(Q44913883)

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The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide

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Europe PubMed Central

PubMed publication ID

7 December 2017

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Continued use of retracted papers: Temporal trends in citations and (lack of) awareness of retractions shown in citation contexts in biomedicine

The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

1 reference

based on heuristic

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1 reference

based on heuristic

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7

object named as

Paul Dent

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

6

object named as

Sarah Spiegel

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

author name string

Roberto R Rosato

1

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Sonia C Maggio

2

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Jorge A Almenara

3

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Shawn G Payne

4

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Peter Atadja

5

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

Steven Grant

8

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

publication date

27 September 2005

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Europe PubMed Central

PubMed publication ID

7 December 2017

Molecular Pharmacology

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Europe PubMed Central

PubMed publication ID

7 December 2017

69

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Europe PubMed Central

PubMed publication ID

7 December 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

216-225

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Europe PubMed Central

PubMed publication ID

7 December 2017

Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells

1 reference

30 December 2023

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Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Cellular Events Involved in Butyric Acid-Induced T Cell Apoptosis

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

1 reference

30 December 2023

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Histone deacetylase inhibitors in clinical development

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Evidence of a functional role for the cyclin-dependent kinase-inhibitor p21WAF1/CIP1/MDA6 in promoting differentiation and preventing mitochondrial dysfunction and apoptosis induced by sodium butyrate in human myelomonocytic leukemia cells (U937).

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Ceramide in apoptosis: an overview and current perspectives

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Ceramide and cell death receptor clustering

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Histone acetylation/deacetylation and cancer: an "open" and "shut" case?

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.017145

Identifiers

10.1124/MOL.105.017145

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 December 2017

ResearchGate publication ID

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