Papers by Ahmad Salimzadeh
Arthritis Research & Therapy
Background/objective Osteoporosis is a global health concern with an increasing prevalence worldw... more Background/objective Osteoporosis is a global health concern with an increasing prevalence worldwide. Denosumab is an antiresoptive agent that has been demonstrated to be effective and safe in osteoporotic patients. This study aimed to compare the efficacy and safety of the biosimilar denosumab candidate (Arylia) to the originator product (Prolia®) in postmenopausal osteoporotic patients. Methods In this randomized, double-blind, active-controlled, noninferiority trial, postmenopausal osteoporotic patients received 60 mg of subcutaneous Arylia or Prolia® at months 0, 6, and 12 and were followed up for 18 months. The primary endpoint was the noninferiority of the biosimilar product to the reference product in the percentage change of bone mineral density (BMD) in 18 months at the lumbar spine (L1-L4), total hip, and femoral neck. The secondary endpoints were safety assessment, the incidence of new vertebral fractures, and the trend of bone turnover markers (BTMs). Results A total of ...
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2011
Although patients with chronic diseases are at high-risk for symptoms of anxiety and depression, ... more Although patients with chronic diseases are at high-risk for symptoms of anxiety and depression, few studies have compared patients with different chronic conditions in this regard. This study aimed to compare patients with different chronic medical conditions in terms of anxiety and depression symptoms after controlling for the effects of socio-demographic and clinical data. This cross-sectional study enrolled 2234 adults, either healthy (n = 362) or patients with chronic medical conditions (n = 1872). Participants were recruited from the outpatient clinic of Baqiyatallah Hospital, Tehran, Iran. Patients had one of the following five medical conditions: coronary artery disease (n = 675), renal transplantation (n = 383), chronic hemodialysis (n = 68), rheumatoid conditions (rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus and ankylosing spondylitis) (n = 666) and viral hepatitis (n = 80). Independent factors included socio-demographic data, pain disability, and som...
International Journal of Rheumatic Diseases, 2014
AimThe presence of a direct relationship between body mass index (BMI) and bone mineral density (... more AimThe presence of a direct relationship between body mass index (BMI) and bone mineral density (BMD) is frequently reported. However, data on the relationship between visceral fat and bone density varies, with positive, negative or no relationship having been reported. This study aims to examine the relationship between abdominal visceral fat and BMD.MethodsA cross sectional study was carried out on 95 premenopausal, overweight and obese women aged 30–50 years referred to Sina Hospital, Tehran, Iran in 2011–2012. Anthropometric indices and visceral fat levels were measured.ResultsMultiple linear regression analysis showed that proximal femur BMD (P = 0.856) and lumbar spine BMD (P = 0.558) were not significantly related to visceral fat level. However, BMI had a direct and significant positive relationship with proximal femur BMD (P = 0.001) and lumbar spine BMD (P = 0.031). Menarche age was negatively related to lumbar spine BMD (P = 0.003).ConclusionsIn this study, after adjusting...
Garlic is known as anherbal, which is one of the traditional treatments of reducing the risk of c... more Garlic is known as anherbal, which is one of the traditional treatments of reducing the risk of cardiovascular disease. Inthe elderly, especially in obese individuals,controlling of blood sugar maybedisruptedbyvarious factors.In this double blind study we have investigated the effect of 12 weeks of garlic supplement on fasting blood sugar in 80 post-menopausal overweight or obese women with knee osteoarthritis that were randomly divided into two groups: Garlic(500 mg twice a day) and placebo(500 mg lactose twice a day).Blood samples were collected at the beginning and after 12 weeks of intervention. Weight, height, waist and hip circumference and food intake were measured at the beginning and the end of the study.At the end of the study, we found significant decrease on fasting blood sugar in garlic group compare with the placebo (98.82±19.35 to 96.11±14.49 mg/dl P= 0.03). Body weight, waist and hip circumferencedid not have significant decrease after the end of the study in garlic group compare with placebo group.
Genetics and Molecular Research, 2011
The myogenic determination 1 (MyoD1) gene is a member of the MyoD gene family. It encodes for ske... more The myogenic determination 1 (MyoD1) gene is a member of the MyoD gene family. It encodes for skeletal musclespecific transcription factors containing highly conserved basic helixloop-helix regions that perform important roles in the initiation, maintenance, and regulation of phenotypic traits. We investigated a new single nucleotide polymorphism (SNP) in the MyoD1 gene to evaluate whether this polymorphism affects meat quality traits in five Chinese indigenous cattle breeds, namely Qinchuan (QC), Xia-Nan (XN), Nan-yang (NY), Luxi (LX), and Jia-xian red (JXR). A C→G transversion at position 624 was detected in exon 1 of the MyoD1 gene; it causes an amino acid substitution (624 serine/ 624 cysteine). Least squares analysis showed that this SNP is not significantly associated with back
Gastroenterology, 2000
Introduction: Few studies in gastroenterological disorders have compared the use of disease-speci... more Introduction: Few studies in gastroenterological disorders have compared the use of disease-specific and generic quality of life questionnaires. There are theoretical reasons to suggest that the two types of questionnaire tap into different areas of the patients experience of health. Aims: This study aims to assess whether quality of life measured by a disease-specific questionnaire (the IBDQ) and a generic questionnaire (the SF36) are affected by the same or different variables. We predicted that disease activity and extent would affect disease-specific quality of life whereas age and the presence of other diseases (i.e. co-morbidity) would have more effect on the generic quality of life. Design: Single cross-sectional survey. Methods: 107 subjects completed the SF-36, the IBDQ, the CAl (symptom activity) and reported any co-morbid conditions. The effect of age and symptom activity were assessed using Pearson correlations. The effect of gender, disease extent and co-morbidity was assessed using t-test and ANOV A. The IBDQ total score and SF-36 component scores were compared with respect to the 5 factors already mentioned. Results: Age was negatively correlated with SF-36 Physical Functioning and Role Limitation -Physical domain scores, but was positively correlated with the mDQ Emotional domain and SF-36 Mental Component Scores. The only difference between males and females was in SF-36Health Perception domain. Symptom activity showed moderate to strong negative correlation with all IBDQ domain and total scores (r values between -0.58 and -0.80), but only weak to moderate correlation with the SF-36 domain and component scores (r values between -0.22 and -0.55). The only difference between those with distal and total colitis was in the SF-36 Energy and Vitality domain. Co-morbidity (principally musculoskeletal and cardiovascular) was associated with lower SF-36 Physical Functioning, Role Limitation -Physical, Health Perception, Bodily Pain and Physical Component Scores (p values a[[<0.05 or <0.001). Comorbidity did not affect the total IBDQ score but did influence the social domain (p<0.05). Summary: As hypothesised, the IBDQ was more sensitive to differences in symptom activity and the SF-36 to age and presence of co-morbidity. The choice of using a disease-specific or generic quality of life questionnaire should be informed by the questions to be answered. Both disease-specific and generic questionnaires may be needed to capture the full picture.
Introduction: The bone mass density (BMD) may vary in different countries due to different geneti... more Introduction: The bone mass density (BMD) may vary in different countries due to different genetic and environmental factors. This study was performed to determine the BMD of the normal population in Iran. Methods and Materials: Subjects were selected randomly from different works and social classes in Tehran (from the lowest to the highest). For each decade and sexes, 20 normal subjects were selected (140 men and 140 women). BMD was measured with a Hologic 1000 plus machine by dual energy x-ray absorptiometry (DEXA) method for the lumber spine (L1, L2, L3, L4, L1-L4) and the femoral neck (neck, trochanter, intertrochanter, ward, total). Data were treated by polynomial approximation (3 rd degree). The obtained curves were compared with the standard Hologic curves for Caucasians. Results: In female the peak bone mass (PBM) was 1.019 g/cm² for the lumbar spine and 0.832 for the femoral neck. In male the peak bone mass (PBM) was 0.987 g/cm² for the lumbar spine and 0.907 for the femoral neck. The BMD of both lumbar spine and femoral neck were lower than the Hologic standards. For the lumbar spine the mean difference was 6.5 percent (2 to 21 percent, CI=1) for women and 13.8 percent (2 to 36 percent, CI=1.45) for men. In femoral neck the mean difference was 5.4 percent (2 to 16 percent, CI=0.96) for women and 4.6 percent (1 to 14 percent, CI=0.96) for men. Conclusion: The BMD of the lumbar spine and the femoral neck was lower in Iranian compared to the Hologic standards for Caucasians. This was seen in all age groups and in both sexes. It was less pronounced for the PBM in spine was lower in men than woman. The lower BMD of the spine in men was also seen in a cohort of patients with different diseases (inflammatory and non-inflammatory).
APLAR Journal of Rheumatology, 2005
Background: Bone mineral density (BMD) of the spine and the femoral neck are accurate indicators... more Background: Bone mineral density (BMD) of the spine and the femoral neck are accurate indicators of the bone mass and thus useful predictors of fracture risk. Dual energy X‐ray absorptiometry (DEXA) is the easiest, yet the most precise and non‐invasive technique. The need for a population‐specific normative BMD data is vital in preventing mislabelling or misdiagnosis of osteopenia or even osteoporosis.Aim: This study was performed to determine the lumbar vertebral and the proximal femur BMD measured by DEXA in 280 normal Iranian men and women.Method: Subjects were selected randomly from different social economic classes in Tehran. Normal subjects were selected for each decade and both sexes. BMD was measured with a Hologic QDR 1000+ densitometer, for the lumbar spine (L1, L2, L3, L4, L1–L4) and the femoral neck (neck, trochanter, intertrochanter, ward triangle, total). Data were treated by polynomial approximation (3rd degree).Results: In women, the highest BMD recorded was 1.02...
Singapore medical journal, 2007
Low back pain and lumbar radicular pain are the leading causes of job loss worldwide. Therapeutic... more Low back pain and lumbar radicular pain are the leading causes of job loss worldwide. Therapeutic approaches to lumbar radicular pain, including sciatica and spinal canal stenosis, are diverse. Many clinicians use 80 mg long-acting glucocorticoids in epidural steroid injections (ESI). The aim of this study is to compare the clinical response of 80 mg versus 40 mg methylprednisolone in ESI. 84 patients with newly exacerbated lumbar radicular pain were randomly al located into two groups. 43 patients under went ESI with 80 mg Depo-Medrol and 41 age- and sex-matched cases received 40 mg Depo-Medrol as the comparison group. The pain in the second week, and every month thereafter was assessed using a visual analogue scale (VAS). Remarkable improvement in one month VAS occurred in 64 cases (75 percent) from both groups. VAS values between 80 mg and 40 mg groups were comparable in the two-week (p-value is 0.827) and three-month (p-value is greater than 0.746) post-injection periods. Slight...
Medical journal of the Islamic Republic of Iran, 2014
To estimate the prevalence and characteristics of Rheumatoid Arthritis (RA) in an urban area of T... more To estimate the prevalence and characteristics of Rheumatoid Arthritis (RA) in an urban area of Tehran. A total of 50 clusters were randomly selected in Tehran and 10291 subjects completed the COPCORD Core Questionnaire during 2004 and 2005. Patients with rheumatic complaints were examined and diagnosed by subspecialty fellows in rheumatology. Laboratory and radiology tests were also performed if required. A total of 35 subjects (5 men and 30 women) were diagnosed with RA, with a prevalence of 0.33% (95% CI: 0.22-0.46). Our results demonstrated that RA was six times more common in women than men. The mean age (± SD) of patients was 52.3 (± 17.6) years. Morning stiffness > 1 hour was reported in 37.1% of patients. Rheumatic signs were commonly found in wrist (60%), knee (60%), metacarpophalangeal (48.6%) and proximal interphalangeals of hand (40%). Approximately 46% of patients had difficulty carrying out daily activities. According to our study, the prevalence of RA in Iran seems...
BMC musculoskeletal disorders, 2006
The study was aimed at determining the prevalence of secondary amyloidosis in a group of Iranian ... more The study was aimed at determining the prevalence of secondary amyloidosis in a group of Iranian patients with Rheumatoid Arthritis (RA), and the assessment of its correlation with the clinical and laboratory findings and data. A total number of 220 patients (167 female and 53 male) with a minimum five-year history of RA were selected. Congo red staining method was used for staining the specimens obtained by abdominal subcutaneous fat biopsy (ASFB) method. All of the specimens were examined for apple-green birefringence under polarized light microscope. Clinical and laboratory characteristics of the patients were assessed. Chi-square test and unpaired student's t-test were run for intergroup comparisons. Amyloid deposition test yielded positive results in 15 out of the 220 cases (6.8%) examined by the ASFB technique. Thirteen patients were found to have minimal amyloid deposits. Of all the clinically significant cases, 8 (53%) presented with proteinuria, and 7 cases (46.6%) had ...
The objective of this study was to validate the use of bone mineral measurements of the calcaneus... more The objective of this study was to validate the use of bone mineral measurements of the calcaneus bone by dual X-ray and laser (DXL) in a cross-sectional study carried out in an osteoporosis clinic. Measurements of bone mineral density (BMD) at proximal femur and spine were obtained by dualenergy photon X-ray absorptiometry (DEXA). Osteoporosis was defined by a DEXA T-score <-2.5 at the femoral neck or lumbar spine. Sensitivity, specificity and kappa statistics for DXL were calculated, assuming the DEXA measurement as the gold-standard. The study included 475 women with a mean age of 54±11.9 years. 15% had osteoporosis while 39% were osteopenic (-2.5<T-score between<-1) at the femoral neck or spine. A significant correlation (p<0.001) was found between BMD values as measured by DXL at femoral neck and DEXA at the lumbar spine. Assuming the same T-score cutoff value for the diagnosis osteoporosis and a modified cutoff value for the diagnosis of osteopenia (-2.5<T-score<-1.5), yields a sensitivity of 83% and a specificity of 74% to 86% for the DXL device. In conclusion, BMD measured at the calcaneal bone by DXL, has a good correlation with that measured by axial DEXA.
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Papers by Ahmad Salimzadeh