(Q36444277)

14 August 2017

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title

Premature senescence of endothelial cells: Methusaleh's dilemma (English)

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14 August 2017

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Jun Chen

1

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14 August 2017

Michael S Goligorsky

series ordinal

2

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14 August 2017

publication date

1 May 2006

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American Journal of Physiology Heart and Circulatory Physiology

14 August 2017

published in

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14 August 2017

volume

290

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14 August 2017

issue

5

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14 August 2017

page(s)

H1729-39

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Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria

14 August 2017

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Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism

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Tumor suppressors and oncogenes in cellular senescence.

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Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen

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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

21 January 2018

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High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts

21 January 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

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Immortalisation and transformation revisited

21 January 2018

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Insights on immunological aging derived from the T lymphocyte cellular senescence model

21 January 2018

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Molecular events in kidney ageing

21 January 2018

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Oncogenic ras and p53 cooperate to induce cellular senescence

21 January 2018

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Endothelial dysfunction as a modifier of angiogenic response in Zucker diabetic fat rat: amelioration with Ebselen

21 January 2018

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DNA damage checkpoint kinase Chk2 triggers replicative senescence

21 January 2018

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Oxidative stress and aging: beyond correlation

21 January 2018

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Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis

21 January 2018

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Latest advances in antiaging medicine

21 January 2018

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Calorie restriction--the SIR2 connection

21 January 2018

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The future of aging therapies

21 January 2018

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Differential regulation of apoptotic cell death in senescent human cells.

21 January 2018

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Telomeres shorten during ageing of human fibroblasts

21 January 2018

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The serial cultivation of human diploid cell strains

21 January 2018

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Impaired progenitor cell activity in age-related endothelial dysfunction

21 January 2018

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

21 January 2018

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Circulating endothelial progenitor cells, vascular function, and cardiovascular risk

21 January 2018

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Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM.

21 January 2018

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Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy

21 January 2018

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Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Estrogen reduces angiotensin II-induced acceleration of senescence in endothelial progenitor cells

21 January 2018

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Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction

21 January 2018

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Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension

21 January 2018

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Mechanisms of cellular senescence in human and mouse cells.

21 January 2018

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Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury

21 January 2018

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Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence

21 January 2018

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Pluripotency of mesenchymal stem cells derived from adult marrow

21 January 2018

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Telomere shortening and cellular senescence in a model of chronic renal allograft rejection

21 January 2018

1 reference

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Accumulation of oxidative DNA damage, 8-oxo-2'-deoxyguanosine, and change of repair systems during in vitro cellular aging of cultured human skin fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

The plasticity of aging: insights from long-lived mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Increased p53 Protein Associated with Aging in Human Diploid Fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Improved Inhibitors of Glucosylceramide Synthase

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Senescence stimulates U937-endothelial cell interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Kinetic study of the reaction of ebselen with peroxynitrite.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Cell senescence and cancer

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization

21 January 2018

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Emerging neuroprotective strategies for Alzheimer's disease: dietary restriction, telomerase activation, and stem cell therapy

21 January 2018

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

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Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

21 January 2018

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Vascular cell senescence and vascular aging

21 January 2018

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Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Aging decreases the production of PGI2 in rat aortic endothelial cells

21 January 2018

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Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Mobilized bone marrow cells repair the infarcted heart, improving function and survival

21 January 2018

1 reference

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Induction of senescence by oncogenic Ras.

21 January 2018

1 reference

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Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

21 January 2018

1 reference

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

21 January 2018

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Aging, anti-aging, and hormesis

21 January 2018

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Aging, progenitor cell exhaustion, and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Caspase inhibition switches doxorubicin-induced apoptosis to senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Origin of endothelial progenitors in human postnatal bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society

21 January 2018

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Youthful prospects for human stem-cell therapy. In another few decades, revised attitudes toward stem cells could lead to disease prevention and life extension

21 January 2018

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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

21 January 2018

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Reduction of Nitric Oxide Producing Activity Associated with in Vitro Aging in Cultured Human Umbilical Vein Endothelial Cell

21 January 2018

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Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice

21 January 2018

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Monocytes coexpress endothelial and macrophagocytic lineage markers and form cord-like structures in Matrigel under angiogenic conditions

21 January 2018

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Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes

21 January 2018

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Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53.

21 January 2018

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Putting the stress on senescence

21 January 2018

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

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Microarray analysis of replicative senescence

21 January 2018

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Oxidative stress, caloric restriction, and aging

21 January 2018

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Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells.

21 January 2018

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Decrease and senescence of endothelial progenitor cells in patients with preeclampsia.

21 January 2018

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Senescence-associated cell death of human endothelial cells: the role of oxidative stress

21 January 2018

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Endothelial progenitor cells: characterization and role in vascular biology

21 January 2018

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Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Enhanced peroxynitrite formation is associated with vascular aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Telomerase as a universal tumor-associated antigen for cancer immunotherapy

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Glucose, glycation, and RAGE: implications for amplification of cellular dysfunction in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Circulating endothelial progenitor cells and cardiovascular outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Increased circulating endothelial progenitor cells in patients with bacterial pneumonia: evidence that bone marrow derived cells contribute to lung repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Lysosomal destabilization in p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01103.2005

10.1152/AJPHEART.01103.2005

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference