL (DAL) facilities, compared with long-term care (LTC) facilities, and identify resident- and facility-level predictors of hospitalization among DAL residents. Participants were 609 DAL (mean age 85.7 ± 6.6 years) and 691 LTC (86.4 ± 6.9 years) residents with dementia enrolled in the Alberta Continuing Care Epidemiological Studies. Research nurses completed a standardized comprehensive assessment of residents and interviewed family caregivers at baseline (2006-2008) and 1 year later. Standardized administrator interviews provided facility level data. Hospitalization was determined via linkage with the provincial Inpatient Discharge Abstract Database. Multivariable Cox proportional hazards models were used to identify predictors of hospitalization. The cumulative annual incidence of hospitalization was 38.6% (34.5%-42.7%) for DAL and 10.3% (8.0%-12.6%) for LTC residents with dementia. A significantly increased risk for hospitalization was observed for DAL residents aged 90+ years, with poor social relationships, less severe cognitive impairment, greater health instability, fatigue, high medication use (11+ medications), and 2+ hospitalizations in the preceding year. Residents from DAL facilities with a smaller number of spaces, no chain affiliation, and from specific health regions showed a higher risk of hospitalization. DAL residents with dementia had a hospitalization rate almost 4-fold higher than LTC residents with dementia. Our findings raise questions about the ability of some AL facilities to adequately address the needs of cognitively impaired residents and highlight potential clinical, social, and policy areas for targeted interventions to reduce hospitalization risk.
Background: Epilepsy severity has been recognized as a significant predictor of health-related qu... more Background: Epilepsy severity has been recognized as a significant predictor of health-related quality of life in patients with epilepsy. However, clinical markers of epilepsy severity such as seizure frequency often fail to capture important aspects of the disease. This study investigates the factors associated with patient-reported severity of epilepsy, assessed by the Global Assessment of Severity of Epilepsy (GASE) scale in adults with epilepsy. Methods: Data from a cohort of 250 patients consecutively enrolled in the Neurological Diseases and Depression Study (NEEDS) were used to assess the determinants of epilepsy severity as measured by the GASE scale. Multiple linear regression analyses were used to examine the mediation effect of clinical and sociodemographic characteristics on patients' ratings on the GASE scale. Results: The mean age of the study participants was 39.8 (SD = 14.9) years, of which 44.4% were male. About 66.8% of the participants reported "not at all severe" or "a little severe" epilepsy, while 0.4% reported "extremely severe" epilepsy. One-year seizure freedom, number of antiseizure medications, medication side effects, depression, anxiety, and seizure-related disability were identified as significant determinants of patients' ratings of epilepsy severity. Seizure-related disability mediated the effects of 1-year seizure freedom, number of antiseizure medications, and medication side effects on epilepsy severity. Conclusion: Overall, patients with epilepsy who reported higher GASE scores were less likely to achieve 1-year seizure freedom and more likely to be on more antiseizure medications, experience more side effects from medication, endorse more depression and anxiety symptoms, and have increased self-reported seizure-related disability. The identified determinants of global, self-rated epilepsy severity can aid the design of appropriate interventions and support services for patients with severe epilepsy.
Depression and anxiety are common among people with multiple sclerosis (MS), as are adverse healt... more Depression and anxiety are common among people with multiple sclerosis (MS), as are adverse health behaviours, but the associations between these factors are unclear. To evaluate the associations between cigarette smoking, alcohol use, and depression and anxiety in MS in a cross-Canada prospective study. From July 2010 to March 2011 we recruited consecutive MS patients from four MS clinics. At three visits over two years, clinical and demographic information was collected, and participants completed questionnaires regarding health behaviours and mental health. Of 949 participants, 75.2% were women, with a mean age of 48.6 years; most had a relapsing-remitting course (72.4%). Alcohol dependence was associated with increased odds of anxiety (OR: 1.84; 95% CI: 1.32-2.58) and depression (OR: 1.53; 95% CI: 1.05-2.23) adjusting for age, sex, Expanded Disability Status Scale (EDSS), and smoking status. Smoking was associated with increased odds of anxiety (OR: 1.29; 95% CI: 1.02-1.63) and depression (OR: 1.37; 95% CI: 1.04-1.78) adjusting for age, sex, EDSS, and alcohol dependence. Alcohol dependence was associated with an increased incidence of depression but not anxiety. Depression was associated with an increased incidence of alcohol dependence. Alcohol dependence and smoking were associated with anxiety and depression. Awareness of the effects of adverse health behaviours on mental health in MS might help target counselling and support for those &amp;amp;amp;amp;#39;at risk&amp;amp;amp;amp;#39;.
Seizure-related disability is an important contributor to health-related quality of life in perso... more Seizure-related disability is an important contributor to health-related quality of life in persons with epilepsy. Yet, there is little information on patient-centered reports of seizure-related disability, as most studies focus on specific constructs of health-related disability, rather than epilepsy. We investigated how patients rate their own disability and how these ratings correlate with various clinical and sociodemographic characteristics. In a prospective cohort of 250 adults with epilepsy consecutively enrolled in the Neurological Disease and Depression Study (NEEDs), we obtained a broad range of clinical and patient-reported measures, including patients&amp;amp;#39; ratings of seizure-related disability and epilepsy severity using self-completed, single-item, 7-point response global assessment scales. Spearman&amp;amp;#39;s correlation, multiple linear regression, and mediation analyses were used to examine the association between seizure-related disability scores and clinical and demographic characteristics of persons with epilepsy. The mean age and duration of epilepsy was 39.8 and 16.7 years, respectively. About 29.5% of the patients reported their seizures as &amp;amp;quot;not at all disabling,&amp;amp;quot; whereas 5.8% of the patients reported them as &amp;amp;quot;extremely disabling.&amp;amp;quot; Age, seizure freedom at 1 year, anxiety, and epilepsy severity were identified as statistically significant predictors of disability scores. The indirect effects of age and seizure freedom, attributable to mediation through epilepsy severity, accounted for 25.0% and 30.3% of the total effects of these determinants on seizure-related disability, respectively. Measuring seizure-related disability has heuristic value and it has important correlates and mediators that can be targeted for intervention in practice. Addressing modifiable factors associated with disability (e.g., seizure freedom and anxiety) could have a significant impact on decreasing the burden of disability in people with epilepsy.
Please cite this article as: Ganesh A, et al. Corrigendum to "The case for vitamin D supplementat... more Please cite this article as: Ganesh A, et al. Corrigendum to "The case for vitamin D supplementation in multiple sclerosis" [Mult. Scler. Relat. Disord. 2 (2013) 281-306]. Multiple Sclerosis and Related Disorders (2014), http://dx.
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