Well, the system requirements page for the product show that it supports Windows Server 2012:
VIPRE Agent (Windows)
Operating systems
- Windows 8 (32- & 64-bit)
- Windows 7 (32- & 64-bit)
- Windows Vista, Vista SP1+(32- & 64-bit)
- Windows XP Professional SP2+ (32- & 64-bit)
- Windows Server 2012
- Windows Small Business Server 2011, 2008 and 2003
- Windows Server 2008 and 2008 R2 (excluding Server 2008 Core)
- Windows Server 2003 SP1+ (32 & 64-bit)
- Windows 2000 Server with SP4 RU1 or later (supports legacy 5.0 agents for upgrade only)
- Windows 2000 Professional with SP4 RU1 or later (supports legacy 5.0 agents for upgrade only)
- Windows Embedded for Point of Service (WEPOS) platforms
Please take the 5 minutes to check the obvious places first and/or work through the actual software vendor first. As far as if it runs well, I think that's a very open ended question and can't really be answered easily here. What works for one person doesn't always behave the same way for other people.