This study aimed to evaluate the association between physical activity level and health-related q... more This study aimed to evaluate the association between physical activity level and health-related quality of life in community-dwelling middle aged and older adults in Egypt. Between May and August 2017, a cross-sectional study of 184 middle-aged and older adults between the ages of 55 and 64 years old (129 males and 55 females) with a mean age of 58 ± 4.3 years old participated in this study. Study participants were classified into 3 groups based on their level of physical activity (walking duration); low level of physical activity (<150 minutes/week), moderate level of physical activity (150–300 minutes/week), and high level of physical activity (>300 minutes/week). The health-related quality of life (HRQoL) was calculated using the Euro-Quality of life-5dimensions-3 levels scale questionnaire (EuroQol-5D-3L). Spearman's correlation coefficient was performed to determine the correlation between the physical activity level and HRQoL scores in community-dwelling middle-aged ...
To optimal manage of lithium-ion (Li-ion) batteries, different features like the state of charge ... more To optimal manage of lithium-ion (Li-ion) batteries, different features like the state of charge (SOC), state of health (SOH) should be considered. This consideration should also consider good reliability and precision for the battery modeling. This study introduces a new fractional model for a Lithium-ion battery by considering several operating conditions, temperatures, and SOCs. To achieve a suitable model, the parameters of the fractional model were optimized based on a newly developed design of the Krill Herd (DKH) optimizer. After verifying and comparing the capability of the algorithm with several different metaheuristics, it has been applied to the model and the best values have been obtained. The optimized fractional-order model is then validated by various characteristics regarding precision and reliability. The test data was considered under different SOC ranges, working conditions, and temperatures. The results showed that the ability of the proposed DKH method based on dynamic stress test (DST), test of hybrid pulse power characteristic (HPPC), and FUDS simulated condition in the ambient temperature is 7.18 mV, 8.75 mV, and 6.83 mV that are small RMSE values and shows higher reliability of the in different performing condition. The small value of RMDE was also proved in temperature and SOC which show its proper efficiency in different condition vales. Finally, the model has been compared with an RC integer equivalent circuit model. The comparison results showed that the proposed DKH method with 0.040 % relative mean error provides higher accuracy than the Second-order RC model with 0.045 % relative mean error which displays its excellence toward that model.
Background: Breast cancer stands out among the most widely recognized forms of cancer among women... more Background: Breast cancer stands out among the most widely recognized forms of cancer among women. It has been observed that upper extremity lymphedema is one of the most risky and prevalent complication following breast cancer surgery that prompts functional impairment, psychological, and social problems. Purpose: To compare the effects of Kinesio taping and the application of the pressure garment on secondary lymphedema of the upper extremity. Methods: 66 women were randomly allocated to the Kinesio taping (KT) group (n=33) and pressure garment (PG) group (n=33). The KT group received Kinesio taping application (2 times per week for 3 weeks), while the PG group received pressure garment (20-60 mmHg) for at least 15-18 hours per day for 3 weeks. The outcome measures were limb circumference, Shoulder Pain and Disability Index questionnaire (SPADI), hand grip strength, and quality of life at the baseline and end of intervention. Results: The sum of limb circumferences, SPADI, hand grip strength, and quality of life significantly improved after treatment in the KT group (P<0.05). While the PG group showed no significant improvement in SPADI, hand grip strength, physical, role, pain, and fatigue score p>0.05, while the sum of limb circumferences significantly decreased (P<0.05). Significant differences were observed between the KT and PG groups at the end of the intervention (P<0.05). Conclusion: KT had significant changes in limb circumference, SPADI, hand grip strength and overall quality of life than PG in the treatment of subjects diagnosed with lymphedema after mastectomy.
Background: It has been documented that aerobic exercise may increase pulmonary functions and aer... more Background: It has been documented that aerobic exercise may increase pulmonary functions and aerobic capacity, but limited data has evaluated a child's satisfaction and pediatric quality of life (PQoL) with exercise training. Objectives: This study aimed to investigate the effects of moderate-intensity exercise training on asthmatic school-aged children. Subjects and methods: This study included 38 school-aged children with asthma (23 males and 15 females) aged between 8-12 years. They were randomly assigned to two groups, aerobic exercise (AE) and conventional treatment (Con ttt) groups. The AE group received a program of moderateintensity aerobic exercise for 10 weeks with asthma medications and the Con ttt group received only asthma medications without exercise intervention. A home respiratory exercise was recommended for the two groups. Aerobic capacity was investigated using maximal oxygen uptake (VO 2max), 6-minute walk test (6MWT), and fatigue index. PQoL was evaluated using Pediatric Quality of Life Questionnaire (PQoLQ). Also, pulmonary function tests were performed, and the results recorded. Results: The findings of this study showed significant improvements in pulmonary functions and VO 2max in the two groups; however, this improvement was significantly higher in the AE group than in the Con ttt group (p,0.05). The 6MWT and fatigue index improved in the AE group (p,0.05) but not in the Con ttt group (p.0.05). All dimensions of PQoL significantly improved in the AE group (p,0.05), but there was no significant improvement in the Con ttt group after the 10-week intervention period (p.0.05). Conclusion: Ten weeks of physical exercise had beneficial effects on pulmonary functions, aerobic capacity, and PQoL in school-aged children with asthma. Effort and awareness should be dedicated to encouraging the active lifestyle among different populations, especially asthmatic children.
BACKGROUND Stress urinary incontinence is common in men after prostate cancer surgery. Rehabilita... more BACKGROUND Stress urinary incontinence is common in men after prostate cancer surgery. Rehabilitative interventions incorporate pelvic floor muscle training, biofeedback, electrical stimulation, lifestyle changes, or a combination of these strategies. However, little is known about the physiological impact of whole-body vibration for stress urinary incontinence after radical prostatectomy. OBJECTIVE To investigate the effect of whole-body vibration training on stress urinary incontinence after prostate cancer surgery. DESIGN Randomised controlled trial. SETTING Tertiary university hospitals. PARTICIPANTS Sixty-one patients with mild stress urinary incontinence after radical prostatectomy. INTERVENTION Group 1 included 30 patients who performed pelvic floor muscle training and whole-body vibration training with a frequency and amplitude of 20Hz/2mm for the first two sessions and 40Hz/4mm for the rest of the intervention. Group 2 included 31 patients who performed pelvic floor muscle training alone. The intervention in both groups was conducted three times per week for 4 weeks. MAIN OUTCOMES Incontinence Visual Analogue Scale (I-VAS) score, International Consultation on Incontinence Questionnaire-Urinary Incontinence-Short Form (ICIQ-UI-SF) score and 24-hour pad test result. RESULTS I-VAS score, ICIQ-UI-SF score and 24-hour pad test result showed significant within-group differences at each assessment with the exception of the baseline and post-intervention I-VAS score in Group 2. For example, Group 1 I-VAS score had a median difference of 3.9cm [95% confidence interval (CI) -4.0 to -3.8] from baseline to first follow-up, and a median difference of -2.0cm (95% CI -2.2 to -1.8) at 4-week follow-up. Comparisons between the groups demonstrated significant differences in favour of Group 1 after 4 weeks of intervention and at follow-up for all measured parameters. CONCLUSION Whole-body vibration training is an effective modality for treating patients with stress urinary incontinence after prostatectomy. TRIAL REGISTRATION Clinicaltrial.gov (NCT03325660).
Background: Impairment of peripheral skeletal muscle function is a common phenomenon in patients ... more Background: Impairment of peripheral skeletal muscle function is a common phenomenon in patients with cystic fibrosis (CF) in addition to great clinical connotations, such as lack of exercise tolerance and decrease of health-related quality of life. There is very limited data on the effects of maximal exercise on muscle fatiguability and exercise capacity in children with cystic fibrosis. Objectives: The aim of this study was to evaluate the effect of progressive maximal exercise training of the lower extremities on exercise capacity and muscle fatiguability in children with cystic fibrosis. Study design: Between June and September 2017, eighteen children aged 8-12 years were recruited in this study. This study had two groups of children; the CF group consisted of nine children (6 males and 3 females) with cystic fibrosis and the control group consisted of nine healthy age matched children (6 males and 3 females). The children underwent a progressive maximal cardiopulmonary exercise cycling test (CPET), muscle fatigue test, and magnetic resonance imaging (MRI) to measure a muscle cross-section area (CSA). Also, pulmonary functions were assessed. Results: The findings of this study showed that the CF children had less pulmonary functions, had a less exercise capacity, and had a higher breathing reserve index and oxygen desaturation when compared with healthy children (p<0.05). On the other hand, there was a non-significant difference in muscle fatiguability, muscle cross-section area, and maximal voluntary contraction between the CF and healthy children (p>0.05). Conclusion: This study indicates that progressive maximal exercise doesn't affect muscle fatiguability, muscle cross-section area, and maximal voluntary contraction in CF children with moderate respiratory diseases but includes lower exercise capacity. CF children and healthy age matched children have similar responses to maximal exercise in muscle fatiguability, muscle cross-section area, and maximal voluntary contractions but lower exercise capacity in the CF group.
Endocrine, metabolic & immune disorders drug targets, 2021
BACKGROUND It was defined that exercise and dietary interventions are used to control dyslipidemi... more BACKGROUND It was defined that exercise and dietary interventions are used to control dyslipidemia and depression in obese individuals, whilst rare investigations have examined the concurrent effects of a low-fat diet and moderate-intensity aerobic exercise training (MIAET) on dyslipidemia and depression in obese patients. Hence, we assessed the potential influences of a low-fat diet combined with MIAET on blood lipids and depression in those individuals. METHODS Forty-two obese patients aged 30-50 years have been enrolled in this randomized controlled trial. They have been randomized equally into MIAET group (n=14, 60-70% of the maximum heart rate (Max HR), three sessions a week), a low-fat diet group (n=14, fat, 30% Kcal/day), and a low-fat diet plus MIAET (n=14) for 10 consecutive weeks. Body mass index (BMI), lipid profile, and Hamilton depression rating scale (HDRS) have been assessed in two occasions, pre and post- 10 weeks. RESULTS It was demonstrated that a low-fat diet grou...
OBJECTIVE To determine the effects of isokinetic training of the knee muscles on bone morphogenet... more OBJECTIVE To determine the effects of isokinetic training of the knee muscles on bone morphogenetic proteins and inflammatory biomarkers in post-traumatic osteoarthritis after anterior cruciate ligament injury in university football players. METHODS A total of 60 participants with post-traumatic osteoarthritis after anterior cruciate ligament injury were randomly allocated into 3 groups: isokinetic training (n = 20), sensory motor training (n = 20) and control (n = 20) groups. The groups underwent different training programmes for 4 weeks. Clinical and biochemical values were measured at baseline, 4-week, 8-week and 6-month follow-ups. RESULTS Four weeks after training the isokinetic group showed more significant changes in pain intensity and functional disability than the sensory motor training or control groups (p < 0.001). There was no significant improvement in bone morphogenic protein measures, (e.g. bone morphogenic proteins 2, 4, 6, and 7) in any of the groups. There was a...
Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers ... more Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen receptor (CAR)-engineered T (CAR-T) cells in the treatment of cancer, especially hematological cancers, has exposed CAR’s potential. However, the toxicity and significant limitations of CAR-T cell immunotherapy prompted research into other immune cells as potential candidates for CAR engineering. NK cells are a major component of the innate immune system, especially for tumor immunosurveillance. They have a higher propensity for immunotherapy in hematologic malignancies because they can detect and eliminate cancerous cells more effectively. In comparison to CAR-T cells, CAR-NK cells can be prepared from allogeneic donors and are safer with a lower chance of cytokine release syndrome and graft-versus-host disease, as well as being a more efficient antitumor activity with high efficiency for off-the-shelf...
Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers ... more Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen receptor (CAR)-engineered T (CAR-T) cells in the treatment of cancer, especially hematological cancers, has exposed CAR’s potential. However, the toxicity and significant limitations of CAR-T cell immunotherapy prompted research into other immune cells as potential candidates for CAR engineering. NK cells are a major component of the innate immune system, especially for tumor immunosurveillance. They have a higher propensity for immunotherapy in hematologic malignancies because they can detect and eliminate cancerous cells more effectively. In comparison to CAR-T cells, CAR-NK cells can be prepared from allogeneic donors and are safer with a lower chance of cytokine release syndrome and graft-versus-host disease, as well as being a more efficient antitumor activity with high efficiency for off-the-shelf...
Endocrine, Metabolic & Immune Disorders - Drug Targets
Backgrounds: Both exercise and metformin are used to control blood glucose levels in patients wit... more Backgrounds: Both exercise and metformin are used to control blood glucose levels in patients with type 2 diabetes mellitus (T2DM), while no previous studies have investigated the effect of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. Objectives: This study was conducted to compare the effects of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. Methods: A total of fifty-seven T2DM patients with a mean age of 46.2±8.3 years were randomized to three study groups; each group included nineteen patients. The first group conducted a resistance exercise program (REP, 50-60% of 1RM, for 40-50 min) combined with metformin, the second group conducted an aerobic exercise program (AEP, 50-70% maxHR, for 40-50 min) combined with metformin, and the third group received only metformin without exercise intervention (Met group). The study program was conducted thrice weekly for consecutive twe...
BACKGROUND: Evidence on the latest technologies in rehabilitation for reducing pain and altering ... more BACKGROUND: Evidence on the latest technologies in rehabilitation for reducing pain and altering serum stress hormones in low back pain (LBP) was lacking. OBJECTIVE: To find the clinical and hormonal effects of virtual reality training (VRT) and isokinetic training (IKT) in chronic LBP patients. METHODS: Through the simple random sampling method, 60 university football players with chronic LBP were allocated into three groups: NVRT= 20, NIKT= 20 and NCONTROL= 20. The three groups underwent different exercises for 4 weeks. Clinical (pain intensity and kinesiophobia) and hormonal (glucose, insulin, HOMA-IR, growth hormone, prolactin, ACTH and cortisol) values were measured at baseline, after 4 weeks and 6 months. RESULTS: Four weeks following training, the VRT and IKT groups showed significant changes in pain intensity and kinesiophobia in comparison to the control group (p< 0.05). Hormonal measures also showed significant improvement in the VRT group in comparison to the other two...
Acute myeloid leukemia (AML) is a serious, life-threatening, and hardly curable hematological mal... more Acute myeloid leukemia (AML) is a serious, life-threatening, and hardly curable hematological malignancy that affects the myeloid cell progenies and challenges patients of all ages but mostly occurs in adults. Although several therapies are available including chemotherapy, allogeneic hematopoietic stem cell transplantation (alloHSCT), and receptor-antagonist drugs, the 5-year survival of patients is quietly disappointing, less than 30%. alloHSCT is the major curative approach for AML with promising results but the treatment has severe adverse effects such as graft-versus-host disease (GVHD). Therefore, as an alternative, more efficient and less harmful immunotherapy-based approaches such as the adoptive transferring T cell therapy are in development for the treatment of AML. As such, chimeric antigen receptor (CAR) T cells are engineered T cells which have been developed in recent years as a breakthrough in cancer therapy. Interestingly, CAR T cells are effective against both solid...
This study aimed to evaluate the association between physical activity level and health-related q... more This study aimed to evaluate the association between physical activity level and health-related quality of life in community-dwelling middle aged and older adults in Egypt. Between May and August 2017, a cross-sectional study of 184 middle-aged and older adults between the ages of 55 and 64 years old (129 males and 55 females) with a mean age of 58 ± 4.3 years old participated in this study. Study participants were classified into 3 groups based on their level of physical activity (walking duration); low level of physical activity (<150 minutes/week), moderate level of physical activity (150–300 minutes/week), and high level of physical activity (>300 minutes/week). The health-related quality of life (HRQoL) was calculated using the Euro-Quality of life-5dimensions-3 levels scale questionnaire (EuroQol-5D-3L). Spearman's correlation coefficient was performed to determine the correlation between the physical activity level and HRQoL scores in community-dwelling middle-aged ...
To optimal manage of lithium-ion (Li-ion) batteries, different features like the state of charge ... more To optimal manage of lithium-ion (Li-ion) batteries, different features like the state of charge (SOC), state of health (SOH) should be considered. This consideration should also consider good reliability and precision for the battery modeling. This study introduces a new fractional model for a Lithium-ion battery by considering several operating conditions, temperatures, and SOCs. To achieve a suitable model, the parameters of the fractional model were optimized based on a newly developed design of the Krill Herd (DKH) optimizer. After verifying and comparing the capability of the algorithm with several different metaheuristics, it has been applied to the model and the best values have been obtained. The optimized fractional-order model is then validated by various characteristics regarding precision and reliability. The test data was considered under different SOC ranges, working conditions, and temperatures. The results showed that the ability of the proposed DKH method based on dynamic stress test (DST), test of hybrid pulse power characteristic (HPPC), and FUDS simulated condition in the ambient temperature is 7.18 mV, 8.75 mV, and 6.83 mV that are small RMSE values and shows higher reliability of the in different performing condition. The small value of RMDE was also proved in temperature and SOC which show its proper efficiency in different condition vales. Finally, the model has been compared with an RC integer equivalent circuit model. The comparison results showed that the proposed DKH method with 0.040 % relative mean error provides higher accuracy than the Second-order RC model with 0.045 % relative mean error which displays its excellence toward that model.
Background: Breast cancer stands out among the most widely recognized forms of cancer among women... more Background: Breast cancer stands out among the most widely recognized forms of cancer among women. It has been observed that upper extremity lymphedema is one of the most risky and prevalent complication following breast cancer surgery that prompts functional impairment, psychological, and social problems. Purpose: To compare the effects of Kinesio taping and the application of the pressure garment on secondary lymphedema of the upper extremity. Methods: 66 women were randomly allocated to the Kinesio taping (KT) group (n=33) and pressure garment (PG) group (n=33). The KT group received Kinesio taping application (2 times per week for 3 weeks), while the PG group received pressure garment (20-60 mmHg) for at least 15-18 hours per day for 3 weeks. The outcome measures were limb circumference, Shoulder Pain and Disability Index questionnaire (SPADI), hand grip strength, and quality of life at the baseline and end of intervention. Results: The sum of limb circumferences, SPADI, hand grip strength, and quality of life significantly improved after treatment in the KT group (P<0.05). While the PG group showed no significant improvement in SPADI, hand grip strength, physical, role, pain, and fatigue score p>0.05, while the sum of limb circumferences significantly decreased (P<0.05). Significant differences were observed between the KT and PG groups at the end of the intervention (P<0.05). Conclusion: KT had significant changes in limb circumference, SPADI, hand grip strength and overall quality of life than PG in the treatment of subjects diagnosed with lymphedema after mastectomy.
Background: It has been documented that aerobic exercise may increase pulmonary functions and aer... more Background: It has been documented that aerobic exercise may increase pulmonary functions and aerobic capacity, but limited data has evaluated a child's satisfaction and pediatric quality of life (PQoL) with exercise training. Objectives: This study aimed to investigate the effects of moderate-intensity exercise training on asthmatic school-aged children. Subjects and methods: This study included 38 school-aged children with asthma (23 males and 15 females) aged between 8-12 years. They were randomly assigned to two groups, aerobic exercise (AE) and conventional treatment (Con ttt) groups. The AE group received a program of moderateintensity aerobic exercise for 10 weeks with asthma medications and the Con ttt group received only asthma medications without exercise intervention. A home respiratory exercise was recommended for the two groups. Aerobic capacity was investigated using maximal oxygen uptake (VO 2max), 6-minute walk test (6MWT), and fatigue index. PQoL was evaluated using Pediatric Quality of Life Questionnaire (PQoLQ). Also, pulmonary function tests were performed, and the results recorded. Results: The findings of this study showed significant improvements in pulmonary functions and VO 2max in the two groups; however, this improvement was significantly higher in the AE group than in the Con ttt group (p,0.05). The 6MWT and fatigue index improved in the AE group (p,0.05) but not in the Con ttt group (p.0.05). All dimensions of PQoL significantly improved in the AE group (p,0.05), but there was no significant improvement in the Con ttt group after the 10-week intervention period (p.0.05). Conclusion: Ten weeks of physical exercise had beneficial effects on pulmonary functions, aerobic capacity, and PQoL in school-aged children with asthma. Effort and awareness should be dedicated to encouraging the active lifestyle among different populations, especially asthmatic children.
BACKGROUND Stress urinary incontinence is common in men after prostate cancer surgery. Rehabilita... more BACKGROUND Stress urinary incontinence is common in men after prostate cancer surgery. Rehabilitative interventions incorporate pelvic floor muscle training, biofeedback, electrical stimulation, lifestyle changes, or a combination of these strategies. However, little is known about the physiological impact of whole-body vibration for stress urinary incontinence after radical prostatectomy. OBJECTIVE To investigate the effect of whole-body vibration training on stress urinary incontinence after prostate cancer surgery. DESIGN Randomised controlled trial. SETTING Tertiary university hospitals. PARTICIPANTS Sixty-one patients with mild stress urinary incontinence after radical prostatectomy. INTERVENTION Group 1 included 30 patients who performed pelvic floor muscle training and whole-body vibration training with a frequency and amplitude of 20Hz/2mm for the first two sessions and 40Hz/4mm for the rest of the intervention. Group 2 included 31 patients who performed pelvic floor muscle training alone. The intervention in both groups was conducted three times per week for 4 weeks. MAIN OUTCOMES Incontinence Visual Analogue Scale (I-VAS) score, International Consultation on Incontinence Questionnaire-Urinary Incontinence-Short Form (ICIQ-UI-SF) score and 24-hour pad test result. RESULTS I-VAS score, ICIQ-UI-SF score and 24-hour pad test result showed significant within-group differences at each assessment with the exception of the baseline and post-intervention I-VAS score in Group 2. For example, Group 1 I-VAS score had a median difference of 3.9cm [95% confidence interval (CI) -4.0 to -3.8] from baseline to first follow-up, and a median difference of -2.0cm (95% CI -2.2 to -1.8) at 4-week follow-up. Comparisons between the groups demonstrated significant differences in favour of Group 1 after 4 weeks of intervention and at follow-up for all measured parameters. CONCLUSION Whole-body vibration training is an effective modality for treating patients with stress urinary incontinence after prostatectomy. TRIAL REGISTRATION Clinicaltrial.gov (NCT03325660).
Background: Impairment of peripheral skeletal muscle function is a common phenomenon in patients ... more Background: Impairment of peripheral skeletal muscle function is a common phenomenon in patients with cystic fibrosis (CF) in addition to great clinical connotations, such as lack of exercise tolerance and decrease of health-related quality of life. There is very limited data on the effects of maximal exercise on muscle fatiguability and exercise capacity in children with cystic fibrosis. Objectives: The aim of this study was to evaluate the effect of progressive maximal exercise training of the lower extremities on exercise capacity and muscle fatiguability in children with cystic fibrosis. Study design: Between June and September 2017, eighteen children aged 8-12 years were recruited in this study. This study had two groups of children; the CF group consisted of nine children (6 males and 3 females) with cystic fibrosis and the control group consisted of nine healthy age matched children (6 males and 3 females). The children underwent a progressive maximal cardiopulmonary exercise cycling test (CPET), muscle fatigue test, and magnetic resonance imaging (MRI) to measure a muscle cross-section area (CSA). Also, pulmonary functions were assessed. Results: The findings of this study showed that the CF children had less pulmonary functions, had a less exercise capacity, and had a higher breathing reserve index and oxygen desaturation when compared with healthy children (p<0.05). On the other hand, there was a non-significant difference in muscle fatiguability, muscle cross-section area, and maximal voluntary contraction between the CF and healthy children (p>0.05). Conclusion: This study indicates that progressive maximal exercise doesn't affect muscle fatiguability, muscle cross-section area, and maximal voluntary contraction in CF children with moderate respiratory diseases but includes lower exercise capacity. CF children and healthy age matched children have similar responses to maximal exercise in muscle fatiguability, muscle cross-section area, and maximal voluntary contractions but lower exercise capacity in the CF group.
Endocrine, metabolic & immune disorders drug targets, 2021
BACKGROUND It was defined that exercise and dietary interventions are used to control dyslipidemi... more BACKGROUND It was defined that exercise and dietary interventions are used to control dyslipidemia and depression in obese individuals, whilst rare investigations have examined the concurrent effects of a low-fat diet and moderate-intensity aerobic exercise training (MIAET) on dyslipidemia and depression in obese patients. Hence, we assessed the potential influences of a low-fat diet combined with MIAET on blood lipids and depression in those individuals. METHODS Forty-two obese patients aged 30-50 years have been enrolled in this randomized controlled trial. They have been randomized equally into MIAET group (n=14, 60-70% of the maximum heart rate (Max HR), three sessions a week), a low-fat diet group (n=14, fat, 30% Kcal/day), and a low-fat diet plus MIAET (n=14) for 10 consecutive weeks. Body mass index (BMI), lipid profile, and Hamilton depression rating scale (HDRS) have been assessed in two occasions, pre and post- 10 weeks. RESULTS It was demonstrated that a low-fat diet grou...
OBJECTIVE To determine the effects of isokinetic training of the knee muscles on bone morphogenet... more OBJECTIVE To determine the effects of isokinetic training of the knee muscles on bone morphogenetic proteins and inflammatory biomarkers in post-traumatic osteoarthritis after anterior cruciate ligament injury in university football players. METHODS A total of 60 participants with post-traumatic osteoarthritis after anterior cruciate ligament injury were randomly allocated into 3 groups: isokinetic training (n = 20), sensory motor training (n = 20) and control (n = 20) groups. The groups underwent different training programmes for 4 weeks. Clinical and biochemical values were measured at baseline, 4-week, 8-week and 6-month follow-ups. RESULTS Four weeks after training the isokinetic group showed more significant changes in pain intensity and functional disability than the sensory motor training or control groups (p < 0.001). There was no significant improvement in bone morphogenic protein measures, (e.g. bone morphogenic proteins 2, 4, 6, and 7) in any of the groups. There was a...
Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers ... more Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen receptor (CAR)-engineered T (CAR-T) cells in the treatment of cancer, especially hematological cancers, has exposed CAR’s potential. However, the toxicity and significant limitations of CAR-T cell immunotherapy prompted research into other immune cells as potential candidates for CAR engineering. NK cells are a major component of the innate immune system, especially for tumor immunosurveillance. They have a higher propensity for immunotherapy in hematologic malignancies because they can detect and eliminate cancerous cells more effectively. In comparison to CAR-T cells, CAR-NK cells can be prepared from allogeneic donors and are safer with a lower chance of cytokine release syndrome and graft-versus-host disease, as well as being a more efficient antitumor activity with high efficiency for off-the-shelf...
Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers ... more Adoptive cell therapy has received a great deal of interest in the treatment of advanced cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen receptor (CAR)-engineered T (CAR-T) cells in the treatment of cancer, especially hematological cancers, has exposed CAR’s potential. However, the toxicity and significant limitations of CAR-T cell immunotherapy prompted research into other immune cells as potential candidates for CAR engineering. NK cells are a major component of the innate immune system, especially for tumor immunosurveillance. They have a higher propensity for immunotherapy in hematologic malignancies because they can detect and eliminate cancerous cells more effectively. In comparison to CAR-T cells, CAR-NK cells can be prepared from allogeneic donors and are safer with a lower chance of cytokine release syndrome and graft-versus-host disease, as well as being a more efficient antitumor activity with high efficiency for off-the-shelf...
Endocrine, Metabolic & Immune Disorders - Drug Targets
Backgrounds: Both exercise and metformin are used to control blood glucose levels in patients wit... more Backgrounds: Both exercise and metformin are used to control blood glucose levels in patients with type 2 diabetes mellitus (T2DM), while no previous studies have investigated the effect of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. Objectives: This study was conducted to compare the effects of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. Methods: A total of fifty-seven T2DM patients with a mean age of 46.2±8.3 years were randomized to three study groups; each group included nineteen patients. The first group conducted a resistance exercise program (REP, 50-60% of 1RM, for 40-50 min) combined with metformin, the second group conducted an aerobic exercise program (AEP, 50-70% maxHR, for 40-50 min) combined with metformin, and the third group received only metformin without exercise intervention (Met group). The study program was conducted thrice weekly for consecutive twe...
BACKGROUND: Evidence on the latest technologies in rehabilitation for reducing pain and altering ... more BACKGROUND: Evidence on the latest technologies in rehabilitation for reducing pain and altering serum stress hormones in low back pain (LBP) was lacking. OBJECTIVE: To find the clinical and hormonal effects of virtual reality training (VRT) and isokinetic training (IKT) in chronic LBP patients. METHODS: Through the simple random sampling method, 60 university football players with chronic LBP were allocated into three groups: NVRT= 20, NIKT= 20 and NCONTROL= 20. The three groups underwent different exercises for 4 weeks. Clinical (pain intensity and kinesiophobia) and hormonal (glucose, insulin, HOMA-IR, growth hormone, prolactin, ACTH and cortisol) values were measured at baseline, after 4 weeks and 6 months. RESULTS: Four weeks following training, the VRT and IKT groups showed significant changes in pain intensity and kinesiophobia in comparison to the control group (p< 0.05). Hormonal measures also showed significant improvement in the VRT group in comparison to the other two...
Acute myeloid leukemia (AML) is a serious, life-threatening, and hardly curable hematological mal... more Acute myeloid leukemia (AML) is a serious, life-threatening, and hardly curable hematological malignancy that affects the myeloid cell progenies and challenges patients of all ages but mostly occurs in adults. Although several therapies are available including chemotherapy, allogeneic hematopoietic stem cell transplantation (alloHSCT), and receptor-antagonist drugs, the 5-year survival of patients is quietly disappointing, less than 30%. alloHSCT is the major curative approach for AML with promising results but the treatment has severe adverse effects such as graft-versus-host disease (GVHD). Therefore, as an alternative, more efficient and less harmful immunotherapy-based approaches such as the adoptive transferring T cell therapy are in development for the treatment of AML. As such, chimeric antigen receptor (CAR) T cells are engineered T cells which have been developed in recent years as a breakthrough in cancer therapy. Interestingly, CAR T cells are effective against both solid...
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