Sepiapterin reduktaza (formira L-treo-7,8-dihidrobiopterin)
| Sepiapterin reduktaza (formira L-treo-7,8-dihidrobiopterin) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.325 | ||||||||
| CAS broj | 9059-48-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Sepiapterin reduktaza (formira L-treo-7,8-dihidrobiopterin) (EC 1.1.1.325, sepiapterinska reduktaza) je enzim sa sistematskim imenom L-treo-7,8-dihidrobiopterin:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) L-treo-7,8-dihidrobiopterin + NADP+ sepiapterin + NADPH + H+
- (2) L-treo-tetrahidrobiopterin + 2 NADP+ 6-piruvoil-5,6,7,8-tetrahidropterin + 2 NADPH + 2 H+
Ovaj enzim izolovan iz bakterije Hlorobium tepidum katalizuje finalni korak de novo sinteze tetrahidrobiopterina iz GTP-a, cf. EC 1.1.1.153, sepiapterinska reduktaza (formira L-eritro-7,8-dihidrobiopterin).
Reference
[уреди | уреди извор]- ^ Cho, S.H., Na, J.U., Youn, H., Hwang, C.S., Lee, C.H. and Kang, S.O. (1999). „Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum”. Biochem. J. 340: 497—503. PMID 10333495.
- ^ Supangat, S., Choi, Y.K., Park, Y.S., Son, D., Han, C.D. and Lee, K.H. (2005). „Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 202—204. PMID 16510994.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Sepiapterin+reductase+(L-threo-7,8-dihydrobiopterin+forming) на US National Library of Medicine Medical Subject Headings (MeSH)
