Papers by Dr. Javesh K Patil
International journal for research in applied science and engineering technology, May 31, 2024
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Onychomycosis is a frequent fungal infection of the nails that is difficult to cure and is not we... more Onychomycosis is a frequent fungal infection of the nails that is difficult to cure and is not well controlled by standard medications, therapeutic options are limited. Herbal remedies have drawn interest as a result of this due to their potential as complementary therapies. The composition and effectiveness of a novel herbal anti-fungal cream that combines the powerful anti-fungal qualities of clove oil, turmeric, and pure peppermint are examined in this abstract. The strong anti-fungal properties of clove oil's high eugenol content are enhanced by curcumin, an anti-inflammatory and anti-microbial compound found in turmeric. Pure peppermint contributes antifungal and calming qualities as well as a pleasant element. The combination of these components offers a viable way to cure onychomycosis, possibly more effectively than conventional therapies because it is allnatural.
This study explores the creation and properties of a cosmetic herbal face pack derived from natur... more This study explores the creation and properties of a cosmetic herbal face pack derived from natural constituents. The background of the research emphasizes the long-known benefits of vegetables for skin health and the historical use of natural ingredients in cosmetics. The research problem addressed is the increasing demand for herbal cosmetics due to their purity and lack of adverse effects on health. The aim of the paper is to develop a natural face pack using fig, banana peel, orange peel, and strawberry and evaluate its efficacy. The methodology involves the procurement of natural materials, preparation of the face pack, and evaluation through organoleptic, physico-chemical, and general powder characteristics, Washability test, Spreadability test, Irritancy test ,PH test etc. Results indicate that the multiherbal fruit face mask exhibited antibacterial properties and suitability for cosmetic use. The implications of the study suggest the growing acceptance and demand for herbal remedies in the cosmetics industry due to their perceived safety benefits.
Gel formulations prepared with Carbopol 934, HPMC K 4M polymers. In which Amla, Aritha, Shikakai ... more Gel formulations prepared with Carbopol 934, HPMC K 4M polymers. In which Amla, Aritha, Shikakai and Neem fruit extract are used as a crude drug. They are better suited for primary healthcare due to their lower side effects, greater compatibility with the human body, and greater cultural acceptability. Herbal remedies are made of plants or plant parts that are used to treat ailments, diseases, or accidents. The formulation no. F3 (formulation based on HPMC) and C1(Formulation based on Carbopol) are showed good homogeneity, no skin irritation, good stability, anti-fungal and anti-dandruff activity. Nevertheless, the gel based on HPMC K proved to be the optimal formula, exhibiting the maximum proportion of good rheological characteristics and spreadability.
The popularity of anti-aging face serums as a crucial part of skincare routines has been driven b... more The popularity of anti-aging face serums as a crucial part of skincare routines has been driven by the desire for youthful and radiant skin. This research aims to provide a comprehensive analysis of the effectiveness behind these serums. By extensively examining scientific literature, we explore the wide range of active ingredients commonly found in these serums, such as retinoids, hyaluronic acid, peptides, antioxidants, and growth factors.we delve into how these ingredients work, including collagen stimulation, hydration retention, oxidative stress reduction, and cellular repair This research focuses on developing an anti-aging serum leveraging the synergistic benefits of aloe vera, green tea extract, and fig fruit oil. The formulation process involves meticulous blending to harness the individual properties of each ingredient, aiming to create a potent solution for combating signs of ageing. We also consider the clinical evidence supporting the effectiveness of anti-aging face serums, with a particular focus on their ability to reduce wrinkles, improve skin texture, and rejuvenate the overall appearance of the skin. There are various types of serums available, including gel-based and oil-based serum,etc. Various types of evaluation parameters were studied. Our formulation showed good viscosity, pH range was also within limits, it exhibited good spreadability, and serum stability was maintained at all temperatures. By integrating scientific analysis with natural ingredients, this study aimed to contribute to the development of effective skincare solutions.
This article is a review of the history of the development of various methods and validation of f... more This article is a review of the history of the development of various methods and validation of fexofenadine. Fexofenadine is a second-generation antihistamine derived from terfenadine. This medication has been authorized by the FDA to treat seasonal allergic rhinitis and chronic idiopathic urticaria. Fexofenadine is a drug used to manage allergic rhinitis and persistent hives. Analytical technique development and validation is the process of proving an analytical method is appropriate for assessing medications, particularly active pharmaceutical ingredients (APIs). This makes it possible to monitor medication efficacy precisely and consistently. The development and validation of pharmaceutical methods can be costly, time-consuming, and complex. This calls for advanced instruments as well as a deep comprehension of pertinent chemical processes and current regulatory standards.
The most prevalent fungal infection of fingernails or toenails in the general public is onychomyc... more The most prevalent fungal infection of fingernails or toenails in the general public is onychomycosis. The previous ten years have shown an upsurge in the incidence rate, primarily as a result of immunocompromised conditions. Since the pathogen's antifungal capabilities are being countered by medication resistance, the high incidence of fungal infections is becoming an increasingly pressing issue in medical science. One of the safer, more affordable, less harmful side effect-prone alternatives to synthetic medications for treating fungal infections is the use of medicinal plants and herbal products. This review attempts to investigate the scientific effects of traditionally used herbal medication against onychomycosis. Further research is necessary to fully comprehend the role that herbal plants play in combating the developing pathogens that cause a variety of dermatological health issues in the dynamic environment.
The popularity of anti-aging face serums as a crucial part of skincare routines has been driven b... more The popularity of anti-aging face serums as a crucial part of skincare routines has been driven by the desire for youthful and radiant skin. This review aims to provide a comprehensive analysis of the effectiveness behind these serums. By extensively examining scientific literature, I explore the wide range of active ingredients commonly found in these serums, such as retinoids, hyaluronic acid, peptides, antioxidants, and growth factors. I delve into how these ingredients work, including collagen stimulation, hydration retention, oxidative stress reduction, and cellular repair. I also consider the clinical evidence supporting the effectiveness of anti-aging face serums, with a particular focus on their ability to reduce wrinkles, improve skin texture, and rejuvenate the overall appearance of the skin. To provide a balanced perspective, I discuss potential side effects and contraindications associated with the use of these products. There are various types of serums available, including gel-based and oil-based serums. Different carrier oils and essential oils, such as argan oil, almond oil, hibiscus oil, and ber fruit extract, are used in their formulation. Various parameters are used in the formulation of face serum like spread ability tests, viscosity tests, clearance tests, etc.
The use of transdermal drug delivery has significantly improved medical procedures. The transderm... more The use of transdermal drug delivery has significantly improved medical procedures. The transdermal drug delivery system (TDDS) is a method of delivering a drug's active ingredient through the skin, improving the drug's therapeutic efficacy and safety while also reducing size and dose. As a cutting-edge tool for controlled release, TDDS attracted a lot of interest. Drugs enter the body through the skin in this type of TDDS, bypassing the first pass metabolism and entering the systemic circulation instead. The dosage form for TDDS is made up of patches. Transdermal patches penetrate the skin by means of a matrix and reservoir system. We now use a novel drug delivery system instead of the convectional dosage form we used in the past. Transdermal patches are among the most innovative forms of novel drug delivery. The transdermal drug delivery system has the benefit of being a painless method of drug administration.
This research focuses on creating and validating a HPLC method to concurrently measure Tamsulosin... more This research focuses on creating and validating a HPLC method to concurrently measure Tamsulosin HCL and Fexofenadine in pharmaceutical products. The method development involved optimizing chromatographic conditions using a Symmetry C18 column and a mobile phase composed of Buffer, Methanol, and Acetonitrile (BMA, 50:10:40, pH 5 adjusted with OPA). These conditions resulted in welldefined peaks with satisfactory separation and symmetry for both substances. Validation of the method included assessing linearity over a concentration range of 4+1800 to 12+5400μg/ml for each compound, demonstrating strong correlation coefficients (R^2 > 0.999). Specificity testing confirmed that there were no interferences from excipients, ensuring precise quantification of the drugs. Accuracy studies showed recovery rates between 95-103%, indicating the method's reliability in determining drug concentrations. Precision studies revealed low %RSD values (<2%) for both intra-day and inter-day variability, indicating excellent repeatability and reproducibility. The method's sensitivity was assessed with LODs of 0.36μg/ml for Tamsulosin HCL and 163.75μg/ml for Fexofenadine, and LOQs of 1.08μg/ml and 496.20μg/ml, respectively. The developed RP-HPLC method was successfully applied to analyze a synthetic mixture containing Tamsulosin HCL and Fexofenadine, confirming its suitability for routine quality control
Tamsulosin is a medication that men with enlarged prostates or benign prostatic hyperplasia (BPH)... more Tamsulosin is a medication that men with enlarged prostates or benign prostatic hyperplasia (BPH) can use to treat their symptoms. Creating and certifying screening tests is a crucial phase in the creation of new drugs. This review's primary goals are to give the reader an overview of both new and current drug analysis techniques based on structured raw data and to ascertain whether medications remain stable in the presence of excipients and other stresses that shorten their shelf lives. Because of its great selectivity, specificity, and dependability, this technique can be used for simultaneous drug analysis. The terms accuracy, specificity, precision, limit of quantification (LOQ), limit of detection (LOD), robustness, reliability, and system suitability testing (for a particular drug) are used to define validation parameters. Every test parameter is employed for standard and stability analysis.
An amino acid is the basic chemical that serves as a protein building block. A protein is made up... more An amino acid is the basic chemical that serves as a protein building block. A protein is made up of one or more chains of amino acids (called polypeptides) that are encoded in a gene. Some amino acids are synthesised in the body, they arealanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, proline, serine, and tyrosine. Larginine is one of several amino acids required by the body to function effectively. L-arginine, like other amino acids, helps for protein synthesis. Protein is used by the body to help build muscles and repair tissue. It transforms this amino acid into the molecule nitric oxide, which aids in the opening of blood vessels. L-arginine has been studied for its effectiveness in treating high blood pressure and chest pain. Endothelial dysfunction and reduced nitric oxide (NO) bioactivity represent prominent pathophysiological abnormalities associated with hypertensive cardiovascular disease. As we know Hypertension, often known as high or an increase of blood pressure, is a condition characterised by chronically elevated blood vessel pressure. Hypertension is a chronic condition that affects over 972 million people worldwide and 188.3 million people in India. High blood pressure is estimated to cause 7.5 million death worldwide, accounting for around 12.8% of all deaths. In this paper we are focusing on dietary supplements of L-arginine in the treatment of hypertension.
India's traditional medicine, emphasizing Ficus racemosa Linn., a plant widely used in Ayurveda. ... more India's traditional medicine, emphasizing Ficus racemosa Linn., a plant widely used in Ayurveda. Known for treating diabetes, liver disorders, and more, it has diverse pharmacological properties. The review covers traditional uses, phytochemical constituents, and recent findings, underscoring the plant's significant role in healthcare.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Indian Journal of Pharmaceutical Sciences, 2007
Seed oils of Gynandropsis gynandra, Impatiens balsamina, Celastrus paniculata, Embelia ribes and ... more Seed oils of Gynandropsis gynandra, Impatiens balsamina, Celastrus paniculata, Embelia ribes and Mucuna pruriens were investigated for their anthelmintic property against Pheritima posthuma. Three concentrations (10, 50 and 100 mg/ml) of each oil were studied in a bioassay, which involved the determination of time of paralysis and time of death of the worm. All the oils exhibited moderate to significant anthelmintic activity. Embelia ribes showed the best anthelmintic activity in both the parameters. Piperazine citrate (10 mg/ml) was included in the assay as standard reference drug.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
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Papers by Dr. Javesh K Patil