Papers by juster mungiria
Medicine
This study aimed to determine the association between the plasma concentration of nevirapine (NVP... more This study aimed to determine the association between the plasma concentration of nevirapine (NVP) and clinical outcomes. In this cross-sectional study, sociodemographic and clinical data were collected from 233 HIV patients receiving NVP-based first-line antiretroviral therapy (ART) regimens in Nairobi, Kenya. The mean age was 41.2 (SD ± 11.9) years. Fifty-four (23.2%) patients had virological failure (>1000 copies/mL), whereas 23 (9.9%) were infected with drug-resistant HIV strains. Eleven patients had nucleoside reverse transcriptase inhibitor resistance mutations, including M184V and T215Y, whereas 22 had non-nucleoside reverse transcriptase inhibitor resistance mutations, including G190A, K103N, V106A, Y181C, A98G, and Y188L. The median NVP plasma concentration was 6180 ng/mL (IQR 4444–8843 ng/mL), with 38 (16.3%) patients having suboptimal NVP plasma levels of <3400 ng/mL. The majority 23 of the 38 (60.5%) patients with NVP Cmin < 3400 ng/mL were significantly infecte...
This thesis is dedicated to my loving husband, Dr. George Muthaa who steadfastly supported me dur... more This thesis is dedicated to my loving husband, Dr. George Muthaa who steadfastly supported me during my studies, my lovely children Carol, Evelyn and Abigail for their continuous encouragement and inspiration during the period of my study. May this work inspire you to achieve the best in your lives.
F1000Research, 2020
Background:Patients’ clinical outcomes and pharmacogenetic factors are important predictors of ne... more Background:Patients’ clinical outcomes and pharmacogenetic factors are important predictors of nevirapine (NVP) plasma concentration. This study evaluated the association of socio-demographic factors and Cytochrome P450 2B6 (CYP2B6) polymorphisms with NVP plasma concentrations among patients receiving antiretroviral therapy (ART) treatment in western and coastal Kenya.Methods:Blood samples were collected from 377 consenting HIV adult patients receiving an NVP-based first-line ART regimen. A detailed sociodemographic questionnaire was administered. NVP plasma concentration was measured by liquid chromatography - tandem mass spectrometry (LC-MS/MS). CYP2B6 c.516 G>T rs3745274 and c.983T>C genotypes were evaluated using real-time polymerase chain reaction. HIV drug resistance mutations were detected using an in-house genotypic assay.Results:The patients’ mean age was 41.6 (SD ± 11.5) years and the majority (59.2%) were female. The mean duration of ART was 5.1 (SD ± 4.8) years. Ov...
Journal of Applied Life Sciences International, 2017
Aim: The aim of this study was to determine levels of Plasmodium falciparum parasitaemia in child... more Aim: The aim of this study was to determine levels of Plasmodium falciparum parasitaemia in children and relationship between IgG responses against the parasite and nutritional status of children. Study Design: Cross sectional study of children diagnosed positive for P. faciparum in Ishiara District Hospital, Embu county, Kenya was done between August 2011 and June 2012. Methodology: A total of 380 children, under 5 years who tested positive to P. faciparum infection were used for the study. Children with less than-2 Z score of height-forage were classified as stunted and those with less than-2 Z score of weight-for-height were classified as wasted. Malnourished children were identified by the criteria of WHO. P. faciparum parasitaemia was determined by microscopy, using Giemsa stained thin and thick blood smears while the parasite`s IgG antibody responses were assessed by the Enzyme linked immune-sorbent assay.
Journal of Applied Life Sciences International, 2016
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Papers by juster mungiria