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The AID/APOBEC family of nucleic acid mutators.
scientific article published on 17 June 2008
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Europe PubMed Central
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2481415
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18598372%20AND%20SRC:MED&resulttype=core&format=json
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10 January 2020
review article
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Europe PubMed Central
title
The AID/APOBEC family of nucleic acid mutators
(English)
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Europe PubMed Central
PMC publication ID
2481415
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18598372%20AND%20SRC:MED&resulttype=core&format=json
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10 January 2020
main subject
enzyme
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PubMed
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28 September 2019
author
Silvestro G. Conticello
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1
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Europe PubMed Central
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2481415
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18598372%20AND%20SRC:MED&resulttype=core&format=json
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10 January 2020
author name string
Silvestro G Conticello
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1
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Europe PubMed Central
PMC publication ID
2481415
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18 August 2017
language of work or name
English
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publication date
17 June 2008
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PubMed Central
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28 September 2019
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Europe PubMed Central
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2481415
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18598372%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
published in
Genome Biology
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PubMed Central
retrieved
28 September 2019
stated in
Europe PubMed Central
PMC publication ID
2481415
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18598372%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
volume
9
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Europe PubMed Central
PMC publication ID
2481415
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18598372%20AND%20SRC:MED&resulttype=core&format=json
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10 January 2020
issue
6
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Europe PubMed Central
PMC publication ID
2481415
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18598372%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
page(s)
229
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Europe PubMed Central
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2481415
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retrieved
10 January 2020
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Crystal structures of Streptococcus mutans 2'-deoxycytidylate deaminase and its complex with substrate analog and allosteric regulator dCTP x Mg2+
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The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD, and human immunodeficiency virus type 1 restriction
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Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses
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Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1.
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Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation
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Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.
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Derepression of microRNA-mediated protein translation inhibition by apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and its family members
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Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection
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6 September 2017
Targeting of AID-mediated sequence diversification by cis-acting determinants
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DNA deamination in immunity: AID in the context of its APOBEC relatives.
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An adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNA.
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Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase
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Molecular mechanisms of antibody somatic hypermutation.
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6 September 2017
APOBEC-mediated viral restriction: not simply editing?
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6 September 2017
Newly synthesized APOBEC3G is incorporated into HIV virions, inhibited by HIV RNA, and subsequently activated by RNase H
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6 September 2017
Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice.
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6 September 2017
The APOBEC-2 crystal structure and functional implications for the deaminase AID
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6 September 2017
Inhibition of tRNA₃(Lys)-primed reverse transcription by human APOBEC3G during human immunodeficiency virus type 1 replication
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6 September 2017
Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication
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6 September 2017
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation
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6 September 2017
Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies
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Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
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6 September 2017
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
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6 September 2017
Uracil DNA glycosylase is dispensable for human immunodeficiency virus type 1 replication and does not contribute to the antiviral effects of the cytidine deaminase Apobec3G.
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6 September 2017
Evolution and developmental patterning of the vertebrate skeletal muscles: perspectives from the lamprey
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6 September 2017
APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis
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Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality
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6 September 2017
Viral RNA is required for the association of APOBEC3G with human immunodeficiency virus type 1 nucleoprotein complexes
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6 September 2017
Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities
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6 September 2017
Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging
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6 September 2017
APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo
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6 September 2017
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
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6 September 2017
Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G
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6 September 2017
Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication
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6 September 2017
Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase
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6 September 2017
Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes
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6 September 2017
A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif).
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6 September 2017
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
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6 September 2017
Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex
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6 September 2017
The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity.
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6 September 2017
The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay
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6 September 2017
Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif
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6 September 2017
DNA deamination mediates innate immunity to retroviral infection
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6 September 2017
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
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6 September 2017
The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA
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6 September 2017
Hypermutation of HIV-1 DNA in the Absence of the Vif Protein
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6 September 2017
In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)
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6 September 2017
Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business
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6 September 2017
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
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6 September 2017
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators
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6 September 2017
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.
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6 September 2017
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
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6 September 2017
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
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6 September 2017
An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22
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6 September 2017
Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor
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6 September 2017
RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA
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6 September 2017
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
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6 September 2017
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
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6 September 2017
Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
An adenosine deaminase that generates inosine at the wobble position of tRNAs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
Molecular cloning of an apolipoprotein B messenger RNA editing protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
Apolipoprotein B mRNA editing is an intranuclear event that occurs posttranscriptionally coincident with splicing and polyadenylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
6 September 2017
Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
14 September 2017
MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
14 September 2017
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
14 September 2017
APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
14 September 2017
Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
14 September 2017
Transcriptional regulation of APOBEC3G, a cytidine deaminase that hypermutates human immunodeficiency virus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
14 September 2017
APOBEC-mediated editing of viral RNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
14 September 2017
The interaction between HIV-1 Gag and APOBEC3G.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
14 September 2017
Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
14 September 2017
AID is essential for immunoglobulin V gene conversion in a cultured B cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
28 September 2017
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
28 September 2017
Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
28 September 2017
Cloning and expression of the AID gene in the channel catfish
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
26 June 2018
AID is required for germinal center-derived lymphomagenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
AID is required for c-myc/IgH chromosome translocations in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
Rapid evolution of primate antiviral enzyme APOBEC3G.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
Separate domains of AID are required for somatic hypermutation and class-switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
Constitutive expression of AID leads to tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
3 September 2018
Phylogenetic relationship of muscle tissues deduced from superimposition of gene trees
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2481415
retrieved
20 October 2018
Insights into DNA deaminases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18598372
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18598372
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1186/GB-2008-9-6-229
1 reference
stated in
Europe PubMed Central
PMC publication ID
2481415
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18598372%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
Dimensions Publication ID
1021664284
0 references
PMC publication ID
2481415
1 reference
stated in
Europe PubMed Central
PMC publication ID
2481415
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18598372%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
PubMed publication ID
18598372
1 reference
stated in
Europe PubMed Central
PMC publication ID
2481415
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18598372%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 January 2020
ResearchGate publication ID
5253804
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