The plants of Bombax ceiba are traditionally used as home remedy in the treatment of jaundice, sp... more The plants of Bombax ceiba are traditionally used as home remedy in the treatment of jaundice, spleen enlargement and in some literature as Hepatoprotective activity. In the current days, the majority of the widespread diseases and nutritional disorders are treated with natural medicines. The efficiency of any herbal medication is reliant on the delivery of efficient level of the therapeutically active compound. But a harsh limitation exists in their bioavailability when administered orally or by topical applications. Phytosomes are lately introduced herbal formulations that are superior absorbed and as a result produced superior bioavailability and actions than the conformist phyto molecules or botanical extracts. The ethanolic extract of phytosome was prepared in soya lecithin. Soya lecithin has antioxidant activity. Evaluation of phytosomes for solubility study, entrapment efficiency, transition temperature, particle size and size distribution, optical microscopic study, zeta pot...
Conventional vaginal dosage forms frequently produce leakages and drip. There is a need for the d... more Conventional vaginal dosage forms frequently produce leakages and drip. There is a need for the development of innovative vaginal formulation technology that fulfills certain criteria such as desirable product dispersion throughout the vagina, retention for intended intervals, and adequate release of drug. These features can be achieved by the use of bioadhesive based novel delivery systems. In-situ gelation is a process of gel formation at the site of application after the composition or formulation has been applied the site. Formulation and evaluation of one such bioadhesive based novel drug delivery system for an effective and patient friendly use of an antifungal drug to formulated In-situ gel. Quercus infectoria is medicinally important plant grown wildly in India and is useful in the treatment of fungal and microbial infection by tribal’s of India. The plant is used by tribal women to treat vaginal infection as mentioned in folk-lore. Therefore, the present plant as selected t...
Journal of emerging technologies and innovative research, 2019
Trigonella foenum-graecum L. (Fenugreek) commonly known as methi (in Hindi) has been used as a cu... more Trigonella foenum-graecum L. (Fenugreek) commonly known as methi (in Hindi) has been used as a culinary spice, a flavoring agent and as a medicinal plant from ancient time. The present study comprises physicochemical and phytochemical evaluation of different extracts of Trigonella foenum-graecum. The physico chemical evaluation was carried out by the determination of ash values, extractive values and moisture content. Whereas phytochemical evaluation was carried out to estimate the presence of carbohydrates, glycosides, flavonoids, tannins, phytosterols and phenolic compounds in different extracts of Trigonella foenum-graecum. Results revealed the presence of carbohydrates, proteins, alkaloids, saponons, tannins, phytosterols, flavonoids, glycosides, fats and phenolic compounds. The present study will helpful in determining the quality and purity of a crude drug.
International Journal of Scientific Research in Science and Technology, 2019
The aim of present study was to formulate and evaluate herbal gel containing Solanum nigrum extra... more The aim of present study was to formulate and evaluate herbal gel containing Solanum nigrum extract for prevention of wound healing. Topical gel formulation was designed by using Solanum nigrum extract as API and HPMC E5 as a gelling agent. The herbaceous plant Solanum nigrum (kamuni) reported for healing action and newer research studies and methodologies are being carried to find active chemical constituents which not only promise fast healing but also will reduce the complication and cost. Extracts of this medicinal plant are useful in the treatment of several health problems such as bacterial infections, ulcer, cancer, tuberculosis, arthritis and inflammatory. The plant Solanum nigrum (kamuni) leaves is the best traditional medicine for the study of wound healing activity. The concept of wound healing is changing from day to day. Ayurveda is the richest source of plant drugs for management of wounds and Solanum nigrum L. is one such. The plant is used as haemostatic and wound he...
Bombax ceiba L is a big deciduous tree found in tropical and subtropical regions of Asia, Africa ... more Bombax ceiba L is a big deciduous tree found in tropical and subtropical regions of Asia, Africa and Australia. Conventional systems of medicine such as Ayurveda, Siddha and Unani have been highlighted the use of B. ceiba parts (bark, leaves and flower) for the treatment of manydiseases like hypertension, HIV infections, inflammation, catarrhal affection, ulcer, acne, gynecological disorders, fever, dysentery, algesia, hepatotoxicity, piles and urinary infections. The aim of the present study was to evaluate pharmacognostic, physicochemical, qualitative and quantitative phytochemical analysis of leaf and bark of B. ceiba collected from Bhopal region of Madhya Pradesh. The pharmacognostic studies out in terms of various investigations like organoleptic or morphological characters, microscopic or anatomical studies, physicochemical evaluations (loss on drying, ash value, extractive values and acid insoluble ash value). Qualitative analysis of various phytochemical constituents and qu...
Bombax ceiba L is a big deciduous tree found in tropical and subtropical regions of Asia, Africa ... more Bombax ceiba L is a big deciduous tree found in tropical and subtropical regions of Asia, Africa and Australia. Conventional systems of medicine such as Ayurveda, Siddha and Unani have been highlighted the use of B. ceiba parts (bark, leaves and flower) for the treatment of manydiseases like hypertension, HIV infections, inflammation, catarrhal affection, ulcer, acne, gynecological disorders, fever, dysentery, algesia, hepatotoxicity, piles and urinary infections. The aim of the present study was to evaluate pharmacognostic, physicochemical, qualitative and quantitative phytochemical analysis of leaf and bark of B. ceiba collected from Bhopal region of Madhya Pradesh. The pharmacognostic studies out in terms of various investigations like organoleptic or morphological characters, microscopic or anatomical studies, physicochemical evaluations (loss on drying, ash value, extractive values and acid insoluble ash value). Qualitative analysis of various phytochemical constituents and qu...
Journal of Emerging Technologies and Innovative Research, 2019
Miconazole nitrate bearing patches were prepared to deliver drug in buccal cavity for local actio... more Miconazole nitrate bearing patches were prepared to deliver drug in buccal cavity for local action for effective management oral candidiasis. It were prepared by solvent cast method employing the varieties of polymers ratios and then studied for their % drug entrapment efficiency, patch thickness, folding endurance, tensile strength and moisture content and uptake. The optimized formulations were further assessing for their in-vitro muco-adhesion and drug diffusion efficiency. The drug content was found 95.7±4.7%. Thickness was 0.95± 0.03 mm. Folding endurance and tensile strength of the optimized formulation BPT-9 was 214±14 and 11.8±0.3(kg/mm 2) respectively. The mucoadhesive strength was revealed 31.6±2.4 g/cm.s 2 of the optimized formulation. The drug release study was also performed to check the drug release kinetic. It was shown 60.9±3.4 % drug release from optimized formulation (BPT-9) in 24 hr. The optimized formulations were shown matrix diffusion Huguchi release kinetics.
Nanoparticles (NP) are defined as particles with a diameter smaller than 100 nm, are increasingly... more Nanoparticles (NP) are defined as particles with a diameter smaller than 100 nm, are increasingly used in different applications, including drug carrier systems and to pass organ barriers such as the blood-brain barrier. Because of their unique properties Nanocrystals (quantum dots) and other nanoparticles (gold colloids, nanobars, dendrimers and nanoshells) have been receiving a lot of attention for potential use in Therapeutics, Bioengineering and therapeutics drug discovery. The use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more specifically for cancer therapy. Interestingly pharmaceutical sciences are using nanoparticles to reduce toxicity and side effects of drugs and up to recently did not realize that carrier systems themselves may impose risks to the patient. The present paper deals with all these aspects of NP.
Plants offer a large range of natural co mpounds belonging to different molecular families which ... more Plants offer a large range of natural co mpounds belonging to different molecular families which have various properties to humans. These molecules possess interesting biological activities wh ich attracted several researchers to their elucidation to provide knowledge that will lead to advancement medicine. The present paper deals with the screening of various phytochemical present in various extract v iz., Aqueous, Ethanolic , chloroform and petroleu m ether of Sarcostemma acidum Wight. & Arn.
The plants of Bombax ceiba are traditionally used as home remedy in the treatment of jaundice, sp... more The plants of Bombax ceiba are traditionally used as home remedy in the treatment of jaundice, spleen enlargement and in some literature as Hepatoprotective activity. In the current days, the majority of the widespread diseases and nutritional disorders are treated with natural medicines. The efficiency of any herbal medication is reliant on the delivery of efficient level of the therapeutically active compound. But a harsh limitation exists in their bioavailability when administered orally or by topical applications. Phytosomes are lately introduced herbal formulations that are superior absorbed and as a result produced superior bioavailability and actions than the conformist phyto molecules or botanical extracts. The ethanolic extract of phytosome was prepared in soya lecithin. Soya lecithin has antioxidant activity. Evaluation of phytosomes for solubility study, entrapment efficiency, transition temperature, particle size and size distribution, optical microscopic study, zeta pot...
Conventional vaginal dosage forms frequently produce leakages and drip. There is a need for the d... more Conventional vaginal dosage forms frequently produce leakages and drip. There is a need for the development of innovative vaginal formulation technology that fulfills certain criteria such as desirable product dispersion throughout the vagina, retention for intended intervals, and adequate release of drug. These features can be achieved by the use of bioadhesive based novel delivery systems. In-situ gelation is a process of gel formation at the site of application after the composition or formulation has been applied the site. Formulation and evaluation of one such bioadhesive based novel drug delivery system for an effective and patient friendly use of an antifungal drug to formulated In-situ gel. Quercus infectoria is medicinally important plant grown wildly in India and is useful in the treatment of fungal and microbial infection by tribal’s of India. The plant is used by tribal women to treat vaginal infection as mentioned in folk-lore. Therefore, the present plant as selected t...
Journal of emerging technologies and innovative research, 2019
Trigonella foenum-graecum L. (Fenugreek) commonly known as methi (in Hindi) has been used as a cu... more Trigonella foenum-graecum L. (Fenugreek) commonly known as methi (in Hindi) has been used as a culinary spice, a flavoring agent and as a medicinal plant from ancient time. The present study comprises physicochemical and phytochemical evaluation of different extracts of Trigonella foenum-graecum. The physico chemical evaluation was carried out by the determination of ash values, extractive values and moisture content. Whereas phytochemical evaluation was carried out to estimate the presence of carbohydrates, glycosides, flavonoids, tannins, phytosterols and phenolic compounds in different extracts of Trigonella foenum-graecum. Results revealed the presence of carbohydrates, proteins, alkaloids, saponons, tannins, phytosterols, flavonoids, glycosides, fats and phenolic compounds. The present study will helpful in determining the quality and purity of a crude drug.
International Journal of Scientific Research in Science and Technology, 2019
The aim of present study was to formulate and evaluate herbal gel containing Solanum nigrum extra... more The aim of present study was to formulate and evaluate herbal gel containing Solanum nigrum extract for prevention of wound healing. Topical gel formulation was designed by using Solanum nigrum extract as API and HPMC E5 as a gelling agent. The herbaceous plant Solanum nigrum (kamuni) reported for healing action and newer research studies and methodologies are being carried to find active chemical constituents which not only promise fast healing but also will reduce the complication and cost. Extracts of this medicinal plant are useful in the treatment of several health problems such as bacterial infections, ulcer, cancer, tuberculosis, arthritis and inflammatory. The plant Solanum nigrum (kamuni) leaves is the best traditional medicine for the study of wound healing activity. The concept of wound healing is changing from day to day. Ayurveda is the richest source of plant drugs for management of wounds and Solanum nigrum L. is one such. The plant is used as haemostatic and wound he...
Bombax ceiba L is a big deciduous tree found in tropical and subtropical regions of Asia, Africa ... more Bombax ceiba L is a big deciduous tree found in tropical and subtropical regions of Asia, Africa and Australia. Conventional systems of medicine such as Ayurveda, Siddha and Unani have been highlighted the use of B. ceiba parts (bark, leaves and flower) for the treatment of manydiseases like hypertension, HIV infections, inflammation, catarrhal affection, ulcer, acne, gynecological disorders, fever, dysentery, algesia, hepatotoxicity, piles and urinary infections. The aim of the present study was to evaluate pharmacognostic, physicochemical, qualitative and quantitative phytochemical analysis of leaf and bark of B. ceiba collected from Bhopal region of Madhya Pradesh. The pharmacognostic studies out in terms of various investigations like organoleptic or morphological characters, microscopic or anatomical studies, physicochemical evaluations (loss on drying, ash value, extractive values and acid insoluble ash value). Qualitative analysis of various phytochemical constituents and qu...
Bombax ceiba L is a big deciduous tree found in tropical and subtropical regions of Asia, Africa ... more Bombax ceiba L is a big deciduous tree found in tropical and subtropical regions of Asia, Africa and Australia. Conventional systems of medicine such as Ayurveda, Siddha and Unani have been highlighted the use of B. ceiba parts (bark, leaves and flower) for the treatment of manydiseases like hypertension, HIV infections, inflammation, catarrhal affection, ulcer, acne, gynecological disorders, fever, dysentery, algesia, hepatotoxicity, piles and urinary infections. The aim of the present study was to evaluate pharmacognostic, physicochemical, qualitative and quantitative phytochemical analysis of leaf and bark of B. ceiba collected from Bhopal region of Madhya Pradesh. The pharmacognostic studies out in terms of various investigations like organoleptic or morphological characters, microscopic or anatomical studies, physicochemical evaluations (loss on drying, ash value, extractive values and acid insoluble ash value). Qualitative analysis of various phytochemical constituents and qu...
Journal of Emerging Technologies and Innovative Research, 2019
Miconazole nitrate bearing patches were prepared to deliver drug in buccal cavity for local actio... more Miconazole nitrate bearing patches were prepared to deliver drug in buccal cavity for local action for effective management oral candidiasis. It were prepared by solvent cast method employing the varieties of polymers ratios and then studied for their % drug entrapment efficiency, patch thickness, folding endurance, tensile strength and moisture content and uptake. The optimized formulations were further assessing for their in-vitro muco-adhesion and drug diffusion efficiency. The drug content was found 95.7±4.7%. Thickness was 0.95± 0.03 mm. Folding endurance and tensile strength of the optimized formulation BPT-9 was 214±14 and 11.8±0.3(kg/mm 2) respectively. The mucoadhesive strength was revealed 31.6±2.4 g/cm.s 2 of the optimized formulation. The drug release study was also performed to check the drug release kinetic. It was shown 60.9±3.4 % drug release from optimized formulation (BPT-9) in 24 hr. The optimized formulations were shown matrix diffusion Huguchi release kinetics.
Nanoparticles (NP) are defined as particles with a diameter smaller than 100 nm, are increasingly... more Nanoparticles (NP) are defined as particles with a diameter smaller than 100 nm, are increasingly used in different applications, including drug carrier systems and to pass organ barriers such as the blood-brain barrier. Because of their unique properties Nanocrystals (quantum dots) and other nanoparticles (gold colloids, nanobars, dendrimers and nanoshells) have been receiving a lot of attention for potential use in Therapeutics, Bioengineering and therapeutics drug discovery. The use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more specifically for cancer therapy. Interestingly pharmaceutical sciences are using nanoparticles to reduce toxicity and side effects of drugs and up to recently did not realize that carrier systems themselves may impose risks to the patient. The present paper deals with all these aspects of NP.
Plants offer a large range of natural co mpounds belonging to different molecular families which ... more Plants offer a large range of natural co mpounds belonging to different molecular families which have various properties to humans. These molecules possess interesting biological activities wh ich attracted several researchers to their elucidation to provide knowledge that will lead to advancement medicine. The present paper deals with the screening of various phytochemical present in various extract v iz., Aqueous, Ethanolic , chloroform and petroleu m ether of Sarcostemma acidum Wight. & Arn.
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Papers by Shailesh Gupta