DOAJ (DOAJ: Directory of Open Access Journals), 2018
Background & objectives: Therapeutic abortion in the second trimester of pregnancy can be done by... more Background & objectives: Therapeutic abortion in the second trimester of pregnancy can be done by a number of medical or mechanical methods. The aim of this study was to compare the efficacy of vaginal misoprostol with and without letrozole and combination of misoprostol and laminaria in preoperative cervical ripening among women with under second-trimester abortion. Methods: In this interventional study, 120 pregnant women with the gestational age of 20 weeks, who were candidates for therapeutic abortion, were selected and randomly divided into three groups (n=40). Proper counseling was done and a written informed consent was obtained before starting the treatment regimen. The first group received vaginal misoprostol alone and the second group received misoprostol in combination with laminaria and oral placebo. In the third group, in addition to cervical placebo on the first and second days, letrozole was prescribed, and on the third day, the patients were hospitalized and received vaginal misoprostol and third dose of letrozole. The patients were regularly examined every 4 hours, and in the absence of abortion, vaginal misoprostol was repeated after 4 hours. Results: The results showed that termination of pregnancy was caused by embryo anomaly in 23 cases and fetal death in 97 cases. In this study, response to treatment was 90% in the group receiving laminaria and misoprostol 85% in the group receiving letrozole and misoprostol and 67% in the group receiving misoprostol. Regarding the duration and amount of bleeding, the groups receiving laminaria and misoprostol had the lowest duration and severity of bleeding, but this difference was not statistically significant. Combination of misoprostol and laminaria caused a significantly shorter time interval from the initiation of intervention to abortion, and pain relief was also higher than the other two groups. Conclusion: Based on the obtained results, a combination of misoprostol and laminaria is recommended for induction of second-trimester therapeutic abortion.
Background & Objectives: Infants are more sensitive than adults in pain staining due to disformat... more Background & Objectives: Infants are more sensitive than adults in pain staining due to disformation of descending control system. Since, non-pharmacological methods are recommended for infants’ pain control, this study aimed to determine combined effect of breastfeeding and maternal-infant skin to skin contact on pain of first injection in healthy term infants. Methods: This clinical trial study was conducted on case and control groups in delivery room of Alavi Hospital for a period of 8 months in 1389. 200 infants were randomly selected and divided in four groups; group1: Control, group2: breast-feeding, Group 3: skin to skin contact of mother and infant, and group4: breastfeeding and skin to skin contact of mother and infants. Researchers observed all the DAN scale factors and completed observation paper from the moment of injection until 45 seconds later. Data were analyzed by chisq square and t test using SPSS software. Results: Average pain severity was 5.34 for group 1, 3.70 ...
Journal of Ardabil University of Medical Sciences, 2018
Background & objectives: Therapeutic abortion in the second trimester of pregnancy can be done by... more Background & objectives: Therapeutic abortion in the second trimester of pregnancy can be done by a number of medical or mechanical methods. The aim of this study was to compare the efficacy of vaginal misoprostol with and without letrozole and combination of misoprostol and laminaria in preoperative cervical ripening among women with under second-trimester
DOAJ (DOAJ: Directory of Open Access Journals), 2018
Background & objectives: Therapeutic abortion in the second trimester of pregnancy can be done by... more Background & objectives: Therapeutic abortion in the second trimester of pregnancy can be done by a number of medical or mechanical methods. The aim of this study was to compare the efficacy of vaginal misoprostol with and without letrozole and combination of misoprostol and laminaria in preoperative cervical ripening among women with under second-trimester abortion. Methods: In this interventional study, 120 pregnant women with the gestational age of 20 weeks, who were candidates for therapeutic abortion, were selected and randomly divided into three groups (n=40). Proper counseling was done and a written informed consent was obtained before starting the treatment regimen. The first group received vaginal misoprostol alone and the second group received misoprostol in combination with laminaria and oral placebo. In the third group, in addition to cervical placebo on the first and second days, letrozole was prescribed, and on the third day, the patients were hospitalized and received vaginal misoprostol and third dose of letrozole. The patients were regularly examined every 4 hours, and in the absence of abortion, vaginal misoprostol was repeated after 4 hours. Results: The results showed that termination of pregnancy was caused by embryo anomaly in 23 cases and fetal death in 97 cases. In this study, response to treatment was 90% in the group receiving laminaria and misoprostol 85% in the group receiving letrozole and misoprostol and 67% in the group receiving misoprostol. Regarding the duration and amount of bleeding, the groups receiving laminaria and misoprostol had the lowest duration and severity of bleeding, but this difference was not statistically significant. Combination of misoprostol and laminaria caused a significantly shorter time interval from the initiation of intervention to abortion, and pain relief was also higher than the other two groups. Conclusion: Based on the obtained results, a combination of misoprostol and laminaria is recommended for induction of second-trimester therapeutic abortion.
Background & Objectives: Infants are more sensitive than adults in pain staining due to disformat... more Background & Objectives: Infants are more sensitive than adults in pain staining due to disformation of descending control system. Since, non-pharmacological methods are recommended for infants’ pain control, this study aimed to determine combined effect of breastfeeding and maternal-infant skin to skin contact on pain of first injection in healthy term infants. Methods: This clinical trial study was conducted on case and control groups in delivery room of Alavi Hospital for a period of 8 months in 1389. 200 infants were randomly selected and divided in four groups; group1: Control, group2: breast-feeding, Group 3: skin to skin contact of mother and infant, and group4: breastfeeding and skin to skin contact of mother and infants. Researchers observed all the DAN scale factors and completed observation paper from the moment of injection until 45 seconds later. Data were analyzed by chisq square and t test using SPSS software. Results: Average pain severity was 5.34 for group 1, 3.70 ...
Journal of Ardabil University of Medical Sciences, 2018
Background & objectives: Therapeutic abortion in the second trimester of pregnancy can be done by... more Background & objectives: Therapeutic abortion in the second trimester of pregnancy can be done by a number of medical or mechanical methods. The aim of this study was to compare the efficacy of vaginal misoprostol with and without letrozole and combination of misoprostol and laminaria in preoperative cervical ripening among women with under second-trimester
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