(Q28854318)

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

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PubMed publication ID

28 February 2017

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway (English)

1 reference

PubMed publication ID

28 February 2017

Alzheimer's disease

1 reference

based on heuristic

inferred from title

Amyloid beta precursor protein

1 reference

GOA release 2020-03-11

regulation of NMDA receptor activity

1 reference

GOA release 2020-03-11

Brenda L Bloodgood

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

Dennis J. Selkoe

5

object named as

Dennis J Selkoe

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

Bernardo L. Sabatini

6

object named as

Bernardo L Sabatini

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

author name string

Matthew Townsend

3

2 references

PubMed publication ID

28 February 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

Ganesh M Shankar

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

Dominic M Walsh

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

language of work or name

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publication date

14 March 2007

1 reference

PubMed publication ID

28 February 2017

Journal of Neuroscience

2 references

PubMed publication ID

28 February 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

27

2 references

PubMed publication ID

28 February 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

11

2 references

PubMed publication ID

28 February 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

2866-2875

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression mechanisms underlying NMDA receptor-dependent long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor-mediated subthreshold Ca(2+) signals in spines of hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical practice. Early Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium/calmodulin-dependent protein kinase II contributes to activity-dependent filopodia growth and spine formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The number of glutamate receptors opened by synaptic stimulation in single hippocampal spines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis of long-term potentiation in single dendritic spines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendrite and dendritic spine alterations in Alzheimer models

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bidirectional activity-dependent morphological plasticity in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple method for organotypic cultures of nervous tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of beta-amyloid peptide from human cerebrospinal fluid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+ signaling requirements for long-term depression in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postsynaptic levels of [Ca2+]i needed to trigger LTD and LTP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17360908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4970-06.2007

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672572&resulttype=core&format=json

16 May 2020

ResearchGate publication ID

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