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Folliculos stimulans hormon

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FSH cum receptorio suo

Folliculos stimulans hormon, abbreviatura FSH, est hormon e duabus catenis, alpha (FSHA, OMIM: 118850) et beta (FSHB, OMIM: 136530), compositum. FSH de cellulis gonadotropicis lobi anterioris hypophysis secernitur. Et in viribus et in mulieribus hormonti FSH munera diversa sunt.

Physiologia FSH

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Secretio hormontis folliculos stimulantis praecipue ab hypothalamo per hormon liberationis gonadotropinorum (GnRH), quod est decapeptidum, moderatur; secretio ipsa a cellulis gonadotropicis, quae in lobo anteriori hypophysis sitae sunt, fit[1]. Intra hypophysem, complexus proteinorum et activini (biosynthesis FSH ↑) et inhibini (biosynthesis FSH ↓), velut follistatinum in edita moderandis agunt[2]. Activinum genum promotorem Fshb subunitatis beta lectum incitat. Subunitas alpha, ut LH, genum alphaGSU requirit.

Cyclus menstrualis mulierum

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Secretio hormontis FSH secundum cyclum muliebrem

Cyclo menstruali ineunte FSH folliculos immaturos in ovariis stimulat. In medio cyclo maior effusio ipsius ovulationem incitat[3].

Spermatogenesis in viris

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FSH spermatozoa in testibus virorum stimulat[4].

  1. Sharma T. P., Nett T. M., Karsch F. J., Phillips D. J., Lee J. S., Herkimer C., Padmanabhan V. (2012). "Neuroendocrine control of FSH secretion: IV. Hypothalamic control of pituitary FSH-regulatory proteins and their relationship to changes in FSH synthesis and secretion". Biology of reproduction 86 (6): 171 doi:10.1095/biolreprod.111.098442
  2. Bilezikjian L. M., Justice N. J., Blackler A. N., Wiater E., Vale W. W. (Aug 2021). "Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin". Molecular and cellular endocrinology 359 (1-2): 43-52 doi:10.1016/j.mce.2012.01.025
  3. Messinis I. E., Messini C. I., Dafopoulos K. (2014). "Novel aspects of the endocrinology of the menstrual cycle". Reproductive biomedicine online 28 (6): 714-22 
  4. Huhtaniemi I. (2015). "A short evolutionary history of FSH-stimulated spermatogenesis". Hormones (Athens, Greece) 14 (4): 468-78 

Nexus interni

Nexus externi

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  • Laboratorium et FSH. (Anglice)
stipula

Haec stipula ad biologiam spectat. Amplifica, si potes!