CoronaVac COVID-19 Vaccine-Induced Anaphylaxis: Clinical Characteristics and Revaccination Outcomes

Wannada Laisuan; Chamard Wongsa; Chirawat Chiewchalermsri; Torpong Thongngarm; Ticha Rerkpattanapipat; Pansa Iamrahong; Chulapha Ruangwattanachok; Sira Nanthapisal; Mongkhon Sompornrattanaphan

doi:10.2147/JAA.S333098

CoronaVac COVID-19 Vaccine-Induced Anaphylaxis: Clinical Characteristics and Revaccination Outcomes

J Asthma Allergy. 2021 Oct 7:14:1209-1215. doi: 10.2147/JAA.S333098. eCollection 2021.

Authors

Wannada Laisuan¹, Chamard Wongsa², Chirawat Chiewchalermsri³, Torpong Thongngarm², Ticha Rerkpattanapipat¹, Pansa Iamrahong⁴, Chulapha Ruangwattanachok⁴, Sira Nanthapisal⁵, Mongkhon Sompornrattanaphan²

Affiliations

¹ Division of Allergy, Immunology and Rheumatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
² Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
³ Department of Medicine, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Nonthaburi, Thailand.
⁴ Clinical Pharmacy Section, Pharmacy Division, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
⁵ Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.

Abstract

Anaphylaxis to CoronaVac, an inactivated vaccine against COVID-19, is extremely rare. We report 12 cases of anaphylaxis after CoronaVac administration, focusing on clinical characteristics and management outcomes. Skin test and graded vaccine challenge were successfully performed in our cases and might be considered if an inactivated vaccine is the only remaining option.

Keywords: COVID-19; COVID-19 vaccine; anaphylaxis; drug allergy; excipient; skin testing; vaccine allergy.

Publication types

Case Reports