(Q34282234)

1 August 2017

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title

Microtubule-targeted anticancer agents and apoptosis (English)

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1 August 2017

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Kapil N Bhalla

1

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1 August 2017

language of work or name

English

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publication date

1 December 2003

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1 August 2017

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1 August 2017

volume

22

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1 August 2017

issue

56

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1 August 2017

page(s)

9075-9086

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The Bcl-2 protein family: arbiters of cell survival

1 August 2017

cites work

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts

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7 January 2021

Unwinding the loop of Bcl-2 phosphorylation

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7 January 2021

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

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7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Structural basis of caspase-7 inhibition by XIAP

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

BCL-2 family: regulators of cell death

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7 January 2021

Crystal structure of aurora-2, an oncogenic serine/threonine kinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

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7 January 2021

Roles of BRCA1 in centrosome duplication

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Substoichiometric binding of taxol suppresses microtubule dynamics.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Microtubule polymerization dynamics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Measurement of the Force-Velocity Relation for Growing Microtubules

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

On the role of aurora-A in centrosome function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Microtubule dynamic instability and GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Insights into programmed cell death through structural biology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

The 4 A X-ray structure of a tubulin:stathmin-like domain complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Inactivation of Bcl-2 by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

The biochemistry of apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Dynamics and mechanics of the microtubule plus end

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Structural Basis of Caspase Inhibition by XIAP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Heat shock protein 90 as a molecular target for cancer therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Bcl-2 phosphorylation required for anti-apoptosis function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

The mitotic spindle: a self-made machine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Control of apoptosis and mitotic spindle checkpoint by survivin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

MEK inhibition enhances paclitaxel-induced tumor apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Dynamic instability of microtubule growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Localization of an exchangeable GTP binding site at the plus end of microtubules

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Sequence-dependent enhancement of paclitaxel toxicity in non-small cell lung cancer by 17-allylamino 17-demethoxygeldanamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

High-resolution model of the microtubule

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Characterization of the Taxol Binding Site on the Microtubule

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

BIRinging chromosomes through cell division--and survivin' the experience

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Structural basis for the inhibition of caspase-3 by XIAP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

BRCA1 gene in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

1 reference

7 January 2021

The spindle assembly checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Direct observation of microtubule dynamics in living cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

The role of ERK 1/2 and p38 MAP-kinase pathways in taxol-induced apoptosis in human ovarian carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

1 reference

7 January 2021

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

BAD partly reverses paclitaxel resistance in human ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Loss of the bcl-2 phosphorylation loop domain increases resistance of human leukemia cells (U937) to paclitaxel-mediated mitochondrial dysfunction and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Paclitaxel-induced cell death: where the cell cycle and apoptosis come together

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

Role of BRCA1 in cellular resistance to paclitaxel and ionizing radiation in an ovarian cancer cell line carrying a defective BRCA1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207233

7 January 2021

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1128/MCB.19.12.8469

Identifiers

DOI

10.1038/SJ.ONC.1207233

1 reference

Dimensions Publication ID

1 August 2017

1029903729

0 references

1 reference