Papers by Asaduzzaman Asad
Scientific Reports, 2022
Complement activation plays a critical role in the pathogenesis of Guillain-Barré syndrome (GBS),... more Complement activation plays a critical role in the pathogenesis of Guillain-Barré syndrome (GBS), a debilitating immune-mediated neuropathy. Mannose-binding lectin (MBL) is a complement activation factor of lectin pathway which as genetic host factor may influence the susceptibility or severity of GBS. We investigated the frequency of MBL2 promoter (− 550H/L and − 221X/Y) and functional region (exon 1 A/O) polymorphisms and their association with disease susceptibility, clinical features and serum MBL among GBS patients (n = 300) and healthy controls (n = 300) in Bangladesh. The median patient age was 30 years (IQR: 18-42; males, 68%). MBL2 polymorphisms were not significantly associated with GBS susceptibility compared to healthy controls. HL heterozygosity in GBS patients was significantly associated with mild functional disability at enrolment (P = 0.0145, OR, 95% CI 2.1, 1.17-3.82). The HY, YA, HA and HYA heterozygous haplotypes were more common among mildly affected (P = 0.0067, P = 0.0086, P = 0.0075, P = 0.0032, respectively) than severely affected patients with GBS. Reduced serum MBL was significantly associated with the LL, OO and no HYA variants and GBS disease severity. No significant association was observed between MBL2 polymorphisms and electrophysiological variants, recent Campylobacter jejuni infection or anti-ganglioside (GM1) antibody responses in GBS. In conclusion, MBL2 gene polymorphisms are related to reduced serum MBL and associated with the severity of GBS.
Iranian Journal of Basic Medical Sciences, 2021
The recent pandemics caused by coronavirus infections have become major challenges in 21st centur... more The recent pandemics caused by coronavirus infections have become major challenges in 21st century human health. Scientists are struggling hard to develop a complete cure for infectious diseases, for example, drugs or vaccines against these deadly infectious diseases. We have searched papers on thymoquinone (TQ) and its effects on different infectious diseases in databases like Pubmed, Web of Science, Scopus, and Google Scholar, and reviewed them in this study. To date research suggests that natural products may become a potential therapeutic option for their prodigious anti-viral or anti-microbial effects on infectious diseases. TQ, a natural phytochemical from black seeds, is known for its health-beneficial activities against several diseases, including infections. It is evident from different in vitro and in vivo studies that TQ is effective against tuberculosis, influenza, dengue, Ebola, Zika, hepatitis, malaria, HIV, and even recent pandemics caused by severe acute respiratory ...
Guillain-Barré syndrome (GBS) is a post-infection sequela of Campylobacter jejuni-induced enterit... more Guillain-Barré syndrome (GBS) is a post-infection sequela of Campylobacter jejuni-induced enteritis. Clustered regularly interspaced short palindromic repeats and associated genes (CRISPR-Cas) confers adaptive immunity and plays role in virulence in many bacteria. We investigated C. jejuni CRISPR type (CT) to explore association of CRISPR-Cas with risk of developing GBS. We analysed CRISPR-Cas in C. jejuni isolated from 30 patients with GBS, 60 patients with enteritis and 52 healthy controls from Bangladesh. CRISPR types were determined by PCR followed by CRISPR array sequencing. Statistical and genomic analyses were performed using SPSS and multiple web-based software respectively. We found preserved CRISPR array was significantly more frequent in GBS-related strains than healthy control-related strains (P = 0.02, OR = 2.95). Increased CRISPR array length was significantly associated with GBS compared to healthy control- (P = 0.003, AUC = 0.7) and enteritis-related strains (P = 0.0...
The emergence of multidrug-resistant (MDR) Shigella strains has impaired the efficacy of first-li... more The emergence of multidrug-resistant (MDR) Shigella strains has impaired the efficacy of first-line antimicrobials and exacerbated diarrhea-associated morbidity and mortality worldwide. We report the draft genome sequences of 11 MDR Shigella strains isolated from the stool specimens of diarrheal patients in Bangladesh. ABSTRACT The emergence of multidrug-resistant (MDR) Shigella strains has impaired the efficacy of first-line antimicrobials and exacerbated diarrhea-associated morbidity and mortality worldwide. We report the draft genome sequences of 11 MDR Shigella strains isolated from the stool specimens of diarrheal patients in Bangladesh.
Campylobacter jejuni is the pathogen most commonly associated with Guillain-Barré syndrome (GBS).... more Campylobacter jejuni is the pathogen most commonly associated with Guillain-Barré syndrome (GBS). The present work describes the draft genome sequences of 3 C. jejuni strains, BD39, BD67, and BD75, isolated from stool specimens of C. jejuni-triggered patients with GBS using Illumina technologies. ABSTRACT Campylobacter jejuni is the pathogen most commonly associated with Guillain-Barré syndrome (GBS). The present work describes the draft genome sequences of 3 C. jejuni strains, BD39, BD67, and BD75, isolated from stool specimens of patients with C. jejuni-triggered GBS using Illumina technologies.
Currently, the present world is facing a new deadly challenge against a pandemic disease called C... more Currently, the present world is facing a new deadly challenge against a pandemic disease called COVID-19, which is caused by a coronavirus, named SARS-CoV-2. To date, there is no drug or vaccine that can treat COVID-19 completely, but some drugs have been used primarily, and they are in different stages of clinical trials. This review article discussed and compared those drugs which are running ahead in COVID-19 treatments. We have explored PUBMED, SCOPUS, WEB OF SCIENCE, as well as press release of WHO, NIH and FDA for articles about COVID-19, and reviewed them. Drugs like favipiravir, remdesivir, lopinavir/ritonavir, hydroxychloroquine, azithromycin, ivermectin, corticosteroids and interferons have been found effective in some extents, and partially approved by FDA and WHO to treat COVID-19 at different phases of pandemic. However, some of these drugs have been disapproved later, although clinical trials are going on. In parallel, plasma therapy has been found fruitful in some ext...
The genetic material of organelles has been studied by The inheritance of leaf pigmentation in pl... more The genetic material of organelles has been studied by The inheritance of leaf pigmentation in plants, Antibiotic resistance in algae, and Metabolic competence in yeast. Organelle heredity does not follow simple Mendelian rules Characterized by unequal contributions of the two parents and by an irregular segregation of alleles. Organelle heredity is therefore non-Mendelian heredity.
Eukaryotic DNA is associated with tightly bound basic proteins, called histones. These serve to o... more Eukaryotic DNA is associated with tightly bound basic proteins, called histones. These serve to order the DNA into fundamental structural units, called nucleosomes, that resemble beads on a string. Nucleosomes are further arranged into increasingly more complex structures that organize and condense the long DNA molecules into chromosomes that can be segregated during cell division.
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNAby the enzyme RNA polymerase. The process of eukaryotic transcription is separated into three phases, initiation, elongation, and termination. It is a complex process involving various cell signaling techniques as well as the action of many enzymes. The following information is a detailed description of eukaryotic transcription.
The transcription of eukaryotic genes is regulated by interactions between proteins and DNA sequences within or near the genes. Transcription is initiated in the promoter of a gene, the region recognized by the RNA polymerase. However, the accurate initiation of transcription from eukaryotic gene promoters requires several accessory proteins, or basal transcription factors.
Transcriptome can be defined as the complete set of RNA transcripts produced by the genome at a given time. Transcriptome is highly dynamic and complex in comparison to the relatively stable genome.
Post transcriptional modification is a process in cell biology by which, in eukaryotic cells, primary transcript RNA is converted into mature RNA. A notable example is the conversion of precursor messenger RNA into mature messenger RNA, which occurs prior to protein synthesis.
Eukaryotic DNA is tightly bound to basic proteins called histones; the combination
is called chro... more Eukaryotic DNA is tightly bound to basic proteins called histones; the combination
is called chromatin. DNA wraps around an octamer of core histones to form a
nucleosome, blocking access to many potential DNA binding sites .Changes in
chromatin structure play a major role in regulating gene expression. Enhancers can
modulate gene expression from more than 1000 bp away from the start site of
transcription by perturbing local chromatin structure. Enhancers are often specific
for certain cell types, depending on which DNA-binding proteins are present.
1. STAT6 is necessary for Th2 responses using STAT6-/- mice
2. Treatment approaches for IgE medi... more 1. STAT6 is necessary for Th2 responses using STAT6-/- mice
2. Treatment approaches for IgE mediated allergy (target step, mechanism, specific approach)
3.The role of effector T cell on type IV hypersensitive reaction
A great leader is able to align the dreams of others with his own larger dream, thus forming a ju... more A great leader is able to align the dreams of others with his own larger dream, thus forming a juggernaut that elevates him into power. The dream has to be large and embracive enough so that the dreams of others can be included in the action.
Leaders treat people how they want to be treated. They are extremely ethical and believe that honesty, effort, and reliability form the foundation of success. They embody these values so overtly that no employee doubts their integrity for a minute. They share information openly and avoid spin control.
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Papers by Asaduzzaman Asad
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNAby the enzyme RNA polymerase. The process of eukaryotic transcription is separated into three phases, initiation, elongation, and termination. It is a complex process involving various cell signaling techniques as well as the action of many enzymes. The following information is a detailed description of eukaryotic transcription.
The transcription of eukaryotic genes is regulated by interactions between proteins and DNA sequences within or near the genes. Transcription is initiated in the promoter of a gene, the region recognized by the RNA polymerase. However, the accurate initiation of transcription from eukaryotic gene promoters requires several accessory proteins, or basal transcription factors.
Transcriptome can be defined as the complete set of RNA transcripts produced by the genome at a given time. Transcriptome is highly dynamic and complex in comparison to the relatively stable genome.
Post transcriptional modification is a process in cell biology by which, in eukaryotic cells, primary transcript RNA is converted into mature RNA. A notable example is the conversion of precursor messenger RNA into mature messenger RNA, which occurs prior to protein synthesis.
is called chromatin. DNA wraps around an octamer of core histones to form a
nucleosome, blocking access to many potential DNA binding sites .Changes in
chromatin structure play a major role in regulating gene expression. Enhancers can
modulate gene expression from more than 1000 bp away from the start site of
transcription by perturbing local chromatin structure. Enhancers are often specific
for certain cell types, depending on which DNA-binding proteins are present.
2. Treatment approaches for IgE mediated allergy (target step, mechanism, specific approach)
3.The role of effector T cell on type IV hypersensitive reaction
Leaders treat people how they want to be treated. They are extremely ethical and believe that honesty, effort, and reliability form the foundation of success. They embody these values so overtly that no employee doubts their integrity for a minute. They share information openly and avoid spin control.
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNAby the enzyme RNA polymerase. The process of eukaryotic transcription is separated into three phases, initiation, elongation, and termination. It is a complex process involving various cell signaling techniques as well as the action of many enzymes. The following information is a detailed description of eukaryotic transcription.
The transcription of eukaryotic genes is regulated by interactions between proteins and DNA sequences within or near the genes. Transcription is initiated in the promoter of a gene, the region recognized by the RNA polymerase. However, the accurate initiation of transcription from eukaryotic gene promoters requires several accessory proteins, or basal transcription factors.
Transcriptome can be defined as the complete set of RNA transcripts produced by the genome at a given time. Transcriptome is highly dynamic and complex in comparison to the relatively stable genome.
Post transcriptional modification is a process in cell biology by which, in eukaryotic cells, primary transcript RNA is converted into mature RNA. A notable example is the conversion of precursor messenger RNA into mature messenger RNA, which occurs prior to protein synthesis.
is called chromatin. DNA wraps around an octamer of core histones to form a
nucleosome, blocking access to many potential DNA binding sites .Changes in
chromatin structure play a major role in regulating gene expression. Enhancers can
modulate gene expression from more than 1000 bp away from the start site of
transcription by perturbing local chromatin structure. Enhancers are often specific
for certain cell types, depending on which DNA-binding proteins are present.
2. Treatment approaches for IgE mediated allergy (target step, mechanism, specific approach)
3.The role of effector T cell on type IV hypersensitive reaction
Leaders treat people how they want to be treated. They are extremely ethical and believe that honesty, effort, and reliability form the foundation of success. They embody these values so overtly that no employee doubts their integrity for a minute. They share information openly and avoid spin control.