(Q40448359)

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Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

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Europe PubMed Central

PubMed publication ID

20 September 2017

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725159&resulttype=core&format=json

12 May 2020

long-term potentiation

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Dennis J. Selkoe

8

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Dennis J Selkoe

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725159&resulttype=core&format=json

12 May 2020

author name string

Dominic M Walsh

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725159&resulttype=core&format=json

12 May 2020

Matthew Townsend

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725159&resulttype=core&format=json

12 May 2020

Marcia B Podlisny

3

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12 May 2020

Ganesh M Shankar

4

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12 May 2020

Julia V Fadeeva

5

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12 May 2020

Omar El Agnaf

6

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12 May 2020

Dean M Hartley

7

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12 May 2020

language of work or name

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publication date

1 March 2005

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20 September 2017

Journal of Neuroscience

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12 May 2020

25

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12 May 2020

10

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12 May 2020

2455-2462

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725159&resulttype=core&format=json

12 May 2020

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid fibrillogenesis: themes and variations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide inhibitors of beta amyloid aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel beta-sheet breaker, RS-0406, reverses amyloid beta-induced cytotoxicity and impairment of long-term potentiation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease is a synaptic failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel compound RS-0466 reverses beta-amyloid-induced cytotoxicity through the Akt signaling pathway in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic approaches to protein-misfolding diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the production and maintenance of long-term potentiation in rat hippocampal slices by a monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells†

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methods for whole-cell recording from visually preselected neurons of perirhinal cortex in brain slices from young and aging rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15758153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4391-04.2005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725159&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725159&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725159&resulttype=core&format=json

12 May 2020

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