Papers by olufemi oderinlo
Aims: To report the efficacy of transscleral diode laser photocoagulation and compare outcomes be... more Aims: To report the efficacy of transscleral diode laser photocoagulation and compare outcomes between the continuous wave (CW) and micropulse wave (MP) protocols for refractory glaucoma in African eyes. Methods: A non-randomized prospective comparative study of patients who had transscleral diode laser photocoagulation for refractory glaucoma between January 2021 and December 2021in Eye Foundation Hospital Lagos, Nigeria was done. Results: A total of 52 eyes of 52 patients were analyzed. Mean age of patients was 66 ± 12.5 years. The mean preoperative intraocular pressure (IOP) was 31.2 ± 11.9 mmHg. Overall post-operative mean IOP was 17.9 ± 8.6 mmHg at 4 weeks, 21.0 ± 9.9 mmHg at 8 weeks and 20.6 ± 11.4 mmHg at 12 weeks. The difference between mean preoperative and postoperative IOP measured at week 12 was statistically significant (p<0.001). Both continuous wave and micropulse wave protocols were effective at reducing intraocular pressures, the micropulse group had a mean difference between preoperative IOP and postoperative IOP at week 12 of 7.5 ± 6.7 mmHg (p=0.001), while the continuous wave laser group had a mean difference of 11.7 ± 13.7 mmHg (p<0.001). The micropulse group achieved a higher percentage of success in 11 eyes (78.6%) compared with 24 eyes (63.2%) in the continuous wave group. This difference was not statistically significant (p=0.341). Conclusion: Both the continuous wave (CW) and micropulse wave (MP) protocols of transscleral diode laser photocoagulation were found effective at significantly reducing IOP in our study of African eyes with refractory glaucoma. Although the MP group achieved a higher percentage of absolute success, this was not statistically significant.
PubMed, Dec 1, 2017
To report the rare and dramatic event of bilateral macular infarction in a sickle cell hemoglobin... more To report the rare and dramatic event of bilateral macular infarction in a sickle cell hemoglobinopathy (SS genotype) patient, resulting in bilateral severe reduction in visual acuity. Without any intervention, the patient's vision gradually improved over the follow-up period. Central visual field defects however persisted. A 21-year-old male Nigerian, presented with a 1-week history of bilateral sudden painless loss of vision. His symptom was associated with fever, feeling of heaviness in the chest and head, and a dizzy spell. Visual acuity was reduced to 20/200 in both eyes and near acuity was; right eye: N24, left eye: N36. Funduscopy showed a pale, milky white, thickened retinal patch superotemporal to the fovea in both eyes. Fluorescein Angiograph: revealed features consistent with occlusion of the parafoveal terminal arterioles in both eyes. Although he did not receive any ocular treatment, and exchange blood transfusion was not done, he regained near-normal visual acuity in both eyes over a 17-month follow-up period, central visual field defects persisted in both eyes. Visual recovery in this patient demonstrates that macular function could improve over time following macular ischemia, without any treatment. Patients and caring physicians should be aware of this possibility.
Current trends in ophthalmology, Mar 1, 2018
Aim: To investigate the outcome of the inverted Internal Limiting Membrane (ILM) flap technique f... more Aim: To investigate the outcome of the inverted Internal Limiting Membrane (ILM) flap technique for extra large idiopathic macular holes (MHs). Methods: A retrospective non-comparative surgical case series of seven eyes of 7 patients with MHs (base diameter of at least 1000 μm) was conducted. All the MHs were treated using pars plana vitrectomy and brilliant blue G (BBG)-assisted inverted ILM flap technique. Spectral Domain-Optical Coherence Tomography (SD-OCT) images were used to assess the anatomical outcomes of surgery including the macular microstructure, while Best Corrected Snellen Visual Acuity (BCSVA) was used to evaluate the functional outcomes. Results: The average MH size was 1241microns and average symptom duration was nineteen months. All eyes achieved successful anatomical closure and there was no occurrence of a flat open type closure. SD-OCT microstructural study revealed a reconstruction of the Ellispod Zone (EZ) and External Limiting Membrane (ELM), in only 3 eyes. There was an improvement in visual acuity in 5 eyes, while 2 eyes maintained the same as pre operative vision. The largest increase in post operative visual acuity gain was a 4-line improvement in Best Corrected Snellen Visual Acuity (BCSVA) noted in one of the 3 eyes with reconstructed EZ and ELM. The 3 months symptom duration in this patient was the shortest in this series. Conclusion: Inverted ILM flap technique is a safe and effective approach for the management of extra large chronic idiopathic MHs with demonstrably good anatomical and limited functional results in a majority of cases. Postoperative reconstruction of the microstructure is however seen only in a minority of eyes. Despite an absence of the outer retina (EZ and ELM), some eyes still experience an improvement in vision. The symptom duration may play a vital role in functional outcome in this subset of extra large chronic MHs.
Nigerian journal of ophthalmology, Jan 20, 2005
Nigerian Journal of Clinical Practice, 2016
Objectives: To evaluate the indication and safety profile of same-session bilateral intravitreal ... more Objectives: To evaluate the indication and safety profile of same-session bilateral intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF). Methods: This is a retrospective case series of all the patients that received same-session bilateral intravitreal anti-VEGF in Eye Foundation Hospital, Ikeja, Lagos, from March 2013 to March 2015. Data retrieved from the patients' medical records includes demographics, indications for injections, complications, and systemic comorbidities. Results: During the study period, a total of 442 injections were performed on 126 eyes of 63 patients (M:F ratio; 1.4:1) whose mean age was 55.7 ± 15.6 standard deviation years. The modal age group was 51-70 years. All the patients received injection Bevacizumab (Avastin; Genentech Inc., South San Francisco, California, USA-1.25 mg). The most common primary indication for initiating bilateral intravitreal therapy was diabetic macular edema 23 (36.5%). Mean follow-up period was 40.6 days (range: 1-364 days). A combined diabetes mellitus and hypertension accounted for most of the systemic comorbidities 28 (44.4%). Subconjunctival hemorrhage was the only complication seen in these patients with 6 (9.5%) occurring intraoperatively and 9 (14.3%) postoperatively. There was no association between intraoperative complication and age (P = 0.66) or gender (P = 0.96). Furthermore, there exist no association between postoperative complication and age (P = 0.49) or gender (P = 0.99). Conclusions: No major systemic or ocular adverse events were noted. Given that there are potentially serious complications following anti-VEGF injection, further study with a larger number of patients will be necessary to definitively prove the safety of this treatment modality.
Eye, 2008
Purpose To compare the measurements of intraocular pressure (IOP) with dynamic contour tonometry ... more Purpose To compare the measurements of intraocular pressure (IOP) with dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) in healthy and glaucomatous eyes and to evaluate the influence of corneal thickness (CCT), corneal curvature (CC), axial length (AL), and age on these tonometric alternatives. Methods Three hundred eyes of 100 healthy subjects, 100 patients with primary open angle glaucoma, and 100 patients with primary angle-closure glaucoma underwent IOP evaluation with DCT and GAT, and measurements of CCT, CC, and AL. Bland-Altman plots were used to evaluate the agreement between tonometers. Regression analysis was used to evaluate the influence of ocular structural factors on IOP measurements obtained with both tonometers. Results Bland-Altman plots indicated that the 95% limits of agreement between tonometers were À1.4 to 6.6 mmHg. DCT values measured 2.6 ± 1.9 mmHg higher than GAT readings (Po0.001). The mean IOP difference between DCT and GAT (DIOP) was higher in healthy than in glaucomatous eyes and the magnitude of difference increased with increasing CCT. A significant reduction of DIOP with an increase in both CCT (Po0.001) and IOP values (Po0.001) was found. Regression analysis showed no effect of CC, AL, and age on both DCT and GAT readings. In contrast to GAT (Po0.001), DCT measurements were not influenced by CCT (P ¼ 0.43). Conclusions IOP readings obtained by DCT were higher and less affected by CCT than those by GAT. The DIOP was higher in healthy than in glaucomatous eyes and decreased in relation to increased CCT and IOP values.
Journal of Global Medicine
Topic: A review of outcomes of laser photocoagulation for Goldberg stage 3 proliferative sickle c... more Topic: A review of outcomes of laser photocoagulation for Goldberg stage 3 proliferative sickle cell retinopathy (PSR) in a Eye Foundation Hospital. Aims and objectives: To report regression of retina neovascularization and visual outcomes after prophylactic scatter retina laser photocoagulation for Goldberg stage 3 PSR in a tertiary private hospital in sub-Saharan Africa. Methods: A retrospective review of case files of patients who were treated with prophylactic scatter retina laser photocoagulation between January 2017 and June 2022 following a diagnosis of PSR in a Eye Foundation Hospital, Ikeja, Lagos, Nigeria, was done. Results: A total of 124 eyes of 62 patients with PSR were seen within the period under consideration. A majority of patients (49 (79.0%)) had hemoglobin (Hb) genotype SC, while 13 patients (21%) were Hb genotype SS. At presentation, 29 eyes (23.3%) had Goldberg stage 2 PSR, 55 eyes (44.4%) had Goldberg stage 3 PSR, 27 eyes (21.8%) had stage 4 PSR, while 13 eyes...
Nigerian Journal of Vitreoretinal Diseases
Nigerian Journal of Ophthalmology, 2008
Objective: To assess the best corrected visual acuity and average intraocular pressure at 6 month... more Objective: To assess the best corrected visual acuity and average intraocular pressure at 6 months and one (1) year in patients with cataracts in glaucoma that had combined trabeculectomy and cataract surgery with lens implantation. Methods: A retrospective review of the case notes of patients who underwent combined glaucoma and cataract surgery with lens implantation in a private eye centre, The Eye Foundation Hospital, was carried out, using the following parameters: age, pre-operative intraocular pressure (IOP), post-operative intraocular pressure preoperative and postoperative visual acuity, the number of preoperative antiglaucoma medications, and the number of postoperative antiglaucoma medications at one (1) year or more. Results: 68 eyes of 67 patients were assessed during the study. Thirty-one (44.93%) had preoperative visual acuity (VA) of light perception (LP)-6/60 (very poor). At 6 months post operatively, 50 patients were followed up, 40% (n=20) had a visual acuity of 6/12-6/5 (very good). At one year, 37 patients followed up, of those, 48.65% (n=18) maintained a visual acuity of 6/12-6/5(very good). Mean preoperative intraocular pressure was 18.96 ± 7.38mmHg. At 6 months, mean IOP was 11.77± 3.61mmHg; one (1) year postoperatively IOP was 13.93 ± 3.21mmHg. There was a statistically significant improvement in VA (p<0.05) and intraocular pressure (p = 0.05). Conclusion: Combined trabeculectomy and cataract surgery should be considered as a good operative choice in elderly patients who present with significant cataracts in glaucoma and who require two or more antiglaucoma drugs to maintain a normal intraocular pressure. Though a more difficult operation than either procedure alone, good results can be achieved in experienced hands with significant improvement in VA (p<0.05) and Intraocular pressure(p=0.05).
Nigerian journal of ophthalmology, 2012
Aim: To identify the prognostic factors associated with good visual outcome after surgery for ret... more Aim: To identify the prognostic factors associated with good visual outcome after surgery for retinal detachment in a series of 103 eyes. Materials and methods: Data were obtained from the case files of patients who had retina re-attachment surgery for rhegmatogenous retinal detachment between June 2006 and December 2007 at the Eye Foundation Hospital, Lagos, Nigeria. The factors associated with good visual outcome were analysed using multiple logistic regression. Results: A hundred and three eyes of 103 patients were evaluated. There were 80 males and 23 females with ages ranging from 10 to 69 years and a mean age of 46.1 +14.1 years. Preoperatively, 82 eyes (79.6%) had visual acuity (VA) worse than 3/60. In 78 eyes (75.7%), the macula was off, giant tears were seen in 9 eyes (8.7%), proliferative vitreoretinopathy (PVR) of grade C-1 and worse was seen in 30 eyes (29.1%). Primary anatomic reattachment was achieved in 83 eyes (80.5%), while final anatomic success was achieved in 93 eyes (90.2%). A good visual outcome was achieved in 40 eyes (38.8%). Three factors favourably affected visual outcome and were of statistical significance in the multiple logistic regression analysis, viz absence of advanced PVR grade C-1 and worse (p=0.015), preoperative VA 6/60 and better (p=0.037), and primary anatomic success (p=0.052). Conclusion: A good visual outcome after surgery for rhegmatogenous retinal detachment is favourably influenced by preoperative VA of 6/60 and better, absence of PVR of grade C-1 and worse, as well as the achievement of primary anatomic success.
Nigerian Journal of Clinical Practice, 2020
Aim: To present the anatomical and visual outcome and compare different techniques in the surgica... more Aim: To present the anatomical and visual outcome and compare different techniques in the surgical treatment of proliferative vitreoretinopathy (PVR) in Nigerians.Method: Comparative retrospective review of PVR grade C and D eyes that had vitreoretinal surgery with silicone oil between April 2005 and December 2012. Data was extracted from consecutive case notes after exclusion of eyes with PVR associated with proliferative diabetic retinopathy (PDR), proliferative sickle cell retinopathy (PSCR) and eyes with nonuse of silicone oil. A comparison of the outcome of vitrectomy alone (Vit.), versus combined with a scleral buckle (Vit.+SB), versus with retinectomy (Vit.+RT), versus with all three procedures (Vit.+SB+RT) was done. Statistical analysis was done using the Statistical Package for Social Sciences version 16 software. Pearson Chi-square test and Fisher's exact T-test were used to determine the effect of relationships. Results: 138 eyes of 138 patients had grades C (100 eyes...
Investigative Ophthalmology & Visual Science, 2011
Nigerian Journal of Ophthalmology, 2009
Objective: To report the rare case of a 33-year-old female Nigerian who presented to our retina c... more Objective: To report the rare case of a 33-year-old female Nigerian who presented to our retina clinic with a chronic total retinal detachment and visual acuity of no light perception in her left eye. Re-attachment surgery in the eye was not attempted as prognosis for return of vision was poor. She was later noted to harbor a progressively enlarging ciliary body mass in the inferotemporal quadrant. Method: An observational case report was performed, with documentation of findings as patient was seen in the clinic. Conclusion: This is the first report of a ciliary body mass lesion in a Nigerian. The ciliary body mass could be a ciliary melanoma (ciliary body lesion being rarer than a choroidal mass) but other benign differential diagnoses must be borne in mind. Enucleation and histological assessment of the specimen will give the definitive diagnosis. Difficulties with patient acceptance of enucleating a non seeing eye though harboring a potentially harmful disease still abound in our environment.
Nigerian Journal of Ophthalmology, 2005
Nigerian Journal of Ophthalmology, 2008
Aim: To report a case of successful treatment of a classic subfoveal choroidal neovascularization... more Aim: To report a case of successful treatment of a classic subfoveal choroidal neovascularization with a transpupillary thermotherapy protocol. Case Report: A 67-year old pensioner presented with a sixmonth history of reduced vision in both eyes. He had been previously diagnosed with primary open angle glaucoma. After anterior and posterior segment examination and fundus fluorescein angiography were done, a diagnosis of a classic subfoveal choroidal neovascularization secondary to exudative age-related macular degeneration OS with bilateral cataracts and primary open angle glaucoma OU was made. Complete resolution of the choroidal neovascular membrane was achieved with transpupillary thermotherapy.
Nigerian Journal of Ophthalmology, 2005
Archives of Ophthalmology, 1994
To provide detailed information specific to the initial visual acuity and initial lesion size on ... more To provide detailed information specific to the initial visual acuity and initial lesion size on the outcome of patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration. The 189 eyes assigned to laser photocoagulation and the 184 eyes assigned to observation in the Subfoveal New CNV Study were divided into nine subgroups based on initial visual acuity and initial lesion size. The pattern of visual acuity loss for both treated and untreated eyes through 4 years of follow-up was compared among the subgroups. Reading speed and contrast thresholds also were examined. Four patterns (A, B, C, D) of visual acuity loss in treated eyes relative to untreated eyes were identified. Eyes in group A (small lesion and moderate or poor initial visual acuity or medium lesion and poor visual acuity) had the best visual outcome with treatment; treated eyes were better throughout follow-up. Eyes in group B (small lesion and good initial visual acuity or medium lesion and moderate or good visual acuity) had substantial treatment benefit by 12 months, but were worse immediately after treatment. Eyes in group C (large lesion and poor initial visual acuity) had a small treatment benefit throughout follow-up. Eyes in group D (large lesion and moderate or good visual acuity) had the worst visual outcome with treatment; treated eyes were substantially worse for the first 18 months and were not appreciably better through 4 years of follow-up. Recommendations for treatment of subfoveal CNV should take account of the initial visual acuity and lesion size. Eyes in group D are poor candidates for laser treatment.
American Journal of Ophthalmology, 1988
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Papers by olufemi oderinlo