(Q33653958)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361981%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

review article

1 reference

title

Biology of presenilins as causative molecules for Alzheimer disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361981%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

0 references

Peter Henry St George-Hyslop

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361981%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

author name string

M Nishimura

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361981%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

G Yu

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361981%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

publication date

1 April 1999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361981%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361981%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

volume

55

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361981%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361981%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

page(s)

219-225

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361981%20AND%20SRC:MED&resulttype=core&format=json

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.

8 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Evidence for a six-transmembrane domain structure of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Presenilin 1 is actively degraded by the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Alzheimer's Disease Associated Presenilin-1 Holoprotein and Its 18−20 kDa C-Terminal Fragment Are Death Substrates for Proteases of the Caspase Family

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

A detergent-insoluble membrane compartment contains A beta in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Effects of PS1 deficiency on membrane protein trafficking in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Protein precipitation: a common etiology in neurodegenerative disorders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

Protein topology of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

7 January 2021

inferred from DOI database lookup

Tau phosphorylation in cells transfected with wild-type or an Alzheimer's disease mutant Presenilin 1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1399-0004.1999.550401.X

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1034/J.1399-0004.1999.550401.X

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/efncdozd5zc6pjlrmhkm37ldiy

30 July 2022

mapped directly with Wikidata item

Fatcat ID

release_efncdozd5zc6pjlrmhkm37ldiy

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/efncdozd5zc6pjlrmhkm37ldiy

30 July 2022

mapped directly with Wikidata item

https://api.fatcat.wiki/v0/release/efncdozd5zc6pjlrmhkm37ldiy

1 reference

30 July 2022