Papers by emilio valladares
Physiological research, 2012
The aim of the present research was to study the uptake of DHEAS, and to establish the intracrine... more The aim of the present research was to study the uptake of DHEAS, and to establish the intracrine capacity of human platelets to produce sex steroid hormones. The DHEAS transport was evaluated through the uptake of [(3)H]-DHEAS in the presence or absence of different substrates through the organic anion transporting polypeptide (OATP) family. The activity of sulfatase enzyme was evaluated, and the metabolism of DHEAS was measured by the conversion of [(3)H]-DHEAS to [(3)H]-androstenedione, [(3)H]-testosterone, [(3)H]-estrone and [(3)H]-17beta-estradiol. Results indicated the existence in the plasma membrane of an OATP with high affinity for DHEAS and estrone sulphate (E(1)S). The platelets showed the capacity to convert DHEAS to active DHEA by the steroid-sulfatase activity. The cells resulted to be a potential site for androgens production, since they have the capacity to produce androstenedione and testosterone; in addition, they reduced [(3)H]-estrone to [(3)H]-17beta-estradiol. ...
Razon Y Fe Revista Hispanoamericana De Cultura, 2012
Liturgia Y Parroquia Hoy La Parroquia Una Familia De Familias Jornadas Nacionales De Liturgia Celebradas Del 21 Al 24 De Octubre De 2008 En Alicante 2009 Isbn 978 84 7141 695 7 Pags 269 298, 2009
Experimental and Therapeutic Medicine, 2010
the aim of the present study was to identify the possible mechanisms by which certain estradiol r... more the aim of the present study was to identify the possible mechanisms by which certain estradiol receptor (Er)-positive mammary tumor cells remain resistant to treatment with anti-estrogens or inhibitors of local estradiol (E 2) production. to this end, we compared the proliferative effects on mammary cancer cells of the novel selective Er modulator 27-hydroxycholesterol (27Ohc) to those of E 2 , and evaluated their inhibition by ici 182,780 (ici). analysis of the effects on the cell cycle of 27Ohc and E 2 in the absence or presence of ici was conducted. in Er-positive mammary tumor cells, we detected the blocking of 27Ohc proliferationstimulatory activity by simvastatin, as well as the inhibition of E 2-stimulated proliferation by an α-fetoprotein-derived cyclic nonapeptide. the effects reported herein may be extrapolated to infiltrating mammary cancer, where the activity of local macrophages may stimulate tumor growth. We suggest that increased breast cancer growth in obese patients may be related to increased 27Ohc circulatory levels.
... Febrero 1980). DS Denzinger H.- Schónmetzer A., Enchiridion Symbolo-rum ..., Barcelona 1967. ... more ... Febrero 1980). DS Denzinger H.- Schónmetzer A., Enchiridion Symbolo-rum ..., Barcelona 1967. EDIL Enchiridion documentorum instaurationis liturgicae, Kac-zynski R. (ed.), I (1963-1973), Marieta 1976; II (4.12. 1973 - 4.12 ...
Oncology Reports, 2008
A cyclic peptide derived from the active domain of α-fetoprotein (AFP) significantly inhibited th... more A cyclic peptide derived from the active domain of α-fetoprotein (AFP) significantly inhibited the proliferation of MCF7 cells stimulated with the epidermal growth factor (EGF) or estradiol (E 2). The action of these three agents on cell growth was independent of the presence of calf serum in the culture medium. Our results demonstrated that the cyclic peptide interfered markedly with the regulation of MAPK by activated c-erbB2. The cyclic peptide showed no effect on the E 2-stimulated release of matrix metalloproteinases 2 and 9 nor on the shedding of heparin-binding EGF into the culture medium. We propose that the AFP-derived cyclic peptide represents a valuable novel antiproliferative agent for treating breast cancer.
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Papers by emilio valladares