2-Metil-2-butanol
| 2-Metil-2-butanol | |||
|---|---|---|---|
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2-Metil-2-butanol[1] | |||
| Naziv po klasifikaciji | 2-Metilbutan-2-ol[1] | ||
| Drugi nazivi | terc-Amil alkohol[1] Amylene hydrate[1] | ||
| Identifikacija | |||
| CAS registarski broj | 75-85-4 
| ||
| PubChem[2][3] | 6405 | ||
| ChemSpider[4] | 6165
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| UNII | 69C393R11Z
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| EINECS broj | |||
| UN broj | 1105 | ||
| KEGG[5] | |||
| MeSH | |||
| ChEMBL[6] | CHEMBL44658
| ||
| RTECS registarski broj toksičnosti | SC0175000 | ||
| Bajlštajn | 1361351 | ||
| Jmol-3D slike | Slika 1 | ||
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| Svojstva | |||
| Molekulska formula | C5H12O | ||
| Molarna masa | 88.15 g mol−1 | ||
| Agregatno stanje | Bezbojna tečnost | ||
| Miris | miris kamfora, peperminta | ||
| Gustina | 805 mg cm−3 | ||
| Tačka topljenja |
-9 °C, 264 K, 16 °F | ||
| Tačka ključanja |
101-103 °C, 374-376 K, 214-217 °F | ||
| Rastvorljivost u vodi | 120 g dm−3 | ||
| log P | 1,095 | ||
| Napon pare | 1,6 kPa (na 20 °C) | ||
| Indeks prelamanja (nD) | 1,405 | ||
| Termohemija | |||
| Standardna entalpija stvaranja jedinjenja ΔfH |
−380,0–−379,0 kJ mol−1 | ||
| Std entalpija sagorevanja ΔcH |
−3,3036–−3.3026 MJ mol−1 | ||
| Standardna molarna entropija S |
229,3 J K−1 mol−1 | ||
| Opasnost | |||
| Podaci o bezbednosti prilikom rukovanja (MSDS) | hazard.com | ||
| EU-klasifikacija |  F  Xn
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| EU-indeks | 603-007-00-2 | ||
| NFPA 704 |
 3
1
0
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| R-oznake | R11, R20, R37/38 | ||
| S-oznake | S2, S46 | ||
| Tačka paljenja | 19 °C | ||
| Tačka spontanog paljenja | 437 °C | ||
| Eksplozivni limiti | 9% | ||
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Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
| Infobox references | |||
2-Metil-2-butanol (terc-amil alkohol, 2M2B, amilen hidrat) je jedan od izomera amil alkohola. On je čista, bezbojna tečnost sa jakim mirisom peperminta ili kamfora.[7][8] Kod ljudi on ispoljava sedativno, hipnotičko, i antikonvulsivno dejstvo slično etanolu pri gutanju ili udisanju. Ranije je korišten u medicini za te svrhe.[9] On je aktivan u dozama u opsegu od 2.000-4.000 mg, te je 20 puta potentniji od etanol.a[10][11] Njegov hipnotički potencijal je između hloral hidrata i paraldehida.[12] In humans, 2-methyl-2-butanol is metabolized primarily via gluconoridation and oxidation to 2,3-dihydroxy-2-methylbutane.[13] Prekomerna doza proizvodi simptome slične alkoholnom trovanju.
- ↑ 1,0 1,1 1,2 1,3 1,4 1,5 „tert-amyl alcohol - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005.. Identification and Related Records. Pristupljeno 13. 12. 2011.
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Coblentz, Virgil (1899). The Newer Remedies: A reference manual for physicians, pharmacists, and students (3rd izd.). Philadelphia: P. Blakiston's Son & Co. str. 18.
- ↑ H. C. Wood & R. M. Smith, ur. (1887-09-15). „Amylene hydrate - a new hypnotic”. Therapeutic Gazette - A monthly journal of physiological and clinical therapeutics (Detroit MI and Philadelpia PA: G. S. Davis) 3: 605–606.
- ↑ Lewis, Robert A. (1998). Lewis' Dictionary of Toxicology. CRC Press. str. 45. ISBN 1-56670-223-2.
- ↑ Hans Brandenberger & Robert A. A. Maes, ur. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. str. 401. ISBN 3-11-010731-7.
- ↑ D. W. Yandell et al. (1888). „Amylene hydrate, a new hypnotic”. The American Practitioner and News (Lousville KY: John P. Morton & Co) 5: 88–89.
- ↑ F. A. Castle & C. Rice (March 1888). „Amylene and amylene hydrate”. The American Druggist 17 (3): 58–59.
- ↑ Collins, A. S.; Sumner, S. C.; Borghoff, S. J.; Medinsky, M. A. (1999). „A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures”. Toxicological sciences : an official journal of the Society of Toxicology 49 (1): 15–28. DOI:10.1093/toxsci/49.1.15. PMID 10367338.
- Hans Brandenberger & Robert A. A. Maes, ur. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. str. 401. ISBN 3-11-010731-7.
- Coblentz, Virgil (1899). The Newer Remedies: A reference manual for physicians, pharmacists, and students (3rd izd.). Philadelphia: P. Blakiston's Son & Co. str. 18.
- Lewis, Robert A. (1998). Lewis' Dictionary of Toxicology. CRC Press. str. 45. ISBN 1-56670-223-2.