International Journal of Research Publication and Reviews, 2024
Background: Helminth infections are one of the utmost health and economic problems in developing ... more Background: Helminth infections are one of the utmost health and economic problems in developing tropical countries. Synthetic anthelmintics are present and have some limitations, like inaccessibility and drug resistance, and so alternative anthelmintics become inevitable. Among medicinal plants, Macaranga peltata shows many bioactive compounds. Therefore, it can prove to be a drug, as well. Objectives: The anthelmintic activity of the extract of leaves of Macaranga peltata along with Albendazole compared between aqueous and alcoholic extracts. Methods: Macaranga peltata leaves were collected, authenticated, and processed for extract preparation. Phytochemical analysis revealed the presence of alkaloids, flavonoids, tannins, saponins, and terpenoids. Different concentrations of the prepared extracts (25 mg/ml and 50 mg/ml) were administered to Pheretima posthuma worms, and the efficacy was determined as measured by time to paralysis (P) and death (D). Statistical analysis was carried on the gathered data. Results: The anthelmintic activity was more significant from the ethanolic extract compared to the aqueous extract, with paralysis occurring after 18.91 ± 1.21 min and death after 35.14 ± 1.56 min at 50 mg/ml. It has been scientifically proven that phytochemicals present in the ethanolic extract, especially alkaloids and flavonoids, enhance the anthelmintic action. Conclusion: Macaranga peltata has promising anthelmintic activity and was found to be effective approximately similar to Albendazole in its ethanolic extract. These findings are promising for its potential as a natural anthelmintic, but further research is required in safety and optimal use.
Worldwide, Bryophyllum pinnatum is extensively used to treat the various ailments in folk medicin... more Worldwide, Bryophyllum pinnatum is extensively used to treat the various ailments in folk medicine. The plant is enriched with a diverse range of active therapeutic constituents which are responsible for various significant pharmacological effects. The objective of current study is to highlight the latest evidence-based information regarding pharmacognostical, phytochemical and pharmacological profile of the medicinal plant. Data for the present study was taken from previously published work and to ensure the credibility only indexed research and review articles were used. The databases were included: Scopus, Google Scholar, PubMed, Science Direct, and MEDLINE. Bryophyllum pinnatum contains valuable phytochemicals such as polyphenols, tannins, glycosaponins, flavonoids, steroidal glycosides and many other important chemical constituents that are responsible for its anti-oxidant, anti-pyretic, anti-inflammatory, antiarthritic, anti-allergic, analgesic, antiseptic , sedative, anti-depression, wound healing, hepatoprotective, nephroprotective, tocolysis, urolithic, anti-psychotic, muscle relaxant, anti-protozoal, anti-microbial and anti-diabetic effects. Bufadienolides have been isolated from the leaves of plant which could be the potential chemotherapeutic agents and hence plant has anti-tumor activity as well. Although, many aspects of the herb have been explored still there is need to carry out a more comprehensive investigation in order to confirm its therapeutic efficacy and to appraise rationale behind its use in folk medicines.
Journal of prevention, diagnosis and management of human diseases, Mar 9, 2024
Kidney injury, a global health challenge, necessitates a nuanced understanding of molecular intri... more Kidney injury, a global health challenge, necessitates a nuanced understanding of molecular intricacies for effective interventions. Long non-coding RNAs (lncRNAs), once dismissed as transcriptional noise, now emerge as pivotal players in orchestrating renal health. Dysregulation of specific lncRNAs like TUG1, MALAT1, H19, and NEAT1 provides molecular signatures, distinguishing physiological states from pathological conditions. In acute kidney injury (AKI), TUG1 and MALAT1 regulate apoptosis, inflammation, and fibrosis. Chronic kidney disease (CKD) involves lncRNAs like H19 and NEAT1 modulating cell proliferation and apoptosis. Beyond diagnostics, lncRNAs actively shape inflammation, apoptosis, and fibrosis, positioning them as master regulators in the intricate ballet of kidney health. Recent strides in research, coupled with cutting-edge genomics and bioinformatics tools, highlight their roles and therapeutic potential. Challenges in understanding their intricate roles and interactions necessitate the exploration of promising avenues, including single-cell RNA sequencing and artificial intelligence, paving the way for personalized interventions and regenerative medicine in kidney diseases.
Journal of Emerging Technologies and Innovative Research (JETIR), 2024
Golden shower tree, or Cassia fistula, is a well-known medicinal plant with a long history of tra... more Golden shower tree, or Cassia fistula, is a well-known medicinal plant with a long history of traditional use. The purpose of this thorough investigation is to clarify Cassia fistula's phytochemical components and pharmacological properties. The plant is rich in bioactive substances like flavonoids, tannins, saponins, and anthraquinones, according to extensive phytochemical studies. Its various pharmacological qualities, including as antibacterial, anti-inflammatory, antioxidant, hepatoprotective, and anticancer effects, are attributed to these components. Particularly noteworthy is the antibacterial action against a wide range of bacterial and fungal infections. The plant's ability to scavenge free radicals and strengthen cellular antioxidant defenses is what is thought to provide it antioxidant qualities. On the other hand, its anti-inflammatory actions are mediated through the suppression of important inflammatory mediators. Hepatoprotective effects are supported by the mitigation of liver damage induced by various toxins. Additionally, emerging evidence suggests potential anticancer properties, as certain compounds in Cassia fistula exhibit cytotoxic effects on cancer cell lines. This review underscores the therapeutic potential of Cassia fistula and advocates for further clinical studies to validate its efficacy and safety in medical applications.
Calotropis gigantea belonging to the Asclepiadaceae family, is a glabrous or hairy, lactiferous s... more Calotropis gigantea belonging to the Asclepiadaceae family, is a glabrous or hairy, lactiferous shrubs or small trees, commonly known as "the swallow-wort or milkweed". Calotropis gigantea is a well known medicinal herb commonly known as crown flower/ giant milkweed. It has been used for years Unani, Ayurveda and Siddha system of medicine. Herbal medicines can be used to treat a variety of chronic inflammatory illnesses, like rheumatoid arthritis, psoriasis and leprosy. Objective: Calotropis gigantea, is a versatile medicinal herb. It also known as a "Madar", it has a huge history of traditional uses in medical systems like Unani, Ayurveda, and Siddha. It mainly well known for effective treatment for various chronic inflammatory conditions such as psoriasis, rheumatoid arthritis and leprosy. Calotropis gigantea stands out for its therapeutic versatility and wide range of applications. From its root to its flowers, different parts of Calotropis gigantea are known for their medicinal properties. Its potential includes wide spectrum of pharmacological activities, medicinal properties, healing properties making it a promising candidate for the development of novel effective drugs. This has been used in folk medicines for the treatment of bronchitis, asthma, leprosy, eczema and elephantiasis. Although the whole plant is used for skin diseases. Calotropis gigantea are used to treat snake bites, toothache, scorpion stings, fevers, and agues, intestinal diseases, powdered root bark have the ability to cure elephantiasis, dysentery, the stem bark is important for gastrointestinal, lung disease, spleen complaints, ringworm and pneumonia. Conclusion: This review emphasizes on the phytochemistry, uses, pharmacological profile of Calotropis gigantea.
INTELLIGENT SYSTEMS AND APPLICATIONS IN ENGINEERING, 2024
This research examines the viable usage of blockchain innovation in pharmaceutical supply chain a... more This research examines the viable usage of blockchain innovation in pharmaceutical supply chain administration. Through an arrangement of tests and comparative examinations, the ponder assesses the effect of blockchain on key execution pointers such as traceability, straightforwardness, security, and proficiency. Results show noteworthy changes in traceability, with blockchain empowering real-time following of pharmaceutical items from fabricating to conveyance. Straightforwardness is improved through the utilisation of decentralized records, giving partners perceivability into supply chain operations. Security measures such as cryptographic hashing and computerized marks guarantee information keenness and ensure against extortion and unauthorized get to. Besides, the mechanization of forms by means of shrewd contracts leads to expanded proficiency in exchange preparation and compliance confirmation. The discoveries of this investigation highlight the transformative potential of blockchain innovation in revolutionizing pharmaceutical supply chain administration. Moving forward, it is basic for partners to address challenges such as adaptability and administrative compliance to completely realize the benefits of blockchain in guaranteeing the secure and effective conveyance of pharmaceutical items.
The emergence of the Omicron variant of SARS-CoV-2 has raised concerns about the effectiveness of... more The emergence of the Omicron variant of SARS-CoV-2 has raised concerns about the effectiveness of existing COVID-19 vaccines. Initially, spike protein was identified as a key target for vaccine development, leading to the creation of mRNA vaccines like Pfizer-BioNTech and Moderna, which have shown high efficacy. The immune response to SARS-CoV-2 involves both innate and adaptive systems, with B and T lymphocytes playing crucial roles. Protein-based subunit vaccines have also demonstrated effectiveness. However, the ongoing evolution of the virus necessitates the exploration of strategies such as developing new vaccines, updating existing ones, and administering booster shots. Ongoing research and adaptation of vaccination strategies are essential in the battle against COVID-19.
Zenodo (CERN European Organization for Nuclear Research), Sep 19, 2022
The present study was conducted to examine the anti-inflammatory activity of aqueous fruits extra... more The present study was conducted to examine the anti-inflammatory activity of aqueous fruits extract of Malus sylvestris using suitable experimental models. Wister rats were divided into 5 groups of n=6 each using Aspirin (300 mg/kg, p.o) as the standard drug. The Aqueous extract of Malus sylvestris was given at three doses of 200 mg/kg, 400 mg/kg and 800 mg/kg p.o. in distilled water respectively. Prepared extract was administered orally once daily for 7 consecutive days one hour prior to the administration of 0.1ml carrageenan injection in sub-plantar region. The volume of the rat paw was measured at the end of 7 th day. The present study reveals that the aqueous extract of Malus sylvestris at the doses of 400 mg/kg and 800 mg/kg significantly reduced the carrageenan induced paw edema (P<0.001) at 3hr and 6hr in a dose dependent manner as compared to the vehicle control. Whereas 200mg/kg does not show any significance with that of control. As a result of the foregoing findings, the aqueous extract of Malus sylvestris fruit was found to have considerable anti-inflammatory activity in the carrageenan induced paw edema but was unable to completely prevent the inflammation.
The expression "Locked in Syndrome" was established by Plum and Posner in 1966 which ad... more The expression "Locked in Syndrome" was established by Plum and Posner in 1966 which adverts to a neurological condition identified with ventral pons infarction. The disorder is symbolized by quadriplegia, inferior paralysis of the cranial nerve and aphonic sustaining only the upward look and motion of eyelid. Patients with locked in syndrome is unerringly sealed within the human form, conscious of their surroundings but with a confined capacity to communicate with it. Cerebrovascular malady is the most driving etiology of LIS. Infarction of the ventral pontine following hindrance of basilar arteries is usually the result. Another significant and recurrent instigation of LIS is brain injury due to trauma. Conveying of messages for LIS persons involves using alternative broadcasting, such as eye blinks or eye movements for a yes-no code or communication boards with alphabets or marks suggested by eye gestures. The initial treatment is on the preservation of an airway and ad...
World Journal of Current Medical and Pharmaceutical Research, Oct 20, 2022
Aim of the study: Averrhoa bilimbi is used to treat a variety of illnesses, including those that ... more Aim of the study: Averrhoa bilimbi is used to treat a variety of illnesses, including those that affect the central nervous system. In this study, albino rats were given methanolic extract of Averrhoa bilimbi leaves (MEAB) to investigate its effects using behavioral assays that are sensitive to antidepressants with clinical efficacy. Methodology: When mice were subjected to the Tail suspension test (TST) and Forced swim test (FST), the extract (125,250, and 500mg/kg) was able to reduce the immobility duration of the mice dose-dependently; the effects are comparable to those of standard medicines, i.e., imipramine (10mg/kg). Results: Our research revealed that MEAB, when administered at greater concentrations, significantly (p<0.0001) reduced immobility in tail suspension and forced swim model of depression comparable to Imipramine. These findings showed that AB exhibited in vivo effects that were selectively antidepressant. Conclusion: The results of this study, in summary, revealed that AB extracts may have antidepressant properties that make them potentially useful for treating patients with depressive disorders. However, more research is required to comprehend the mechanism of action and to pinpoint the key ingredient that produces antidepressant-like activity.
Indian Journal of Pharmacy and Drug Studies (IJPDS) , 2023
siRNA-mediated silencing of oncogenes holds great promise as a potential cancer therapy. By selec... more siRNA-mediated silencing of oncogenes holds great promise as a potential cancer therapy. By selectively silencing genes involved in cancer progression, siRNA-based therapies have the potential to be highly specific and effective, while minimizing off-target effects and toxicity. However, several challenges need to be addressed before siRNA-based therapies can be widely used in clinical settings. One of the major challenges is the development of efficient and safe delivery systems for siRNAs. Additionally, more clinical trials are needed to evaluate the safety and efficacy of siRNA-based therapies for cancer treatment. Despite these challenges, ongoing research and development in the field of siRNA-based therapies are promising. New delivery systems, personalized medicine approaches, and combination therapies are being explored, which could potentially lead to more effective and personalized cancer treatment. With continued research and development, it is hoped that siRNA-based therapies will eventually become cancer treatments, providing patients with a more targeted and effective treatment option.
Zenodo (CERN European Organization for Nuclear Research), Jul 1, 2022
Acanthosis nigricans (AN) is an uncommon skin condition that involves dermatosis, hyperkeratosis,... more Acanthosis nigricans (AN) is an uncommon skin condition that involves dermatosis, hyperkeratosis, and skin darkening followed by velvety thickening of the epidermis. It mostly affects the posterior neck fold, axillae, umbilicus and flexor skin surfaces although it can also affect the mucosal surfaces. Despite the fact that the majority of causes are benign, it has been related to gastrointestinal and other cancers. Gastroenterologists, dermatologists, and oncologists all need to collaborate closely. An Acanthosis nigricans is thought to be linked with insulin resistance, a disorder characterised by inadequate physiologic responses to insulin. Insulin resistance, according to some experts, leads to a build-up of the hormone in the blood, which subsequently enters skin cells. Obesity and Type-II diabetes mellitus have both been linked to insulin resistance.
International Journal of Pharmaceutical Sciences Review and Research
The Staircase Model (SCM) and Light and Dark Chamber (LDM) in albino rats are used in this study ... more The Staircase Model (SCM) and Light and Dark Chamber (LDM) in albino rats are used in this study to investigate the possible anxiolytic-like effects of the Hydroalcoholic extract of leaves of Plectranthus scutellarioides (HEPS). The creatures were split up into four groups of six apiece. The HEPS was administered orally in 2 doses of 100 mg/kg and 200 mg/kg to control rats, while positive control animals received diazepam (2 mg/kg) treatment. One hour before the experiment, after anxiety induction, the test sample was administered orally. According to the current study, albino rats in the staircase model experience (P>0.05), considerably less climbing and rearing steps when given HEPS orally at doses of 100 mg/kg and 200 mg/kg. Additionally, in the Light and Dark Model, albino rats spend less time in the dark compared to the vehicle control, in a dose-dependent manner(P>0.05). It was discovered that the HEPS of the dose 200mg/kg body weight was quite similar to that of benzodi...
A thesis submitted as part of the requirements for the degree of Doctor of Philosophy awarded by ... more A thesis submitted as part of the requirements for the degree of Doctor of Philosophy awarded by the Robert Gordon University
International Journal of Research Publication and Reviews, 2024
Background: Helminth infections are one of the utmost health and economic problems in developing ... more Background: Helminth infections are one of the utmost health and economic problems in developing tropical countries. Synthetic anthelmintics are present and have some limitations, like inaccessibility and drug resistance, and so alternative anthelmintics become inevitable. Among medicinal plants, Macaranga peltata shows many bioactive compounds. Therefore, it can prove to be a drug, as well. Objectives: The anthelmintic activity of the extract of leaves of Macaranga peltata along with Albendazole compared between aqueous and alcoholic extracts. Methods: Macaranga peltata leaves were collected, authenticated, and processed for extract preparation. Phytochemical analysis revealed the presence of alkaloids, flavonoids, tannins, saponins, and terpenoids. Different concentrations of the prepared extracts (25 mg/ml and 50 mg/ml) were administered to Pheretima posthuma worms, and the efficacy was determined as measured by time to paralysis (P) and death (D). Statistical analysis was carried on the gathered data. Results: The anthelmintic activity was more significant from the ethanolic extract compared to the aqueous extract, with paralysis occurring after 18.91 ± 1.21 min and death after 35.14 ± 1.56 min at 50 mg/ml. It has been scientifically proven that phytochemicals present in the ethanolic extract, especially alkaloids and flavonoids, enhance the anthelmintic action. Conclusion: Macaranga peltata has promising anthelmintic activity and was found to be effective approximately similar to Albendazole in its ethanolic extract. These findings are promising for its potential as a natural anthelmintic, but further research is required in safety and optimal use.
Worldwide, Bryophyllum pinnatum is extensively used to treat the various ailments in folk medicin... more Worldwide, Bryophyllum pinnatum is extensively used to treat the various ailments in folk medicine. The plant is enriched with a diverse range of active therapeutic constituents which are responsible for various significant pharmacological effects. The objective of current study is to highlight the latest evidence-based information regarding pharmacognostical, phytochemical and pharmacological profile of the medicinal plant. Data for the present study was taken from previously published work and to ensure the credibility only indexed research and review articles were used. The databases were included: Scopus, Google Scholar, PubMed, Science Direct, and MEDLINE. Bryophyllum pinnatum contains valuable phytochemicals such as polyphenols, tannins, glycosaponins, flavonoids, steroidal glycosides and many other important chemical constituents that are responsible for its anti-oxidant, anti-pyretic, anti-inflammatory, antiarthritic, anti-allergic, analgesic, antiseptic , sedative, anti-depression, wound healing, hepatoprotective, nephroprotective, tocolysis, urolithic, anti-psychotic, muscle relaxant, anti-protozoal, anti-microbial and anti-diabetic effects. Bufadienolides have been isolated from the leaves of plant which could be the potential chemotherapeutic agents and hence plant has anti-tumor activity as well. Although, many aspects of the herb have been explored still there is need to carry out a more comprehensive investigation in order to confirm its therapeutic efficacy and to appraise rationale behind its use in folk medicines.
Journal of prevention, diagnosis and management of human diseases, Mar 9, 2024
Kidney injury, a global health challenge, necessitates a nuanced understanding of molecular intri... more Kidney injury, a global health challenge, necessitates a nuanced understanding of molecular intricacies for effective interventions. Long non-coding RNAs (lncRNAs), once dismissed as transcriptional noise, now emerge as pivotal players in orchestrating renal health. Dysregulation of specific lncRNAs like TUG1, MALAT1, H19, and NEAT1 provides molecular signatures, distinguishing physiological states from pathological conditions. In acute kidney injury (AKI), TUG1 and MALAT1 regulate apoptosis, inflammation, and fibrosis. Chronic kidney disease (CKD) involves lncRNAs like H19 and NEAT1 modulating cell proliferation and apoptosis. Beyond diagnostics, lncRNAs actively shape inflammation, apoptosis, and fibrosis, positioning them as master regulators in the intricate ballet of kidney health. Recent strides in research, coupled with cutting-edge genomics and bioinformatics tools, highlight their roles and therapeutic potential. Challenges in understanding their intricate roles and interactions necessitate the exploration of promising avenues, including single-cell RNA sequencing and artificial intelligence, paving the way for personalized interventions and regenerative medicine in kidney diseases.
Journal of Emerging Technologies and Innovative Research (JETIR), 2024
Golden shower tree, or Cassia fistula, is a well-known medicinal plant with a long history of tra... more Golden shower tree, or Cassia fistula, is a well-known medicinal plant with a long history of traditional use. The purpose of this thorough investigation is to clarify Cassia fistula's phytochemical components and pharmacological properties. The plant is rich in bioactive substances like flavonoids, tannins, saponins, and anthraquinones, according to extensive phytochemical studies. Its various pharmacological qualities, including as antibacterial, anti-inflammatory, antioxidant, hepatoprotective, and anticancer effects, are attributed to these components. Particularly noteworthy is the antibacterial action against a wide range of bacterial and fungal infections. The plant's ability to scavenge free radicals and strengthen cellular antioxidant defenses is what is thought to provide it antioxidant qualities. On the other hand, its anti-inflammatory actions are mediated through the suppression of important inflammatory mediators. Hepatoprotective effects are supported by the mitigation of liver damage induced by various toxins. Additionally, emerging evidence suggests potential anticancer properties, as certain compounds in Cassia fistula exhibit cytotoxic effects on cancer cell lines. This review underscores the therapeutic potential of Cassia fistula and advocates for further clinical studies to validate its efficacy and safety in medical applications.
Calotropis gigantea belonging to the Asclepiadaceae family, is a glabrous or hairy, lactiferous s... more Calotropis gigantea belonging to the Asclepiadaceae family, is a glabrous or hairy, lactiferous shrubs or small trees, commonly known as "the swallow-wort or milkweed". Calotropis gigantea is a well known medicinal herb commonly known as crown flower/ giant milkweed. It has been used for years Unani, Ayurveda and Siddha system of medicine. Herbal medicines can be used to treat a variety of chronic inflammatory illnesses, like rheumatoid arthritis, psoriasis and leprosy. Objective: Calotropis gigantea, is a versatile medicinal herb. It also known as a "Madar", it has a huge history of traditional uses in medical systems like Unani, Ayurveda, and Siddha. It mainly well known for effective treatment for various chronic inflammatory conditions such as psoriasis, rheumatoid arthritis and leprosy. Calotropis gigantea stands out for its therapeutic versatility and wide range of applications. From its root to its flowers, different parts of Calotropis gigantea are known for their medicinal properties. Its potential includes wide spectrum of pharmacological activities, medicinal properties, healing properties making it a promising candidate for the development of novel effective drugs. This has been used in folk medicines for the treatment of bronchitis, asthma, leprosy, eczema and elephantiasis. Although the whole plant is used for skin diseases. Calotropis gigantea are used to treat snake bites, toothache, scorpion stings, fevers, and agues, intestinal diseases, powdered root bark have the ability to cure elephantiasis, dysentery, the stem bark is important for gastrointestinal, lung disease, spleen complaints, ringworm and pneumonia. Conclusion: This review emphasizes on the phytochemistry, uses, pharmacological profile of Calotropis gigantea.
INTELLIGENT SYSTEMS AND APPLICATIONS IN ENGINEERING, 2024
This research examines the viable usage of blockchain innovation in pharmaceutical supply chain a... more This research examines the viable usage of blockchain innovation in pharmaceutical supply chain administration. Through an arrangement of tests and comparative examinations, the ponder assesses the effect of blockchain on key execution pointers such as traceability, straightforwardness, security, and proficiency. Results show noteworthy changes in traceability, with blockchain empowering real-time following of pharmaceutical items from fabricating to conveyance. Straightforwardness is improved through the utilisation of decentralized records, giving partners perceivability into supply chain operations. Security measures such as cryptographic hashing and computerized marks guarantee information keenness and ensure against extortion and unauthorized get to. Besides, the mechanization of forms by means of shrewd contracts leads to expanded proficiency in exchange preparation and compliance confirmation. The discoveries of this investigation highlight the transformative potential of blockchain innovation in revolutionizing pharmaceutical supply chain administration. Moving forward, it is basic for partners to address challenges such as adaptability and administrative compliance to completely realize the benefits of blockchain in guaranteeing the secure and effective conveyance of pharmaceutical items.
The emergence of the Omicron variant of SARS-CoV-2 has raised concerns about the effectiveness of... more The emergence of the Omicron variant of SARS-CoV-2 has raised concerns about the effectiveness of existing COVID-19 vaccines. Initially, spike protein was identified as a key target for vaccine development, leading to the creation of mRNA vaccines like Pfizer-BioNTech and Moderna, which have shown high efficacy. The immune response to SARS-CoV-2 involves both innate and adaptive systems, with B and T lymphocytes playing crucial roles. Protein-based subunit vaccines have also demonstrated effectiveness. However, the ongoing evolution of the virus necessitates the exploration of strategies such as developing new vaccines, updating existing ones, and administering booster shots. Ongoing research and adaptation of vaccination strategies are essential in the battle against COVID-19.
Zenodo (CERN European Organization for Nuclear Research), Sep 19, 2022
The present study was conducted to examine the anti-inflammatory activity of aqueous fruits extra... more The present study was conducted to examine the anti-inflammatory activity of aqueous fruits extract of Malus sylvestris using suitable experimental models. Wister rats were divided into 5 groups of n=6 each using Aspirin (300 mg/kg, p.o) as the standard drug. The Aqueous extract of Malus sylvestris was given at three doses of 200 mg/kg, 400 mg/kg and 800 mg/kg p.o. in distilled water respectively. Prepared extract was administered orally once daily for 7 consecutive days one hour prior to the administration of 0.1ml carrageenan injection in sub-plantar region. The volume of the rat paw was measured at the end of 7 th day. The present study reveals that the aqueous extract of Malus sylvestris at the doses of 400 mg/kg and 800 mg/kg significantly reduced the carrageenan induced paw edema (P<0.001) at 3hr and 6hr in a dose dependent manner as compared to the vehicle control. Whereas 200mg/kg does not show any significance with that of control. As a result of the foregoing findings, the aqueous extract of Malus sylvestris fruit was found to have considerable anti-inflammatory activity in the carrageenan induced paw edema but was unable to completely prevent the inflammation.
The expression "Locked in Syndrome" was established by Plum and Posner in 1966 which ad... more The expression "Locked in Syndrome" was established by Plum and Posner in 1966 which adverts to a neurological condition identified with ventral pons infarction. The disorder is symbolized by quadriplegia, inferior paralysis of the cranial nerve and aphonic sustaining only the upward look and motion of eyelid. Patients with locked in syndrome is unerringly sealed within the human form, conscious of their surroundings but with a confined capacity to communicate with it. Cerebrovascular malady is the most driving etiology of LIS. Infarction of the ventral pontine following hindrance of basilar arteries is usually the result. Another significant and recurrent instigation of LIS is brain injury due to trauma. Conveying of messages for LIS persons involves using alternative broadcasting, such as eye blinks or eye movements for a yes-no code or communication boards with alphabets or marks suggested by eye gestures. The initial treatment is on the preservation of an airway and ad...
World Journal of Current Medical and Pharmaceutical Research, Oct 20, 2022
Aim of the study: Averrhoa bilimbi is used to treat a variety of illnesses, including those that ... more Aim of the study: Averrhoa bilimbi is used to treat a variety of illnesses, including those that affect the central nervous system. In this study, albino rats were given methanolic extract of Averrhoa bilimbi leaves (MEAB) to investigate its effects using behavioral assays that are sensitive to antidepressants with clinical efficacy. Methodology: When mice were subjected to the Tail suspension test (TST) and Forced swim test (FST), the extract (125,250, and 500mg/kg) was able to reduce the immobility duration of the mice dose-dependently; the effects are comparable to those of standard medicines, i.e., imipramine (10mg/kg). Results: Our research revealed that MEAB, when administered at greater concentrations, significantly (p<0.0001) reduced immobility in tail suspension and forced swim model of depression comparable to Imipramine. These findings showed that AB exhibited in vivo effects that were selectively antidepressant. Conclusion: The results of this study, in summary, revealed that AB extracts may have antidepressant properties that make them potentially useful for treating patients with depressive disorders. However, more research is required to comprehend the mechanism of action and to pinpoint the key ingredient that produces antidepressant-like activity.
Indian Journal of Pharmacy and Drug Studies (IJPDS) , 2023
siRNA-mediated silencing of oncogenes holds great promise as a potential cancer therapy. By selec... more siRNA-mediated silencing of oncogenes holds great promise as a potential cancer therapy. By selectively silencing genes involved in cancer progression, siRNA-based therapies have the potential to be highly specific and effective, while minimizing off-target effects and toxicity. However, several challenges need to be addressed before siRNA-based therapies can be widely used in clinical settings. One of the major challenges is the development of efficient and safe delivery systems for siRNAs. Additionally, more clinical trials are needed to evaluate the safety and efficacy of siRNA-based therapies for cancer treatment. Despite these challenges, ongoing research and development in the field of siRNA-based therapies are promising. New delivery systems, personalized medicine approaches, and combination therapies are being explored, which could potentially lead to more effective and personalized cancer treatment. With continued research and development, it is hoped that siRNA-based therapies will eventually become cancer treatments, providing patients with a more targeted and effective treatment option.
Zenodo (CERN European Organization for Nuclear Research), Jul 1, 2022
Acanthosis nigricans (AN) is an uncommon skin condition that involves dermatosis, hyperkeratosis,... more Acanthosis nigricans (AN) is an uncommon skin condition that involves dermatosis, hyperkeratosis, and skin darkening followed by velvety thickening of the epidermis. It mostly affects the posterior neck fold, axillae, umbilicus and flexor skin surfaces although it can also affect the mucosal surfaces. Despite the fact that the majority of causes are benign, it has been related to gastrointestinal and other cancers. Gastroenterologists, dermatologists, and oncologists all need to collaborate closely. An Acanthosis nigricans is thought to be linked with insulin resistance, a disorder characterised by inadequate physiologic responses to insulin. Insulin resistance, according to some experts, leads to a build-up of the hormone in the blood, which subsequently enters skin cells. Obesity and Type-II diabetes mellitus have both been linked to insulin resistance.
International Journal of Pharmaceutical Sciences Review and Research
The Staircase Model (SCM) and Light and Dark Chamber (LDM) in albino rats are used in this study ... more The Staircase Model (SCM) and Light and Dark Chamber (LDM) in albino rats are used in this study to investigate the possible anxiolytic-like effects of the Hydroalcoholic extract of leaves of Plectranthus scutellarioides (HEPS). The creatures were split up into four groups of six apiece. The HEPS was administered orally in 2 doses of 100 mg/kg and 200 mg/kg to control rats, while positive control animals received diazepam (2 mg/kg) treatment. One hour before the experiment, after anxiety induction, the test sample was administered orally. According to the current study, albino rats in the staircase model experience (P>0.05), considerably less climbing and rearing steps when given HEPS orally at doses of 100 mg/kg and 200 mg/kg. Additionally, in the Light and Dark Model, albino rats spend less time in the dark compared to the vehicle control, in a dose-dependent manner(P>0.05). It was discovered that the HEPS of the dose 200mg/kg body weight was quite similar to that of benzodi...
A thesis submitted as part of the requirements for the degree of Doctor of Philosophy awarded by ... more A thesis submitted as part of the requirements for the degree of Doctor of Philosophy awarded by the Robert Gordon University
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Papers by Ramdas Bhat