Papers by nora sarishvili
Nephrology Dialysis Transplantation, Jun 1, 2023
Introduction: Systemic sclerosis (SS) is a rare connective tissue disorder characterized by wides... more Introduction: Systemic sclerosis (SS) is a rare connective tissue disorder characterized by widespread vascular dysfunction and progressive skin and internal organ fibrosis. Scleroderma renal crisis (SRC) is a life-threatening complication of SS. The estimated incidence of SSc is approximately 20 cases per million per year, and SRC affects about 5-15% of those patients. Case Description: A 32-year-old female was admitted to the hospital with dyspnea, edema, HTN, COPD. 4 months before the hospitalization, she had an abrupt onset of HTN (230/120 mm/Hg) and seizures (no abnormal waveforms on EEG). Vital signs: HR 90' , RR 22' , BP 197/121 mmHg, SpO 2 90% on room air. PEx: severe jugular venous dilation, crackles in both lungs, 3+ pitting edema bilaterally. The skin appeared abnormal with a modified Rodnan score "9" out of "51" with puffy hands, sclerodactyly, telangiectasia, and Raynaud's phenomena.
Nephrology Dialysis Transplantation
Introduction Systemic sclerosis (SS) is a rare connective tissue disorder characterized by widesp... more Introduction Systemic sclerosis (SS) is a rare connective tissue disorder characterized by widespread vascular dysfunction and progressive skin and internal organ fibrosis. Scleroderma renal crisis (SRC) is a life-threatening complication of SS. The estimated incidence of SSc is approximately 20 cases per million per year, and SRC affects about 5-15% of those patients. Case Description A 32-year-old female was admitted to the hospital with dyspnea, edema, HTN, COPD. 4 months before the hospitalization, she had an abrupt onset of HTN (230/120 mm/Hg) and seizures (no abnormal waveforms on EEG). Vital signs: HR 90’, RR 22’, BP 197/121 mmHg, SpO2 90% on room air. PEx: severe jugular venous dilation, crackles in both lungs, 3+ pitting edema bilaterally. The skin appeared abnormal with a modified Rodnan score “9” out of “51” with puffy hands, sclerodactyly, telangiectasia, and Raynaud's phenomena. Lab: creatinine 406 mcmol/L, urea 20.8 mmol/L, T.Ca 2.04 mmol/L, P 1.71 mmol/L, PTH 255....
Georgian medical news
The aim of our study was to use non-cytotoxic, easily available agent - 3% NaCl (hypertonic) sali... more The aim of our study was to use non-cytotoxic, easily available agent - 3% NaCl (hypertonic) saline compresses as prophylaxis measure for long-term prevention of ESI and avoid antibiotic resistance later. Advantages of hypertonic saline include excellent patient acceptance, ease of use, lack of adverse effects on exit site, adjacent skin, catheter or systemic reaction, and minimal expense. During the observational time of 36 months a total of 78 patients were enrolled in this study. Patients were randomized into three groups: in group A 36 patients, were using 3% saline compresses as ESI prophylaxis 3 times weekly, group B 22 patients were using mupirocine 2% ointment 3 times weekly as exit-site dressing and group C 30 patients were using no aseptic agents for exit-site care. Group A showed the minimal rate of ESI compare to groups B and C. None of the tunnel infections was complicated with peritonitis and catheter loss. The use hypertonic saline compresses as routinely daily or thr...
Georgian medical news
Aim of the study - assessment of the presence of M-type phospholipase A2 receptor antibodies in G... more Aim of the study - assessment of the presence of M-type phospholipase A2 receptor antibodies in Georgian patients with biopsy proven IMN and their correlation with the disease activity for the appliance and monitoring of immunosuppressive therapy. A total 37 patients, after exclusion of the possible secondary factors, with biopsy proven IMN entered the study. All patients received standard immunosuppressive therapy: cyclosporine combined with methylprednisolone. There were 28 (76%) patients with PLA2R-AB positive and 9 (24%) negative (assessed as 1:<10) at baseline. Among the 28 patients under immunosuppressive therapy at month 6 in 11 of them PLA2R-AB turned negative, in 14 decreased quantitatively but were persistent positive and in 3 of them PLA2R-AB once turned negative then relapsed after withdrawn of immunosuppressive therapy. Among 11 PLA2R-AB negative patients, 9 patients got complete remission of proteinuria and the other 2 patients only partial remission. At month 12 th...
Nephrology Dialysis Transplantation, 2021
Background and Aims Kidney biopsy registry has been established in Georgia in 2011 by Dialysis, N... more Background and Aims Kidney biopsy registry has been established in Georgia in 2011 by Dialysis, Nephrology and Kidney Transplantation Union of Georgia (DNT Union) to address the natural history of kidney disease, describe the clinical features, improve disease understanding and tracking, healthcare planning, patient care and outcomes. This report is the first review of histological data over a period of 10 years (2011-2020) covering the entire population of 3.7 million inhabitants and demonstrates the current data on trends of kidney disease in Georgia. Method 1267 ultrasound-guided kidney biopsies were performed during the 10 years. Data were extracted from the DNT Union kidney biopsy registry as of 1st of December 2020. Data on kidney function, urinalysis, treatment options and outcomes were also included in biopsy registry database. After exclusion of transplant and re-biopsies, kidney biopsies were analyzed for evaluation main trends in kidney biopsy rates and diagnosis of glome...
A structured and algorithmic model of the control system, which allows multi-level complex monito... more A structured and algorithmic model of the control system, which allows multi-level complex monitoring on the basis of measuring channels controlled by variable range for remote detection of leakage sites in the main pipelines, has been developed. The air-gas composition change in the leak site of the pipeline leads to changes in the absorption and radiation intensity due to its impact on the radiation obtained from that site. The used liquid crystal filters have a wider range of bandwidth control and is polarized-independent providing to obtain the results of a two-color measurement. The values of measurement results obtained from the infrared range in the monitoring system represent the current leakage state and obtaining the appropriate data in the visible range allow the confirmation of the obtained data in the infrared range and thereby increase the reliability of the received information about the leakage. Decoding infrared data in the visible range makes it possible to visuali...
Nephrology Dialysis Transplantation
Background and Aims Kidney biopsy registry has been established in Georgia in 2011 by Dialysis, N... more Background and Aims Kidney biopsy registry has been established in Georgia in 2011 by Dialysis, Nephrology and Kidney Transplantation Union of Georgia (DNT Union) to address the natural history of kidney disease, describe the clinical features, improve disease understanding and tracking, healthcare planning, patient care and outcomes. This report is the first review of histological data over a period of 10 years (2011-2020) covering the entire population of 3.7 million inhabitants and demonstrates the current data on trends of kidney disease in Georgia. Method 1267 ultrasound-guided kidney biopsies were performed during the 10 years. Data were extracted from the DNT Union kidney biopsy registry as of 1st of December 2020. Data on kidney function, urinalysis, treatment options and outcomes were also included in biopsy registry database. After exclusion of transplant and re-biopsies, kidney biopsies were analyzed for evaluation main trends in kidney biopsy rates and diagnosis of glome...
Nephrology Dialysis Transplantation, May 1, 2018
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Papers by nora sarishvili