(4S)-beta-felandrenska sintaza (geranil-difosfat-ciklizacija)
| (4S)-beta-felandrenska sintaza (geranil-difosfat-ciklizacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.52 | ||||||||
| CAS broj | 137010-34-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
(4S)-beta-felandrenska sintaza (geranil-difosfat-ciklizacija) (EC 4.2.3.52, felandrenska sintaza, (-)-beta-phelandrenska sintaza, (-)-(4S)-beta-felandrenska sintaza) je enzim sa sistematskim imenom geranil-difosfat difosfat-lijaza (ciklizacija, formira (4S)-beta-felandren).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranil difosfat (4S)-beta-felandren + difosfat
Za dejstvo ovog enzima je neophodan jon Mn2+.
- ↑ Savage, T.J., Hatch, M.W. and Croteau, R. (1994). „Monoterpene synthases of Pinus contorta and related conifers. A new class of terpenoid cyclase”. J. Biol. Chem. 269: 4012-4020. PMID 8307957.
- ↑ Bohlmann, J., Phillips, M., Ramachandiran, V., Katoh, S. and Croteau, R. (1999). „cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis)”. Arch. Biochem. Biophys. 368: 232-243. PMID 10441373.
- ↑ Wagschal, K., Savage, T.J. and Croteau, R. (1991). „Isotopically sensitive branching as a tool for evaluating multiple product formation by monoterpene cyclases”. Tetrahedron 31: 5933-5944.
- ↑ LaFever, R.E. and Croteau, R. (1993). „Hydride shifts in the biosynthesis of the p-menthane monoterpenes α-terpinene, γ-terpinene, and β-phellandrene”. Arch. Biochem. Biophys. 301: 361-366. PMID 8460944.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.