Lipoksigenaza
| Lipoksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 1.13.11.12 | ||||||||
| CAS broj | 9029-60-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Lipoksigenaza (EC 1.13.11.12, 13-lipoksidaza, karotenksa oksidaza, 13-lipoperoksidaza, masna oksidaza, 13-lipoksidaza, lionoleat:O2 13-oksidoreduktaza) je enzim sa sistematskim imenom linoleat:kiseonik 13-oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) linoleat + O2 (9Z,11E,13S)-13-hidroperoksioktadeka-9,11-dienoat
- (2) alfa-linolenat + O2 (9Z,11E,13S,15Z)-13-hidroperoksioktadeka-9,11,15-trienoat
Ovaj enzim sadrži nehemno gvožđe. Rasprostanjena biljna lipoksigenaza oksiduje linoleat i alfa-linolenat, dve najzastupljenije polinezasićene masne kiseline kod biljki, putem umetanja molekularnog kiseonika na C-13 poziciju (S)-konfiguracijom.
Reference
[уреди | уреди извор]- ^ Christopher, J., Pistorius, E. and Axelrod, B. (1970). „Isolation of an enzyme of soybean lipoxidase”. Biochim. Biophys. Acta. 198: 12—19. PMID 5461103.
- ^ Theorell, H., Holman, R.T. and Åkesson, Å. (1947). „Crystalline lipoxidase”. Acta Chem. Scand. 1: 571—576. PMID 18907700.
- ^ Zimmerman, D.C. (1970). „Specificity of flaxseed lipoxidase”. Lipids. 5: 392—397. PMID 5447012.
- ^ Royo, J., Vancanneyt, G., Perez, A.G., Sanz, C., Stormann, K., Rosahl, S. and Sanchez-Serrano, J.J. (1996). „Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns”. J. Biol. Chem. 271: 21012—21019. PMID 8702864.
- ^ Bachmann, A., Hause, B., Maucher, H., Garbe, E., Voros, K., Weichert, H., Wasternack, C. and Feussner, I. (2002). „Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts”. Biol. Chem. 383: 1645—1657. PMID 12452441.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Linoleate+13S-lipoxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
