Considering the prevalence of obesity, diabetes and cardiovascular diseases, significant interest... more Considering the prevalence of obesity, diabetes and cardiovascular diseases, significant interest has been focused on the gut microbiota-diabetes and cardiovascular system interaction, because the gut microbiota has been recognized as a modulator of human health. Dysbiosis, characterized by pathological changes in the gut microbiota, has been reported in cardimetabolic disorders, such as overweight and obesity, dyslipidaemia, atherosclerosis and hypertension. Furthermore, dysbiosis can disturb gut immunity, which increases the risk of acute cardiometabolic events. Therefore, the changes in the composition of the gut microbiota can affect host metabolism and immunity. The aim of this review is to look through the current knowledge over gut microbiata and expand the view on key roles of intestinal microflora during development of cardiometabolic diseases as T2DM, hypertension, dyslipidemia and atherosclerosis, also discuss the roles of microbiata regulating agents such as pre-and probiotics.
Kronik lenfositik tiroidit olarak da tanımlanan Hashimoto tiroiditi (HT) çocuk ve ergenlerde sık ... more Kronik lenfositik tiroidit olarak da tanımlanan Hashimoto tiroiditi (HT) çocuk ve ergenlerde sık görülen endokrin
A grubu beta hemolitik streptokok (AGBHS) çocukta akut bakteriyel farenjitin en s›k rastlanan etk... more A grubu beta hemolitik streptokok (AGBHS) çocukta akut bakteriyel farenjitin en s›k rastlanan etkenidir ve akut romatizmal atefl, akut glomerülonefrit gibi ciddi komplikasyonlara yol açabilir. Bu çal›flman›n amac› ‹stanbul Kartal Dr. Lütfi K›rdar Kartal E¤itim ve Araflt›rma Hastanesi Aile Hekimli¤i Poliklini¤i'ne baflvuran okul öncesi çocuklarda AGBHS tafl›y›c›l›¤› oran›n› belirlemektir. Yöntem: Ocak-Mart 2008 tarihleri aras›nda aile hekimli¤i polikli-ni¤imize bo¤az a¤r›s› d›fl›ndaki nedenlerle baflvuran üç ila alt› yafl aras› ard›fl›k 150 çocuk hasta randomize flekilde çal›flmaya dâhil edildi. Anamnez ve fizik muayene sonras› bakteri kültürü ve ta-n›mlama için bo¤az sürüntüsü ile antistreptolizin O (ASO) testi için kan örne¤i al›nd›. Bulgular: ‹ncelenen 128 hastan›n 18'inin (%14.06) bo¤az kültürü, AGBHS pozitifti; kültürü pozitif olanlar›n 8'inde ise (%44.44) herhangi bir streptokok enfeksiyonu bulgusu olmaks›z›n ASO yükselmesi saptand›. Sonuç: Daha önceki çal›flmalarda, sa¤l›kl› okul öncesi çocuklarda %2-25.9 oranlar›nda faringeal AGBHS tafl›y›c›l›¤› bulunmufltu, ça-l›flmam›zdaki AGBHS tafl›y›c›l›¤› Türkiye'nin bat› yörelerindeki sonuçlarla uyumludur.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018
To assess the frequency of sarcopenia in type 2 diabetes mellitus (DM) patients using different f... more To assess the frequency of sarcopenia in type 2 diabetes mellitus (DM) patients using different formulas of bioimpedance analysis (BIA). Cross-sectional study. Obesity Clinic, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey, between March and June 2015. The present study included DM patients at >18 years of age with BMI >30 kg/m2. BIA measurements consisted of body weight, height, total muscle mass and sum of the muscle masses of the four limbs (ALM). Skeletal muscle index, total muscle index, skeletal muscle percentage, total muscle percentage, and ALM/BMI were used for muscle-related analyses. The data were presented as frequency, mean ± standard deviation, and percentage. Student t-test was used to compare differences between two independent groups. A total of 295 DM patients were enrolled in the study, of whom 176 (59.66%) were females, 119 (40.34%) were males, 47 (15.93%) were over the age of 65 years, and the mean age was 53.39 +10.39 years. Sarc...
A grubu beta hemolitik streptokok (AGBHS) çocukta akut bakteriyel farenjitin en s›k rastlanan etk... more A grubu beta hemolitik streptokok (AGBHS) çocukta akut bakteriyel farenjitin en s›k rastlanan etkenidir ve akut romatizmal atefl, akut glomerülonefrit gibi ciddi komplikasyonlara yol açabilir. Bu çal›flman›n amac› ‹stanbul Kartal Dr. Lütfi K›rdar Kartal E¤itim ve Araflt›rma Hastanesi Aile Hekimli¤i Poliklini¤i'ne baflvuran okul öncesi çocuklarda AGBHS tafl›y›c›l›¤› oran›n› belirlemektir. Yöntem: Ocak-Mart 2008 tarihleri aras›nda aile hekimli¤i polikli-ni¤imize bo¤az a¤r›s› d›fl›ndaki nedenlerle baflvuran üç ila alt› yafl aras› ard›fl›k 150 çocuk hasta randomize flekilde çal›flmaya dâhil edildi. Anamnez ve fizik muayene sonras› bakteri kültürü ve ta-n›mlama için bo¤az sürüntüsü ile antistreptolizin O (ASO) testi için kan örne¤i al›nd›. Bulgular: ‹ncelenen 128 hastan›n 18'inin (%14.06) bo¤az kültürü, AGBHS pozitifti; kültürü pozitif olanlar›n 8'inde ise (%44.44) herhangi bir streptokok enfeksiyonu bulgusu olmaks›z›n ASO yükselmesi saptand›. Sonuç: Daha önceki çal›flmalarda, sa¤l›kl› okul öncesi çocuklarda %2-25.9 oranlar›nda faringeal AGBHS tafl›y›c›l›¤› bulunmufltu, ça-l›flmam›zdaki AGBHS tafl›y›c›l›¤› Türkiye'nin bat› yörelerindeki sonuçlarla uyumludur.
Summary Objective: Burnout syndrome was first described in health - care professionals and to dat... more Summary Objective: Burnout syndrome was first described in health - care professionals and to date, it is known to be a great problem. Bur- nout syndrome has been described comprehensively by Maslach and Jackson as emotional exhaustion, depersonalization and dec- rease in personal competence and success. The aim of this study was to assess Burnout and related factors in medical
Vitamin D has been determined to have some effects on b cell function and insulin sensitivity, an... more Vitamin D has been determined to have some effects on b cell function and insulin sensitivity, and it is known that type 2 diabetes mellitus and hyperparathyroidism can cause obesity. The aim of our study was to investigate if vitamin D deficiency without diabetes mellitus and metabolic syndrome is associated with obesity and abdominal obesity. The study included 276 healthy premenopausal women. To exclude other causes of obesity, postmenopausal women and subjects with diabetes mellitus and metabolic syndrome were excluded. Women were divided into two groups depending on their 25-hydroxyvitaminD(3) [25(OH)D(3)] levels: subjects with vitamin D deficiency (Group 1) and subjects without vitamin D deficiency (Group 2). Body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) were compared between the two groups. BMI, WC, WHR, rates of obesity, and abdominal obesity according to WC and WHR of Group 2 were lower than those of Group 1 (p = 0.0005, p = 0.0001, p = 0.004...
Thyroid autoimmunity has been suggested as a risk factor for atherosclerosis independent of thyro... more Thyroid autoimmunity has been suggested as a risk factor for atherosclerosis independent of thyroid function in several studies. The aim of this study was to investigate whether thyroid autoimmunity had any effect on hyperlipidaemia, obesity and abdominal obesity independent of thyroid function. 184 premenopausal female patients with Hashimoto's thyroiditis (HT) and 150 healthy premenopausal female volunteers as control group (CG) were included in the study. According to thyroid function status, the patients were divided into three subgroups: overt hypothyroid patients (ohp), subclinical hypothyroid patients (shp) and euthyroid patients (ep). Body mass index (BMI), waist to hip ratios, waist circumference (WC), and serum lipid levels of all the participants were determined. These parameters of ep were compared with those of ohp, shp and CG. Relationships among thyroid stimulating hormone (TSH), thyroid autoantibodies and lipid levels were investigated. There were no significant ...
Considering the prevalence of obesity, diabetes and cardiovascular diseases, significant interest... more Considering the prevalence of obesity, diabetes and cardiovascular diseases, significant interest has been focused on the gut microbiota-diabetes and cardiovascular system interaction, because the gut microbiota has been recognized as a modulator of human health. Dysbiosis, characterized by pathological changes in the gut microbiota, has been reported in cardimetabolic disorders, such as overweight and obesity, dyslipidaemia, atherosclerosis and hypertension. Furthermore, dysbiosis can disturb gut immunity, which increases the risk of acute cardiometabolic events. Therefore, the changes in the composition of the gut microbiota can affect host metabolism and immunity. The aim of this review is to look through the current knowledge over gut microbiata and expand the view on key roles of intestinal microflora during development of cardiometabolic diseases as T2DM, hypertension, dyslipidemia and atherosclerosis, also discuss the roles of microbiata regulating agents such as pre-and probiotics.
Kronik lenfositik tiroidit olarak da tanımlanan Hashimoto tiroiditi (HT) çocuk ve ergenlerde sık ... more Kronik lenfositik tiroidit olarak da tanımlanan Hashimoto tiroiditi (HT) çocuk ve ergenlerde sık görülen endokrin
A grubu beta hemolitik streptokok (AGBHS) çocukta akut bakteriyel farenjitin en s›k rastlanan etk... more A grubu beta hemolitik streptokok (AGBHS) çocukta akut bakteriyel farenjitin en s›k rastlanan etkenidir ve akut romatizmal atefl, akut glomerülonefrit gibi ciddi komplikasyonlara yol açabilir. Bu çal›flman›n amac› ‹stanbul Kartal Dr. Lütfi K›rdar Kartal E¤itim ve Araflt›rma Hastanesi Aile Hekimli¤i Poliklini¤i'ne baflvuran okul öncesi çocuklarda AGBHS tafl›y›c›l›¤› oran›n› belirlemektir. Yöntem: Ocak-Mart 2008 tarihleri aras›nda aile hekimli¤i polikli-ni¤imize bo¤az a¤r›s› d›fl›ndaki nedenlerle baflvuran üç ila alt› yafl aras› ard›fl›k 150 çocuk hasta randomize flekilde çal›flmaya dâhil edildi. Anamnez ve fizik muayene sonras› bakteri kültürü ve ta-n›mlama için bo¤az sürüntüsü ile antistreptolizin O (ASO) testi için kan örne¤i al›nd›. Bulgular: ‹ncelenen 128 hastan›n 18'inin (%14.06) bo¤az kültürü, AGBHS pozitifti; kültürü pozitif olanlar›n 8'inde ise (%44.44) herhangi bir streptokok enfeksiyonu bulgusu olmaks›z›n ASO yükselmesi saptand›. Sonuç: Daha önceki çal›flmalarda, sa¤l›kl› okul öncesi çocuklarda %2-25.9 oranlar›nda faringeal AGBHS tafl›y›c›l›¤› bulunmufltu, ça-l›flmam›zdaki AGBHS tafl›y›c›l›¤› Türkiye'nin bat› yörelerindeki sonuçlarla uyumludur.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018
To assess the frequency of sarcopenia in type 2 diabetes mellitus (DM) patients using different f... more To assess the frequency of sarcopenia in type 2 diabetes mellitus (DM) patients using different formulas of bioimpedance analysis (BIA). Cross-sectional study. Obesity Clinic, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey, between March and June 2015. The present study included DM patients at >18 years of age with BMI >30 kg/m2. BIA measurements consisted of body weight, height, total muscle mass and sum of the muscle masses of the four limbs (ALM). Skeletal muscle index, total muscle index, skeletal muscle percentage, total muscle percentage, and ALM/BMI were used for muscle-related analyses. The data were presented as frequency, mean ± standard deviation, and percentage. Student t-test was used to compare differences between two independent groups. A total of 295 DM patients were enrolled in the study, of whom 176 (59.66%) were females, 119 (40.34%) were males, 47 (15.93%) were over the age of 65 years, and the mean age was 53.39 +10.39 years. Sarc...
A grubu beta hemolitik streptokok (AGBHS) çocukta akut bakteriyel farenjitin en s›k rastlanan etk... more A grubu beta hemolitik streptokok (AGBHS) çocukta akut bakteriyel farenjitin en s›k rastlanan etkenidir ve akut romatizmal atefl, akut glomerülonefrit gibi ciddi komplikasyonlara yol açabilir. Bu çal›flman›n amac› ‹stanbul Kartal Dr. Lütfi K›rdar Kartal E¤itim ve Araflt›rma Hastanesi Aile Hekimli¤i Poliklini¤i'ne baflvuran okul öncesi çocuklarda AGBHS tafl›y›c›l›¤› oran›n› belirlemektir. Yöntem: Ocak-Mart 2008 tarihleri aras›nda aile hekimli¤i polikli-ni¤imize bo¤az a¤r›s› d›fl›ndaki nedenlerle baflvuran üç ila alt› yafl aras› ard›fl›k 150 çocuk hasta randomize flekilde çal›flmaya dâhil edildi. Anamnez ve fizik muayene sonras› bakteri kültürü ve ta-n›mlama için bo¤az sürüntüsü ile antistreptolizin O (ASO) testi için kan örne¤i al›nd›. Bulgular: ‹ncelenen 128 hastan›n 18'inin (%14.06) bo¤az kültürü, AGBHS pozitifti; kültürü pozitif olanlar›n 8'inde ise (%44.44) herhangi bir streptokok enfeksiyonu bulgusu olmaks›z›n ASO yükselmesi saptand›. Sonuç: Daha önceki çal›flmalarda, sa¤l›kl› okul öncesi çocuklarda %2-25.9 oranlar›nda faringeal AGBHS tafl›y›c›l›¤› bulunmufltu, ça-l›flmam›zdaki AGBHS tafl›y›c›l›¤› Türkiye'nin bat› yörelerindeki sonuçlarla uyumludur.
Summary Objective: Burnout syndrome was first described in health - care professionals and to dat... more Summary Objective: Burnout syndrome was first described in health - care professionals and to date, it is known to be a great problem. Bur- nout syndrome has been described comprehensively by Maslach and Jackson as emotional exhaustion, depersonalization and dec- rease in personal competence and success. The aim of this study was to assess Burnout and related factors in medical
Vitamin D has been determined to have some effects on b cell function and insulin sensitivity, an... more Vitamin D has been determined to have some effects on b cell function and insulin sensitivity, and it is known that type 2 diabetes mellitus and hyperparathyroidism can cause obesity. The aim of our study was to investigate if vitamin D deficiency without diabetes mellitus and metabolic syndrome is associated with obesity and abdominal obesity. The study included 276 healthy premenopausal women. To exclude other causes of obesity, postmenopausal women and subjects with diabetes mellitus and metabolic syndrome were excluded. Women were divided into two groups depending on their 25-hydroxyvitaminD(3) [25(OH)D(3)] levels: subjects with vitamin D deficiency (Group 1) and subjects without vitamin D deficiency (Group 2). Body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) were compared between the two groups. BMI, WC, WHR, rates of obesity, and abdominal obesity according to WC and WHR of Group 2 were lower than those of Group 1 (p = 0.0005, p = 0.0001, p = 0.004...
Thyroid autoimmunity has been suggested as a risk factor for atherosclerosis independent of thyro... more Thyroid autoimmunity has been suggested as a risk factor for atherosclerosis independent of thyroid function in several studies. The aim of this study was to investigate whether thyroid autoimmunity had any effect on hyperlipidaemia, obesity and abdominal obesity independent of thyroid function. 184 premenopausal female patients with Hashimoto's thyroiditis (HT) and 150 healthy premenopausal female volunteers as control group (CG) were included in the study. According to thyroid function status, the patients were divided into three subgroups: overt hypothyroid patients (ohp), subclinical hypothyroid patients (shp) and euthyroid patients (ep). Body mass index (BMI), waist to hip ratios, waist circumference (WC), and serum lipid levels of all the participants were determined. These parameters of ep were compared with those of ohp, shp and CG. Relationships among thyroid stimulating hormone (TSH), thyroid autoantibodies and lipid levels were investigated. There were no significant ...
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