(Q33861931)

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Telmisartan protects central neurons against nutrient deprivation-induced apoptosis in vitro through activation of PPARγ and the Akt/GSK-3β pathway

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Europe PubMed Central

PubMed publication ID

29 July 2017

Telmisartan protects central neurons against nutrient deprivation-induced apoptosis in vitro through activation of PPARγ and the Akt/GSK-3β pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Tao Pang

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Li-Xin Sun

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Tao Wang

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Zhen-Zhou Jiang

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Hong Liao

5

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Lu-Yong Zhang

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

publication date

5 May 2014

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Acta Pharmacologica Sinica

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

35

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

727-737

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Losartan protects liver against ischaemia/reperfusion injury through PPAR-γ activation and receptor for advanced glycation end-products down-regulation

1 reference

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5 July 2018

Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways

1 reference

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5 July 2018

Peroxisome proliferator-activated receptor gamma (PPAR-γ) and neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease.

1 reference

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5 July 2018

Cardiomyocyte death: mechanisms and translational implications

1 reference

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5 July 2018

Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytes

1 reference

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5 July 2018

GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

1 reference

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5 July 2018

Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Angiotensin II AT1 receptor blockade ameliorates brain inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

PPAR modulation of kinase-linked receptor signaling in physiology and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Losartan inhibits LPS-induced inflammatory signaling through a PPARgamma-dependent mechanism in human THP-1 macrophages

1 reference

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5 July 2018

Choosing an angiotensin-receptor blocker: blood pressure lowering, cardiovascular protection or both?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Angiotensins in Alzheimer's disease - friend or foe?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Cognitive deficit in amyloid-beta-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator-activated receptor-gamma activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Peroxisome Proliferator-Activated Receptor-gamma in Amyotrophic Lateral Sclerosis and Huntington's Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Molecular activation of PPARgamma by angiotensin II type 1-receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Angiotensin II attenuates NMDA receptor-mediated neuronal cell death and prevents the associated reduction in Bcl-2 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Apoptosis in the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

International union of pharmacology. XXIII. The angiotensin II receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

CREB couples neurotrophin signals to survival messages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

5 July 2018

Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

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Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

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Programmed cell death and the control of cell survival: lessons from the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

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Identification of renin and angiotensinogen messenger RNA sequences in mouse and rat brains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086392

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Exaggeration of focal cerebral ischemia in transgenic mice carrying human Renin and human angiotensinogen genes

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

The inflammatory response in the MPTP model of Parkinson's disease is mediated by brain angiotensin: relevance to progression of the disease.

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

The ACCESS Study: evaluation of Acute Candesartan Cilexetil Therapy in Stroke Survivors

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES).

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Candesartan but not ramipril pretreatment improves outcome after stroke and stimulates neurotrophin BNDF/TrkB system in rats

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Inhibitory effects of angiotensin on NMDA-induced cytotoxicity in primary neuronal cultures.

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Peroxisome proliferator-activated receptor-γ activation with angiotensin II type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Distinct phosphorylation patterns underlie Akt activation by different survival factors in neurons

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2013.199

21 January 2018

Effects and mechanism of oridonin on pulmonary hypertension induced by chronic hypoxia-hypercapnia in rats.

1 reference

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29 October 2018

Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

1 reference

https://pubmed.ncbi.nlm.nih.gov/24793312

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Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/24793312

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based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of orally and intravenously administered telmisartan in healthy young and elderly volunteers and in hypertensive patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/24793312

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cerebral peroxisome proliferator‐activated receptors γ (PPARγ) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/24793312

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense inhibition of AT1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24793312

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for energy failure following irreversible traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/24793312

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based on heuristic

inferred from PubMed ID database lookup

Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/24793312

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Inhibition of protein kinase C promotes neuronal survival in low potassium through an Akt-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/24793312

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based on heuristic

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Identifiers

10.1038/APS.2013.199

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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