(Q36845667)

16 August 2017

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title

Targeting of AID-mediated sequence diversification by cis-acting determinants (English)

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16 August 2017

Shu Yuan Yang

1

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16 August 2017

David G Schatz

series ordinal

2

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16 August 2017

publication date

1 January 2007

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16 August 2017

published in

Advances in Immunology

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16 August 2017

volume

94

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16 August 2017

page(s)

109-125

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Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

16 August 2017

cites work

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7 January 2021

Increased transcription levels induce higher mutation rates in a hypermutating cell line

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7 January 2021

Mutations in immunoglobulin-producing mouse myeloma cells

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7 January 2021

Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors

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7 January 2021

The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination

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7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

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7 January 2021

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

The chicken Ig light chain 3'-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

AID mediates hypermutation by deaminating single stranded DNA.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Somatic hypermutation in the heavy chain locus correlates with transcription

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7 January 2021

Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Retroviral restriction by APOBEC proteins

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

AID is essential for immunoglobulin V gene conversion in a cultured B cell line

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

What functions do linker histones provide?

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Estimating Hypermutation Rates from Clonal Tree Data

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Mechanisms of chromosomal translocations in B cell lymphomas

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https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Methylation protects cytidines from AID-mediated deamination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Interchromosomal interactions and olfactory receptor choice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

AID in somatic hypermutation and class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Somatic hypermutation of the AID transgene in B and non-B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Transcription-coupled events associating with immunoglobulin switch region chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Targeting of somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Histone modifications associated with somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

The AID enzyme induces class switch recombination in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

AID mutates a non-immunoglobulin transgene independent of chromosomal position.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Dual reporter system to dissect cis- and trans-effects influencing the mutation rate in a hypermutating cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Episomal vectors to monitor and induce somatic hypermutation in human Burkitt-Lymphoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

E-proteins directly regulate expression of activation-induced deaminase in mature B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

E2A expression stimulates Ig hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Dynamic association of capping enzymes with transcribing RNA polymerase II

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Interchromosomal associations between alternatively expressed loci

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

The transcriptional promoter regulates hypermutation of the antibody heavy chain locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Genome-wide somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

AID-dependent histone acetylation is detected in immunoglobulin S regions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a κ transgene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

The dynamic organization of gene-regulatory machinery in nuclear microenvironments

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994004-8

7 January 2021

10.1016/S0065-2776(06)94004-8

Identifiers

DOI

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16 August 2017

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