(Q30320504)

17 June 2017

title

Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions (English)

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17 June 2017

Stephan Schilling

1

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17 June 2017

Torsten Hoffmann

2

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17 June 2017

Susanne Manhart

3

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17 June 2017

Matthias Hoffmann

4

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17 June 2017

Hans-Ulrich Demuth

5

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17 June 2017

language of work or name

English

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publication date

1 April 2004

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17 June 2017

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17 June 2017

volume

563

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17 June 2017

issue

1-3

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17 June 2017

page(s)

191-196

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Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins

17 June 2017

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Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides

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Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

21 January 2018

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Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain

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N-terminal Heterogeneity of Parenchymal and Cerebrovascular Aβ Deposits

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Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival

21 January 2018

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Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains

21 January 2018

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Formation of N-pyroglutamyl peptides from N-Glu and N-Gln precursors in Aplysia neurons

21 January 2018

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Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42.

21 January 2018

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Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons

21 January 2018

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Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators

21 January 2018

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Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity

21 January 2018

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21 January 2018

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Substrate specificity of glutaminyl cyclases from plants and animals

21 January 2018

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Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

21 January 2018

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Cysteine proteases are the major β‐secretase in the regulated secretory pathway that provides most of the β‐amyloid in Alzheimer's disease: Role of BACE 1 in the constitutive secretory pathway

21 January 2018

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Alzheimer’s Disease as Proteolytic Disorders: Anabolism and Catabolism of β-Amyloid

21 January 2018

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Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins

21 January 2018

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21 January 2018

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Glutaminyl-cyclase expression in the bovine/porcine hypothalamus and pituitary

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Involvement of polyglutamine endolysis followed by pyroglutamate formation in the pathogenesis of triplet repeat/polyglutamine-expansion diseases

7 January 2021

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Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain

7 January 2021

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7 January 2021

Identifiers

DOI

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17 June 2017

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