(Q21985352)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P37237

Cytokine IL1/FGF

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P37237

1 reference

25 May 2022

1 reference

25 May 2022

fibroblast growth factor receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

1 reference

9 May 2019

type 1 fibroblast growth factor receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

type 2 fibroblast growth factor receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

growth factor activity

chemoattractant activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

intracellular anatomical structure

cell component

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P37237&geneProductId=UniProtKB:P37237

extracellular space

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

external side of plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

embryonic hindlimb morphogenesis

biological process

1 reference

9 May 2019

Analysis of the regulation of lin-41 during chick and mouse limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

negative regulation of neuron apoptotic process

1 reference

9 May 2019

Analysis of the regulation of lin-41 during chick and mouse limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

branching involved in salivary gland morphogenesis

cell migration involved in mesendoderm migration

1 reference

9 May 2019

Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

dopaminergic neuron differentiation

The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease

3 references

9 May 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

1 reference

9 May 2019

cell fate commitment

1 reference

9 May 2019

Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

male genitalia development

1 reference

9 May 2019

Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

limb morphogenesis

1 reference

9 May 2019

The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

lung morphogenesis

1 reference

9 May 2019

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

corticotropin hormone secreting cell differentiation

1 reference

9 May 2019

Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

organ induction

1 reference

9 May 2019

FGF8 initiates inner ear induction in chick and mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

kidney development

1 reference

9 May 2019

Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

lung development

1 reference

9 May 2019

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

epithelial to mesenchymal transition involved in endocardial cushion formation

neural plate morphogenesis

1 reference

9 May 2019

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

forebrain dorsal/ventral pattern formation

1 reference

9 May 2019

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

heart morphogenesis

1 reference

9 May 2019

Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

outflow tract morphogenesis

1 reference

9 May 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

signal transduction involved in regulation of gene expression

1 reference

9 May 2019

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

negative regulation of apoptotic process

Fgf8 is required for anterior heart field development

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Analysis of the regulation of lin-41 during chick and mouse limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

regulation of odontogenesis of dentin-containing tooth

1 reference

9 May 2019

Antagonistic Interactions between FGF and BMP Signaling Pathways: A Mechanism for Positioning the Sites of Tooth Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

aorta morphogenesis

1 reference

9 May 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

BMP signaling pathway

1 reference

9 May 2019

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

generation of neurons

1 reference

9 May 2019

Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

MAPK cascade

1 reference

9 May 2019

Fgf8 is required for anterior heart field development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

embryonic heart tube development

1 reference

9 May 2019

Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

outflow tract septum morphogenesis

1 reference

9 May 2019

Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

mesonephros development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

1 reference

9 May 2019

heart looping

1 reference

9 May 2019

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

embryo development ending in birth or egg hatching

1 reference

9 May 2019

Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

fibroblast growth factor receptor signaling pathway

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Analysis of the regulation of lin-41 during chick and mouse limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Genomic structure, mapping, activity and expression of fibroblast growth factor 17

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

blood vessel remodeling

1 reference

9 May 2019

Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

branching involved in ureteric bud morphogenesis

1 reference

9 May 2019

Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

telencephalon development

1 reference

9 May 2019

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

determination of left/right symmetry

1 reference

9 May 2019

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

positive regulation of gene expression

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Antagonistic Interactions between FGF and BMP Signaling Pathways: A Mechanism for Positioning the Sites of Tooth Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

pallium development

1 reference

9 May 2019

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

midbrain-hindbrain boundary development

1 reference

9 May 2019

Differential requirements for FGF3, FGF8 and FGF10 during inner ear development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

inner ear morphogenesis

1 reference

9 May 2019

Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

odontogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

forebrain morphogenesis

1 reference

9 May 2019

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

branching involved in blood vessel morphogenesis

1 reference

9 May 2019

Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

canonical Wnt signaling pathway

1 reference

9 May 2019

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

thyroid-stimulating hormone-secreting cell differentiation

1 reference

9 May 2019

Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

cell proliferation in forebrain

1 reference

9 May 2019

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

positive regulation of mitotic nuclear division

1 reference

9 May 2019

Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

metanephros development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

positive regulation of cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

1 reference

9 May 2019

subpallium development

1 reference

9 May 2019

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

pharyngeal system development

1 reference

9 May 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

apoptotic process

1 reference

14 February 2019

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

mesodermal cell migration

1 reference

9 May 2019

Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

positive regulation of cell population proliferation

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Fgf8 is required for anterior heart field development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Analysis of the regulation of lin-41 during chick and mouse limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

9 May 2019

Genomic structure, mapping, activity and expression of fibroblast growth factor 17

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

otic vesicle formation

regulation of signaling receptor activity

TAS

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

response to oxidative stress

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

motor neuron axon guidance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

forebrain neuron development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

central nervous system neuron development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

dorsal/ventral axon guidance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

positive chemotaxis

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

positive regulation of G protein-coupled receptor signaling pathway

1 reference

9 May 2019

Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37237