(Q33888976)

29 July 2017

1 reference

title

The sites and topology of mitochondrial superoxide production (English)

1 reference

29 July 2017

Martin D Brand

1

1 reference

29 July 2017

language of work or name

1 reference

11 January 2010

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29 July 2017

published in

Experimental Gerontology

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29 July 2017

volume

45

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29 July 2017

issue

7-8

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29 July 2017

page(s)

466-472

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Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions

29 July 2017

cites work

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28 July 2018

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28 July 2018

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Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism

28 July 2018

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Diabetic Cardiomyopathy in OVE26 Mice Shows Mitochondrial ROS Production and Divergence Between In Vivo and In Vitro Contractility

28 July 2018

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High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates

28 July 2018

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28 July 2018

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28 July 2018

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A semiquinone intermediate generated at the Qo site of the cytochrome bc1 complex: importance for the Q-cycle and superoxide production

28 July 2018

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Is the mitochondrial free radical theory of aging intact?

28 July 2018

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Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism

28 July 2018

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28 July 2018

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Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

28 July 2018

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Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I).

28 July 2018

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Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane

28 July 2018

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Oxidative stress, toxicology, and pharmacology of CYP2E1.

28 July 2018

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Mitochondrial formation of reactive oxygen species

28 July 2018

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Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes

28 July 2018

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Oxidative stress and aging: beyond correlation

28 July 2018

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Production of reactive oxygen species by mitochondria: central role of complex III.

28 July 2018

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Mitochondrial reactive oxygen species regulate spatial profile of proinflammatory responses in lung venular capillaries

28 July 2018

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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

28 July 2018

1 reference

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Topology of superoxide production from different sites in the mitochondrial electron transport chain

28 July 2018

1 reference

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Mechanism of superoxide and hydrogen peroxide formation by fumarate reductase, succinate dehydrogenase, and aspartate oxidase.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

28 July 2018

1 reference

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The quantitative measurement of H2O2 generation in isolated mitochondria

28 July 2018

1 reference

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Succinate dehydrogenase and human diseases: new insights into a well-known enzyme

28 July 2018

1 reference

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Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster

28 July 2018

1 reference

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The neutrophil NADPH oxidase

28 July 2018

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Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes

28 July 2018

1 reference

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Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons

28 July 2018

1 reference

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Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: a model of Down's syndrome

28 July 2018

1 reference

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Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

28 July 2018

1 reference

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Oxidants, oxidative stress and the biology of ageing

28 July 2018

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Uncoupling to survive? The role of mitochondrial inefficiency in ageing

28 July 2018

1 reference

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Mitochondria, oxygen free radicals, disease and ageing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Mitochondrial free radical generation, oxidative stress, and aging

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

The free radical theory of aging matures

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Generating, Partitioning, Targeting and Functioning of Superoxide in Mitochondria

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

28 July 2018

1 reference

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Oxidative stress, caloric restriction, and aging

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Low mitochondrial free radical production per unit O2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

28 July 2018

1 reference

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Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

28 July 2018

1 reference

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Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

28 July 2018

1 reference

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The biologic clock: the mitochondria?

28 July 2018

1 reference

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The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

28 July 2018

1 reference

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The cellular production of hydrogen peroxide

28 July 2018

1 reference

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Partial resolution of the enzymes catalyzing oxidative phosphorylation. XV. Reverse electron transfer in the flavin-cytochrome beta region of the respiratory chain of beef heart submitochondrial particles.

28 July 2018

1 reference

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Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span

28 July 2018

1 reference

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Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

28 July 2018

1 reference

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The effect of antimycin A on cytochromes b561, b566, and their relationship to ubiquinone and the iron-sulfur centers S-1 (+ N − 2) and S-3

28 July 2018

1 reference

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Hydroperoxide metabolism in mammalian organs

28 July 2018

1 reference

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The overexpression of major antioxidant enzymes does not extend the lifespan of mice

28 July 2018

1 reference

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The production of reactive oxygen species by complex I.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Dissociation of superoxide production by mitochondrial complex I from NAD(P)H redox state

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

'Mild Uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Characteristics of alpha-glycerophosphate-evoked H2O2 generation in brain mitochondria

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Bioenergetic analysis of cerebellar granule neurons undergoing apoptosis by potassium/serum deprivation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

The topology of superoxide production by complex III and glycerol 3-phosphate dehydrogenase in Drosophila mitochondria

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

NADH-Ubiquinone oxidoreductase: substrate-dependent oxygen turnover to superoxide anion as a function of flavin mononucleotide

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

A possible site of superoxide generation in the complex I segment of rat heart mitochondria

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Complex III releases superoxide to both sides of the inner mitochondrial membrane

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Shift in the localization of sites of hydrogen peroxide production in brain mitochondria by mitochondrial stress

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Characterization of superoxide-producing sites in isolated brain mitochondria

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Superoxide and hydrogen peroxide production by Drosophila mitochondria

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

External alternative NADH dehydrogenase of Saccharomyces cerevisiae: a potential source of superoxide

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Rates of behavior and aging specified by mitochondrial function during development

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Reactive oxygen species production by the mitochondrial respiratory chain in isolated rat hepatocytes and liver mitochondria: studies using myxothiazol

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and its activation by ferricyanide

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Generation of reactive oxygen species by the mitochondrial electron transport chain

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Mitochondrial cytochrome bc1 complex.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Reduced fertility in female mice lacking copper-zinc superoxide dismutase

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Substrate and Site Specificity of Hydrogen Peroxide Generation in Mouse Mitochondria

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Oxidative damage and mitochondrial decay in aging

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879443

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

29 October 2018

1 reference

12 December 2020

Titrating the effects of mitochondrial complex I impairment in the cell physiology

1 reference

12 December 2020

Inhibitors of NADH-ubiquinone reductase: an overview

1 reference

12 December 2020

Generation of hydrogen peroxide by brown adipose tissue mitochondria

1 reference

12 December 2020

No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8

1 reference

12 December 2020

Implication of Mitochondrial Hydrogen Peroxide Generation in Ceramide-induced Apoptosis

1 reference

12 December 2020

Antimycin-insensitive oxidation of succinate and reduced nicotinamide-adenine dinucleotide in electron-transport particles. I. pH dependency and hydrogen peroxide formation

1 reference

12 December 2020

Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase

1 reference

12 December 2020

Effect of electron transfer inhibitors on superoxide generation in the cytochrome bc1 site of the mitochondrial respiratory chain

1 reference

12 December 2020

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

1 reference

12 December 2020

10.1016/J.EXGER.2010.01.003

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference