(Q74293115)

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Identification of two topologically independent domains in RAG1 and their role in macromolecular interactions relevant to V(D)J recombination

scientific article published on 30 July 2001

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9 November 2019

Identification of two topologically independent domains in RAG1 and their role in macromolecular interactions relevant to V(D)J recombination (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11479318%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Karla K Rodgers

5

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9 November 2019

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Arbuckle JL

1

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9 November 2019

Fauss LA

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11479318%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Simpson R

3

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9 November 2019

Ptaszek LM

4

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9 November 2019

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30 July 2001

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9 November 2019

Journal of Biological Chemistry

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9 November 2019

276

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9 November 2019

40

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9 November 2019

37093-37101

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9 November 2019

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Similarities between initiation of V(D)J recombination and retroviral integration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Assembly of a 12/23 Paired Signal Complex: A Critical Control Point in V(D)J Recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

DNA hairpin opening mediated by the RAG1 and RAG2 proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

How to make ends meet in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Comparative architecture of transposase and integrase complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

The Effect of Me2+ Cofactors at the Initial Stages of V(D)J Recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Integrating DNA: transposases and retroviral integrases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

The three chemical steps of Tn10/IS10 transposition involve repeated utilization of a single active site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Definition of minimal domains of interaction within the recombination-activating genes 1 and 2 recombinase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Distinct Roles of RAG1 and RAG2 in Binding the V(D)J Recombination Signal Sequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

A zinc-binding domain involved in the dimerization of RAG1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Three-dimensional structure of the Tn5 synaptic complex transposition intermediate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Stimulation of V(D)J cleavage by high mobility group proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Structural domains of IS10 transposase and reconstitution of transposition activity from proteolytic fragments lacking an interdomain linker

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

The construction of DNA helical duplexes along prescribed 3-D curves

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105988200

21 January 2018

Identifiers

10.1074/JBC.M105988200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11479318%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11479318%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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