Papers by Clarissa Moreira
Malaria Journal, 2012
Antimalarial efficacy is dependent on administration of a curative dose determined by the pharmac... more Antimalarial efficacy is dependent on administration of a curative dose determined by the pharmacokinetic and dynamic profile of the drug and the age and weight of the patient. Optimal dosing strategies are frequently compromised by pragmatic constraints resulting in patients receiving a wide range of mg/kg dose. WWARN has established a scientific research project aiming at pooling all relevant patient level data from ACTs studies conducted in malaria endemic areas. This study aimed at investigating the consequences of variance in dosing strategies of key ACTs and their effect on clinical efficacy.
by Bernhards Ogutu, Jacques Lebras, Philippe J Guerin, Erasmus Kamugisha, Gabrielle Fröberg, Teferi Eshetu, Samuel Nsobya, Anastasia Grivoyannis, Billy Ngasala, Mehul Dhorda, Clarissa Moreira, Steffen Borrmann, Carol Sibley, Maja Malmberg, Christian Nsanzabana, and Prabin Dahal The American journal of tropical medicine and hygiene, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artem... more Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been clearly defined. Individual patient data from 31 clinical trials were harmonized and pooled by using standardized methods from the WorldWide Antimalarial Resistance Network. Data for more than 7,000 patients were analyzed to assess relationships between parasite polymorphisms in pfcrt and pfmdr1 and clinically relevant outcomes after treatment with AL or ASAQ. Presence of the pfmdr1 gene N86 (adjusted hazards ratio = 4.74, 95% confidence interval = 2.29 - 9.78, P < 0.001) and increased pfmdr1 cop...
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Papers by Clarissa Moreira