Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q33930350)
Watch
English
Tumor suppressors and oncogenes in cellular senescence.
scientific article
In more languages
default for all languages
No label defined
No description defined
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
Tumor suppressors and oncogenes in cellular senescence
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
author
Manuel Serrano
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
author name string
F Bringold
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
publication date
1 May 2000
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
published in
Experimental Gerontology
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
volume
35
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
issue
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
page(s)
317-329
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
cites work
Investigation of the role of G1/S cell cycle mediators in cellular senescence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased activity of p53 in senescing fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p14ARF links the tumour suppressors RB and p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Function of the c-Myc oncogenic transcription factor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin D1 and human neoplasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The complexity of p53 modulation: emerging patterns from divergent signals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The genetics of hereditary melanoma and nevi. 1998 update
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Creation of human tumour cells with defined genetic elements
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p16(INK4a) and the control of cellular proliferative life span.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
How viral oncogenes make the cell cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras versus cyclin-dependent kinase inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p66shc adaptor protein controls oxidative stress response and life span in mammals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 gene amplification database
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MYC oncogenes and human neoplastic disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p19ARF links the tumour suppressor p53 to Ras
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of apoptosis by c-Myc
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the INK4a locus in tumor suppression and cell mortality.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The tumor suppressor protein p16INK4a.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21Cip1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PIK3CA is implicated as an oncogene in ovarian cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor surveillance via the ARF-p53 pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CDK inhibitors: positive and negative regulators of G1-phase progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc activates telomerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct activation of TERT transcription by c-MYC.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constructing immortalized human cell lines.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Senescence of human fibroblasts induced by oncogenic Raf.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0531-5565%2800%2900083-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0531-5565(00)00083-8
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
PubMed publication ID
10832053
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10832053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10832053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit