(Q34988224)

5 August 2017

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title

Therapeutic strategies for Alzheimer's disease. (English)

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5 August 2017

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Michael S Wolfe

1

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5 August 2017

publication date

1 November 2002

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Nature Reviews Drug Discovery

5 August 2017

published in

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5 August 2017

volume

1

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5 August 2017

issue

11

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5 August 2017

page(s)

859-866

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

5 August 2017

cites work

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

31 March 2020

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

31 March 2020

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31 March 2020

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The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

31 March 2020

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

31 March 2020

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31 March 2020

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31 March 2020

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

31 March 2020

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

31 March 2020

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31 March 2020

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Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

31 March 2020

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

31 March 2020

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

31 March 2020

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Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

31 March 2020

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The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

31 March 2020

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

31 March 2020

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The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

31 March 2020

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Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin

31 March 2020

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Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

31 March 2020

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Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

31 March 2020

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

31 March 2020

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

31 March 2020

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

31 March 2020

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

31 March 2020

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

31 March 2020

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

31 March 2020

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

31 March 2020

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Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

31 March 2020

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

31 March 2020

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Gamma -secretase inhibitors repress thymocyte development

31 March 2020

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Presenilin-dependent gamma-secretase activity modulates thymocyte development

31 March 2020

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

31 March 2020

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Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

31 March 2020

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Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate

31 March 2020

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Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

31 March 2020

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

31 March 2020

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Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

31 March 2020

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Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

31 March 2020

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Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

31 March 2020

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Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

31 March 2020

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Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD938

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Dimensions Publication ID

5 August 2017

1043389647

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