Papers by Dr. Pankaj H . Chaudhary
International Research Journal of Modernization in Engineering Technology and Science, 2024
Overexploitation of India's abundant medicinal plant biodiversity is endangering it, thus urgent ... more Overexploitation of India's abundant medicinal plant biodiversity is endangering it, thus urgent conservation
action is required. The purpose of the medicinal plant is to promote healing. Only treatments are used in
traditional medical systems like Ayurveda, Siddha, and Unani. One of the most important biotechnological tools
for the reproduction and preservation of outstanding and endangered medicinal plant genotypes is tissue
culture technology. It meets both ecological and commercial needs by providing quick and consistent bulk
propagation of plants that are difficult to regenerate using traditional techniques. Biodiversity can be
maintained while satisfying the growing need for medicinal plants in the pharmaceutical sector by combining in
situ and ex situ conservation strategies, including in vitro treatments. This strategy guarantees the survival of
endangered and uncommon species, makes it easier to cultivate them on a broad scale
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES, 2024
At various points throughout the life cycle of a pharmaceutical product, analytical
procedures m... more At various points throughout the life cycle of a pharmaceutical product, analytical
procedures must be established. If these tasks are not appropriately simplified based on
scientific knowledge and process understanding, it could result in an extremely
expensive and time-consuming approach. The pharmaceutical industry is constantly
looking for new guidelines or components to add to or replace the current components
of the quality and risk management system The idea of Quality by Design was first
introduced by renowned quality expert Joseph M. Juran. (QbD). Analytical method
development, or AQbD, can be thought of as an extension of QbD. A methodical
approach to development known as "Quality by Design" starts with predetermined
objects and places a strong emphasis on process control, product and process
understanding, and understanding .contemporary method approach The current review
article's primary goal is to outline the various QbD processes while also addressing
implementation-related issues. ATP (Analytical Target Profile), CP (Performance
Attributes), MODR (Method Operable Design Region), Control Strategy, and Continual
Method Improvement are all included in the creation of an analytical method
International Research Journal of Modernization in Engineering Technology and Science, 2024
Drug addiction is a growing worldwide problem that has serious effects on society, the economy, a... more Drug addiction is a growing worldwide problem that has serious effects on society, the economy, and health.
India faces a serious problem with drug addiction, which is becoming more common among young people and
other vulnerable groups. This has significant effects on mortality and morbidity. Narcotic medicines are those
that cause sleep, whereas psychotropic drugs affect the mind and change a person's mental capacity. In order to
examine state-by-state trends in drug prevalence, consumption patterns across age groups, educational
backgrounds of drug users, the most commonly consumed substances, and substance abuse trends across
Indian states, this review synthesizes findings from multiple studies, emphasizing regional challenges and
demographic variations. Nearly 70% of drug users are between the ages of 20 and 40, which is a worrying
trend that has resulted in an alarming rise in suicide rates.
To secure a sustainable and drug-free future, public health systems, legislators, and communities must work
together to address this complex issue
Asian Journal of Pharmaceutical Analysis, 2024
In this study, we developed and validated a rapid and precise RP-HPLC method to quantify leflunom... more In this study, we developed and validated a rapid and precise RP-HPLC method to quantify leflunomide in bulk
and tablet dosage forms. The analysis was performed using an Inertsil-ODS C18 column (250x4.6mm, 5μm)
with a mobile phase composed of 95:5 methanol/water at a flow rate of 1mL/min. Leflunomide demonstrated a
linear range between 20-70μg/ml with a high correlation coefficient (R² = 0.995). Adhering to ICH guidelines,
the method was designed to be accurate, precise, sensitive, selective, repeatable, and robust. The validation
parameters included system suitability, specificity, linearity, accuracy, precision, detection limit, quantitation
limit, robustness, and stability. The results indicated excellent accuracy and precision, with recoveries close to
100% and relative standard deviations well within acceptable limits. The method's sensitivity allowed for
reliable detection and quantification at low concentrations, making it ideal for routine quality control.
Additionally, robustness studies confirmed the method's reliability despite minor changes in experimental
conditions. This HPLC method is both efficient and cost-effective, enabling faster analysis while maintaining
high quality. The validated method was successfully applied to the analysis of leflunomide in pharmaceutical
formulations, proving its suitability for routine use in quality control laboratories. Overall, this method offers a
comprehensive solution for accurately estimating leflunomide in various dosage forms.
International Research Journal of Modernization in Engineering Technology and Science, 2024
Mimosa pudica Linn., also known as the "touch-me-not" plant, is a creeping perennial herb recogni... more Mimosa pudica Linn., also known as the "touch-me-not" plant, is a creeping perennial herb recognized for its
fast leaf-folding response to touch. This review examines the botanical, phytochemical, pharmacological, and
therapeutic properties of M. pudica. The plant contains numerous bioactive chemicals, including alkaloids,
flavonoids, tannins, saponins, and glycosides, which contribute to its diverse therapeutic qualities. Traditionally,
it was used to heal wounds, skin problems, diarrhea, and inflammation. Recent pharmacological research have
shown that it has antioxidant, antibacterial, anti-inflammatory, analgesic, antidiabetic, and hepatoprotective
properties. Its distinct thigmonastic response has piqued attention in plant physiology and environmental
adaptation research.
Afr. J. Biomed. Res, 2024
Hypercholesterolemia, or high blood cholesterol, increases the risk of atherosclerosis and corona... more Hypercholesterolemia, or high blood cholesterol, increases the risk of atherosclerosis and coronary artery disease. Elevated cholesterol levels, especially high LDL and low HDL, are key risk factors. LDL contributes to plaque formation through oxidative modification, while HDL helps remove cholesterol and prevent LDL oxidation. Key contributors include high-fat diets, lack of exercise, and hypertension. Management involves dietary changes, exercise, and medications such as statins, fibrates, and cholesterol absorption inhibitors. Antioxidants can reduce oxidative damage. Traditional and alternative medicine, including Ayurveda and Syzygium cumini (L.), offer additional therapeutic options.
Journal of Pharmacy & Pharmacognosy Research
Context: Bombax ceiba Linn. (Bombacaceae) is a well-known plant for its antihypertensive, antioxi... more Context: Bombax ceiba Linn. (Bombacaceae) is a well-known plant for its antihypertensive, antioxidant, antidiabetic, aphrodisiac and uterine tonicity properties. Aims: To study pharmacognostical, physicochemical and phytochemically the roots of this plant. Methods: Pharmacognostical study included the macroscopic characters like size, color, surface characteristics, texture, fracture characteristics and odor of the roots. The intact root as well as powdered drug were studied under a microscope to analyze the cellular characteristics of the drug. Physicochemical parameter like extractive values, loss on drying (LOD), total ash, water-soluble and acid insoluble ash, foaming index and hemolytic index of Bombax ceiba root powder were determined as per WHO guidelines. Preliminary phytochemical screening and qualitative chemical examination studies have been carried out for the various phytoconstituents. HPTLC have also carried out using cyclohexane: diethyl ether: ethyl acetate as mobile...
Pharmacognosy Communications, 2012
Plants have been an important source of medicines since the beginning of cultivation. There is a ... more Plants have been an important source of medicines since the beginning of cultivation. There is a growing demand for plant-based medicines, health products, pharmaceuticals, food supplements, cosmetics etc. Bombax ceiba Linn. (Bombacaceae) is a tall tree buttressed at the base that is widely distributed throughout India, Ceylon and Malaya, upto 1500 m of altitude. Many parts of the plant (root, stem bark, gum, leaf, prickles, flower, fruit, seed and heartwood) are used by various tribal communities and forest dwellers for the treatment of a variety of ailments. The plant literature survey shows the plant possesses astringent, cooling, stimulant, diuretic, aphrodisiac, demulcent, and tonic effects and also helps in dysentery. It also possesses important pharmacological activity such as aphrodisiac, anti-inflammatory and hepatoprotective activity in addition to anticancer and anti-HIV activity, anti-Helicobacter pylori, antiangiogenic, analgesic and antioxidant activity and hypotensive, hypoglycemic and antimicrobial activity. It is reported to contain important phytoconstituents such as naphthol, naphthoquinones, polysaccharides, anthocyanins, shamimin and lupeol.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES , 2024
Ficus racemosa Linn. (Family: Moraceae), commonly referred to as the gular or cluster
fig tree, ... more Ficus racemosa Linn. (Family: Moraceae), commonly referred to as the gular or cluster
fig tree, is a well-known medicinal plant in India. This herb is mentioned in all the
ancient writings on Ayurveda, Siddha, Unani, and homeopathy. Bark, roots, leaves,
fruits, and latex are among the many plant parts that are used as carminatives,
astringents, vermifuges, and anti-dysentery medicines. It is a helpful remedy for eating
too much. Menorrhagia, diabetes, leucoderma, hepatoprotection, refrigerant,
antioxidant, and antiulcer diseases are all treated with fruit extract. It is given topically
to treat skin lesions, fibrositis, lymphadenitis, and sprains to lessen swelling. This study
aims to formulate and evaluate the herbal tablets made from Ficus racemosa Linn.bark
extract.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES , 2024
Candidal infections pose a significant health burden. Cutaneous candidiasis, caused by
yeast-lik... more Candidal infections pose a significant health burden. Cutaneous candidiasis, caused by
yeast-like fungi of the genus Candida, is a common skin infection. The conventional
antifungal drugs, such as azoles, often exhibit adverse effects, including hypersensitivity
reactions (itching, inflammation, eczema). These symptoms can overlap with the
manifestations of fungal infections, leading to diagnostic challenges and patient
discomfort. Seeking alternative solutions, we explored the antifungal efficacy of clove
and turmeric oils, both renowned for their medicinal properties. Our study investigated
the synergistic potential of these oils, combined in 1:1, 3:1 and 1:3 ratios, against
Candida species. Using steam distillation, we extracted essential oils from clove and
turmeric powders. Samples, comprising individual oils and various mixtures, were
prepared and subjected to the Kirby-Bauer disk diffusion method for antifungal
assessment. Results revealed a promising synergism in the 3:1 mixture of clove and
turmeric oils. Although the observed zone of inhibition was shorter than that of
ketoconazole, a synthetic antifungal, the efficacy of the natural blend underscores its
potential as an alternative therapeutic option. Our findings suggest that clove and
turmeric oils possess inherent antifungal properties, with the potential for enhanced
efficacy when combined synergistically. Further research is warranted to optimize the
blend ratio and investigate its clinical applicability. Embracing plant-based alternatives
may herald safer and more sustainable strategies for combating fungal infections,
offering hope for improved patient outcomes.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES, 2024
To study a qualitative and quantitative phytochemical screening on Wedelia trilobata L. Material ... more To study a qualitative and quantitative phytochemical screening on Wedelia trilobata L. Material and Methods : Extractive values, loss on drying (LOD), total ash, water-soluble, and acid-insoluble ash were determined per WHO guidelines. Preliminary phytochemical screening and qualitative chemical studies were conducted for various phytoconstituents. UV-VIS spectrum, FTIR spectral analysis, and TLC analysis is done using four solvents.(Aqueous ,ethanol,Chloroform And Benzene). Results: Chemical evaluation and TLC revealed alkaloids, glycosides, flavonoids, steroids, saponins, and tannins, with steroids confirmed via TLC fingerprinting. UV-VIS spectrum identified peaks for four solvents. FTIR spectrum indicated alcohols, phenols, alkanes, alkynes, alkyl halides, aldehydes, aromatics, nitro compounds, and amines. Conclusions: Preliminary phytochemical screening of Wedelia trilobata aids in standardization and avoiding adulteration. Physicochemical data support monograph development. Chromatographic fingerprinting can standardize extracts and formulations. Evaluating Wedelia trilobata is essential for its practical clinical applications.
International Journal of Pharmacognosy and Pharmaceutical Sciences, 2024
Passilora Incarnata commonly known as passiflower, belongs to family Passiflora. The fruit of Pas... more Passilora Incarnata commonly known as passiflower, belongs to family Passiflora. The fruit of Passiflora has several seeds which contain drinkable juice. Its medicinal use has been reported in the traditional system of medicine such as Ayurveda, Siddha and Unani. Passiflora incarnate contains phytochemicals such as alkaloids, flavonoids which are effective sedative that is not addictive. Phenols and flavonoids present in Passiflora have high antioxidant properties that show significant scavenger activity of free radicals. The genus Passiflora incarnate has long been used in traditional herbal medicine for treatment of insomnia and anxiety. It has been used as sedative tea and also been used to cure subjects affected by opiate dependence in India. This review aims to provide up to date information about habitat, ecology, pharmacognostic evaluation, phytochemical studies, pharmacology, toxicology and herbal preparatioin which used to reduce anxiety particularly before surgery, also for variety of problems including pain, ADHD, stress, sleeplessness.
International Journal of Scientific Development and Research, 2024
Ficus glomerata Roxb. (Family: Moraceae) is known as the cluster fig tree or Gular. A moderate-si... more Ficus glomerata Roxb. (Family: Moraceae) is known as the cluster fig tree or Gular. A moderate-sized tree found throughout India either wild or cultivated for its fruits eaten by villagers. Ayurveda and Unani, the traditional Indian medical system, has employed the popular medicinal plant Ficus racemosa for many years to treat a variety of illnesses and disorders, including skeleton diseases, diabetes, inflammatory, hyperlipidemia, hemorrhoids, respiratory, liver dysfunction, antitussive, hepatoprotective, antimicrobial, and various GIT disorders. Numerous phytoconstituent components have been different parts of extracts and phytochemical screening of the Ficus racemosa. In light of the numerous recent results on this plant, that is much more significant. A thorough explanation of this plant is traditionally beneficial, phytoconstituents, and biological effects on this review. Ficus glomerata is a large deciduous tree dispersed all over India which is generally known as Gular, fig, cluster fig or country fig. It is a sacred tree of Hindus and Buddhists.
International Journal of Scientific Development and Research, 2024
The giant calotropis Linn, often called milk weed or a popular restorative plant, has been used i... more The giant calotropis Linn, often called milk weed or a popular restorative plant, has been used in Indian medicine for many years. The systematic position, background information on the plant, morphological analysis, phytochemistry, and economic benefits of the Calotropis gigantea are covered in this paper. It has a smooth stem and round, light green leaves. The plant may grow naturally in a variety of soils and environments and doesn't require any special gardening techniques. Numerous pharmacological effects have been reported, including antioxidant, anti-malarial, antimicrobial, cytotoxic, antipyretic, anti-asthmatic, antiinflammatory, analgesic, insecticidal, wound healing, and anti-diarrheal effects. Furthermore, various pharmaceutical aspects have been reported in this paper.
International Journal of Pharmaceutical Research and Applications, 2024
Sphagneticolatrilobata (L.) Pruski, also known as Wedeliatrilobata (L.), is a tropical perennial ... more Sphagneticolatrilobata (L.) Pruski, also known as Wedeliatrilobata (L.), is a tropical perennial flowering plant which is distributed across various parts of the world.The aim of the study was to evaluate antimicrobial, antioxidant and antiinflammatory activity of dry and fresh parts of leaf, stem and flower from the water extract of Wedeliatrilobata.The extracts were subjected to qualitative phytochemical screening using standard procedures. From the results, it was observed that of the thirteen phytochemicals screened, ten were found present in various solvent extracts. They are alkaloids, flavonoids, saponins, terpenoids, steroids, glycosides, tannins, proteins, aminoacids and carbohydrates.Inall, more phytochemicals were found present in extract prepared with ethanol.Preliminary phytochemical investigation showed the presence of alkaloids, glycosides, tannins, triterpenoids, carbohydrates and flavonoids.Anatomical and histochemical investigations of Sphagneticolatrilobata (L.) Pruski, Asteraceae, secretory structures in leaves and stems and the seasonal variation of essential oils were carried out.
Journal of Ayurveda and Integrated Medical Sciences, 2024
Botanical description L.cristata is commonly known as Nakkapidi, Lankapindi (Yanadi tribal), Mull... more Botanical description L.cristata is commonly known as Nakkapidi, Lankapindi (Yanadi tribal), Mullabanthi (Telugu), Karappan poondu
Eur. Chem. Bull., 2023
remarkable % cumulative drug release of 75.47±1.14% over 8 hours, accompanied by the highest % dr... more remarkable % cumulative drug release of 75.47±1.14% over 8 hours, accompanied by the highest % drug absorption at 4.987±0.41within 120 minutes. Conclusion: In summation, the evidence points towards Formulation F5 as the harbinger of heightened bio-enhancement, surpassing its peers within the realm of Fenofibrate-laden patches infused with the ethanolic essence of Cinnamon bark.
INTERNATIONAL JOURNAL IN PHARMACEUTICAL SCIENCES, 2023
Context: Moringa oleifera Lam. (Moringaceae) is a well-known plant for its Abortifacient, Antican... more Context: Moringa oleifera Lam. (Moringaceae) is a well-known plant for its Abortifacient, Anticancer, Anti-inflammatory, Anti-diarrheal, Anthelmintics, and Antitumor activity. Aims: To study pharmacognostical, physicochemical and phytochemical investigation of roots of this plant. Methods: Pharmacognostical study included the macroscopic characters like size, color, surface characteristics, texture, fracture characteristics and odor of the roots. Physicochemical parameter like extractive values, loss on drying (LOD), total ash, water-soluble and acid insoluble ash of Moringa oleifera root powder were determined as per WHO guidelines. Preliminary phytochemical screening and qualitative chemical examination by TLC studies have been carried out for the various phytoconstituents. Results: Chemical evaluation and TLC studies shown presence of alkaloids, glycosides, flavonoids, steroids, saponins and tannins. The microscopic characters have shown presence of cork, xylem vessels, calcium oxalate crystals and phloem fibers. Conclusions: Pharmacognostical and preliminary phytochemical screening of Moringa oleifera roots will be useful in order to authenticate, standardize and avoid any adulteration in the raw material. The diagnostic microscopic characters and physicochemical data will be helpful in the development of a monograph.
International Journal of Pharmaceutical Research and Applications, 2023
Pomegranate (Punica granatum Linn.) is a member of the Punicaceae family and native of Iran, know... more Pomegranate (Punica granatum Linn.) is a member of the Punicaceae family and native of Iran, known for its large, globular fruit with numerous seeds, sweet, edible pulp and rough skin. It is one of the most significant fruit crops in the world's dry and semiarid regions and is grown in India on over 1.13 lakh hectares with a production volume of 7.44 lakh tonnes and a productivity of 6.6 tonnes/ha. It has been picked and eaten due to its phytochemicals, anti-inflammatory, antiviral, and antioxidant properties, as well as the detection of microbicide activity against bacteria and fungus. However, fruit peel is not used in the treatment of the fruit. Globular fruit exports to Mexico and India are a major contributor to the global economy. Perfect fruit quality, enhanced high nutritional worth, immense therapeutic potential, massive demand on the domestic and foreign markets, and extended shelf life makesit a notable fruit crop in the modern era.
https://www.pharmacognosyjournal.net/, 2023
One of the most important medicinal plants in Indian traditional systems of medicine is Phyllanth... more One of the most important medicinal plants in Indian traditional systems of medicine is Phyllanthus emblica Linn. or Emblica officinalis Gaertn., also known as Indian gooseberry or Amla (Ayurveda, Unani and Siddha). It is a well-known fact that all components of Amla are beneficial in the treatment of a variety of illnesses. Fruit is the most vital element of all. The amla fruit is widely used in medical devices all over the world. Amla fruit is widely used in pharmaceuticals all over the world as an antioxidant, hepatoprotective, cardioprotective, stomach ulcer protective, hair energizer, and sickness, either alone or in combination with other herbs. According to various studies, it contains a large number of biochemical components, particularly alkaloids, phenols, tannins, multivitamins, and inorganic compounds. Ellagic acid, Gallic acid, Emblicanin A & B, Phyllembein, Quercetin, and Ascorbic acid are among the organic chemical constituents found in amla that have been shown to be beneficial to health. In this text, we discuss the geographical distribution, nutritional value, biochemical components, pharmacological importance, ethnomedicinal uses of Amla.
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Papers by Dr. Pankaj H . Chaudhary
action is required. The purpose of the medicinal plant is to promote healing. Only treatments are used in
traditional medical systems like Ayurveda, Siddha, and Unani. One of the most important biotechnological tools
for the reproduction and preservation of outstanding and endangered medicinal plant genotypes is tissue
culture technology. It meets both ecological and commercial needs by providing quick and consistent bulk
propagation of plants that are difficult to regenerate using traditional techniques. Biodiversity can be
maintained while satisfying the growing need for medicinal plants in the pharmaceutical sector by combining in
situ and ex situ conservation strategies, including in vitro treatments. This strategy guarantees the survival of
endangered and uncommon species, makes it easier to cultivate them on a broad scale
procedures must be established. If these tasks are not appropriately simplified based on
scientific knowledge and process understanding, it could result in an extremely
expensive and time-consuming approach. The pharmaceutical industry is constantly
looking for new guidelines or components to add to or replace the current components
of the quality and risk management system The idea of Quality by Design was first
introduced by renowned quality expert Joseph M. Juran. (QbD). Analytical method
development, or AQbD, can be thought of as an extension of QbD. A methodical
approach to development known as "Quality by Design" starts with predetermined
objects and places a strong emphasis on process control, product and process
understanding, and understanding .contemporary method approach The current review
article's primary goal is to outline the various QbD processes while also addressing
implementation-related issues. ATP (Analytical Target Profile), CP (Performance
Attributes), MODR (Method Operable Design Region), Control Strategy, and Continual
Method Improvement are all included in the creation of an analytical method
India faces a serious problem with drug addiction, which is becoming more common among young people and
other vulnerable groups. This has significant effects on mortality and morbidity. Narcotic medicines are those
that cause sleep, whereas psychotropic drugs affect the mind and change a person's mental capacity. In order to
examine state-by-state trends in drug prevalence, consumption patterns across age groups, educational
backgrounds of drug users, the most commonly consumed substances, and substance abuse trends across
Indian states, this review synthesizes findings from multiple studies, emphasizing regional challenges and
demographic variations. Nearly 70% of drug users are between the ages of 20 and 40, which is a worrying
trend that has resulted in an alarming rise in suicide rates.
To secure a sustainable and drug-free future, public health systems, legislators, and communities must work
together to address this complex issue
and tablet dosage forms. The analysis was performed using an Inertsil-ODS C18 column (250x4.6mm, 5μm)
with a mobile phase composed of 95:5 methanol/water at a flow rate of 1mL/min. Leflunomide demonstrated a
linear range between 20-70μg/ml with a high correlation coefficient (R² = 0.995). Adhering to ICH guidelines,
the method was designed to be accurate, precise, sensitive, selective, repeatable, and robust. The validation
parameters included system suitability, specificity, linearity, accuracy, precision, detection limit, quantitation
limit, robustness, and stability. The results indicated excellent accuracy and precision, with recoveries close to
100% and relative standard deviations well within acceptable limits. The method's sensitivity allowed for
reliable detection and quantification at low concentrations, making it ideal for routine quality control.
Additionally, robustness studies confirmed the method's reliability despite minor changes in experimental
conditions. This HPLC method is both efficient and cost-effective, enabling faster analysis while maintaining
high quality. The validated method was successfully applied to the analysis of leflunomide in pharmaceutical
formulations, proving its suitability for routine use in quality control laboratories. Overall, this method offers a
comprehensive solution for accurately estimating leflunomide in various dosage forms.
fast leaf-folding response to touch. This review examines the botanical, phytochemical, pharmacological, and
therapeutic properties of M. pudica. The plant contains numerous bioactive chemicals, including alkaloids,
flavonoids, tannins, saponins, and glycosides, which contribute to its diverse therapeutic qualities. Traditionally,
it was used to heal wounds, skin problems, diarrhea, and inflammation. Recent pharmacological research have
shown that it has antioxidant, antibacterial, anti-inflammatory, analgesic, antidiabetic, and hepatoprotective
properties. Its distinct thigmonastic response has piqued attention in plant physiology and environmental
adaptation research.
fig tree, is a well-known medicinal plant in India. This herb is mentioned in all the
ancient writings on Ayurveda, Siddha, Unani, and homeopathy. Bark, roots, leaves,
fruits, and latex are among the many plant parts that are used as carminatives,
astringents, vermifuges, and anti-dysentery medicines. It is a helpful remedy for eating
too much. Menorrhagia, diabetes, leucoderma, hepatoprotection, refrigerant,
antioxidant, and antiulcer diseases are all treated with fruit extract. It is given topically
to treat skin lesions, fibrositis, lymphadenitis, and sprains to lessen swelling. This study
aims to formulate and evaluate the herbal tablets made from Ficus racemosa Linn.bark
extract.
yeast-like fungi of the genus Candida, is a common skin infection. The conventional
antifungal drugs, such as azoles, often exhibit adverse effects, including hypersensitivity
reactions (itching, inflammation, eczema). These symptoms can overlap with the
manifestations of fungal infections, leading to diagnostic challenges and patient
discomfort. Seeking alternative solutions, we explored the antifungal efficacy of clove
and turmeric oils, both renowned for their medicinal properties. Our study investigated
the synergistic potential of these oils, combined in 1:1, 3:1 and 1:3 ratios, against
Candida species. Using steam distillation, we extracted essential oils from clove and
turmeric powders. Samples, comprising individual oils and various mixtures, were
prepared and subjected to the Kirby-Bauer disk diffusion method for antifungal
assessment. Results revealed a promising synergism in the 3:1 mixture of clove and
turmeric oils. Although the observed zone of inhibition was shorter than that of
ketoconazole, a synthetic antifungal, the efficacy of the natural blend underscores its
potential as an alternative therapeutic option. Our findings suggest that clove and
turmeric oils possess inherent antifungal properties, with the potential for enhanced
efficacy when combined synergistically. Further research is warranted to optimize the
blend ratio and investigate its clinical applicability. Embracing plant-based alternatives
may herald safer and more sustainable strategies for combating fungal infections,
offering hope for improved patient outcomes.
action is required. The purpose of the medicinal plant is to promote healing. Only treatments are used in
traditional medical systems like Ayurveda, Siddha, and Unani. One of the most important biotechnological tools
for the reproduction and preservation of outstanding and endangered medicinal plant genotypes is tissue
culture technology. It meets both ecological and commercial needs by providing quick and consistent bulk
propagation of plants that are difficult to regenerate using traditional techniques. Biodiversity can be
maintained while satisfying the growing need for medicinal plants in the pharmaceutical sector by combining in
situ and ex situ conservation strategies, including in vitro treatments. This strategy guarantees the survival of
endangered and uncommon species, makes it easier to cultivate them on a broad scale
procedures must be established. If these tasks are not appropriately simplified based on
scientific knowledge and process understanding, it could result in an extremely
expensive and time-consuming approach. The pharmaceutical industry is constantly
looking for new guidelines or components to add to or replace the current components
of the quality and risk management system The idea of Quality by Design was first
introduced by renowned quality expert Joseph M. Juran. (QbD). Analytical method
development, or AQbD, can be thought of as an extension of QbD. A methodical
approach to development known as "Quality by Design" starts with predetermined
objects and places a strong emphasis on process control, product and process
understanding, and understanding .contemporary method approach The current review
article's primary goal is to outline the various QbD processes while also addressing
implementation-related issues. ATP (Analytical Target Profile), CP (Performance
Attributes), MODR (Method Operable Design Region), Control Strategy, and Continual
Method Improvement are all included in the creation of an analytical method
India faces a serious problem with drug addiction, which is becoming more common among young people and
other vulnerable groups. This has significant effects on mortality and morbidity. Narcotic medicines are those
that cause sleep, whereas psychotropic drugs affect the mind and change a person's mental capacity. In order to
examine state-by-state trends in drug prevalence, consumption patterns across age groups, educational
backgrounds of drug users, the most commonly consumed substances, and substance abuse trends across
Indian states, this review synthesizes findings from multiple studies, emphasizing regional challenges and
demographic variations. Nearly 70% of drug users are between the ages of 20 and 40, which is a worrying
trend that has resulted in an alarming rise in suicide rates.
To secure a sustainable and drug-free future, public health systems, legislators, and communities must work
together to address this complex issue
and tablet dosage forms. The analysis was performed using an Inertsil-ODS C18 column (250x4.6mm, 5μm)
with a mobile phase composed of 95:5 methanol/water at a flow rate of 1mL/min. Leflunomide demonstrated a
linear range between 20-70μg/ml with a high correlation coefficient (R² = 0.995). Adhering to ICH guidelines,
the method was designed to be accurate, precise, sensitive, selective, repeatable, and robust. The validation
parameters included system suitability, specificity, linearity, accuracy, precision, detection limit, quantitation
limit, robustness, and stability. The results indicated excellent accuracy and precision, with recoveries close to
100% and relative standard deviations well within acceptable limits. The method's sensitivity allowed for
reliable detection and quantification at low concentrations, making it ideal for routine quality control.
Additionally, robustness studies confirmed the method's reliability despite minor changes in experimental
conditions. This HPLC method is both efficient and cost-effective, enabling faster analysis while maintaining
high quality. The validated method was successfully applied to the analysis of leflunomide in pharmaceutical
formulations, proving its suitability for routine use in quality control laboratories. Overall, this method offers a
comprehensive solution for accurately estimating leflunomide in various dosage forms.
fast leaf-folding response to touch. This review examines the botanical, phytochemical, pharmacological, and
therapeutic properties of M. pudica. The plant contains numerous bioactive chemicals, including alkaloids,
flavonoids, tannins, saponins, and glycosides, which contribute to its diverse therapeutic qualities. Traditionally,
it was used to heal wounds, skin problems, diarrhea, and inflammation. Recent pharmacological research have
shown that it has antioxidant, antibacterial, anti-inflammatory, analgesic, antidiabetic, and hepatoprotective
properties. Its distinct thigmonastic response has piqued attention in plant physiology and environmental
adaptation research.
fig tree, is a well-known medicinal plant in India. This herb is mentioned in all the
ancient writings on Ayurveda, Siddha, Unani, and homeopathy. Bark, roots, leaves,
fruits, and latex are among the many plant parts that are used as carminatives,
astringents, vermifuges, and anti-dysentery medicines. It is a helpful remedy for eating
too much. Menorrhagia, diabetes, leucoderma, hepatoprotection, refrigerant,
antioxidant, and antiulcer diseases are all treated with fruit extract. It is given topically
to treat skin lesions, fibrositis, lymphadenitis, and sprains to lessen swelling. This study
aims to formulate and evaluate the herbal tablets made from Ficus racemosa Linn.bark
extract.
yeast-like fungi of the genus Candida, is a common skin infection. The conventional
antifungal drugs, such as azoles, often exhibit adverse effects, including hypersensitivity
reactions (itching, inflammation, eczema). These symptoms can overlap with the
manifestations of fungal infections, leading to diagnostic challenges and patient
discomfort. Seeking alternative solutions, we explored the antifungal efficacy of clove
and turmeric oils, both renowned for their medicinal properties. Our study investigated
the synergistic potential of these oils, combined in 1:1, 3:1 and 1:3 ratios, against
Candida species. Using steam distillation, we extracted essential oils from clove and
turmeric powders. Samples, comprising individual oils and various mixtures, were
prepared and subjected to the Kirby-Bauer disk diffusion method for antifungal
assessment. Results revealed a promising synergism in the 3:1 mixture of clove and
turmeric oils. Although the observed zone of inhibition was shorter than that of
ketoconazole, a synthetic antifungal, the efficacy of the natural blend underscores its
potential as an alternative therapeutic option. Our findings suggest that clove and
turmeric oils possess inherent antifungal properties, with the potential for enhanced
efficacy when combined synergistically. Further research is warranted to optimize the
blend ratio and investigate its clinical applicability. Embracing plant-based alternatives
may herald safer and more sustainable strategies for combating fungal infections,
offering hope for improved patient outcomes.