Neklasični eikozanoid

Neklasični eikozanoidi su biološki aktivni signalni molekuli formirani oksigenacijom masnih kiselina dugih dvadeset ugljenika koje nisu klasični eikozanoidi.

Terminologija

Eikozanoid je kolektivni^[1] naziv za oksigenisane derivate tri različite esencijalne masne kiseline: eikozapentaenoinska kiselina (EPA), arahidonska kiselina (AA) i dihomo-gama-linolna kiselina (DGLA).

Sadašnja upotreba ograničava termini na leukotriene (LT) i tri tipa prostanoida–prostaglandina (PG) prostaciklina (PGI), i tromboksana (TX). Međutim, nekoliko drugih klasa se tehnički može smatrati eikozanoidima, uključujući hepoksiline, resolvine, isofurans, izoprostane, lipoksine, epilipoksine, epoksieikozatrienoinske kiseline (EET) i endokanabinoide. Leukotrieni i prostanoidi se ponekad nazivaju klasičnim eikozanoidima^[2]^[3]^[4] u kontrastu sa novim, neklasičnim eikozanoidima.^[5]^[6]^[7]^[8]

Reference

↑ Funk, Colin D. (30 November 2001). „Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology”. Science 294 (5548): 1871–1875. DOI:10.1126/science.294.5548.1871. PMID 11729303. Pristupljeno 2007-01-08.
↑ Van Dyke TE, Serhan CN (2003). „Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases”. J. Dent. Res. 82 (2): 82–90. DOI:10.1177/154405910308200202. PMID 12562878.
↑ Serhan CN, Gotlinger K, Hong S, Arita M (2004). „Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis”. Prostaglandins Other Lipid Mediat. 73 (3–4): 155–72. DOI:10.1016/j.prostaglandins.2004.03.005. PMID 15290791.
↑ Anderle P, Farmer P, Berger A, Roberts MA (2004). „Nutrigenomic approach to understanding the mechanisms by which dietary long-chain fatty acids induce gene signals and control mechanisms involved in carcinogenesis”. Nutrition (Burbank, Los Angeles County, Calif.) 20 (1): 103–8. DOI:10.1016/j.nut.2003.09.018. PMID 14698023.
↑ Evans AR, Junger H, Southall MD i dr.. (2000). „Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons”. J. Pharmacol. Exp. Ther. 293 (3): 912–20. PMID 10869392.
↑ O'Brien WF, Krammer J, O'Leary TD, Mastrogiannis DS (1993). „The effect of acetaminophen on prostacyclin production in pregnant women”. Am. J. Obstet. Gynecol. 168 (4): 1164–9. PMID 8475962.
↑ Behrendt H, Kasche A, Ebner von Eschenbach C, Risse U, Huss-Marp J, Ring J (2001). „Secretion of proinflammatory eicosanoid-like substances precedes allergen release from pollen grains in the initiation of allergic sensitization”. Int. Arch. Allergy Immunol. 124 (1–3): 121–5. DOI:10.1159/000053688. PMID 11306946.
↑ Sarau HM, Foley JJ, Schmidt DB i dr.. (1999). „In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity”. Prostaglandins Leukot. Essent. Fatty Acids 61 (1): 55–64. DOI:10.1054/plef.1999.0074. PMID 10477044.

Povezano

Dokozanoidi

[Funk-1] Funk, Colin D. (30 November 2001). „Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology”. Science 294 (5548): 1871–1875. DOI:10.1126/science.294.5548.1871. PMID 11729303. Pristupljeno 2007-01-08.

[vandyke-2] Van Dyke TE, Serhan CN (2003). „Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases”. J. Dent. Res. 82 (2): 82–90. DOI:10.1177/154405910308200202. PMID 12562878.

[Serhan-3] Serhan CN, Gotlinger K, Hong S, Arita M (2004). „Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis”. Prostaglandins Other Lipid Mediat. 73 (3–4): 155–72. DOI:10.1016/j.prostaglandins.2004.03.005. PMID 15290791.

[Anderle-4] Anderle P, Farmer P, Berger A, Roberts MA (2004). „Nutrigenomic approach to understanding the mechanisms by which dietary long-chain fatty acids induce gene signals and control mechanisms involved in carcinogenesis”. Nutrition (Burbank, Los Angeles County, Calif.) 20 (1): 103–8. DOI:10.1016/j.nut.2003.09.018. PMID 14698023.

[Evans-5] Evans AR, Junger H, Southall MD i dr.. (2000). „Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons”. J. Pharmacol. Exp. Ther. 293 (3): 912–20. PMID 10869392.

[O'Brien-6] O'Brien WF, Krammer J, O'Leary TD, Mastrogiannis DS (1993). „The effect of acetaminophen on prostacyclin production in pregnant women”. Am. J. Obstet. Gynecol. 168 (4): 1164–9. PMID 8475962.

[pmid11306946-7] Behrendt H, Kasche A, Ebner von Eschenbach C, Risse U, Huss-Marp J, Ring J (2001). „Secretion of proinflammatory eicosanoid-like substances precedes allergen release from pollen grains in the initiation of allergic sensitization”. Int. Arch. Allergy Immunol. 124 (1–3): 121–5. DOI:10.1159/000053688. PMID 11306946.

[pmid10477044-8] Sarau HM, Foley JJ, Schmidt DB i dr.. (1999). „In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity”. Prostaglandins Leukot. Essent. Fatty Acids 61 (1): 55–64. DOI:10.1054/plef.1999.0074. PMID 10477044.

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