(Q44047926)

English

Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).

scientific article published in July 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

1 reference

based on heuristic

inferred from title

apoptotic process

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author name string

Almenara J

1

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Rosato R

2

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Europe PubMed Central

PubMed publication ID

29 November 2017

Grant S

3

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

publication date

1 July 2002

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

16

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Europe PubMed Central

PubMed publication ID

29 November 2017

7

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Europe PubMed Central

PubMed publication ID

29 November 2017

1331-1343

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

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Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

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Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

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Mechanisms of action of flavopiridol

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Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275

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Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

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Determination of flavopiridol (L86 8275; NSC 649890) in human plasma by reversed-phase liquid chromatography with electrochemical detection.

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Agents that Down-Regulate or Inhibit Protein Kinase C Circumvent Resistance to 1-β-D-Arabinofuranosylcytosine-Induced Apoptosis in Human Leukemia Cells that Overexpress Bcl-2

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Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade

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Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01).

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Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

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The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway

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Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentation in human myelomonocytic leukemia cells

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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

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Identifiers

10.1038/SJ.LEU.2402535

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

ResearchGate publication ID

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