First, we need to separate MEF and PRISM (since you used it in your tags).
MEF is primarily used to provide inversion of control (IoC). It makes it easy to manage dependencies your viewmodels and other classes to separate concerns and improve testability (amongst other benefits).
PRISM however is primarily designed for the following scenario: You don't know, what view goes into a specific container at compile time, and want ViewA for CustomerA, ViewB for CustomerB and so on. PRISM helps you to losely couple your regions and views in a way, so that the application can decide at runtime, what view will be displayed. Another scenario, is that administrators get one view, other users another etc. PRISM also has other features (like the event aggregator), but I'd say the former is the most important one.
Now, I'd say MEF is never a bad thing to use for a bigger project. But I'd only use PRISM, if you really need the functionality it provides, since it can be very limiting. If you don't, simply add the references as you explained and let MEF know about those assemblies with the AssemblyCatalog.
So for MEF, I'd suggest you learn about Depdendency Injection and IoC. I found this blogpost by Martin Fowler quite good. As for PRISM, get familiar with what it does, and decide if you really need it.
Hope this helps.