Papers by farouq emam hawaiz
Journal of Molecular Structure, 2017
Two new water soluble derivatives of dppz have been synthesized and structurally characterized. T... more Two new water soluble derivatives of dppz have been synthesized and structurally characterized. The DNA binding studies supported that these compounds can intercalate into ct-DNA.
The starting materials alkoxy and benzyloxyacetophenones (1a-j, 2 and 3) have been prepared on th... more The starting materials alkoxy and benzyloxyacetophenones (1a-j, 2 and 3) have been prepared on the basis of Williamson synthesis of ether. The prepared and the available starting materials were reacted with terphthalaldehyde using green methods, Ultrasound , Microwave and solvent-free grinding method to give anew series of bis-chalcones (4a-s).The prepared bis-chalcones were subjected to react with thiosemicarbazide according to the Michael addition reaction to afford new biologically active bispyrazolinedeivatives(5a-s). The structure of the synthesized compounds were characterized by spectral methods: FT-IR, 1 H-nmr, 13 C-nmr andMass spectrometry.
ZANCO Journal of Pure and Applied Sciences, Dec 15, 2016
Some new azo-flavones of 2-(substituted phenyl)-6-(p-tolyldiazenyl)-4 H -chromen-4-ones, have bee... more Some new azo-flavones of 2-(substituted phenyl)-6-(p-tolyldiazenyl)-4 H -chromen-4-ones, have been synthesized in three consecutive main steps. 4-toluidine was used as a diazotizing agent and subjected to coupling reaction with 2-hydroxyacetophenone forming 2-(hydroxyl)-5-[4-methylphenylazo] acetophenone as a key substrate. The prepared starting material reacted with different substituted benzaldehydes affording new 2-hydroxy azo-chalcones which were cyclized by DMSO/I 2 giving the target biological active azo-flavone derivatives. The structures of the newly synthesized products were elucidated by using FT-IR, 1 H-NMR, 13 C-NMR and DEPT-135 spectra. The synthesized flavones were screened with two types of bacteria Escherichia coli gram negative and Staphylococcus aurous gram positive. The results observed a significant effect against gram negative bacteria.
Maǧallaẗ ǧāmiʻaẗ kirkūk, Jun 28, 2012
ZANCO Journal of Pure and Applied Sciences, Jan 22, 2018
RSC Advances, 2023
A well-explained mechanism for synthesizing carbon dots (CDs) is not yet explored and is still a ... more A well-explained mechanism for synthesizing carbon dots (CDs) is not yet explored and is still a subject of great debate and challenge. This study used a one-step hydrothermal method to prepare highly efficient, gram-scale, excellent water solubility, and blue fluorescent nitrogen-doped carbon dots (NCDs) with the particle size average distribution of around 5 nm from 4-aminoantipyrine. The effects of varying synthesis reaction times on the structure and mechanism formation of NCDs were investigated using spectroscopic methods, namely FT-IR, 13 C-NMR, 1 H-NMR, and UV-visible spectroscopies. The spectroscopic results indicated that increasing the reaction time affects the structure of the NCDs. As the hydrothermal synthesis reaction time is extended, the intensity of the peaks in the aromatic region decreases, and new peaks in the aliphatic and carbonyl group regions are generated, which display enhanced intensity. In addition, the photoluminescent quantum yield increases as the reaction time increases. The presence of a benzene ring in 4-aminoantipyrine is thought to contribute to the observed structural changes in NCDs. This is due to the increased noncovalent p-p stacking interactions of the aromatic ring during the carbon dot core formation. Moreover, the hydrolysis of the pyrazole ring in 4aminoantipyrine results in polar functional groups attached to aliphatic carbons. As the reaction time prolongs, these functional groups progressively cover a larger portion of the surface of the NCDs. After 21 h of the synthesis process, the XRD spectrum of the produced NCDs illustrates a broad peak at 21.1°, indicating an amorphous turbostratic carbon phase. The d-spacing measured from the HR-TEM image is about 0.26 nm, which agrees with the (100) plane lattice of graphite carbon and confirms the purity of the NCD product with a surface covered by polar functional groups. This investigation will lead to a greater understanding of the effect of hydrothermal reaction time on the mechanism and structure of carbon dot synthesis. Moreover, it offers a simple, low-cost, and gram-scale method for creating highquality NCDs crucial for various applications.
IUCrData, 2018
The asymmetric unit of the title compound, C22H14O6, consists of two independent molecules differ... more The asymmetric unit of the title compound, C22H14O6, consists of two independent molecules differing in the orientations of the ester groups. In one molecule, the two terminal benzene rings are inclined to the central benzene ring by 4.99 (13) and 77.46 (13)°, while in the other the corresponding angles are 11.03 (13) and 88.09 (12)°. In the crystal, molecules are connected into a ribbon structure running along [101]viaC—H...O and C—H...π interactions. Adjacent ribbons are further linked by additional C—H...O and C—H...π interactions. The crystal studied was a non-merohedral twin [twin law (0.986 − 0.073 − 0.008, 0.323 1.036 0.148, −0.121 − 0.102 0.942)], the ratio of components being 0.937 (4):0.063 (4).
Journal of Structural Chemistry, Jun 1, 2023
Three picrate salt crystals, namely 5-amino-6-methylquinolin-1-ium 2,4,6-trinitrophenolate (I), 3... more Three picrate salt crystals, namely 5-amino-6-methylquinolin-1-ium 2,4,6-trinitrophenolate (I), 3-phenyl-1H-pyrazol-2-ium 2,4,6-trinitrophenolate (II) and 1H-imidazol-3-ium 2,4,6-trinitrophenolate (III) were characterized by X-ray diffraction. Salt I crystallizes in space group of
Current Organic Synthesis, Aug 1, 2021
AIMS This article describes the controlled synthesis and characterization of azo oxazolone as mul... more AIMS This article describes the controlled synthesis and characterization of azo oxazolone as multifunctional group in which contain Carbonyl, imine and carbon double bond carbon bond, and their ring opening to azo-benzamide derivative in fast reaction( 5< min>90%). OBJECTIVE UV, IR, proton-NMR, C13-NMR, Elemental analysis and MS spectrometry all synthesized compounds were tested for antibacterial and antioxidant activity. MATERIALS AND METHODS Azo benzamide derivatives were prepared by ring opening of azo oxazolone. RESULTS AND DISCUSSION Chemically structures of synthesized compounds were characterized upon UV, IR, proton-NMR, C13-NMR, Elemental analysis and MS spectrometry. CONCLUSION The oxazolone and benzamide compounds (5a, 5c, 5f, 5h, 5j) screened by diffusion method, the results of tested ciprofloxacin as standard. according to the results the tested compound exhibits more resist to the Escherichia coli than the Staphylococcus aureus . The highest activity of all compound at 800 µg against both types of bacteria, compound (5c and 5j) have higher activity (inhibition zone 32mm) than the ciprofloxacin (inhibition zone 28mm) against Escherichia coli. But compound (5j) in all concentration was in active against Staphylococcus aureus. Compound (5a, 5c, 5f and 5h) have high activity against E.coli. compound (5c) have low activity in all different concentration. Others: Also the product compound tested for its anti-oxidant activity by both DPPH and FRAP method. The result showed that the some compound have moderate anti-oxidant activity in comparison with ascorbic acid as control typically the compounds bearing OCH3and OCH2CH3 group.
گۆڤاری زانکۆی سلێمانی بەشی A, Jan 25, 2015
E-journal of Chemistry, 2012
A number of 3-[4-(benzyloxy)-3-(2-Chlorophenylazo)-phenyl]-5-(substituted-phenyl)-1-substituted-2... more A number of 3-[4-(benzyloxy)-3-(2-Chlorophenylazo)-phenyl]-5-(substituted-phenyl)-1-substituted-2-pyrazolines(4a-j) and (5a-j) have been synthesized by diazotization of 2-chloroaniline and its coupling reaction with 4-hydroxy acetophenone, followed by benzyloxation of the hydroxyl group to give the substrate [4-benzyloxy-3-(2-chlorophenylazo)acetophenone (1)].The prepared starting material (1) has been reacted with different substituted benzaldehydes to give a new series of chalcone derivatives 1-[(4-benzyloxy)-3-(2-chloro-phenylazo)-phenyl]-3-(substituted phenyl)-2-propen-1-one (3a-j) , in high yields and in a few minutes, and the later compounds were treated with hydrazine hydrate according to Michael addition reaction to afford a new biolological active target compounds (4a-j) and (5a-j). Furthermore, The structures of the newly synthesized compounds were confirmed by FT-IR, 13 C-NMR, 13 C-DEPT & 1 H-NMR spectral data. The chalcone and pyrazoline derivatives were evaluated for their anti bacterial activity against Escherichia coli as gram negative and Staphylococcus aureus as gram positive, the results showed significant activity against both types of bacteria.
IUCrData, 2017
The title compound, C20H19N5S, adopts a `contorted' conformation and the dihedral angle betwe... more The title compound, C20H19N5S, adopts a `contorted' conformation and the dihedral angle between the heterocyclic rings is 86.54 (6)°. In the crystal, complementary N—H...N hydrogen bonds form centrosymmetric dimers, which generateR22(14) loops. The dimers stack along thea-axis direction with adjacent stacks having their aromatic rings directed towards one another.
IUCrData, 2017
The conformation of the title molecule, C16H12N2O3, is partly determined by an intramolecular C=O... more The conformation of the title molecule, C16H12N2O3, is partly determined by an intramolecular C=O...π interaction between one carbonyl group and the five-membered ring of the other indolinone moiety. The crystal packing consists of layers parallel to (001) formed by a combination of N—H...O and O—H...O hydrogen bonds and π–π stacking interactions. Both the N—H...O and O—H...O hydrogen bonds generate inversion dimers.
IUCrData, 2017
With the pyrazolyl andp-tolyl groups lying to one side of the plane through the linking 1,2,4-tri... more With the pyrazolyl andp-tolyl groups lying to one side of the plane through the linking 1,2,4-triazole-5-thione residue [forming dihedral angles of 87.05 (8) and 81.41 (7)°, respectively], the title molecule, C15H17N5S, adopts a…
Tikrit Journal of Pure Science, 2010
Two series of Chalcones (3a-j) and Imines (4a-j) have been synthesized in high yield via simple a... more Two series of Chalcones (3a-j) and Imines (4a-j) have been synthesized in high yield via simple and convenient solventfree process from the same starting material p-amino acetophenone with different substituted benzaldehydes(2a-j) by using the catalysts sodium hydroxide and acetic acid respectively. The structure of the synthesized compounds were elucidated spectroscopically using FT-IR, 1 H-NMR, 13 C-NMR and 13 C-Dept 135 spectra.
Egyptian Journal of Chemistry, 2022
This work synthesized a new series of pyrazoline compounds containing azo linkages via classical ... more This work synthesized a new series of pyrazoline compounds containing azo linkages via classical and one-pot three-component reactions. The progress started with 3-chloro,4-methyl aniline, which has been diazotized and coupled with 4-hydroxy acetophenone to form azo compound 1-(3-((3-chloro-4-methyl phenyl) diazenyl)-4-hydroxyphenyl) ethan-1-one (1) and converted to 1-(4-(benzyloxy)-3-((3-chloro-4-methyl phenyl) diazenyl) phenyl) ethan-1-one (2). The later azo compound was subjected to both classical and one-pot methods to give target pyrazoline derivatives. The structure of all newly obtained compounds was supported by spectral data (1 H-NMR, 13 CNMR, Dept.135, and FT-IR). Finally, some pyrazoline derivatives were estimated for their antibacterial activity against Escherichia coli as gram-negative and Staphylococcus aureus as grampositive. The results showed significant activity against both types of bacteria.
New Journal of Chemistry
In this study, Zinc Oxide Nanoparticles (ZnO NPs) produced utilizing Dill (Anethum graveolens) le... more In this study, Zinc Oxide Nanoparticles (ZnO NPs) produced utilizing Dill (Anethum graveolens) leaf extract and as a very efficient nanocatalyst, have been used for the green preparation of 1H-pyrazolo[1,2-a]pyridazine-5,8-diones...
Egyptian Journal of Chemistry, Nov 1, 2022
Egyptian Journal of Chemistry
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Papers by farouq emam hawaiz